For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSHFGVNFGFLRHNDHSIRATVLVAEWPPRNVDPD PLGVIYFADADSVFARVETMKEPDVLRPEPANADYQRNIEDGTGIPEVSLAAVPLLSGDVTTGTLGFVKF GDREWLSEELNALQAIAALFAQLQARVVAEEQIHYLAEHDELTGLLNRRALIAHLDKRLAPGQPGPVPVV FLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSVIARFGGDEFGVVPAAPMDVEAAESFAHSLHE RLHHPIAIDDEMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEMSTIDTIRNDI ELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQHPTLGLLMPDSFIQVAESINLGAKLGRLVM RSACAQFGQWRSRGVGQGTVLRINVSPVQLVTAGIVDTVAATLDEFGLDPSTVCLEITESVVVQDIDATR QTLFGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDSLKIDKGFVQSLDTNPGDLAIVRSTLALADAFGLDV VAEGVETVAAAETLLSLGCHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPENQHVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3132 | - | - | 100% (621) | GGDEF domain-containing protein |
| M. avium 104 | MAV_1132 | - | 0.0 | 56.60% (606) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. avium 104 | MAV_1410 | - | 4e-56 | 34.25% (435) | cyclic diguanylate phosphodiesterase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 0.0 | 59.44% (604) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4377 | - | 0.0 | 64.33% (614) | diguanylate cyclase/phosphodiesterase with GAF sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 0.0 | 59.44% (604) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 0.0 | 66.83% (618) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_0124 | - | 1e-13 | 37.41% (139) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 0.0 | 62.75% (612) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 0.0 | 62.91% (612) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 0.0 | 64.04% (609) | diguanylate cyclase/phosphodiesterase with GAF sensor |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3132|M.avium_104 -----MSGT-----LDHLVTAAAAELMAATAADAAQISERVLADLVSHFG
MLBr_01750|M.leprae_Br4923 -----MTRS-----LDELVTRVASKLMAATAATAVTISEGVLAILVEHFG
Mflv_4377|M.gilvum_PYR-GCK -----MSES-----LDLVVTSVATRLMGAGAATWAEASQQVLADLVEHFG
Mvan_1967|M.vanbaalenii_PYR-1 -----MSDSDTLRSLDLVITSVATKLMAANAATSVEVSQRVLAELVDYLG
MSMEG_2196|M.smegmatis_MC2_155 -----MSES-----LDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFD
TH_0811|M.thermoresistible__bu -----VSTE-----LDLLVTGVATKLMAADAATARDVSRRVLADLVRAFE
Mb1389c|M.bovis_AF2122/97 -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
Rv1354c|M.tuberculosis_H37Rv -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
MAB_0124|M.abscessus_ATCC_1997 MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
: :* . : * * **. *:
MAV_3132|M.avium_104 VNFG----FLRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADSVF
MLBr_01750|M.leprae_Br4923 VDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVF
Mflv_4377|M.gilvum_PYR-GCK VDVS----FLRRNDHTIRASVLVAEWPVRPGIPDPDPLAVVYFADADPVF
Mvan_1967|M.vanbaalenii_PYR-1 VDVS----FLRYNDHKIRASRLVAEWPVRPGVPDPDPLALVYFADADPVF
MSMEG_2196|M.smegmatis_MC2_155 VDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVF
TH_0811|M.thermoresistible__bu LDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVF
Mb1389c|M.bovis_AF2122/97 VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
Rv1354c|M.tuberculosis_H37Rv VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
MAB_0124|M.abscessus_ATCC_1997 LGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWADISMVV
:. * . : * .: .: : . . *.
MAV_3132|M.avium_104 ARVETMKEPDVLRPEPANADYQRNIEDGTGIPEVSLAAVPLLSGDVTTGT
MLBr_01750|M.leprae_Br4923 AMAEYLKEPAVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGV
Mflv_4377|M.gilvum_PYR-GCK ALAEFQKEPLVFRPDANTDEYQKTIEEGRQVPQVSMAAVPLLSGDVTTGV
Mvan_1967|M.vanbaalenii_PYR-1 AQSEHGKKPMVFRPEPATDDYQKRIEETRAVPATSMAAAPLVSGELTTGV
MSMEG_2196|M.smegmatis_MC2_155 AMAEHLKEPAVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGV
TH_0811|M.thermoresistible__bu ALAEHAKEIHIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGV
Mb1389c|M.bovis_AF2122/97 ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
Rv1354c|M.tuberculosis_H37Rv ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
MAB_0124|M.abscessus_ATCC_1997 GACTLSAPASRLGALAHMGLIG--VFAAFLLGWRVLAVHCVFATVAIFGL
. : . . : : * :.: *
MAV_3132|M.avium_104 LGF-VKFGDREWLSEELN---ALQAIAALFAQLQARVVAEEQ----IHYL
MLBr_01750|M.leprae_Br4923 LGF-VKYGDREWHDDELR---ALQAIATLFAQLQARIVAEEQ----LRYL
Mflv_4377|M.gilvum_PYR-GCK LGF-VKFGDRDWTGVELN---ALKAIASLFAQVQARVEAETQ----LRYL
Mvan_1967|M.vanbaalenii_PYR-1 LGF-IKFGDREWTAEELN---GLEAIASLFAQVQARVQAEEQ----LRYL
MSMEG_2196|M.smegmatis_MC2_155 LGF-VKFGDREWLPAELN---ALKAIASLFAQVQARIEAEER----LRYL
TH_0811|M.thermoresistible__bu LGF-VKYGDRQWHPDELN---ALKAIASLFAQVQARVEAEER----LRYL
Mb1389c|M.bovis_AF2122/97 LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
Rv1354c|M.tuberculosis_H37Rv LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
MAB_0124|M.abscessus_ATCC_1997 MGWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLA
:*: :: *: * : .* ::. * :*. : . : :
MAV_3132|M.avium_104 AEHDELTGLLNRRALIAHLDKRLAPGQPG-PVPVVFLAIDRFKVINGRLG
MLBr_01750|M.leprae_Br4923 AEHDDLTGLLNRRALIAHLDERLADGQRG-PVTLLFLGLDRLKAVNDYLG
Mflv_4377|M.gilvum_PYR-GCK AEHDDLTGLNNRRALLSHLDGRLAEGQPG-PVSALFFDLDRLKAINDYLG
Mvan_1967|M.vanbaalenii_PYR-1 AEHDDLTGLYNRRALLAHLDERLAEGRPG-PVSALFFDLDRLKAINDYLG
MSMEG_2196|M.smegmatis_MC2_155 ADHDHLTGLYNRRALMAHLEARLAPGQPG-PVAVMFFDLDRLKAINDYLG
TH_0811|M.thermoresistible__bu AEHDDLTGLHNRRALLAHLDARLAAGQPG-PVSALYFDLDRLKAVNDYLG
Mb1389c|M.bovis_AF2122/97 ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
Rv1354c|M.tuberculosis_H37Rv ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
MAB_0124|M.abscessus_ATCC_1997 AHQDPLTGLLNRRGVQVALSSLLSGQRATRIVAVVLVDVDELKELNDRLG
*.:* **** ***.: *. *: : *. : . :*.:* :*. **
MAV_3132|M.avium_104 QDAGDRFIDAFAALLREATEIPSVIARFGGDEFGVVPAAPMDVEAAESFA
MLBr_01750|M.leprae_Br4923 HNAGDRLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFA
Mflv_4377|M.gilvum_PYR-GCK HTAGDWFIRVLAERLREGADPRALIARLGGDEFVVVPAGPMDGEAAESLA
Mvan_1967|M.vanbaalenii_PYR-1 HTAGDWFIRVLAERLRRGADCPNIIARLGGDEFVLVPTVPMDGAAAEALA
MSMEG_2196|M.smegmatis_MC2_155 HTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALA
TH_0811|M.thermoresistible__bu HTVGDWFIRVLAERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELA
Mb1389c|M.bovis_AF2122/97 HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
Rv1354c|M.tuberculosis_H37Rv HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
MAB_0124|M.abscessus_ATCC_1997 HDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVG----FFDHADEAT
: .** * .* : : **:***** :: * :
MAV_3132|M.avium_104 HSLHERLHHPIAIDDEMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSA
MLBr_01750|M.leprae_Br4923 HRLQTRLQKQVVIDGEILTRTVSIGVATGLPGRDTTSDLLRWADHAALSA
Mflv_4377|M.gilvum_PYR-GCK HQLQSTLKERVSIDGEMLTRTVSIGVAVGIPGQDTTSDLLRRADQAVLTA
Mvan_1967|M.vanbaalenii_PYR-1 HRLQSTLRERVSIDGEMLTRTVSIGVAQGIPGRDTTSDLLRRADQAVLTA
MSMEG_2196|M.smegmatis_MC2_155 YRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTA
TH_0811|M.thermoresistible__bu NRLRSRLQQQVCVDGEMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTA
Mb1389c|M.bovis_AF2122/97 ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
Rv1354c|M.tuberculosis_H37Rv ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
MAB_0124|M.abscessus_ATCC_1997 GLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGA
:. . :. . : : . .: . ..: . .*. *
MAV_3132|M.avium_104 KAAGGNNVATFRPEMSTIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDM
MLBr_01750|M.leprae_Br4923 KSDG-SKVVVLDHGISAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDM
Mflv_4377|M.gilvum_PYR-GCK KNSGGNRVTVFTEEMSLKQEFNNDIELHLQSVIEN--GALLLHYLPEIDM
Mvan_1967|M.vanbaalenii_PYR-1 KGSGGNEVVVFTDDMSMRHEFNNDIELHLQSVIEN--GALLLHYLPEVDM
MSMEG_2196|M.smegmatis_MC2_155 KGSGGNRVAVFSDAMAMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDM
TH_0811|M.thermoresistible__bu KSAGGNQITVFTDDMSLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDM
Mb1389c|M.bovis_AF2122/97 KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDL
Rv1354c|M.tuberculosis_H37Rv KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDL
MAB_0124|M.abscessus_ATCC_1997 KIERRNGFHAVP--------------------------------------
* . . .
