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MTDTPAPPLFARGPKGNKLKVQPIVPQLSNTAAEGVVSKGLAKGAVGTVSGAILGIACVAPGYTLTASIG LIVAAVGLKMPAIFVFGFIPMFLTAFAYRELNADTPDCGASFTWSTKAFGPYVGWMCGWGMVIATVIVLS NLAAVAVQFFYLLIAGLFDSPGIASLAANRWVDIASTLVFIAGATWVSSRGIQTSERVQGLLVIFQMTVI LGFGVVAIIGAVRGHGPANLSFDFNWFDPFSGLAMGAFVIGVTGSIFSFWGWDTCLTLGEECTDPKKVPG RAGVLCVVSILLTYLLVSVAMMMYAGVGSQGLGLGNPDNSENVFGALARPVLGPWGSQLLFLGILASTLS SLQTTFLPASRCMLAMGAYRAFPQRFSAVSSRFQVPLFSTIAAAIASGAFYTLARLLSERTLLDTIAALG MLVCWYYGITAFACMWYFRKELFTSLRNVVFKFLCPLLGGMMLLLVFVVSVRESMDPRHGSGASIAGVGL VFYLGFGILSLGAVLMVVMRVRQPGFFLGHTLTPSTPALTDDAAIATASHPDAGPDQHH
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2609 | - | - | 100% (549) | hypothetical protein MMAR_2609 |
M. marinum M | MMAR_3554 | - | 1e-98 | 38.15% (540) | hypothetical protein MMAR_3554 |
M. marinum M | MMAR_3621 | rocE | 5e-19 | 25.25% (408) | cationic amino acid transport integral membrane protein RocE |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2347c | rocE | 2e-18 | 25.69% (397) | cationic amino acid transport integral membrane protein RocE |
M. gilvum PYR-GCK | Mflv_4853 | - | 1e-111 | 42.12% (482) | amino acid permease-associated region |
M. tuberculosis H37Rv | Rv2320c | rocE | 2e-18 | 25.69% (397) | cationic amino acid transport integral membrane protein RocE |
M. leprae Br4923 | MLBr_01974 | - | 6e-08 | 23.37% (398) | putative permease |
M. abscessus ATCC 19977 | MAB_4206 | - | 0.0 | 66.40% (500) | putative amino acid transporter |
M. avium 104 | MAV_2087 | - | 5e-20 | 24.23% (392) | amino acid transporter |
M. smegmatis MC2 155 | MSMEG_1625 | - | 0.0 | 72.12% (495) | amino acid transporter, putative |
M. thermoresistible (build 8) | TH_0471 | - | 1e-15 | 23.48% (396) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
M. ulcerans Agy99 | MUL_2787 | - | 5e-97 | 37.78% (540) | hypothetical protein MUL_2787 |
M. vanbaalenii PYR-1 | Mvan_1574 | - | 1e-115 | 42.74% (503) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment Mb2347c|M.bovis_AF2122/97 -------------------------------------------------- Rv2320c|M.tuberculosis_H37Rv -------------------------------------------------- MAV_2087|M.avium_104 -------------------------------------------------- TH_0471|M.thermoresistible__bu -------------------------------------------------- MAB_4206|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_1625|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2609|M.marinum_M -------------------------------------------------- Mflv_4853|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1574|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2787|M.ulcerans_Agy99 -------------------------------------------------- MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ Mb2347c|M.bovis_AF2122/97 ----------MPTTSMSLRELMLRRRPVSG-----------------APV Rv2320c|M.tuberculosis_H37Rv ----------MPTTSMSLRELMLRRRPVSG-----------------APV MAV_2087|M.avium_104 -------------------------------------------------M TH_0471|M.thermoresistible__bu -----------------MTDRLRVKSVEQS-----------------IAD