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RRLSTSAVVLLTFPPVFALSIVAGRATRLGGSEVALVWPAAAVAVMWLLAVHHCSLRQRAIHVTLLGILA YGMNVATGATVSLSAWFVLVNVVLAVVTVGLLHYGRSDAVLRDPADLARLVVAVATGTMCAAVLATLYLT PVTGAPAWETFALFTARNGASALVGVAVWLCLRDVPWKRPRVRPAMLVEGLVVGTIVVFVFAWSFWLNTG TPMTFVVLLPTTWVALRYSTPVSTLFVIAAANWIVFATLSDRGPLLASDLQVRALLAQGMVFSLTVIVLA LALYRDTRVRLIAELEASRDQADQDSELLGAVLDSIHDGVILVDPADRVVLRNARADDSGLVDEVVAAAR AVGHGGADGPEPAVPHDVIVSVEDSRTLELTTTPLPRQPQFDVMAFRDVTEVRRNARELREARDLFAGVL QAASEQAIIGTDQDGLITVFNQGAERLLGWTAEEMIGRPVTDVHDLAEMIVRADELGVPPGFEAFIANVT PDDAEIREWTYVRRDGSHAEVSLAISQMSDADGCCVGYIGVATDITERKKAEHALAESEERFRSAFDTAP MGMFMFTVTPEDAGRITRCNQALADFLGRSTSEVPGMSVTDLGTNENADGTEGLARLLALTDGEPVSAEV RFRRWDGDTMWGAVSASVVAAAGADPYGICLVEDITSRKRAEAELQHLALHDPLTGLANRALLVDRVEQA IADIGRHAPACVGLLYLDLDGFKPVNDTWGHAAGDEVLNAVARRIENSIRPGDTAARLGGDEFAVLCPVI KDSEALHGIAERIRREVRRPLRLRAGRTYDRLSASTGAATSGGNSNAESLIAHTDRLMYRAKRNGKDRVA DDLVPVEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2883 | - | - | 100% (849) | diguanylate cyclase with PAS/PAC sensor |
| M. gilvum PYR-GCK | Mflv_0999 | - | 4e-29 | 33.83% (266) | response regulator receiver modulated diguanylate |
| M. gilvum PYR-GCK | Mflv_2740 | - | 1e-26 | 43.12% (160) | diguanylate cyclase/phosphodiesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 8e-23 | 31.42% (226) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 8e-23 | 31.42% (226) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01419 | - | 8e-28 | 25.40% (504) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_1867 | - | 1e-17 | 38.06% (155) | hypothetical protein MAB_1867 |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1410 | - | 3e-22 | 34.92% (252) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 8e-17 | 28.05% (221) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 1e-20 | 30.45% (220) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3629 | - | 0.0 | 68.24% (847) | diguanylate cyclase with PAS/PAC sensor |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 MKRWAVNPWRRSGVPARVGWLLAGGYGTAALLVLLSSVRGWRGPYGTRPV
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 DDLVMFVCLAVAAMCAARAARAASGRRRYGWLALTTALLGWAVGEVIWAV
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 YDVRPEFEHAAHPAAAEMVLLLFPVGAMTSLVLLSQLSRHSPRRLLLDGL
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 IVATSLFVISWVFVVEAQLREHTGTQVATLAEVFNDIVLMTTAILTLSRA
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 RPGDRPSRSLLACGIATISVTDIAMVFYTGIGSYHTDDIGDLARVAGVGT
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 LALAGLASVYEQPAPGSPDEIEFRTRLWLPYLPLILAAAVGWGHAAGKAI
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 HEPMLAALGILVAAVLARQFVVLVDNQNLLSEVAREAFRDNLTGLANRAL
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 FVHRLEQAVARRHPDGTPIAVLCLDLDNFKAVNDALGHPAGDELLVRVAE
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 RLTAALGDSGTIARLGGDEFAAVIEASVDESQAAAHRILEAFTGAILIDG
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 IPITVRPSIGFTVCTGASTCTVDQLLRHADLAMYAAKREGGQCIRSFMPD
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 LPLPYAFPPPPGSAAPTAVAAVAAGGNGAAPASPPQVATAATSSPSPHDA
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK ----MRRLSTSAVVLLTFPPVFALSIVAGRATRLGGSEVALVWPAAAVAV
Mvan_3629|M.vanbaalenii_PYR-1 ----MKRLSPSAVAFLTFPVVYAVSILAGRATRLGGGEIALVWPAAAVAT
Mb1389c|M.bovis_AF2122/97 --MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDV
Rv1354c|M.tuberculosis_H37Rv --MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDV
MSMEG_2196|M.smegmatis_MC2_155 -------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDV
TH_0811|M.thermoresistible__bu -------VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDF
MAV_1410|M.avium_104 ARRPPRGIRAALGMLAIGVVAFSVSSVAHPDAGHGIFSATALYSALNAVA
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 -------MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQRLVDHSP
Mflv_2883|M.gilvum_PYR-GCK MWLLAVHHCSLRQRAIHVTLLGILAYGMNVATGATVSLSAWFVLVN--VV
Mvan_3629|M.vanbaalenii_PYR-1 VWLLAARRFSRWQRVAHLSALALATFVVNLFTHATPQLSAWFVLVN--LA
Mb1389c|M.bovis_AF2122/97 SFLRHNDRD----------------------RRATRLVAEWPPRL---NI
Rv1354c|M.tuberculosis_H37Rv SFLRHNDRD----------------------RRATRLVAEWPPRL---NI
MSMEG_2196|M.smegmatis_MC2_155 SFLRHNDHR----------------------AHATRLVAEWPPRP---VD
TH_0811|M.thermoresistible__bu SFLRHNDHE----------------------IRASKLIAEWPVRE---NV
MAV_1410|M.avium_104 AGLIALRACRIPADRWAWALIAAG---MACSAVGDVVYAVWVPDGRSPSV
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 NMTCVHESGR--------------------VTYLNPVGVKWMAAQSPEQI
Mflv_2883|M.gilvum_PYR-GCK LAVVTVGLLHYGRSDAVLRDPADLARLVVAVATGTMCAAVLATLYLTPVT
Mvan_3629|M.vanbaalenii_PYR-1 LALVTVEIIHYRRDEVVLRDPTDLVRVIVAVTAGTVCAAALATMYLVPVT
Mb1389c|M.bovis_AF2122/97 PDPDPLRLIYFADADPVFALCEHAKEPLVFRPE---PATEDYQRLIEEAR
Rv1354c|M.tuberculosis_H37Rv PDPDPLRLIYFADADPVFALCEHAKEPLVFRPE---PATEDYQRLIEEAR
MSMEG_2196|M.smegmatis_MC2_155 AATDPIAVVHFADADPVFAMAEHLKEPAVFRPE---PLYDDYQRTIEAGR
TH_0811|M.thermoresistible__bu PDPDPIGVVHFEGADPVFALAEHAKEIHIFRPE---PATDEFQRLIEESS
MAV_1410|M.avium_104 ADPEYLAYYPFVYAGLLLLMRARLKRLPIAVQLDSVVCALTLAAVAAALT
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 IGHPLIEFVHPDSMPAMMSRIAPLREVGDASQP----SEAVLLRLDGTTL
Mflv_2883|M.gilvum_PYR-GCK GAPAWETFALFTARNGA------------SALVGVAVWLCLRDVP-----
Mvan_3629|M.vanbaalenii_PYR-1 GAPAWETFGLFTARNGA------------TALIGVAAWLRLRDVR-----
Mb1389c|M.bovis_AF2122/97 GVPVTSAAAVPLVSG--------------EITTGLLGFIKFGDRK-----
Rv1354c|M.tuberculosis_H37Rv GVPVTSAAAVPLVSG--------------EITTGLLGFIKFGDRK-----
MSMEG_2196|M.smegmatis_MC2_155 HIPATSMACVPLLSG--------------DVTTGVLGFVKFGDRE-----
TH_0811|M.thermoresistible__bu GVPASTVAAVPLVSG--------------EITTGVLGFVKYGDRQ-----
MAV_1410|M.avium_104 AGPLHQAAVHAPKTVWVGLAYPWCDLMLLALAAGMLPILGWRNEIRWALL
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 EVEAVSVLTVWEGKPAY------------QVIFRDLTTQKAAEET-----
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------WKRP--
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------WTRP--
Mb1389c|M.bovis_AF2122/97 --------------------------------------------WHEA--
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------WHEA--
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------WLPA--
TH_0811|M.thermoresistible__bu --------------------------------------------WHPD--
MAV_1410|M.avium_104 VAGLVLFAVADGAYLFQTAAGSYRVGSLLDVCWPASSVLIAMASWAPPPA
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK -------RVRPAMLVEGLVVGTIVVFVFAWSFWLNTGTPMTFVVLLPTTW
Mvan_3629|M.vanbaalenii_PYR-1 -------RLSPAATVEIIVTGGVVGFVLVWIFWLSTGIPLGFLVLLPAMW
Mb1389c|M.bovis_AF2122/97 -------ELN-------------------------------ALMTIATLF
Rv1354c|M.tuberculosis_H37Rv -------ELN-------------------------------ALMTIATLF
MSMEG_2196|M.smegmatis_MC2_155 -------ELN-------------------------------ALKAIASLF
TH_0811|M.thermoresistible__bu -------ELN-------------------------------ALKAIASLF
MAV_1410|M.avium_104 TATQARRRFSPYVTPVASTIVALGVIVLAHHSRSAATLAALSLVVGAGRF
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 ------------------------------------------LRFQAALV
Mflv_2883|M.gilvum_PYR-GCK VALRYSTPVSTLFVIAAANWIVFATLSDRGPLLASDLQVRALLAQG----
Mvan_3629|M.vanbaalenii_PYR-1 VALRYSTTVSTVFLLVAAAWIIYSTLSGRGAFIVPDMQLRALLAQA----
Mb1389c|M.bovis_AF2122/97 AQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGP----
Rv1354c|M.tuberculosis_H37Rv AQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGP----
MSMEG_2196|M.smegmatis_MC2_155 AQVQARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLAPGQPGP----
TH_0811|M.thermoresistible__bu AQVQARVEAEERLRYLAEHDDLTGLHNRRALLAHLDARLAAGQPGP----
MAV_1410|M.avium_104 SLTFRDVSLLHSHDRHAMTDELTALPNRRQLVTALQGLPASASPGAGSMP
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 NHVSDAIIATTSTGMVTSWNPAAEAIYRRSASDVLGMPIGEAVGAP----
Mflv_2883|M.gilvum_PYR-GCK ------MVFSLTVIVLALALYRDTRVRLIAELEASRDQADQDSELLGAVL
Mvan_3629|M.vanbaalenii_PYR-1 ------MVFSLTVLVLALALFRDSRMRLIGQLEAARDRADQDSELLGAVL
Mb1389c|M.bovis_AF2122/97 ------VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
Rv1354c|M.tuberculosis_H37Rv ------VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
MSMEG_2196|M.smegmatis_MC2_155 ------VAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLI
TH_0811|M.thermoresistible__bu ------VSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDLI
MAV_1410|M.avium_104 SRANPRRALLLLSLSDFHEITESIGRQFGDELLCHIANRLAGSVRRDDLL
MAB_1867|M.abscessus_ATCC_1997 --------------------MQNPPYVETGYQYDLVTNALRDTGQLGRLK
MLBr_01419|M.leprae_Br4923 --------------------LDPGAIITEGGVLSTTQYASDGMALAVRVS
:
Mflv_2883|M.gilvum_PYR-GCK DSIHDGVILVDPADRVVLRNARADDSGLVDEVVAAARAVG-HGGADGPEP
Mvan_3629|M.vanbaalenii_PYR-1 DSIHDSVVLADPDGRVVLQNARATDSGLVSDVVSAVHTPGLVDDMAASAS
Mb1389c|M.bovis_AF2122/97 ARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG---------E
Rv1354c|M.tuberculosis_H37Rv ARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG---------E
MSMEG_2196|M.smegmatis_MC2_155 ARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDG---------E
TH_0811|M.thermoresistible__bu ARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDG---------E
MAV_1410|M.avium_104 ARVGDDQFAVLLADGANLTAASAQAGRLLEALSEPIALDP---------I
MAB_1867|M.abscessus_ATCC_1997 TGIGLLCFVIVFLQGVTQFYPLG-PHGIWPRVVHGITAAS----------
MLBr_01419|M.leprae_Br4923 AAVMENGFVLVCSDYTALLRVERRFQTVVALLEEGVIVLD----------
: . : :
Mflv_2883|M.gilvum_PYR-GCK AVPHDVIVSVEDSRTLELTTTPLPRQPQFDVMAFRDVTEVRRNARELREA
Mvan_3629|M.vanbaalenii_PYR-1 HAPRDIVVSVEDSRILELATTPLSRQSQFTVMAFRDVTEERRNARELREA
Mb1389c|M.bovis_AF2122/97 VLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAK---------------
Rv1354c|M.tuberculosis_H37Rv VLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAK---------------
MSMEG_2196|M.smegmatis_MC2_155 MLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAK---------------
TH_0811|M.thermoresistible__bu MLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAK---------------
MAV_1410|M.avium_104 TVQVDGRIAIALCPDHCDHPRELLSRAETALAHAK---------------
MAB_1867|M.abscessus_ATCC_1997 -AVVAGLCWLSFSWPGRRAMAAFVVWADVALAVGA---------------
MLBr_01419|M.leprae_Br4923 --------GDGYVESVNPAALRILGVSDRSALDDP---------------
. .:
Mflv_2883|M.gilvum_PYR-GCK RDLFAGVLQAASEQAIIGTDQDGLITVFNQGAERLLGWTAEEMIGRPVTD
Mvan_3629|M.vanbaalenii_PYR-1 RDLFAGVLEAASEQAIVGTDPSGCITVFNNGAERLLGWTEEEMLGRTPMD
Mb1389c|M.bovis_AF2122/97 --------HAGGDSVAIFTADMSVSGELRNDIELHL----RRGIESDALR
Rv1354c|M.tuberculosis_H37Rv --------HAGGDSVAIFTADMSVSGELRNDIELHL----RRGIESDALR
MSMEG_2196|M.smegmatis_MC2_155 --------GSGGNRVAVFSDAMAMEIDFRNDIELHL----QSVIEGGALV
TH_0811|M.thermoresistible__bu --------SAGGNQITVFTDDMSLEAEFRNDIELHL----QSVIQDEALL
MAV_1410|M.avium_104 ---------SARSKIAVYDSAFEAHRDNDTNLIEELR---TALFDTDELK
MAB_1867|M.abscessus_ATCC_1997 ---------------ALLSDP-----------------------TARICA
MLBr_01419|M.leprae_Br4923 -------------------------------------------VRRAATL
Mflv_2883|M.gilvum_PYR-GCK VHDLAEMIVRADELGVPPGFEAFIANVTPDDAEIREWTYVRRDGSHAEVS
Mvan_3629|M.vanbaalenii_PYR-1 FHYPPEVRARAEELGIPEGFEVFVHNVTPDAAEIREWTFVRRDGGHVDVS
Mb1389c|M.bovis_AF2122/97 LVYLPEVDLRTGDIVGTEALVRWQHPTR----------------------
Rv1354c|M.tuberculosis_H37Rv LVYLPEVDLRTGDIVGTEALVRWQHPTR----------------------
MSMEG_2196|M.smegmatis_MC2_155 LHYLPEIDMRTGEVLAAEALVRWEHPTR----------------------
TH_0811|M.thermoresistible__bu LHFLPEVDMRTGEILATEALVRWHHPTR----------------------
MAV_1410|M.avium_104 LHYQPKIDGRDGSIHSVEAVLRWQHPTR----------------------
MAB_1867|M.abscessus_ATCC_1997 IVYLGPVGLLPTFFLSRRALVAHCAFAT----------------------
MLBr_01419|M.leprae_Br4923 PMYDAQGRLLDHGRGAVREFLRTGTPKTG---------------------
.
Mflv_2883|M.gilvum_PYR-GCK LAISQMSDADGCCVGYIGVATDITERKKAEHALAESEERFRSAFDTAPMG
Mvan_3629|M.vanbaalenii_PYR-1 LAVSLMTDERGTCVGYIGVATDITDQKAAERALAESEERFRLAFDTAPVG
Mb1389c|M.bovis_AF2122/97 ---GLLAPG-----CFIPVAESIN----------LAGELDRWVLRRACNE
Rv1354c|M.tuberculosis_H37Rv ---GLLAPG-----CFIPVAESIN----------LAGELDRWVLRRACNE
MSMEG_2196|M.smegmatis_MC2_155 ---GLLSPD-----SFIGVAESIN----------LAGELGRWVLRTACAE
TH_0811|M.thermoresistible__bu ---GLLAPD-----TFIGVAESVN----------LAGELGRWVMRTACGE
MAV_1410|M.avium_104 ---GTLLPE-----EFLPVAERAG----------LMRKISNRTLSMALQQ
MAB_1867|M.abscessus_ATCC_1997 --------------SLLGAVLAVN------------------VLSGGARM
MLBr_01419|M.leprae_Br4923 --------------FIVGIDRPSD----------------GTRVWLSVNS
: . .
Mflv_2883|M.gilvum_PYR-GCK MFMFTVTPEDAGRITRCNQALADFLGRSTSEVPGMSVTDLGTNENADGTE
Mvan_3629|M.vanbaalenii_PYR-1 MFMFDVTPDGTGRITRCNTTLADFLGRSTADVLGSSTTELGADESTSSTK
Mb1389c|M.bovis_AF2122/97 FSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDA------
Rv1354c|M.tuberculosis_H37Rv FSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDA------
MSMEG_2196|M.smegmatis_MC2_155 FSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPR------
TH_0811|M.thermoresistible__bu FAKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDG------
MAV_1410|M.avium_104 VRSWREE--GLRLTVAVNLSTTNLLDIELVGTVERLLANYDLPA------
MAB_1867|M.abscessus_ATCC_1997 FEQFFYAAPVISAIVLVPAVIQLVLEGGRDSILSAALAAD----------
MLBr_01419|M.leprae_Br4923 RSLNPVDPEDATLLISFTDVTAERQASQYLAHQAAHDTLTGLPN------
Mflv_2883|M.gilvum_PYR-GCK GLARLLALTDGEPVSAEVRFRRWDGDTMWGAVSASVVAAAGADPYGICLV
Mvan_3629|M.vanbaalenii_PYR-1 GLTGLPTLRKGEPWGAEVAFRRADGATVWGAVSASLVAPPGADPYGICLV
Mb1389c|M.bovis_AF2122/97 -----------------------------SSVCLEITEN--------VVV
Rv1354c|M.tuberculosis_H37Rv -----------------------------SSVCLEITEN--------VVV
MSMEG_2196|M.smegmatis_MC2_155 -----------------------------GSVCLEITES--------VVV
TH_0811|M.thermoresistible__bu -----------------------------SSVCLEITES--------VVV
MAV_1410|M.avium_104 -----------------------------DALILEITES---------AL
MAB_1867|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK EDITSRKRAEAELQHLALHDPLTGLANRALLVDRVEQAIADIGRHAPACV
Mvan_3629|M.vanbaalenii_PYR-1 EDITSRKRAEADLQFLALHDPLTGLANRTLLMNRMEQALADEGRHVPGRV
Mb1389c|M.bovis_AF2122/97 QDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT--------
Rv1354c|M.tuberculosis_H37Rv QDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT--------
MSMEG_2196|M.smegmatis_MC2_155 QDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDT--------
TH_0811|M.thermoresistible__bu QDIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDT--------
MAV_1410|M.avium_104 VDSVRSRNTVTALQRLGIRISIDDYGTGWSSLARLQEVSVDE--------
MAB_1867|M.abscessus_ATCC_1997 -----RDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDV--------
MLBr_01419|M.leprae_Br4923 -----RTSILARIDEQRYCGAPDQLLTAVLFID-----------------
:. .
Mflv_2883|M.gilvum_PYR-GCK GLLYLDLDGFKPVNDTWGHAAGDEVLNAVARRIENSIRPGDTAARLGGDE
Mvan_3629|M.vanbaalenii_PYR-1 GLLFLDLDGFKPVNDTWGHAAGDEVLKAVARRIENSIRPGDTAARLGGDE
Mb1389c|M.bovis_AF2122/97 ----LKID--KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEA
Rv1354c|M.tuberculosis_H37Rv ----LKID--KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEA
MSMEG_2196|M.smegmatis_MC2_155 ----LKID--RSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETER
TH_0811|M.thermoresistible__bu ----LKID--KGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEA
MAV_1410|M.avium_104 ----LKLD--RIFVARLAHDARSVAIVRSTVALADNLGADLVAEGVENED
MAB_1867|M.abscessus_ATCC_1997 -------DGLKELNDTHGHGAGDMTLKAVADMLKARTRVGEIAARFGGDE
MLBr_01419|M.leprae_Br4923 ------LDNFKGINDSLGHDVGDVVLQTAAQRLRAGLRSRDVVGRFGGDE
* : . . . : : . . :
Mflv_2883|M.gilvum_PYR-GCK FAVLCPVIKDSEALHGIAERIRREVRRPLRLRAGRTYDRLSASTGAATSG
Mvan_3629|M.vanbaalenii_PYR-1 FAVLCPVIGENGELHGVAERIQTELSRPLTLIGGQSYDQLSASVGVAMSG
Mb1389c|M.bovis_AF2122/97 AARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Rv1354c|M.tuberculosis_H37Rv AARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
MSMEG_2196|M.smegmatis_MC2_155 AALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----
TH_0811|M.thermoresistible__bu AALTLLRHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP------
MAV_1410|M.avium_104 TLDALRRYGCNITQGFVHTPPLPPDELRAWIASHAPDPSQSRG-------
MAB_1867|M.abscessus_ATCC_1997 FLVVAFPGRGEDIESTIRRVSAPRAGIDYWTVSVGAAWQSRTGNKVDLES
MLBr_01419|M.leprae_Br4923 FVALILGKITHTELSKVVDRMHAALSEPTYVADAVLHLRASIGVVAIKGD
:
Mflv_2883|M.gilvum_PYR-GCK GNSNAESLIAHTDRLMYRAKRNGKDRVADDLVPVEG--
Mvan_3629|M.vanbaalenii_PYR-1 CGRTAEELLHHADRLMYHAKRQGNGGLVGDHTPAGA--
Mb1389c|M.bovis_AF2122/97 --------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------
MAV_1410|M.avium_104 --------------------------------------
MAB_1867|M.abscessus_ATCC_1997 LVQQADHALYEAKKTRGMLDPQR---------------
MLBr_01419|M.leprae_Br4923 DPRNIGQILRDADTAMYRAKLSGEGTSYYTDTFNQQPS