For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TEDVVPRQTAPTDSVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAGYLVATVVLG LFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGGIITMAYVVFEASLIGIFAFFFQNFLSSQFGFDI HWLIPALLMLALNCILTYFDVNLTAKVLGVFLVTEIVMLSLGAIAVAVKGGGPDGFAVGEILNPVGAFQP AAIAGASAGLGLFFAFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGLFYVFVSWMAIAGTGPKQA VELAQSADTSSEIFFAPVRTTYGEWAITLFNILLVSGSFACGMAFHNCASRYLYALGREGLSTRLQDTLG ATHKTHGSPHIASFVQTGITLVLILAFFAAGMDPYIHMYTLLAILGTMAILIVQSLCAFSVIAYFHFHKN HPSSAHWFKTFLAPLLGGIGMLYVVYLLWEHKESAAGAASGTLLFKLTPWIVVGLFALGAAMALYFKFND KRRYELIGRIVYDDSEIRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | - | 100% (510) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_2078 | - | e-138 | 51.46% (515) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | e-133 | 47.23% (487) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-22 | 24.83% (431) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 0.0 | 92.13% (508) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 3e-22 | 24.83% (431) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 6e-11 | 24.15% (236) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 0.0 | 60.86% (511) | putative amino acid permease family protein |
| M. marinum M | MMAR_2609 | - | 6e-22 | 24.32% (518) | hypothetical protein MMAR_2609 |
| M. avium 104 | MAV_2087 | - | 1e-21 | 25.18% (409) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0279 | - | 0.0 | 82.78% (511) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 2e-11 | 24.68% (466) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 4e-20 | 22.99% (435) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 -------------------------------------------------M
Rv2320c|M.tuberculosis_H37Rv -------------------------------------------------M
MUL_1244|M.ulcerans_Agy99 -------------------------------------------------M
MAV_2087|M.avium_104 --------------------------------------------------
Mvan_5564|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0279|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MMAR_2609|M.marinum_M -------------------------------------------MTDTPAP
Mb2347c|M.bovis_AF2122/97 PTTSMSLRELMLRRRPVSGAPVASGASGNLKR------------------
Rv2320c|M.tuberculosis_H37Rv PTTSMSLRELMLRRRPVSGAPVASGASGNLKR------------------
MUL_1244|M.ulcerans_Agy99 PATSIRLREQMLRRRPAGGAPVAEGAAGSLKR------------------
MAV_2087|M.avium_104 ---------------------MAPGTADHLRR------------------
Mvan_5564|M.vanbaalenii_PYR-1 -----------MTEDVVPRQTAPTDSVQRLKRN-----------------
Mflv_1244|M.gilvum_PYR-GCK --------MTESAERTAPGQTTPTASVQRLKRN-----------------
MSMEG_0279|M.smegmatis_MC2_155 -----------MTEQSVAGSENAAHDIQRLKRN-----------------
MAB_0950c|M.abscessus_ATCC_199 ---------MSDTIDPPVGTTTEPDSMQRLKPN-----------------
TH_4382|M.thermoresistible__bu -----------------MSGTRTEQAQPELRR------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MMAR_2609|M.marinum_M PLFARGPKGNKLKVQPIVPQLSNTAAEGVVSKGLAKG-------------
.
