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VSAGFTGLMLLAGKLSSRGADCRPDGESARLLALESFEILDTVPETPFDGLTALAAYVCGAPMALLSFVD ATRQWIKSRHGVDVAEIDREVSFCARTLAAASLLEIPDTHLDPRFAPHPMVTGDPHVRFYAGVPIVTGDG HALGALCVMDREPRTLSDPQRVHLQTLADQVLTLLQLRSRTRQTASEIDRRLAADAALRQQQRMLEAVLE HTDVLIFAKDVDGRFVMANRALEHVTRAESTLIGFTDHDFFDAEIADDYRRNDRRIMAGREWQVFSEEVV HPDGSVHTYRSTKFPLFDDGGEVIGTGGVSTDVTELVAARAAHAAAEQRWRALVEQSPAAVIVIDRDGGL SYVNPEAVTLLGGETAEQITAQPGLDFVPAHLRAAAQTLLEVALSGGTPARSQRGLLRRVDGTVIAVEFN GTVVDHSDERSVQLEVRDVSADAAAHAALKLSASTDPLTGALNRRGWDARVAALLADGAAMTVAVLDLDN FKSYNDAHGHTAGDALLQNFAAAAGASIRDGDVFARWGGEEFIVALPDTTPDQAERILNRLRNCVPYGQT CSIGYTAHTPADTLTDTVARADKALYEAKSRGRNQLRLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2109 | - | - | 100% (599) | diguanylate cyclase with PAS/PAC sensor |
| M. vanbaalenii PYR-1 | Mvan_5593 | - | 9e-27 | 27.96% (422) | diguanylate cyclase with PAS/PAC sensor |
| M. vanbaalenii PYR-1 | Mvan_3629 | - | 1e-24 | 28.32% (452) | diguanylate cyclase with PAS/PAC sensor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 8e-17 | 36.99% (173) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4251 | - | 0.0 | 66.89% (601) | diguanylate cyclase with PAS/PAC sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 8e-17 | 36.99% (173) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 6e-21 | 29.49% (295) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 6e-16 | 35.67% (171) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2738 | - | 1e-19 | 40.26% (154) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 6e-15 | 35.67% (171) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 2e-17 | 36.70% (188) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
MSMEG_2196|M.smegmatis_MC2_155 -----MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
Mvan_2109|M.vanbaalenii_PYR-1 ---------MSAGFTGLMLLAGKLSSRG---ADCRPDGESARLLALESFE
Mflv_4251|M.gilvum_PYR-GCK -----------MNVTGWCSLSGKIPGRGPSPGDAK-DDEVARLLALESFD
MAV_2738|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 -------------------------------MDHTTKCDAEQYFQAIVTS
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
Mvan_2109|M.vanbaalenii_PYR-1 ILDTVPETPFDGLTALAAYVCGAP----MALLSFVDATRQWIKSRHGVDV
Mflv_4251|M.gilvum_PYR-GCK ILDTPPEESFDGLTALAAYVCDVP----MALIGFLDAERQWLKSRQGVGH
MAV_2738|M.avium_104 ------------------------------MRLRADAGSVFYRTQQARML
MAB_3940c|M.abscessus_ATCC_199 -----------------------------MIVSYIRSTAWMGFLRQWWTE
MLBr_00397|M.leprae_Br4923 MADGVIVVDIDGRIESIN---------PAATRILGLRAHDVVDMKHGHPF
.:
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
Mvan_2109|M.vanbaalenii_PYR-1 AEIDREVSFCARTLAAA-SLLEIPDTHLDPRFAPHPMVTGDPHVRFYAGV
Mflv_4251|M.gilvum_PYR-GCK SEIARELSFCASTMGDGDTLIEIPDTRLDSRLAGHPMVTGDPHLRFYAGM
MAV_2738|M.avium_104 RIFLG------------------ATTFLYAYGVVFTLFPIRAGLTLSNPA
MAB_3940c|M.abscessus_ATCC_199 PVPTG----WLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQFSDTGPR
MLBr_00397|M.leprae_Br4923 CFYDTD---NQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNV
.
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNR---RA
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNR---RA
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNR---RA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNR---RA
Mvan_2109|M.vanbaalenii_PYR-1 PIVTGDGHALGALCVMDREPRTLSDPQRVHLQTLADQVLTLLQLRSRTRQ
Mflv_4251|M.gilvum_PYR-GCK PIRTAEGHALGTICVMDVEPRTLSDAQRSHLRTLADQVMNLLDLRRRARQ
MAV_2738|M.avium_104 GGIVAVGLGLGALAWLAARP------------------------------
MAB_3940c|M.abscessus_ATCC_199 SMIGRVIVGLCAVGSLGWALRWAVGPWPSLREAVAFVAFADIGIAVACWQ
MLBr_00397|M.leprae_Br4923 SLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTGLANR---RF
::
Mb1389c|M.bovis_AF2122/97 LLQHLDQRLAPGQ-PGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQR
Rv1354c|M.tuberculosis_H37Rv LLQHLDQRLAPGQ-PGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQR
MSMEG_2196|M.smegmatis_MC2_155 LMAHLEARLAPGQ-PGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQR
TH_0811|M.thermoresistible__bu LLAHLDARLAAGQ-PGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAER
Mvan_2109|M.vanbaalenii_PYR-1 TASEIDRRLAADA-ALRQQQRMLEAVLEHTDVLIFAKDVDGRFVMANRAL
Mflv_4251|M.gilvum_PYR-GCK YAVEMTRRLEIDE-ALRQQQRLLSGVLDHTDVLVYTKDVEGRFVMANNAV
MAV_2738|M.avium_104 ------DKPAPAT-VTAIVATPIVMAFHRVIIAEFVCLIAPMFLAMYLRA
MAB_3940c|M.abscessus_ATCC_199 DSDPLAGLVGTVL-FTPVG-AYVSFFLANRLLVAHVAWCAPMIIALSSRL
MLBr_00397|M.leprae_Br4923 AEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQR
. . .:
Mb1389c|M.bovis_AF2122/97 IGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIG
Rv1354c|M.tuberculosis_H37Rv IGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIG
MSMEG_2196|M.smegmatis_MC2_155 LQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVD
TH_0811|M.thermoresistible__bu LREGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVD
Mvan_2109|M.vanbaalenii_PYR-1 EHVTRAESTLIGFTDHDFFDAEIADDYRRNDRRIMAGREWQVFSEEVVHP
Mflv_4251|M.gilvum_PYR-GCK QHVTQADRSMIGATDYDFFDATVADSYRRNDRRIMETREWQVFSEDVVHP
MAV_2738|M.avium_104 FYSPRRGAALVAVLAG----------------------------------
MAB_3940c|M.abscessus_ATCC_199 FAEGTVGAAMTALVKVTS--------------------------------
MLBr_00397|M.leprae_Br4923 LRSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVD
: .
Mb1389c|M.bovis_AF2122/97 GEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTAD
Rv1354c|M.tuberculosis_H37Rv GEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTAD
MSMEG_2196|M.smegmatis_MC2_155 GEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDA
TH_0811|M.thermoresistible__bu GEMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDD
Mvan_2109|M.vanbaalenii_PYR-1 ----DGSVHTYRSTKFPLFDDGGEVIGTGGVSTDVTELVAAR-----AAH
Mflv_4251|M.gilvum_PYR-GCK ----DGSVHTYRSTKFPLISDSGEVLGVGGLSTDVTELAAAR-----AAH
MAV_2738|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 QLTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQ-CAVTPQQ
Mb1389c|M.bovis_AF2122/97 MSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQH
Rv1354c|M.tuberculosis_H37Rv MSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQH
MSMEG_2196|M.smegmatis_MC2_155 MAMEIDFRNDIELHLQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEH
TH_0811|M.thermoresistible__bu MSLEAEFRNDIELHLQSVIQDEALLLHFLPEVDMRTGEILATEALVRWHH
Mvan_2109|M.vanbaalenii_PYR-1 AAAEQRWRALVEQSPAAVIVIDRD--GGLSYVNPEAVTLLGGETAEQITA
Mflv_4251|M.gilvum_PYR-GCK EAAEERWRALVEQSPAPVIVVDAE--GALAYVNPEGLALLGVARGADVSL
MAV_2738|M.avium_104 ------------------------------------------------LS
MAB_3940c|M.abscessus_ATCC_199 ------------------------------------------MLLVVVLI
MLBr_00397|M.leprae_Br4923 LVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGMTFVIM
Mb1389c|M.bovis_AF2122/97 PTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALL
Rv1354c|M.tuberculosis_H37Rv PTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALL
MSMEG_2196|M.smegmatis_MC2_155 PTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVL
TH_0811|M.thermoresistible__bu PTRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVL
Mvan_2109|M.vanbaalenii_PYR-1 QPGLDFVPAHLRAAAQTLLEVALSGGTPARSQRGLLRRVDGTVIAVEFNG
Mflv_4251|M.gilvum_PYR-GCK LPAEDFIPPQLRRATQKLLDETMAGTRVVRGERGVLRRRDGTEITVEINA
MAV_2738|M.avium_104 VAALAVAPTPKLSIDYAIFVIAIIG---AAESFGLLTR------------
MAB_3940c|M.abscessus_ATCC_199 PAVIQFGIAVVRWDALAAQRDPLTGLLNRRGIYAEWQRLYG---------
MLBr_00397|M.leprae_Br4923 AGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVNGIVFA
.
Mb1389c|M.bovis_AF2122/97 RINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARA
Rv1354c|M.tuberculosis_H37Rv RINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARA
MSMEG_2196|M.smegmatis_MC2_155 RINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRT
TH_0811|M.thermoresistible__bu RINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRI
Mvan_2109|M.vanbaalenii_PYR-1 TVVDHSDERSVQLEVRDVSADAAAHAALKLSASTDPLTGALNRRGWDARV
Mflv_4251|M.gilvum_PYR-GCK TVVSHSGERSVQLEIRDVSEVAAAHAALEHSASTDPLTGVLNRKAWDARV
MAV_2738|M.avium_104 --------------------------ALVTAACTDPLTGLLNRAGWEIAT
MAB_3940c|M.abscessus_ATCC_199 -------------ELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHGTGD
MLBr_00397|M.leprae_Br4923 YGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGAMPWILIV
. .
Mb1389c|M.bovis_AF2122/97 TLAR------LKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQ
Rv1354c|M.tuberculosis_H37Rv TLAR------LKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQ
MSMEG_2196|M.smegmatis_MC2_155 TLTG------LHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAE
TH_0811|M.thermoresistible__bu TLEG------LNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQD
Mvan_2109|M.vanbaalenii_PYR-1 AALL------ADGAAMTVAVLDLDN------FKSYNDAHGHTAGDALLQN
Mflv_4251|M.gilvum_PYR-GCK ATLLPEV---SDTSPMTIAVIDLDN------FKTYNDTRGHTAGDALLQQ
MAV_2738|M.avium_104 ADLLSRTR--SATATVTVVALDIDN------FKTLNDTEGHVAGDEYLVR
MAB_3940c|M.abscessus_ATCC_199 RVLID--V--AHALTCGTTGTSVVGRSGGEEFLVVTVCPASAVAEFATRL
MLBr_00397|M.leprae_Br4923 CLFVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAIFAICG
.
Mb1389c|M.bovis_AF2122/97 LGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG-
Rv1354c|M.tuberculosis_H37Rv LGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG-
MSMEG_2196|M.smegmatis_MC2_155 LGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQG-
TH_0811|M.thermoresistible__bu LGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQG-
Mvan_2109|M.vanbaalenii_PYR-1 FAAAAGASIRDGDVFARWGGEEFIVALPDTTPDQAERILNRLRNCVPYGQ
Mflv_4251|M.gilvum_PYR-GCK FAGAAAACLGADDVFARWGGEEFIVALPGADPDRAEPILDRLRGHVPSEQ
MAV_2738|M.avium_104 CAAFWRQVAPAGAVLARFGGDEFAVCIADHHPTSAKADQFVASVRRHTPD
MAB_3940c|M.abscessus_ATCC_199 RQAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMY-
MLBr_00397|M.leprae_Br4923 LTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGT
: : . .
Mb1389c|M.bovis_AF2122/97 ---FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS------------
Rv1354c|M.tuberculosis_H37Rv ---FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS------------
MSMEG_2196|M.smegmatis_MC2_155 ---FLLSKPILGSEMQTLLAKGRVPVHFSAAPRM---------------
TH_0811|M.thermoresistible__bu ---FLLSRPIPSNEMRELLARGRIPMRFSATP-----------------
Mvan_2109|M.vanbaalenii_PYR-1 TCSIGYTAHTPADTLTDTVARADKALYEAKSRGRNQLRLL---------
Mflv_4251|M.gilvum_PYR-GCK TCSIGYTGHVPPEALTDTVIRADKALYQAKRRGKNRIARL---------
MAV_2738|M.avium_104 TSVGTASGAGASADIASLYAAADAELYSAKRRRRDPGLRPARG------
MAB_3940c|M.abscessus_ATCC_199 -----EAKHDGGDQSRILHADDDSEGRYLWRSGA---------------
MLBr_00397|M.leprae_Br4923 LIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK