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STDSAAVETAAPAGLKKGAIGMVAVIFMAVANAAPITAMTGNVPIAVGFGNGLGAPAGFLFATIALTLFA LGYVAMARHITTTGAFYGFISHGLGQVWGMASGFLATFAYVVFEGSLIGGCAYFANDGVNTIAGVDIPWL VFAVAAVVAIAALCHFHISLTAAILGVTLVSEVLILLALAFTVIFSGGGPDGFMLDKTVLLNNAFTSLPE GAFGTAAAAGSMAIGLFFAFWSWVGFETTAVYGEESRNPKKIIPRATLIAVIGLGLFYTFISAMVLAGNG AKASVEASISASPLDLFFNLVDANLGGFLLDVYKILLVIGSFACALAFHNAASRYLFALGREIPSDKVKS TLGAAHPRHGSPYIASAVQALITMVIVLLFFGFTAVQVPDATGVPVDTPSLVPYTNIYGLLALIGTAAIL LVQAICSVAVVWYFWVRKTHRGNVLTTLVCPVLGALAMGYVVWLLWDNRAFAAGYAANSLVFKNAPFFIA GVFLVGLGYALWLRRARPEVYAEIGRTVMEDSHERS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2078 | - | - | 100% (527) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | e-138 | 51.46% (515) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | e-123 | 45.00% (520) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 2e-13 | 20.98% (448) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 1e-138 | 51.06% (521) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 2e-13 | 20.98% (448) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 1e-11 | 20.66% (334) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 1e-140 | 50.19% (516) | putative amino acid permease family protein |
| M. marinum M | MMAR_2609 | - | 7e-18 | 23.00% (474) | hypothetical protein MMAR_2609 |
| M. avium 104 | MAV_2087 | - | 3e-12 | 21.35% (445) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0781 | - | 1e-139 | 49.81% (518) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 2e-11 | 24.20% (500) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-15 | 22.15% (447) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0781|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2078|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MMAR_2609|M.marinum_M --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MAB_0950c|M.abscessus_ATCC_199 --------------------------------MSDTIDPPVG----TTTE
MSMEG_0781|M.smegmatis_MC2_155 --------------------------------MSEIIDPSAPGKAPSGKS
Mflv_1244|M.gilvum_PYR-GCK --------------------------------MTESAERTAPG---QTTP
Mvan_2078|M.vanbaalenii_PYR-1 --------------------------------MSTDS---------AAVE
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MMAR_2609|M.marinum_M ----------------MTDTPAPPLFARGPKGNKLKVQPIVPQLSNTAAE
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVG--ATIGTGIFFVLAQAVPEAGPGVIVS
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVG--STVGTGIFFVLAEAVPEAGPAVIVS
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVG--STIGTGIFFVMSQAVPEAGPAVIVS
MAB_0950c|M.abscessus_ATCC_199 PDSMQRLKPNAVGLIGVLFMAVATAAPITAMVGNVPMAVGFGNGAYAPAG
MSMEG_0781|M.smegmatis_MC2_155 SEAIQRLKPNAVGLVGVMFMAVATAAPITAMVGNVPIAVGFGNGAYAPAG
Mflv_1244|M.gilvum_PYR-GCK TASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mvan_2078|M.vanbaalenii_PYR-1 TAAPAGLKKGAIGMVAVIFMAVANAAPITAMTGNVPIAVGFGNGLGAPAG
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVG--DILGTGIYALVGDVAGEVGGAAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN--SIIGAGIFMTPGEVIKIAGPFAPIA
MMAR_2609|M.marinum_M GVVSKGLAKGAVGTVSGAILGIA-CVAPGYTLTASIGLIVAAVGLKMPAI
.* :: : *
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
MAB_0950c|M.abscessus_ATCC_199 YLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLGRVVGLGSGFLITL
MSMEG_0781|M.smegmatis_MC2_155 YFVATIVLTLFAIGYAAMSKHITATGAFYGYISHGLGRIVGLGAGFLTAL
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
Mvan_2078|M.vanbaalenii_PYR-1 FLFATIALTLFALGYVAMARHITTTGAFYGFISHGLGQVWGMASGFLATF
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVM
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
MMAR_2609|M.marinum_M FVFGFIPMFLTAFAYRELNADTPDCGASFTWSTKAFGPYVGWMCGWGMVI
: .. : : *. .. : :* :
Mb2347c|M.bovis_AF2122/97 EYGVATA---AVAVGWS------GYVNKLLSNLFGFQMPHVLSAAPWDTH
Rv2320c|M.tuberculosis_H37Rv EYGVATA---AVAVGWS------GYVNKLLSNLFGFQMPHVLSAAPWDTH
MUL_1244|M.ulcerans_Agy99 EYGVATA---AVAVGLS------GYVNKLLHNVFGFQLPQALSEAPWDER
MAV_2087|M.avium_104 EYGVATA---AVSVNWS------GYLNKLLSNVVGFQLPHALSAAPWDAQ
MAB_0950c|M.abscessus_ATCC_199 AYMVFEA---SLVGIFS------FFANDLFQTFFQVDVPWVVFAVAMLAT
MSMEG_0781|M.smegmatis_MC2_155 AYMVFEA---SLIGIFS------FFGNDLFKSFFDVDVPWIVFAVVMLAV
Mflv_1244|M.gilvum_PYR-GCK AYIVFEA---SLIGIFA------FFFQNFLSSQLGITIHWLVPALLMLVL
Mvan_2078|M.vanbaalenii_PYR-1 AYVVFEG---SLIGGCA------YFANDGVNTIAGVDIPWLVFAVAAVVA
TH_4382|M.thermoresistible__bu CSGITSA---STASRFF------AANLEVGLGQEWGRLGVAGVALLFMAL
MLBr_01974|M.leprae_Br4923 TASIAWG---VLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAV
MMAR_2609|M.marinum_M ATVIVLSNLAAVAVQFFYLLIAGLFDSPGIASLAANRWVDIASTLVFIAG
: .
Mb2347c|M.bovis_AF2122/97 PG----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMI
Rv2320c|M.tuberculosis_H37Rv PG----WVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMI
MUL_1244|M.ulcerans_Agy99 PGEAAGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVI
MAV_2087|M.avium_104 PG----YVNLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGI
MAB_0950c|M.abscessus_ATCC_199 NA---VLTYFDLNLAARVLGVFLVTEILMLSLLALSVLFAGGGPQGWSWG
MSMEG_0781|M.smegmatis_MC2_155 NT---VLTYFDINLAAKVLGVFLITEIVMLALMALSVVFTGGGPQGWSLG
Mflv_1244|M.gilvum_PYR-GCK NS---ILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGFAIA
Mvan_2078|M.vanbaalenii_PYR-1 IA---ALCHFHISLTAAILGVTLVSEVLILLALAFTVIFSGGGPDGFMLD
TH_4382|M.thermoresistible__bu LAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGADVDFTRV
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVN-NYVTS
MMAR_2609|M.marinum_M ATWVSSRGIQTSERVQGLLVIFQMTVILGFGVVAIIGAVRGHGPANLSFD
: : :
Mb2347c|M.bovis_AF2122/97 IAFSAYSADHLKDFVPFG-------VAG--IGSAAGTIFFSYIGLDAVST
Rv2320c|M.tuberculosis_H37Rv IAFSAYSADHLKDFVPFG-------VAG--IGSAAGTIFFSYIGLDAVST
MUL_1244|M.ulcerans_Agy99 LALTAYDTNHLKDFAPFG-------VAG--VGAAAGTIFFSFIGLDAVST
MAV_2087|M.avium_104 LAFTAFDMHHLDDFAPFG-------VAG--VGTAAGTIFFSYIGLDAVST
MAB_0950c|M.abscessus_ATCC_199 S-LNPLNGFHDLGGVVQGPAG-PLAVAG-SAGVGLFFAFWSWVGFESSAM
MSMEG_0781|M.smegmatis_MC2_155 S-LNPLNGFQSLTGEVAGTDGSMIAVAG-SAGVGLFFAFWSWVGFESSAM
Mflv_1244|M.gilvum_PYR-GCK ETLNPVGAFQ------------PAAIAGASAGLGLFFAFWSWVGFESTAM
Mvan_2078|M.vanbaalenii_PYR-1 KTVLLNNAFTSLPEGAFG----TAAAAG-SMAIGLFFAFWSWVGFETTAV
TH_4382|M.thermoresistible__bu VAFETTTDKS----------------VFLAVSAATSLAFFAMVGFEDSVN
MLBr_01974|M.leprae_Br4923 RSAYQPTTYSLLGVTEIG------KSTAASMTLATIVALYAFTGFESIAN
MMAR_2609|M.marinum_M FNWFDP--FSG--------------LAMGAFVIGVTGSIFSFWGWDTCLT
. . ::: * :
Mb2347c|M.bovis_AF2122/97 AGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG---TQPWQDFAEQE
Rv2320c|M.tuberculosis_H37Rv AGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG---TQPWQDFAEQE
MUL_1244|M.ulcerans_Agy99 AGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALG---TQPWQMFAGQE
MAV_2087|M.avium_104 AGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALG---TQPWQDFGGQQ
MAB_0950c|M.abscessus_ATCC_199 YAEESKNPKKIIPIAIVTSVVGVGLFYVLVSWLAIVGTGPENAVALAQDS
MSMEG_0781|M.smegmatis_MC2_155 YGEESRNPKKIIPIAVVSSVIGIGAFYVIVSWLAIVGTGPQNAIALAQDS
Mflv_1244|M.gilvum_PYR-GCK YGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQQAVELAQSA
Mvan_2078|M.vanbaalenii_PYR-1 YGEESRNPKKIIPRATLIAVIGLGLFYTFISAMVLAGNGAKASVEASISA
TH_4382|M.thermoresistible__bu MAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVA------LVPVGTLQ
MLBr_01974|M.leprae_Br4923 AAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAML---------LGSDK
MMAR_2609|M.marinum_M LGEECTDPKKVPGRAGVLCVVSILLTYLLVSVAMMMYAGVGSQGLGLGNP
.:* * * : * . :
Mb2347c|M.bovis_AF2122/97 TAGLAIILDNVTH--GEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMG
Rv2320c|M.tuberculosis_H37Rv TAGLAIILDNVTH--GEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMG
MUL_1244|M.ulcerans_Agy99 EAGLATILDNVTH--SAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMG
MAV_2087|M.avium_104 EAGLATILDHVTH--GSWASTILAAGAVISIFSVTLVTMYGITRILFAMG
MAB_0950c|M.abscessus_ATCC_199 STAGNIFFGPVQSHLGVWAVNLFKVLLMTGSFACGMAFHNCAARYLYALG
MSMEG_0781|M.smegmatis_MC2_155 ETAGNIFFNPVHEHLGTWAVDLFKILLMTGSFACGMAFHNCAARYLYAIG
Mflv_1244|M.gilvum_PYR-GCK DTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHNCASRYLYALG
Mvan_2078|M.vanbaalenii_PYR-1 S-PLDLFFNLVDANLGGFLLDVYKILLVIGSFACALAFHNAASRYLFALG
TH_4382|M.thermoresistible__bu ASDVPLVEVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMA
MLBr_01974|M.leprae_Br4923 IVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALS
MMAR_2609|M.marinum_M DNSENVFGALARPVLGPWGSQLLFLGILASTLSSLQTTFLPASRCMLAMG
. : : . .* .:.
Mb2347c|M.bovis_AF2122/97 RDGLLP---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP---------
Rv2320c|M.tuberculosis_H37Rv RDGLLP---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP---------
MUL_1244|M.ulcerans_Agy99 RDGLLP---ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVP---------
MAV_2087|M.avium_104 RDGLLP---PRFARVNPRTMTPVNNTVIVAVAAATLAAFIP---------
MAB_0950c|M.abscessus_ATCC_199 RENVIPGMRKTIGSTHSTHGSPHVAGFVQTAFATVVVLFFA---------
MSMEG_0781|M.smegmatis_MC2_155 RENVVPGMRKTIGATHPVHGSPYIAGFVQTAFAAVVVLFFD---------
Mflv_1244|M.gilvum_PYR-GCK REGLSTGLQKTLGATHKTHGSPYIASFVQSGIALVLVLAFF---------
Mvan_2078|M.vanbaalenii_PYR-1 REIPSDKVKSTLGAAHPRHGSPYIASAVQALITMVIVLLFFGFTAVQVPD
TH_4382|M.thermoresistible__bu RQRVLP---PVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVT---------
MLBr_01974|M.leprae_Br4923 DGRILP----TRLSSKNRFGVPIVAFGITAFLTLAFPLSLR---------
MMAR_2609|M.marinum_M AYRAFP---QRFSAVSSRFQVPLFSTIAAAIASGAFYTLAR---------
* : : .
Mb2347c|M.bovis_AF2122/97 -------LDSLADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPG--
Rv2320c|M.tuberculosis_H37Rv -------LDSLADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFKVPG--
MUL_1244|M.ulcerans_Agy99 -------LNRLADMVSIGTLTAFIVVSVGVIILRVREPALPRGFWVPG--
MAV_2087|M.avium_104 -------LQNLADMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFRVPG--
MAB_0950c|M.abscessus_ATCC_199 -------ATGRDPYTGLYGLMALLGTTAILIVQALTAFAVISYFHVLRHH
MSMEG_0781|M.smegmatis_MC2_155 -------LSGRDPYTELYGLMALLGTTAIMIVQALAAFSVISYFHVHKRH
Mflv_1244|M.gilvum_PYR-GCK -------FAGMDPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFHKNH
Mvan_2078|M.vanbaalenii_PYR-1 ATGVPVDTPSLVPYTNIYGLLALIGTAAILLVQAICSVAVVWYFWVRKTH
TH_4382|M.thermoresistible__bu ------AFADSTAIAVLGGTTSLLLLAVFAMVN--VAVLVLRRDESRDPV
MLBr_01974|M.leprae_Br4923 -----FDSLNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFT
MMAR_2609|M.marinum_M ------LLSERTLLDTIAALGMLVCWYYGITAFACMWYFRKELFTSLRN-
: :
Mb2347c|M.bovis_AF2122/97 --------YPVTPVLSVLACGYILASLHWYTWLAFS--------------
Rv2320c|M.tuberculosis_H37Rv --------YPVTPVLSVLACGYILASLHWYTWLAFS--------------
MUL_1244|M.ulcerans_Agy99 --------YPVTPILSILACGYLLYSLHWYTWIAFG--------------
MAV_2087|M.avium_104 --------YPVTPVLSIMACGYILASLHWYTWIAFS--------------
MAB_0950c|M.abscessus_ATCC_199 PETAHWFRTLVAPLLGGLGMVYVVYLLAKHASFAAGTASNDWVFTAIPWV
MSMEG_0781|M.smegmatis_MC2_155 PETAHWFKTFLAPLLGGTGMLYVIYLLAKNASFAAGDAATDWIFAAIPYV
Mflv_1244|M.gilvum_PYR-GCK PSSAHWFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLFKLTPWI
Mvan_2078|M.vanbaalenii_PYR-1 RG--NVLTTLVCPVLGALAMGYVVWLLWDNRAFAAGYAANSLVFKNAPFF
TH_4382|M.thermoresistible__bu VARRHFRTPTFLPVVGFVASLYLVTPLSGRPAQQYLLSVVLIVIG-----
MLBr_01974|M.leprae_Br4923 --------DKVLPITAVVVSAGLMVSFDYRSIFLTRGGP-----------
MMAR_2609|M.marinum_M -----VVFKFLCPLLGG-MMLLLVFVVSVRESMDPRHGSGASIAGVGLVF
. *: . :: .
Mb2347c|M.bovis_AF2122/97 ------GWVAVAVIFYLMWGRHHSALNEEVP-------------------
Rv2320c|M.tuberculosis_H37Rv ------GWVAVAVIFYLMWGRHHSALNEEVP-------------------
MUL_1244|M.ulcerans_Agy99 ------GWVGIALIFYLFWGRHHSRLNAPALHDNPTGEER----------
MAV_2087|M.avium_104 ------GWVLLALIFYFVWGRHHSALNDAAVD--PSGQER----------
MAB_0950c|M.abscessus_ATCC_199 VAAAGIGGIALALTLKYTAPHRYDDLGRTVLEEAHER-------------
MSMEG_0781|M.smegmatis_MC2_155 VGIVGIGGVLLALFLKFKDPNRYAELGRTVLQESHER-------------
Mflv_1244|M.gilvum_PYR-GCK VVGVFAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD------------
Mvan_2078|M.vanbaalenii_PYR-1 IAGVFLVGLGYALWLRRARPEVYAEIGRTVMEDSHERS------------
TH_4382|M.thermoresistible__bu -----VLLFGVTMAINRQLGIPTRAVGDPAKMVLPPD-------------
MLBr_01974|M.leprae_Br4923 ------NYFSISLIAITFIGIPAVAYLHYYRTSGIK--------------
MMAR_2609|M.marinum_M YLGFGILSLGAVLMVVMRVRQPGFFLGHTLTPSTPALTDDAAIATASHPD
:
Mb2347c|M.bovis_AF2122/97 -------
Rv2320c|M.tuberculosis_H37Rv -------
MUL_1244|M.ulcerans_Agy99 -------
MAV_2087|M.avium_104 -------
MAB_0950c|M.abscessus_ATCC_199 -------
MSMEG_0781|M.smegmatis_MC2_155 -------
Mflv_1244|M.gilvum_PYR-GCK -------
Mvan_2078|M.vanbaalenii_PYR-1 -------
TH_4382|M.thermoresistible__bu -------
MLBr_01974|M.leprae_Br4923 -------
MMAR_2609|M.marinum_M AGPDQHH