MAV_3132|M.avium_104 RTGEILGTEALTRWQHPTLGLLMPDSFIQVAESINLGAKLGRLVMRSACA
MLBr_01750|M.leprae_Br4923 STGKVLGTEALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACA
Mflv_4377|M.gilvum_PYR-GCK RTGDILAMEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACT
Mvan_1967|M.vanbaalenii_PYR-1 RTGEILACEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACA
MSMEG_2196|M.smegmatis_MC2_155 RTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACA
TH_0811|M.thermoresistible__bu RTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACG
Mb1389c|M.bovis_AF2122/97 RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
Rv1354c|M.tuberculosis_H37Rv RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3132|M.avium_104 QFGQWRSRGVGQGTVLRINVSPVQLVTAGIVDTVAATLDEFGLDPSTVCL
MLBr_01750|M.leprae_Br4923 EFSRWRSAGVGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCL
Mflv_4377|M.gilvum_PYR-GCK DFARWRALGIGKDAIMRINVSPVQLVTDGFVESVAGIVDEFGLEHGSVCL
Mvan_1967|M.vanbaalenii_PYR-1 DFAGWRARGIGTGTVMRINVSPVQLVTDGFVESVAGIVDEFDLDEGSVCL
MSMEG_2196|M.smegmatis_MC2_155 EFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCL
TH_0811|M.thermoresistible__bu EFAKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCL
Mb1389c|M.bovis_AF2122/97 EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
Rv1354c|M.tuberculosis_H37Rv EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3132|M.avium_104 EITESVVVQDIDATRQTLFGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDS
MLBr_01750|M.leprae_Br4923 EITENVVVQNIDATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDT
Mflv_4377|M.gilvum_PYR-GCK EITESVVVQDIETTRVTLNGLKKAGVLVAIDDFGTGYSALSHLKSLPVDT
Mvan_1967|M.vanbaalenii_PYR-1 EITESVVVQDIETTRVTLKGLKEAGVRIAIDDFGTGYSALSHLKSLPVDT
MSMEG_2196|M.smegmatis_MC2_155 EITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDT
TH_0811|M.thermoresistible__bu EITESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDT
Mb1389c|M.bovis_AF2122/97 EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
Rv1354c|M.tuberculosis_H37Rv EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3132|M.avium_104 LKIDKGFVQSLDTNPGDLAIVRSTLALADAFGLDVVAEGVETVAAAETLL
MLBr_01750|M.leprae_Br4923 IKIDKSFVAELGSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLL
Mflv_4377|M.gilvum_PYR-GCK LKIDKSFVRELGSDPGDLAIVRAIIALAEAFGLELVAEGVETDVGALTLL
Mvan_1967|M.vanbaalenii_PYR-1 LKIDKSFVRELGSDPGDLAIVRAVIALAEAFGLELVAEGVETEAAAMTLL
MSMEG_2196|M.smegmatis_MC2_155 LKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLL
TH_0811|M.thermoresistible__bu LKIDKGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLL
Mb1389c|M.bovis_AF2122/97 LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
Rv1354c|M.tuberculosis_H37Rv LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3132|M.avium_104 SLGCHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQHVV---
MLBr_01750|M.leprae_Br4923 ELGCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
Mflv_4377|M.gilvum_PYR-GCK RHGCHRAQGFLLSRPIPTDAMETLLAQGRIPVSFSKG-------------
Mvan_1967|M.vanbaalenii_PYR-1 RHGCHRAQGFLLSRPIDGAAMKALLARGRVPVSFAKS-------------
MSMEG_2196|M.smegmatis_MC2_155 RHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu RHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP------------
Mb1389c|M.bovis_AF2122/97 DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------