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VQLLVLPRIRYADGRAPPNLGAGGVMGREAAGLNLHGEAMLDAVFEHLYNAMVITDADFDGGPFFQRCNP AFCAMTGYTEEELIGQSPRILQGPETDRKVIDELERKIRAGEFFEGSTINYRKDGLSYVVQWNISPVRDA DGAIVAYVSIQQDITARLAAERERSLLAEALNAATDPVIVMDKNFIIVFANNAFGREVGRPVDDILGHSA FELRPRTAEGLAEPQIRRVLAEGSPYHGVVSFEAPTGKRLHVDLSISSLIGYHDPNGHYVAIAPNITHMV EQQMVLQEMANMDALTGLLNRRSGQIALEIELQKAAESGAPISVAMGDIDHFKRINDRLGHAVGDDVLRS VAGSLRDGLRRNDVAIRWGGEEFLVFLPNTPLDDAVPLTERIRNHVATTPQIASDSVTMSFGVGQWRPGE SVAAFVERIDAAMYEAKSGGRDRVVSSP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5593 | - | - | 100% (448) | diguanylate cyclase with PAS/PAC sensor |
M. vanbaalenii PYR-1 | Mvan_3629 | - | 2e-27 | 28.36% (402) | diguanylate cyclase with PAS/PAC sensor |
M. vanbaalenii PYR-1 | Mvan_2109 | - | 6e-27 | 27.96% (422) | diguanylate cyclase with PAS/PAC sensor |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1389c | - | 5e-17 | 35.54% (166) | hypothetical protein Mb1389c |
M. gilvum PYR-GCK | Mflv_2883 | - | 3e-29 | 29.68% (411) | diguanylate cyclase with PAS/PAC sensor |
M. tuberculosis H37Rv | Rv1354c | - | 6e-17 | 35.54% (166) | hypothetical protein Rv1354c |
M. leprae Br4923 | MLBr_00397 | - | 9e-22 | 31.67% (281) | putative transporter protein |
M. abscessus ATCC 19977 | MAB_0124 | - | 3e-16 | 30.98% (184) | hypothetical protein MAB_0124 |
M. marinum M | - | - | - | - | - |
M. avium 104 | MAV_3132 | - | 4e-15 | 35.15% (165) | GGDEF domain-containing protein |
M. smegmatis MC2 155 | MSMEG_2196 | - | 1e-16 | 34.71% (170) | sensory box/response regulator |
M. thermoresistible (build 8) | TH_0811 | - | 1e-19 | 35.29% (170) | sensory box/response regulator |
M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF MSMEG_2196|M.smegmatis_MC2_155 -----MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF TH_0811|M.thermoresistible__bu -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF MAV_3132|M.avium_104 -----MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSHFGVNFGF Mvan_5593|M.vanbaalenii_PYR-1 ------MQLLVLPRIRYADGRAPPNLGAGGVMGREAAGLNLHGEAMLDAV Mflv_2883|M.gilvum_PYR-GCK --MRRLSTSAVVLLTFPPVFALSIVAGRATRLGGSEVALVWPAAAVAVMW MAB_0124|M.abscessus_ATCC_1997 ----------------MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGL MLBr_00397|M.leprae_Br4923 -----------------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRI : Mb1389c|M.bovis_AF2122/97 LRHNDRDRR-------------------ATRLVAEWPPRLNIPDPDP--- Rv1354c|M.tuberculosis_H37Rv LRHNDRDRR-------------------ATRLVAEWPPRLNIPDPDP--- MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAH-------------------ATRLVAEWPPRPVDAATDP--- TH_0811|M.thermoresistible__bu LRHNDHEIR-------------------ASKLIAEWPVRENVPDPDP--- MAV_3132|M.avium_104 LRHNDHSIR-------------------ATVLVAEWPPR--NVDPDP--- Mvan_5593|M.vanbaalenii_PYR-1 FEHLYNAMV-------------------ITDADFDGGPFFQRCNPAF--- Mflv_2883|M.gilvum_PYR-GCK LLAVHHCSLRQRAIHVTLLGILAYGMNVATGATVSLSAWFVLVNVVLAVV MAB_0124|M.abscessus_ATCC_1997 LCLSIVVLG----------------------------------------- MLBr_00397|M.leprae_Br4923 ESINPAATR----------------------------------------- Mb1389c|M.bovis_AF2122/97 -LRLIYFADADPVFALCEHAK----------------------------- Rv1354c|M.tuberculosis_H37Rv -LRLIYFADADPVFALCEHAK----------------------------- MSMEG_2196|M.smegmatis_MC2_155 -IAVVHFADADPVFAMAEHLK----------------------------- TH_0811|M.thermoresistible__bu -IGVVHFEGADPVFALAEHAK----------------------------- MAV_3132|M.avium_104 -LGVIYFADADSVFARVETMK----------------------------- Mvan_5593|M.vanbaalenii_PYR-1 -CAMTGYTEEELIGQSPRILQ----------------------------- Mflv_2883|M.gilvum_PYR-GCK TVGLLHYGRSDAVLRDPADLARLVVAVATGTMCAAVLATLYLTPVTGAPA MAB_0124|M.abscessus_ATCC_1997 --TLIQFHPLGPHGLWPRLIHG---------------------------- MLBr_00397|M.leprae_Br4923 ---ILGLRAHDVVDMKHGHPFC---------------------------- : Mb1389c|M.bovis_AF2122/97 -----------------------------------EPLVFRPEPATEDYQ Rv1354c|M.tuberculosis_H37Rv -----------------------------------EPLVFRPEPATEDYQ MSMEG_2196|M.smegmatis_MC2_155 -----------------------------------EPAVFRPEPLYDDYQ TH_0811|M.thermoresistible__bu -----------------------------------EIHIFRPEPATDEFQ MAV_3132|M.avium_104 -----------------------------------EPDVLRPEPANADYQ Mvan_5593|M.vanbaalenii_PYR-1 -----------------------------------GPETDR--KVIDELE Mflv_2883|M.gilvum_PYR-GCK WETFALFTARNGASALVGVAVWLCLRDVPWKRPRVRPAMLVEGLVVGTIV MAB_0124|M.abscessus_ATCC_1997 --------------------------------------VLVASALVVGMC MLBr_00397|M.leprae_Br4923 --------------------------------------FYDTDNQRVDLE Mb1389c|M.bovis_AF2122/97 RLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI Rv1354c|M.tuberculosis_H37Rv RLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI MSMEG_2196|M.smegmatis_MC2_155 RTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAI TH_0811|M.thermoresistible__bu RLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAI MAV_3132|M.avium_104 RNIEDGTGIPEVSLAAVPLLSGDVTTGTLGFVKFGDREWLSEELNALQAI Mvan_5593|M.vanbaalenii_PYR-1 RKIRAGEFFEGSTINYR--------KDGLSYVVQWNISPVRDADGAIVAY Mflv_2883|M.gilvum_PYR-GCK VFVFAWSFWLNTGTPMTFVVLLPTTWVALRYSTPVSTLFVIAAANWIVFA MAB_0124|M.abscessus_ATCC_1997 WVVLPWP-RRRVAIAFVWWADISMVVGACTLSAPASRLGALAHMGLIGVF MLBr_00397|M.leprae_Br4923 REVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVS : . : Mb1389c|M.bovis_AF2122/97 AT------LFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLA Rv1354c|M.tuberculosis_H37Rv AT------LFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLA MSMEG_2196|M.smegmatis_MC2_155 AS------LFAQVQARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLA TH_0811|M.thermoresistible__bu AS------LFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLAHLDARLA MAV_3132|M.avium_104 AA------LFAQLQARVVAEEQIHYLAEHDELTGLLNRRALIAHLDKRLA Mvan_5593|M.vanbaalenii_PYR-1 VS------IQQDITARLAAER---------------ERSLLAEALNAATD Mflv_2883|M.gilvum_PYR-GCK TLSDRGPLLASDLQVRALLAQGMVFSLTVIVLALALYRDTRVRLIAELEA MAB_0124|M.abscessus_ATCC_1997 AA------------------------------------------------ MLBr_00397|M.leprae_Br4923 FS---------DISAHHLSIERLTYEATHDCLTGLANRRFAEDQITKSLQ Mb1389c|M.bovis_AF2122/97 PGQPG-PVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESL Rv1354c|M.tuberculosis_H37Rv PGQPG-PVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESL MSMEG_2196|M.smegmatis_MC2_155 PGQPG-PVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKL TH_0811|M.thermoresistible__bu AGQPG-PVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDL MAV_3132|M.avium_104 PGQPG-PVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSV Mvan_5593|M.vanbaalenii_PYR-1 P--------VIVMDKN----------------FIIVFANNAFGREVGRPV Mflv_2883|M.gilvum_PYR-GCK SRDQA-DQDSELLGAVLDSIHDGVILVDPADRVVLRNARADDSGLVDEVV MAB_0124|M.abscessus_ATCC_1997 --------------------------------FLLGWRVLAVHCVFATVA MLBr_00397|M.leprae_Br4923 HDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRLRSAVRPDDV .: Mb1389c|M.bovis_AF2122/97 IARLGG------DEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL Rv1354c|M.tuberculosis_H37Rv IARLGG------DEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL MSMEG_2196|M.smegmatis_MC2_155 IARLGG------DEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGEML TH_0811|M.thermoresistible__bu IARLGG------DEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGEML MAV_3132|M.avium_104 IARFGG------DEFGVVPAAPMDVEAAESFAHSLHERLHHPIAIDDEML Mvan_5593|M.vanbaalenii_PYR-1 DDILGH------SAFELRPR----------TAEGLAEPQIRRVLAEGSPY Mflv_2883|M.gilvum_PYR-GCK AAARAVGHGGADGPEPAVPHDVIVSVEDSRTLELTTTPLPRQPQFDVMAF MAB_0124|M.abscessus_ATCC_1997 IFGLMG-----------------------WNVRLGEATWFDQYVYSAPAL MLBr_00397|M.leprae_Br4923 VARLGG------DEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQLTV Mb1389c|M.bovis_AF2122/97 TRTVSIG-----------VASGTPGQHTPSDLLRRADQAALAAKHAGGDS Rv1354c|M.tuberculosis_H37Rv TRTVSIG-----------VASGTPGQHTPSDLLRRADQAALAAKHAGGDS MSMEG_2196|M.smegmatis_MC2_155 TRTVSIG-----------IAQGIPGKDSTSDVLNRADHAVLTAKGSGGNR TH_0811|M.thermoresistible__bu TRTASIG-----------VAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQ MAV_3132|M.avium_104 SRTVSIG-----------VAAGIPGDESTSDLLRRVDQATRSAKAAGGNN Mvan_5593|M.vanbaalenii_PYR-1 HGVVSFE-----------APTG-----------KRLHVDLSISSLIG--- Mflv_2883|M.gilvum_PYR-GCK RDVTEVRRNARELREARDLFAGVLQAASEQAIIGTDQDGLITVFNQGAER MAB_0124|M.abscessus_ATCC_1997 SSVVLLP------------------------------------------- MLBr_00397|M.leprae_Br4923 PIGASVG----------ILEVRPDDRRRAADILRDADSAMYAAKNKKQCA . . Mb1389c|M.bovis_AF2122/97 VAIFTADMSV------------------SGELRNDIELHLRRGIES--DA Rv1354c|M.tuberculosis_H37Rv VAIFTADMSV------------------SGELRNDIELHLRRGIES--DA MSMEG_2196|M.smegmatis_MC2_155 VAVFSDAMAM------------------EIDFRNDIELHLQSVIEG--GA TH_0811|M.thermoresistible__bu ITVFTDDMSL------------------EAEFRNDIELHLQSVIQD--EA MAV_3132|M.avium_104 VATFRPEMST------------------IDTIRNDIELYLEGMIDGGSGA