Mb2347c|M.bovis_AF2122/97 ----------SFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv ----------SFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
MUL_1244|M.ulcerans_Agy99 ----------SFGTFELTMFGVG--STVGTGIFFVLAEAVPEAGPAVIVS
MAV_2087|M.avium_104 ----------GIGTFQLTMFGVG--STIGTGIFFVMSQAVPEAGPAVIVS
Mvan_5564|M.vanbaalenii_PYR-1 ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mflv_1244|M.gilvum_PYR-GCK ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MSMEG_0279|M.smegmatis_MC2_155 ----------AVGTVGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MAB_0950c|M.abscessus_ATCC_199 ----------AVGLIGVLFMAVATAAPITAMVGNVPMAVGFGNGAYAPAG
TH_4382|M.thermoresistible__bu ----------VLGPGLLLLFIVG--DILGTGIYALVGDVAGEVGGAAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN--SIIGAGIFMTPGEVIKIAGPFAPIA
MMAR_2609|M.marinum_M ----------AVGTVSGAILGIA-CVAPGYTLTASIGLIVAAVGLKMPAI
.* :: : : *
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
Mvan_5564|M.vanbaalenii_PYR-1 YLVATVVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGGIITM
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
MSMEG_0279|M.smegmatis_MC2_155 YFVATVVLGLFAIGYATMAKHITATGAFYGYISHGLGRIVGMAAGGLITM
MAB_0950c|M.abscessus_ATCC_199 YLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLGRVVGLGSGFLITL
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVM
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
MMAR_2609|M.marinum_M FVFGFIPMFLTAFAYRELNADTPDCGASFTWSTKAFGPYVGWMCGWGMVI
: .. : : *. .. : :* . :
Mb2347c|M.bovis_AF2122/97 EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
Mvan_5564|M.vanbaalenii_PYR-1 AYVVFEASLIGIFAFFFQNFLSSQFGFDIHWLIPALLMLALNC----ILT
Mflv_1244|M.gilvum_PYR-GCK AYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVPALLMLVLNS----ILT
MSMEG_0279|M.smegmatis_MC2_155 AYVVFEASLIGIFSFFFQNFLDSQLGIHIHWIIPALLMLATNA----ILT
MAB_0950c|M.abscessus_ATCC_199 AYMVFEASLVGIFSFFANDLFQTFFQVDVPWVVFAVAMLATNA----VLT
TH_4382|M.thermoresistible__bu CSGITSASTAS---RFFAANLEVGLGQEWGRLGVAGVALLFMA------L
MLBr_01974|M.leprae_Br4923 TASIAWGVLAS---SFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAV
MMAR_2609|M.marinum_M ATVIVLSNLAAVAVQFFYLLIAGLFDSPGIASLAANRWVDIAS-------
: . : : .
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
Mvan_5564|M.vanbaalenii_PYR-1 YFDVNLTAKVLGVFLVTEIVMLSLGAIAVAVKGGGPDGFAVGEILNPVGA
Mflv_1244|M.gilvum_PYR-GCK YFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFAIAETLNPVGA
MSMEG_0279|M.smegmatis_MC2_155 YFDVNLTAKVLGVFLVTEIVMLALGAVAVLFRGGGPDGFAVNEILNPAGA
MAB_0950c|M.abscessus_ATCC_199 YFDLNLAARVLGVFLVTEILMLSLLALSVLFAGGGPQGWSWGS-LNPLNG
TH_4382|M.thermoresistible__bu LAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGADVDFTRV
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSR
MMAR_2609|M.marinum_M --TLVFIAGATWVSSRGIQTSERVQGLLVIFQMTVILGFGVVAIIGAVRG
: : . : .: : .
Mb2347c|M.bovis_AF2122/97 HLKDFVPFG-----------VAGIGSAAGTIFFSYIGLDAVSTAGDEVKD
Rv2320c|M.tuberculosis_H37Rv HLKDFVPFG-----------VAGIGSAAGTIFFSYIGLDAVSTAGDEVKD
MUL_1244|M.ulcerans_Agy99 HLKDFAPFG-----------VAGVGAAAGTIFFSFIGLDAVSTAGEEVRN
MAV_2087|M.avium_104 HLDDFAPFG-----------VAGVGTAAGTIFFSYIGLDAVSTAGDEVTN
Mvan_5564|M.vanbaalenii_PYR-1 FQPAA-IAG------------ASAGLGLFFAFWSWVGFESTAMYGEESKD
