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MCLAGNMDVSGLTPIEQTALLTEYCRALDSKAARPILGDRLAEKTVDQIDYDFTTLAATPSVVPLVALRA KMLDERLRAFTARHPDAVVVDLGAGFSSAVFRVDPPSTVDWYSVDLPAVIALREALLPVRDRDRSVPTSL LEPGWADSIPADRPTMLFADGLVAFLTEADVVAILRRITGHFASGVVAFNDYGPVSKLNRLLGRLATSSK TNSPHGQWNFPGFKDAHRPEAWNRDLTLLEEASVMQRPEGALFPAGLRLAAKLSHRVPAIARKARVLQYR F
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3107 | - | - | 100% (281) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3118 | - | 1e-40 | 44.51% (182) | O-methyltransferase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5704 | - | 5e-37 | 36.57% (268) | O-methyltransferase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-18 | 30.22% (182) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_3375 | - | 1e-110 | 69.04% (281) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 2e-19 | 30.77% (182) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1517c | - | 6e-62 | 43.27% (275) | O-methyltransferase Omt |
| M. marinum M | MMAR_2317 | - | 3e-49 | 40.50% (279) | O-methyltransferase |
| M. avium 104 | MAV_4048 | - | 1e-62 | 44.36% (275) | Omt protein |
| M. smegmatis MC2 155 | MSMEG_6473 | - | 2e-37 | 41.05% (190) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. thermoresistible (build 8) | TH_0783 | omt | 7e-25 | 32.81% (192) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 7e-17 | 27.34% (267) | O-methyltransferase Omt_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3107|M.vanbaalenii_PYR-1 --MCLAGNMDVSGLTPIEQTALLTEYCRALDSKAARPILGDRLAEKTVDQ
Mflv_3375|M.gilvum_PYR-GCK --MCLAGGMDVSGLAPIEQTALLTEYCRALDSRSARPILGDSHADATVRR
MAB_1517c|M.abscessus_ATCC_199 ------MGIDVSGITPEEETAFLTLKARAVNDGWRRPILRDPGATAAVSK
MAV_4048|M.avium_104 ------MGIDTSAITPEEETAFLTLQARAINNGWARPILPDPGAADAVTK
MMAR_2317|M.marinum_M ------MSIAMPAFSPAQESLFLTLGGRALDSRLPHPFLGDTIADEILGE
MSMEG_6473|M.smegmatis_MC2_155 -----MTDKLKVDLSGAPQTMLATFYAKALDARLPTPILGDDMAAEIAER
Mb1184c|M.bovis_AF2122/97 MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv MSAHKPAKQRVA-LTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
TH_0783|M.thermoresistible__bu VHESNPDKLDASTLSGVSETALMTLYGRAEQARHPQPIIDDPMAVRLVDR
MUL_4852|M.ulcerans_Agy99 ----MP-VIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
: :: : * :* : .:: * *
Mvan_3107|M.vanbaalenii_PYR-1 IDYDFTTLAATP-------SVVPLVALRAKMLDERLRAFTARHPDAVVVD
Mflv_3375|M.gilvum_PYR-GCK IDHDFASLGATP-------SVVALVALRAKMLDECLSRFVAADPSAVVVD
MAB_1517c|M.abscessus_ATCC_199 IDYDFHALGVIT-------PVVCQSSLRAKLLDDRVRAFVTEHPNAVVVD
MAV_4048|M.avium_104 IDYDFDGLGLVT-------PVVCQTSLRAKLLDDRVRAFIAQHADAVVVD
MMAR_2317|M.marinum_M TGYDLGKFPSLTTKLIDARTKVFDIAVRAKRLDEVAGRFIERHPDAIGLD
MSMEG_6473|M.smegmatis_MC2_155 IDYDWSRTAITP-------SRAPAVTTRSRHFDRWARQFLAVHPEAVVLH
Mb1184c|M.bovis_AF2122/97 IDFGFAKFGPTG----------QGFALRARAFDMAAQHYLDQHPAATVVA
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFGPTG----------QGFALRARAFDMAAQHYLDQHPAATVVA
TH_0783|M.thermoresistible__bu IDFDFTKFGRRG----------QEMALRSLAFDRAALRYLSDHPRATVVA
MUL_4852|M.ulcerans_Agy99 IDYPYHHFGRTH----------QATALRALAFDNSTRDFLQTRPGATVVA
.. : *: :* : . * :
Mvan_3107|M.vanbaalenii_PYR-1 LGAGFSSAVFRVD---PPSTVDWYSVDLPAVIALREALLPVRDRDRSVPT
Mflv_3375|M.gilvum_PYR-GCK LGAGLSSAAFRVD---PPPTVDWVNVDLPGVIGLRNAVVPAHERVRDVAA
MAB_1517c|M.abscessus_ATCC_199 MGAGLDDGYRRIQ---PPATVDWYSVDLPGMATLRDEVMPPGPGEHTVGI
MAV_4048|M.avium_104 LGAGLDDGYARVN---PPDTVDWYSVELPGLAALRDKVMPPGPHEHTIGI
MMAR_2317|M.marinum_M LGAGLDSRVLRIN---PPSTVGWYDVDFPQIVDLRRRLLPAQVGAHNIGA
MSMEG_6473|M.smegmatis_MC2_155 LGCGLDGRFFRLA---PGPGVEWFDVDYPEVIDLRSQLYPEHARCHLVSA
Mb1184c|M.bovis_AF2122/97 LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
Rv1153c|M.tuberculosis_H37Rv LAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQ
TH_0783|M.thermoresistible__bu LAEGLQTTFWRVTDAIPDARFRWLTIDLPPIIELRERLLPAEPRIVTLAQ
MUL_4852|M.ulcerans_Agy99 LAEGLQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQ
:. *:. *: . * :: . : ** : *
Mvan_3107|M.vanbaalenii_PYR-1 SLLEPGWADSIPADRPTMLFADGLVAFLTEADVVAILRRITGHFASGVVA
Mflv_3375|M.gilvum_PYR-GCK NVLEPDWVTAVPPDRPTIVFADGLFAFLDEDAVVSLLRRITGHFPSGVVA
MAB_1517c|M.abscessus_ATCC_199 SITDPNWLGGIPSDRPAMVIADGFFAFLTKEQIIATLRAITDHFSTGQLA
MAV_4048|M.avium_104 SVTDPEWISAIPADRPAIVIADGLFPFLNKEQIIAVMRAITDHFPAGQLA
MMAR_2317|M.marinum_M DLTDPNWLDEVPADRPAVIIADGLVAFLRQHDFAALLSRLTNHFASGEIA
MSMEG_6473|M.smegmatis_MC2_155 SVTDPAWLDEVPTGRPALMLGEGLTMYLTETEGLALLRRVVDRFGTGELQ
Mb1184c|M.bovis_AF2122/97 SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
Rv1153c|M.tuberculosis_H37Rv SALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQML
TH_0783|M.thermoresistible__bu SALDFSWMDRVDTDHGVLITAEGLLMYLQPDEAMTLIERCAARFPGGQML
MUL_4852|M.ulcerans_Agy99 SAFDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLV
. : * : ..: .:*: :* : . . * :
Mvan_3107|M.vanbaalenii_PYR-1 FNDYGPVSKLNRLLGRLATSSKTNSPHGQWNFPGFKDAHRPEAWNRDLTL
Mflv_3375|M.gilvum_PYR-GCK FNDYGRVSKANQVIGRLTSSRNANSPHRQWNFPGFKDARQPESWDPALRL
MAB_1517c|M.abscessus_ATCC_199 FNDYGRMVVG-VWISKLFPQKMFKKVNQLRGFEGYNDPRTPERWNPRLRF
MAV_4048|M.avium_104 FNDYGRMVIG-VWISKLFPQRMFKKVNQLRAFEGYNDPHTPERWSPKLTL
MMAR_2317|M.marinum_M FNLY---TTQAIWATKHLASLAAISAGVVN--PGFNDPRQPERWVAGLEL
MSMEG_6473|M.smegmatis_MC2_155 FDAFNTFGIRTQWTNTVVRRSGATLRWAIDRPDDILDT------VPGTRL
Mb1184c|M.bovis_AF2122/97 FDLPPRWFAGWSR-LGLRTSLRYKVP----RMPFSMSVAQAADLVNKVPG
Rv1153c|M.tuberculosis_H37Rv FDLPPRWFAGWSR-LGLRTSLRYKVP----RMPFSMSVAQAADLVNKVPG
TH_0783|M.thermoresistible__bu FDLPPVLLKKLAP-KGLRASRRYRVP----PMPFSLSPAQLARLADTVPG
MUL_4852|M.ulcerans_Agy99 FDSIPWLLSVYSRRRGFKLSEHYTAP----PMPFWFTADHYDELR-AIPG
*:
Mvan_3107|M.vanbaalenii_PYR-1 LEEASVMQRPEGALFPAGLRLAAKLSHRVPAIARKAR--VLQYRF----
Mflv_3375|M.gilvum_PYR-GCK LDESSAMHRPETAQFPTGLRIASRLSRRVPSIARKAR--VLQYRF----
MAB_1517c|M.abscessus_ATCC_199 VEEFNLVDAPEIELFPTWLRISSQLARYSTSMKRSAR--ILRFEF----
MAV_4048|M.avium_104 VEETSLASVPEVDLFPTWLRIATRMAGWSKRTARSAR--ILRFSF----
MMAR_2317|M.marinum_M AEEILLTRAPEVAELPLVTRLTSRLVAPSAAVSRMIGTTLVRYKF----
MSMEG_6473|M.smegmatis_MC2_155 LAWMSVFEDPVFDELAWHYRLLAKVMRPLSPLRYMAQ--YHRYAF----
Mb1184c|M.bovis_AF2122/97 VVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLT-LLEFSRPARG
Rv1153c|M.tuberculosis_H37Rv VVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLT-LLEFSRPARG
TH_0783|M.thermoresistible__bu VRAVHDLPMPEGRGFFFRAVFPRFWQARPTRQWRGAYT-LLEFG-----
MUL_4852|M.ulcerans_Agy99 VRAVRELPAPAGRGRFLRWALPVAYRLPGLGRLRAPVT-LVEFG-----
* : .: