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M. vanbaalenii PYR-1 Mvan_5593 (-)

annotation: diguanylate cyclase with PAS/PAC sensor
coordinates: 5972279 - 5973625
length: 448

VQLLVLPRIRYADGRAPPNLGAGGVMGREAAGLNLHGEAMLDAVFEHLYNAMVITDADFDGGPFFQRCNP
AFCAMTGYTEEELIGQSPRILQGPETDRKVIDELERKIRAGEFFEGSTINYRKDGLSYVVQWNISPVRDA
DGAIVAYVSIQQDITARLAAERERSLLAEALNAATDPVIVMDKNFIIVFANNAFGREVGRPVDDILGHSA
FELRPRTAEGLAEPQIRRVLAEGSPYHGVVSFEAPTGKRLHVDLSISSLIGYHDPNGHYVAIAPNITHMV
EQQMVLQEMANMDALTGLLNRRSGQIALEIELQKAAESGAPISVAMGDIDHFKRINDRLGHAVGDDVLRS
VAGSLRDGLRRNDVAIRWGGEEFLVFLPNTPLDDAVPLTERIRNHVATTPQIASDSVTMSFGVGQWRPGE
SVAAFVERIDAAMYEAKSGGRDRVVSSP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5593--100% (448)diguanylate cyclase with PAS/PAC sensor
M. vanbaalenii PYR-1Mvan_3629-2e-2728.36% (402) diguanylate cyclase with PAS/PAC sensor
M. vanbaalenii PYR-1Mvan_2109-6e-2727.96% (422) diguanylate cyclase with PAS/PAC sensor

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1389c-5e-1735.54% (166) hypothetical protein Mb1389c
M. gilvum PYR-GCKMflv_2883-3e-2929.68% (411) diguanylate cyclase with PAS/PAC sensor
M. tuberculosis H37RvRv1354c-6e-1735.54% (166) hypothetical protein Rv1354c
M. leprae Br4923MLBr_00397-9e-2231.67% (281) putative transporter protein
M. abscessus ATCC 19977MAB_0124-3e-1630.98% (184) hypothetical protein MAB_0124
M. marinum M-----
M. avium 104MAV_3132-4e-1535.15% (165) GGDEF domain-containing protein
M. smegmatis MC2 155MSMEG_2196-1e-1634.71% (170) sensory box/response regulator
M. thermoresistible (build 8)TH_0811-1e-1935.29% (170) sensory box/response regulator
M. ulcerans Agy99-----

CLUSTAL 2.0.9 multiple sequence alignment


Mb1389c|M.bovis_AF2122/97           MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv        MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
MSMEG_2196|M.smegmatis_MC2_155      -----MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu      -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
MAV_3132|M.avium_104                -----MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSHFGVNFGF
Mvan_5593|M.vanbaalenii_PYR-1       ------MQLLVLPRIRYADGRAPPNLGAGGVMGREAAGLNLHGEAMLDAV
Mflv_2883|M.gilvum_PYR-GCK          --MRRLSTSAVVLLTFPPVFALSIVAGRATRLGGSEVALVWPAAAVAVMW
MAB_0124|M.abscessus_ATCC_1997      ----------------MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGL
MLBr_00397|M.leprae_Br4923          -----------------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRI
                                                                                 :    

Mb1389c|M.bovis_AF2122/97           LRHNDRDRR-------------------ATRLVAEWPPRLNIPDPDP---
Rv1354c|M.tuberculosis_H37Rv        LRHNDRDRR-------------------ATRLVAEWPPRLNIPDPDP---
MSMEG_2196|M.smegmatis_MC2_155      LRHNDHRAH-------------------ATRLVAEWPPRPVDAATDP---
TH_0811|M.thermoresistible__bu      LRHNDHEIR-------------------ASKLIAEWPVRENVPDPDP---
MAV_3132|M.avium_104                LRHNDHSIR-------------------ATVLVAEWPPR--NVDPDP---
Mvan_5593|M.vanbaalenii_PYR-1       FEHLYNAMV-------------------ITDADFDGGPFFQRCNPAF---
Mflv_2883|M.gilvum_PYR-GCK          LLAVHHCSLRQRAIHVTLLGILAYGMNVATGATVSLSAWFVLVNVVLAVV
MAB_0124|M.abscessus_ATCC_1997      LCLSIVVLG-----------------------------------------
MLBr_00397|M.leprae_Br4923          ESINPAATR-----------------------------------------
                                                                                      

Mb1389c|M.bovis_AF2122/97           -LRLIYFADADPVFALCEHAK-----------------------------
Rv1354c|M.tuberculosis_H37Rv        -LRLIYFADADPVFALCEHAK-----------------------------
MSMEG_2196|M.smegmatis_MC2_155      -IAVVHFADADPVFAMAEHLK-----------------------------
TH_0811|M.thermoresistible__bu      -IGVVHFEGADPVFALAEHAK-----------------------------
MAV_3132|M.avium_104                -LGVIYFADADSVFARVETMK-----------------------------
Mvan_5593|M.vanbaalenii_PYR-1       -CAMTGYTEEELIGQSPRILQ-----------------------------
Mflv_2883|M.gilvum_PYR-GCK          TVGLLHYGRSDAVLRDPADLARLVVAVATGTMCAAVLATLYLTPVTGAPA
MAB_0124|M.abscessus_ATCC_1997      --TLIQFHPLGPHGLWPRLIHG----------------------------
MLBr_00397|M.leprae_Br4923          ---ILGLRAHDVVDMKHGHPFC----------------------------
                                       :                                              

Mb1389c|M.bovis_AF2122/97           -----------------------------------EPLVFRPEPATEDYQ
Rv1354c|M.tuberculosis_H37Rv        -----------------------------------EPLVFRPEPATEDYQ
MSMEG_2196|M.smegmatis_MC2_155      -----------------------------------EPAVFRPEPLYDDYQ
TH_0811|M.thermoresistible__bu      -----------------------------------EIHIFRPEPATDEFQ
MAV_3132|M.avium_104                -----------------------------------EPDVLRPEPANADYQ
Mvan_5593|M.vanbaalenii_PYR-1       -----------------------------------GPETDR--KVIDELE
Mflv_2883|M.gilvum_PYR-GCK          WETFALFTARNGASALVGVAVWLCLRDVPWKRPRVRPAMLVEGLVVGTIV
MAB_0124|M.abscessus_ATCC_1997      --------------------------------------VLVASALVVGMC
MLBr_00397|M.leprae_Br4923          --------------------------------------FYDTDNQRVDLE
                                                                                      

Mb1389c|M.bovis_AF2122/97           RLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI
Rv1354c|M.tuberculosis_H37Rv        RLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTI
MSMEG_2196|M.smegmatis_MC2_155      RTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAI
TH_0811|M.thermoresistible__bu      RLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAI
MAV_3132|M.avium_104                RNIEDGTGIPEVSLAAVPLLSGDVTTGTLGFVKFGDREWLSEELNALQAI
Mvan_5593|M.vanbaalenii_PYR-1       RKIRAGEFFEGSTINYR--------KDGLSYVVQWNISPVRDADGAIVAY
Mflv_2883|M.gilvum_PYR-GCK          VFVFAWSFWLNTGTPMTFVVLLPTTWVALRYSTPVSTLFVIAAANWIVFA
MAB_0124|M.abscessus_ATCC_1997      WVVLPWP-RRRVAIAFVWWADISMVVGACTLSAPASRLGALAHMGLIGVF
MLBr_00397|M.leprae_Br4923          REVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVS
                                      :                                         . :   

Mb1389c|M.bovis_AF2122/97           AT------LFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLA
Rv1354c|M.tuberculosis_H37Rv        AT------LFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLA
MSMEG_2196|M.smegmatis_MC2_155      AS------LFAQVQARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLA
TH_0811|M.thermoresistible__bu      AS------LFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLAHLDARLA
MAV_3132|M.avium_104                AA------LFAQLQARVVAEEQIHYLAEHDELTGLLNRRALIAHLDKRLA
Mvan_5593|M.vanbaalenii_PYR-1       VS------IQQDITARLAAER---------------ERSLLAEALNAATD
Mflv_2883|M.gilvum_PYR-GCK          TLSDRGPLLASDLQVRALLAQGMVFSLTVIVLALALYRDTRVRLIAELEA
MAB_0124|M.abscessus_ATCC_1997      AA------------------------------------------------
MLBr_00397|M.leprae_Br4923          FS---------DISAHHLSIERLTYEATHDCLTGLANRRFAEDQITKSLQ
                                                                                      

Mb1389c|M.bovis_AF2122/97           PGQPG-PVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESL
Rv1354c|M.tuberculosis_H37Rv        PGQPG-PVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESL
MSMEG_2196|M.smegmatis_MC2_155      PGQPG-PVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKL
TH_0811|M.thermoresistible__bu      AGQPG-PVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDL
MAV_3132|M.avium_104                PGQPG-PVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSV
Mvan_5593|M.vanbaalenii_PYR-1       P--------VIVMDKN----------------FIIVFANNAFGREVGRPV
Mflv_2883|M.gilvum_PYR-GCK          SRDQA-DQDSELLGAVLDSIHDGVILVDPADRVVLRNARADDSGLVDEVV
MAB_0124|M.abscessus_ATCC_1997      --------------------------------FLLGWRVLAVHCVFATVA
MLBr_00397|M.leprae_Br4923          HDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRLRSAVRPDDV
                                                                    .:                

Mb1389c|M.bovis_AF2122/97           IARLGG------DEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Rv1354c|M.tuberculosis_H37Rv        IARLGG------DEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
MSMEG_2196|M.smegmatis_MC2_155      IARLGG------DEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGEML
TH_0811|M.thermoresistible__bu      IARLGG------DEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGEML
MAV_3132|M.avium_104                IARFGG------DEFGVVPAAPMDVEAAESFAHSLHERLHHPIAIDDEML
Mvan_5593|M.vanbaalenii_PYR-1       DDILGH------SAFELRPR----------TAEGLAEPQIRRVLAEGSPY
Mflv_2883|M.gilvum_PYR-GCK          AAARAVGHGGADGPEPAVPHDVIVSVEDSRTLELTTTPLPRQPQFDVMAF
MAB_0124|M.abscessus_ATCC_1997      IFGLMG-----------------------WNVRLGEATWFDQYVYSAPAL
MLBr_00397|M.leprae_Br4923          VARLGG------DEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQLTV
                                                                                      

Mb1389c|M.bovis_AF2122/97           TRTVSIG-----------VASGTPGQHTPSDLLRRADQAALAAKHAGGDS
Rv1354c|M.tuberculosis_H37Rv        TRTVSIG-----------VASGTPGQHTPSDLLRRADQAALAAKHAGGDS
MSMEG_2196|M.smegmatis_MC2_155      TRTVSIG-----------IAQGIPGKDSTSDVLNRADHAVLTAKGSGGNR
TH_0811|M.thermoresistible__bu      TRTASIG-----------VAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQ
MAV_3132|M.avium_104                SRTVSIG-----------VAAGIPGDESTSDLLRRVDQATRSAKAAGGNN
Mvan_5593|M.vanbaalenii_PYR-1       HGVVSFE-----------APTG-----------KRLHVDLSISSLIG---
Mflv_2883|M.gilvum_PYR-GCK          RDVTEVRRNARELREARDLFAGVLQAASEQAIIGTDQDGLITVFNQGAER
MAB_0124|M.abscessus_ATCC_1997      SSVVLLP-------------------------------------------
MLBr_00397|M.leprae_Br4923          PIGASVG----------ILEVRPDDRRRAADILRDADSAMYAAKNKKQCA
                                       . .                                            

Mb1389c|M.bovis_AF2122/97           VAIFTADMSV------------------SGELRNDIELHLRRGIES--DA
Rv1354c|M.tuberculosis_H37Rv        VAIFTADMSV------------------SGELRNDIELHLRRGIES--DA
MSMEG_2196|M.smegmatis_MC2_155      VAVFSDAMAM------------------EIDFRNDIELHLQSVIEG--GA
TH_0811|M.thermoresistible__bu      ITVFTDDMSL------------------EAEFRNDIELHLQSVIQD--EA
MAV_3132|M.avium_104                VATFRPEMST------------------IDTIRNDIELYLEGMIDGGSGA
Mvan_5593|M.vanbaalenii_PYR-1       --------------------------------YHDPNGHYVAIAPN----
Mflv_2883|M.gilvum_PYR-GCK          LLGWTAEEMIGRPVTDVHDLAEMIVRADELGVPPGFEAFIANVTPDDAEI
MAB_0124|M.abscessus_ATCC_1997      -------------------------------------IIIQVVVEG----
MLBr_00397|M.leprae_Br4923          VTPQQLVPFVALIALFVFFT------AAAGAKFYAPSNLLVILQQTVVLA
                                                                                      

Mb1389c|M.bovis_AF2122/97           LRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGE
Rv1354c|M.tuberculosis_H37Rv        LRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGE
MSMEG_2196|M.smegmatis_MC2_155      LVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGE
TH_0811|M.thermoresistible__bu      LLLHFLPEVDMRTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGE
MAV_3132|M.avium_104                LVLHYLPEFDMRTGEILGTEALTRWQHPTLGLLMPDSFIQVAESINLGAK
Mvan_5593|M.vanbaalenii_PYR-1       --ITHMVEQQMVLQEMANMDALTGLLNRRSGQIALEIELQKAAESGAP--
Mflv_2883|M.gilvum_PYR-GCK          REWTYVRRDGSHAEVSLAISQMSDADGCCVGYIGVATDITERKKAEHALA
MAB_0124|M.abscessus_ATCC_1997      -----GRRSLKAISLAAHQDPLTGLLNRRGVQVALSSLLSGQR-------
MLBr_00397|M.leprae_Br4923          IVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGL
                                                         :          :     :           

Mb1389c|M.bovis_AF2122/97           LDRWVLRRACN------EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDF
Rv1354c|M.tuberculosis_H37Rv        LDRWVLRRACN------EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDF
MSMEG_2196|M.smegmatis_MC2_155      LGRWVLRTACA------EFSRWRANGVGRNIVLRINVSPVQLVTDGFVES
TH_0811|M.thermoresistible__bu      LGRWVMRTACG------EFAKWRAEGIGLDAVLRINVSPVQLVTDGFVAS
MAV_3132|M.avium_104                LGRLVMRSACA------QFGQWRSRGVGQGTVLRINVSPVQLVTAGIVDT
Mvan_5593|M.vanbaalenii_PYR-1       -----ISVAMG------DIDHFK----------RINDRLGHAVGDDVLRS
Mflv_2883|M.gilvum_PYR-GCK          ESEERFRSAFDT--APMGMFMFTVTPEDAGRITRCNQALADFLGRSTSEV
MAB_0124|M.abscessus_ATCC_1997      -----------------ATRIVAVVLVDVDELKELNDRLGHDAGDESIRA
MLBr_00397|M.leprae_Br4923          AAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILG
                                                                       .    .         

Mb1389c|M.bovis_AF2122/97           VADTIGQHGLDA--------------------------------------
Rv1354c|M.tuberculosis_H37Rv        VADTIGQHGLDA--------------------------------------
MSMEG_2196|M.smegmatis_MC2_155      VAGIMKEFGLPR--------------------------------------
TH_0811|M.thermoresistible__bu      VADIIDEFGLDG--------------------------------------
MAV_3132|M.avium_104                VAATLDEFGLDP--------------------------------------
Mvan_5593|M.vanbaalenii_PYR-1       VAGSLRDG------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK          PGMSVTDLGTNENADGTEGLARLLALTDGEPVSAEVRFRRWDGDTMWGAV
MAB_0124|M.abscessus_ATCC_1997      VAAMLATT------------------------------------------
MLBr_00397|M.leprae_Br4923          AMGAMPWILIVC--------------------------------------
                                        :                                             

Mb1389c|M.bovis_AF2122/97           -----SSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAI
Rv1354c|M.tuberculosis_H37Rv        -----SSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAI
MSMEG_2196|M.smegmatis_MC2_155      -----GSVCLEITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVL
TH_0811|M.thermoresistible__bu      -----SSVCLEITESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVL
MAV_3132|M.avium_104                -----STVCLEITESVVVQDIDATRQTLFGLKDIGVQIAIDDFGTGYSVL
Mvan_5593|M.vanbaalenii_PYR-1       ----------------------------LRRNDVAIRWGGEEF-----LV
Mflv_2883|M.gilvum_PYR-GCK          SASVVAAAGADPYGICLVEDITSRKRAEAELQHLALHDPLTGLANRALLV
MAB_0124|M.abscessus_ATCC_1997      ----------------------------TRASDLTARMGGDEF----MVV
MLBr_00397|M.leprae_Br4923          ------LFVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAI
                                                                    .                :

Mb1389c|M.bovis_AF2122/97           SLLQTLPIDT------------------LKIDKTFVRQLGTNTSDLVIVR
Rv1354c|M.tuberculosis_H37Rv        SLLQTLPIDT------------------LKIDKTFVRQLGTNTSDLVIVR
MSMEG_2196|M.smegmatis_MC2_155      SLLKSLPVDT------------------LKIDRSFVAELGSNPGDLPIVR
TH_0811|M.thermoresistible__bu      SHLKTLPVDT------------------LKIDKGFVQDLGNSPGDLAIVR
MAV_3132|M.avium_104                TYLKSLPVDS------------------LKIDKGFVQSLDTNPGDLAIVR
Mvan_5593|M.vanbaalenii_PYR-1       FLPNTPLDDA------------------VPLTERIRNHVATTP---QIAS
Mflv_2883|M.gilvum_PYR-GCK          DRVEQAIADIGRHAPACVGLLYLDLDGFKPVNDTWGHAAGDEVLNAVARR
MAB_0124|M.abscessus_ATCC_1997      GFFDHADEAT-----------------------GLIERIGARRFGIGPHR
MLBr_00397|M.leprae_Br4923          FAICGLTAGLGG----------------IVLASRLGAGTPTAATGFEIDV
                                                                                      

Mb1389c|M.bovis_AF2122/97           GIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMR
Rv1354c|M.tuberculosis_H37Rv        GIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMR
MSMEG_2196|M.smegmatis_MC2_155      AVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQ
TH_0811|M.thermoresistible__bu      AIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPSNEMR
MAV_3132|M.avium_104                STLALADAFGLDVVAEGVETVAAAETLLSLGCHRAQGFLLSRPLDSAGME
Mvan_5593|M.vanbaalenii_PYR-1       DSVTMSFGVGQWRPGE---SVAAFVERIDAAMYEAKSGGRDRVVSSP---
Mflv_2883|M.gilvum_PYR-GCK          IENSIRPGDTAARLGGDEFAVLCPVIKDSEALHGIAERIRREVRRPLRLR
MAB_0124|M.abscessus_ATCC_1997      ASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIERRNGFHAVP-----
MLBr_00397|M.leprae_Br4923          IAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKG
                                        :  .                                 .        

Mb1389c|M.bovis_AF2122/97           HMLSARRLPPTCIPATDPALS-----------------------------
Rv1354c|M.tuberculosis_H37Rv        HMLSARRLPPTCIPATDPALS-----------------------------
MSMEG_2196|M.smegmatis_MC2_155      TLLAKGRVPVHFSAAPRM--------------------------------
TH_0811|M.thermoresistible__bu      ELLARGRIPMRFSATP----------------------------------
MAV_3132|M.avium_104                ALLIKGAIPMRFSDGGAPENQHVV--------------------------
Mvan_5593|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK          AGRTYDRLSASTGAATSGGNSNAESLIAHTDRLMYRAKRNGKDRVADDLV
MAB_0124|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00397|M.leprae_Br4923          IMLAAAVFVFLQRRKIGIIK------------------------------
                                                                                      

Mb1389c|M.bovis_AF2122/97           ----
Rv1354c|M.tuberculosis_H37Rv        ----
MSMEG_2196|M.smegmatis_MC2_155      ----
TH_0811|M.thermoresistible__bu      ----
MAV_3132|M.avium_104                ----
Mvan_5593|M.vanbaalenii_PYR-1       ----
Mflv_2883|M.gilvum_PYR-GCK          PVEG
MAB_0124|M.abscessus_ATCC_1997      ----
MLBr_00397|M.leprae_Br4923          ----