Mflv_1244|M.gilvum_PYR-GCK FQPAA-IAG------------ASAGLGLFFAFWSWVGFESTAMYGEESKD
MSMEG_0279|M.smegmatis_MC2_155 FSPATGIVG------------ASAGLGLFFAFWSWVGFESTAMYGEESRN
MAB_0950c|M.abscessus_ATCC_199 FHDLGGVVQGPAGPLA---VAGSAGVGLFFAFWSWVGFESSAMYAEESKN
TH_4382|M.thermoresistible__bu VAFETTTDKS---------VFLAVSAATSLAFFAMVGFEDSVNMAEETRD
MLBr_01974|M.leprae_Br4923 SAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMNT
MMAR_2609|M.marinum_M HGPANLSFDFNWFDPFSGLAMGAFVIGVTGSIFSFWGWDTCLTLGEECTD
. . ::: * : .:*
Mb2347c|M.bovis_AF2122/97 PQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQETAG----LA
Rv2320c|M.tuberculosis_H37Rv PQKTMPRALIAALVVVTGVYVLVALAALG-TQPWQDFAEQETAG----LA
MUL_1244|M.ulcerans_Agy99 PQQSVPRALIAALFVVTGVYVLVAFAALG-TQPWQMFAGQEEAG----LA
MAV_2087|M.avium_104 PQKTMPRALIAALLTVTGVYVFVALAALG-TQPWQDFGGQQEAG----LA
Mvan_5564|M.vanbaalenii_PYR-1 PKRIIPRATMIAVLGVGLFYVFVSWMAIAGTGPKQAVELAQSADTSSEIF
Mflv_1244|M.gilvum_PYR-GCK PKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQQAVELAQSADTSSEIF
MSMEG_0279|M.smegmatis_MC2_155 PKRIIPRATMIAVLGVGVFYVFISWMAIAGTGPQQSIELAQDANTASEIF
MAB_0950c|M.abscessus_ATCC_199 PKKIIPIAIVTSVVGVGLFYVLVSWLAIVGTGPENAVALAQDSSTAGNIF
TH_4382|M.thermoresistible__bu PVVIFPRALLTGLGIAGAVYVVVAIVAVA----LVPVGTLQASDVP--LV
MLBr_01974|M.leprae_Br4923 PDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATN---------HT
MMAR_2609|M.marinum_M PKKVPGRAGVLCVVSILLTYLLVSVAMMMYAGVGSQGLGLGNPDNSENVF
* * : *:. :
Mb2347c|M.bovis_AF2122/97 IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA
Rv2320c|M.tuberculosis_H37Rv IILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA
MUL_1244|M.ulcerans_Agy99 TILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLPA
MAV_2087|M.avium_104 TILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLPP
Mvan_5564|M.vanbaalenii_PYR-1 FAPVRTTYGEWAITLFNILLVSGSFACGMAFHNCASRYLYALGREGLSTR
Mflv_1244|M.gilvum_PYR-GCK FAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALGREGLSTG
MSMEG_0279|M.smegmatis_MC2_155 FAPVRDTYGEWAITVFNILLVTGSFACGMAFHNCASRYLYALGREGLSRG
MAB_0950c|M.abscessus_ATCC_199 FGPVQSHLGVWAVNLFKVLLMTGSFACGMAFHNCAARYLYALGRENVIPG
TH_4382|M.thermoresistible__bu EVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRVLPP
MLBr_01974|M.leprae_Br4923 VKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILPT
MMAR_2609|M.marinum_M GALARPVLGPWGSQLLFLGILASTLSSLQTTFLPASRCMLAMGAYRAFPQ
. :: : . .* .:.
Mb2347c|M.bovis_AF2122/97 RFAKVNPRTMTP------------VHNTVIVAIFASTLAAFIPLDSLADM
Rv2320c|M.tuberculosis_H37Rv RFAKVNPRTMTP------------VHNTVIVAIFASTLAAFIPLDSLADM
MUL_1244|M.ulcerans_Agy99 RFAAVHPRFQTP------------VSNTVVVAIAAAVLAALVPLNRLADM
MAV_2087|M.avium_104 RFARVNPRTMTP------------VNNTVIVAVAAATLAAFIPLQNLADM
Mvan_5564|M.vanbaalenii_PYR-1 LQDTLGATHKTHGSPHIASFVQTGITLVLILAFFAAGMDPYIHMYTLLAI
Mflv_1244|M.gilvum_PYR-GCK LQKTLGATHKTHGSPYIASFVQSGIALVLVLAFFFAGMDPYIHMYTLLAI
MSMEG_0279|M.smegmatis_MC2_155 LQKTLGATHPTHGSPYIASFVQSAIALVIVLSFLFAGMDPYVHMYTLLAI
MAB_0950c|M.abscessus_ATCC_199 MRKTIGSTHSTHGSPHVAGFVQTAFATVVVLFFAATGRDPYTGLYGLMAL
TH_4382|M.thermoresistible__bu VLGSVHPRRRTP---------WVAIIFTTLIAFGLIFYVTAFADSTAIAV
MLBr_01974|M.leprae_Br4923 RLSSKNR-----------------FGVPIVAFGITAFLTLAFPLSLRFDS
MMAR_2609|M.marinum_M RFSAVSSRFQVP------------LFSTIAAAIASGAFYTLARLLSERTL
.
Mb2347c|M.bovis_AF2122/97 VS------IGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVTPVLS
Rv2320c|M.tuberculosis_H37Rv VS------IGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVTPVLS
MUL_1244|M.ulcerans_Agy99 VS------IGTLTAFIVVSVGVIILRVREPA--LPRGFWVPGYPVTPILS
MAV_2087|M.avium_104 VS------IGTLTAFVVVSVGVIVLRVREPD--LPRGFRVPGYPVTPVLS
Mvan_5564|M.vanbaalenii_PYR-1 LGTMAILIVQSLCAFSVIAY--FHFHKNHPS--SAHWFKTFLAPLLGGIG
Mflv_1244|M.gilvum_PYR-GCK LGTMAILIVQSLCAFSVVAY--FHFHKNHPS--SAHWFKTFLAPLTGGIG
MSMEG_0279|M.smegmatis_MC2_155 LGTMAILIVQSLCAFSVISY--FHIHKNHPE--SKHWFKTLVAPGLGGLG
MAB_0950c|M.abscessus_ATCC_199 LGTTAILIVQALTAFAVISY--FHVLRHHPE--TAHWFRTLVAPLLGGLG
TH_4382|M.thermoresistible__bu LGGTTSLLLLAVFAMVNVAVLVLRRDESRDP--VVARRHFRTPTFLPVVG
MLBr_01974|M.leprae_Br4923 LNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITA
MMAR_2609|M.marinum_M LDTIAALGMLVCWYYGITAFACMWYFRKELFTSLRNVVFKFLCPLLGGMM
:. : . : .
Mb2347c|M.bovis_AF2122/97 VLACGYILAS------------------LHWYTWLAFSGWVAVAVIFYLM
Rv2320c|M.tuberculosis_H37Rv VLACGYILAS------------------LHWYTWLAFSGWVAVAVIFYLM
MUL_1244|M.ulcerans_Agy99 ILACGYLLYS------------------LHWYTWIAFGGWVGIALIFYLF
MAV_2087|M.avium_104 IMACGYILAS------------------LHWYTWIAFSGWVLLALIFYFV
Mvan_5564|M.vanbaalenii_PYR-1 MLYVVYLLWEHKESAAGAASGTLL-FKLTPWIVVGLFALGAAMALYFKFN
Mflv_1244|M.gilvum_PYR-GCK MLYVVYLLWEHKESAAGAASGTLL-FKLTPWIVVGVFAFGAAMALYFKFK
MSMEG_0279|M.smegmatis_MC2_155 MLYVVYLLWEHKDTAAGTASGTLL-FKLTPWIVVSVFVLGAALATYFKLR
MAB_0950c|M.abscessus_ATCC_199 MVYVVYLLAKHASFAAGTASNDWV-FTAIPWVVAAAGIGGIALALTLKYT
TH_4382|M.thermoresistible__bu FVASLYLVTPLSGRP------------AQQYLLSVVLIVIGVLLFGVTMA
MLBr_01974|M.leprae_Br4923 VVVSAGLMVS-------------------FDYRSIFLTRGGPNYFSISLI
MMAR_2609|M.marinum_M LLLVFVVSVRESMDPRHGSGASIAGVGLVFYLGFGILSLGAVLMVVMRVR
.: : .
Mb2347c|M.bovis_AF2122/97 W-----GRHHSALNEEVP-------------------
Rv2320c|M.tuberculosis_H37Rv W-----GRHHSALNEEVP-------------------
MUL_1244|M.ulcerans_Agy99 W-----GRHHSRLNAPALHDNPTGEER----------
MAV_2087|M.avium_104 W-----GRHHSALNDAAVD--PSGQER----------
Mvan_5564|M.vanbaalenii_PYR-1 D-----KRRYELIGRIVYDDSEIRD------------
Mflv_1244|M.gilvum_PYR-GCK D-----KRRYELIGRIVYDDSEVRD------------
MSMEG_0279|M.smegmatis_MC2_155 D-----PRRYGLIGRIVYDEAVERD------------
MAB_0950c|M.abscessus_ATCC_199 A-----PHRYDDLGRTVLEEAHER-------------
TH_4382|M.thermoresistible__bu I-----NRQLGIPTRAVGDPAKMVLPPD---------
MLBr_01974|M.leprae_Br4923 A-----ITFIGIPAVAYLHYYRTSGIK----------
MMAR_2609|M.marinum_M QPGFFLGHTLTPSTPALTDDAAIATASHPDAGPDQHH