Mvan_5593|M.vanbaalenii_PYR-1 --------------------------------YHDPNGHYVAIAPN---- Mflv_2883|M.gilvum_PYR-GCK LLGWTAEEMIGRPVTDVHDLAEMIVRADELGVPPGFEAFIANVTPDDAEI MAB_0124|M.abscessus_ATCC_1997 -------------------------------------IIIQVVVEG---- MLBr_00397|M.leprae_Br4923 VTPQQLVPFVALIALFVFFT------AAAGAKFYAPSNLLVILQQTVVLA Mb1389c|M.bovis_AF2122/97 LRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGE Rv1354c|M.tuberculosis_H37Rv LRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGE MSMEG_2196|M.smegmatis_MC2_155 LVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGE TH_0811|M.thermoresistible__bu LLLHFLPEVDMRTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGE MAV_3132|M.avium_104 LVLHYLPEFDMRTGEILGTEALTRWQHPTLGLLMPDSFIQVAESINLGAK Mvan_5593|M.vanbaalenii_PYR-1 --ITHMVEQQMVLQEMANMDALTGLLNRRSGQIALEIELQKAAESGAP-- Mflv_2883|M.gilvum_PYR-GCK REWTYVRRDGSHAEVSLAISQMSDADGCCVGYIGVATDITERKKAEHALA MAB_0124|M.abscessus_ATCC_1997 -----GRRSLKAISLAAHQDPLTGLLNRRGVQVALSSLLSGQR------- MLBr_00397|M.leprae_Br4923 IVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGL : : : Mb1389c|M.bovis_AF2122/97 LDRWVLRRACN------EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDF Rv1354c|M.tuberculosis_H37Rv LDRWVLRRACN------EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDF MSMEG_2196|M.smegmatis_MC2_155 LGRWVLRTACA------EFSRWRANGVGRNIVLRINVSPVQLVTDGFVES TH_0811|M.thermoresistible__bu LGRWVMRTACG------EFAKWRAEGIGLDAVLRINVSPVQLVTDGFVAS MAV_3132|M.avium_104 LGRLVMRSACA------QFGQWRSRGVGQGTVLRINVSPVQLVTAGIVDT Mvan_5593|M.vanbaalenii_PYR-1 -----ISVAMG------DIDHFK----------RINDRLGHAVGDDVLRS Mflv_2883|M.gilvum_PYR-GCK ESEERFRSAFDT--APMGMFMFTVTPEDAGRITRCNQALADFLGRSTSEV MAB_0124|M.abscessus_ATCC_1997 -----------------ATRIVAVVLVDVDELKELNDRLGHDAGDESIRA MLBr_00397|M.leprae_Br4923 AAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILG . . Mb1389c|M.bovis_AF2122/97 VADTIGQHGLDA-------------------------------------- Rv1354c|M.tuberculosis_H37Rv VADTIGQHGLDA-------------------------------------- MSMEG_2196|M.smegmatis_MC2_155 VAGIMKEFGLPR-------------------------------------- TH_0811|M.thermoresistible__bu VADIIDEFGLDG-------------------------------------- MAV_3132|M.avium_104 VAATLDEFGLDP-------------------------------------- Mvan_5593|M.vanbaalenii_PYR-1 VAGSLRDG------------------------------------------ Mflv_2883|M.gilvum_PYR-GCK PGMSVTDLGTNENADGTEGLARLLALTDGEPVSAEVRFRRWDGDTMWGAV MAB_0124|M.abscessus_ATCC_1997 VAAMLATT------------------------------------------ MLBr_00397|M.leprae_Br4923 AMGAMPWILIVC-------------------------------------- : Mb1389c|M.bovis_AF2122/97 -----SSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAI Rv1354c|M.tuberculosis_H37Rv -----SSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAI MSMEG_2196|M.smegmatis_MC2_155 -----GSVCLEITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVL TH_0811|M.thermoresistible__bu -----SSVCLEITESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVL MAV_3132|M.avium_104 -----STVCLEITESVVVQDIDATRQTLFGLKDIGVQIAIDDFGTGYSVL Mvan_5593|M.vanbaalenii_PYR-1 ----------------------------LRRNDVAIRWGGEEF-----LV Mflv_2883|M.gilvum_PYR-GCK SASVVAAAGADPYGICLVEDITSRKRAEAELQHLALHDPLTGLANRALLV MAB_0124|M.abscessus_ATCC_1997 ----------------------------TRASDLTARMGGDEF----MVV MLBr_00397|M.leprae_Br4923 ------LFVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAI . : Mb1389c|M.bovis_AF2122/97 SLLQTLPIDT------------------LKIDKTFVRQLGTNTSDLVIVR Rv1354c|M.tuberculosis_H37Rv SLLQTLPIDT------------------LKIDKTFVRQLGTNTSDLVIVR MSMEG_2196|M.smegmatis_MC2_155 SLLKSLPVDT------------------LKIDRSFVAELGSNPGDLPIVR TH_0811|M.thermoresistible__bu SHLKTLPVDT------------------LKIDKGFVQDLGNSPGDLAIVR MAV_3132|M.avium_104 TYLKSLPVDS------------------LKIDKGFVQSLDTNPGDLAIVR Mvan_5593|M.vanbaalenii_PYR-1 FLPNTPLDDA------------------VPLTERIRNHVATTP---QIAS Mflv_2883|M.gilvum_PYR-GCK DRVEQAIADIGRHAPACVGLLYLDLDGFKPVNDTWGHAAGDEVLNAVARR MAB_0124|M.abscessus_ATCC_1997 GFFDHADEAT-----------------------GLIERIGARRFGIGPHR MLBr_00397|M.leprae_Br4923 FAICGLTAGLGG----------------IVLASRLGAGTPTAATGFEIDV Mb1389c|M.bovis_AF2122/97 GIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMR Rv1354c|M.tuberculosis_H37Rv GIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMR MSMEG_2196|M.smegmatis_MC2_155 AVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQ TH_0811|M.thermoresistible__bu AIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPSNEMR MAV_3132|M.avium_104 STLALADAFGLDVVAEGVETVAAAETLLSLGCHRAQGFLLSRPLDSAGME Mvan_5593|M.vanbaalenii_PYR-1 DSVTMSFGVGQWRPGE---SVAAFVERIDAAMYEAKSGGRDRVVSSP--- Mflv_2883|M.gilvum_PYR-GCK IENSIRPGDTAARLGGDEFAVLCPVIKDSEALHGIAERIRREVRRPLRLR MAB_0124|M.abscessus_ATCC_1997 ASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIERRNGFHAVP----- MLBr_00397|M.leprae_Br4923 IAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKG : . . Mb1389c|M.bovis_AF2122/97 HMLSARRLPPTCIPATDPALS----------------------------- Rv1354c|M.tuberculosis_H37Rv HMLSARRLPPTCIPATDPALS----------------------------- MSMEG_2196|M.smegmatis_MC2_155 TLLAKGRVPVHFSAAPRM-------------------------------- TH_0811|M.thermoresistible__bu ELLARGRIPMRFSATP---------------------------------- MAV_3132|M.avium_104 ALLIKGAIPMRFSDGGAPENQHVV-------------------------- Mvan_5593|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_2883|M.gilvum_PYR-GCK AGRTYDRLSASTGAATSGGNSNAESLIAHTDRLMYRAKRNGKDRVADDLV MAB_0124|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00397|M.leprae_Br4923 IMLAAAVFVFLQRRKIGIIK------------------------------ Mb1389c|M.bovis_AF2122/97 ---- Rv1354c|M.tuberculosis_H37Rv ---- MSMEG_2196|M.smegmatis_MC2_155 ---- TH_0811|M.thermoresistible__bu ---- MAV_3132|M.avium_104 ---- Mvan_5593|M.vanbaalenii_PYR-1 ---- Mflv_2883|M.gilvum_PYR-GCK PVEG MAB_0124|M.abscessus_ATCC_1997 ---- MLBr_00397|M.leprae_Br4923 ----