MAB_4206|M.abscessus_ATCC_1997 -------------MT--------EDLARAE---LDHAE---------RSE MSMEG_1625|M.smegmatis_MC2_155 -------------MTRSDPQSDPESDPHHA---LEIVE---------QSA MMAR_2609|M.marinum_M -------------MTDTPAPPLFARGPKGN---KLKVQPIVPQLSNTAAE Mflv_4853|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1574|M.vanbaalenii_PYR-1 -------------------------------MAIT---------DEPAVP MUL_2787|M.ulcerans_Agy99 -------------MGHLDADKKTNHQPIEGDCVSQ---------GEATSV MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVP-----EAGPG Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVP-----EAGPG MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVG-STIGTGIFFVMSQAVP-----EAGPA TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVS-VVIGAGIFTVTASTAGN----ITGPA MAB_4206|M.abscessus_ATCC_1997 GLVSKGLAAGRIGTFTGAVLGISTVAPGYTLTASIGLIVAA-----VGLK MSMEG_1625|M.smegmatis_MC2_155 GLRGKGLAAGKVGTFSGAILGISSVAPGYTLTASIGLIVAA-----VGLK MMAR_2609|M.marinum_M GVVSKGLAKGAVGTVSGAILGIACVAPGYTLTASIGLIVAA-----VGLK Mflv_4853|M.gilvum_PYR-GCK -----------------MVIGLGAVAPAYSLAATLGYVVLN-----VQEK Mvan_1574|M.vanbaalenii_PYR-1 AVGGKGLQAGALGLVGNVVIGLGAVAPAYSLAATLGYVVLN-----VQEK MUL_2787|M.ulcerans_Agy99 AVEGKGLKGGAVGLLSSVVIGTASTAPAYSLAATLGLIVASRGELLCGVK MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN-SIIGAGIFMTPGEVIKI-----AGPF ::* . : . Mb2347c|M.bovis_AF2122/97 VIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAA Rv2320c|M.tuberculosis_H37Rv VIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAA MAV_2087|M.avium_104 VIVSFLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAA TH_0471|M.thermoresistible__bu ISVSFIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGW MAB_4206|M.abscessus_ATCC_1997 MPAILIAGFIPMFLTAYAYRELNSRAPDCGASFTWSTKAFGPYVGWMCGW MSMEG_1625|M.smegmatis_MC2_155 MPAIFIAGFIPMFLTAYAYRELNSRAPDCGASFTWSTKAFGPYVGWMCGW MMAR_2609|M.marinum_M MPAIFVFGFIPMFLTAFAYRELNADTPDCGASFTWSTKAFGPYVGWMCGW Mflv_4853|M.gilvum_PYR-GCK APSMFVLAFIPMLLVAFAYKELSQDTPDCGTTFTWATKAFGPWIGWIGGW Mvan_1574|M.vanbaalenii_PYR-1 APAMFVLAFIPMLLVAFAYKELSQDTPDCGTTFTWGTKAFGPWIGWIGGW MUL_2787|M.ulcerans_Agy99 APAIVLLSFIPMYMIAVAYQELNKAEPDCGTTFTWASRAFGPVTGWLGGW MLBr_01974|M.leprae_Br4923 APIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGV . : : * : *::::: ::* . . Mb2347c|M.bovis_AF2122/97 CLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPGWVN Rv2320c|M.tuberculosis_H37Rv CLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPGWVN MAV_2087|M.avium_104 CLLLEYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPGYVN TH_0471|M.thermoresistible__bu DLILEFSVAAAVVAKGWSSYLGEVFE----------FAGATTRLGPITLD MAB_4206|M.abscessus_ATCC_1997 GMVIATIIVLSNLASIGVQYGYQFLGAVTH-----NQTVAELANNKAVNI MSMEG_1625|M.smegmatis_MC2_155 GMVIATIIVLSNLAAIAVEFFYLFVARILN-----TPEIADLADNKLVNI MMAR_2609|M.marinum_M GMVIATVIVLSNLAAVAVQFFYLLIAGLFD-----SPGIASLAANRWVDI Mflv_4853|M.gilvum_PYR-GCK GLAVSAIIVLANVSEIAAIYLYNFLG------------LTSLAESVPATV Mvan_1574|M.vanbaalenii_PYR-1 GLAVSAIIVLANVSEIAAIYLYNFLG------------LDSLAESVPATV MUL_2787|M.ulcerans_Agy99 GIIAADVIVMANLAQIAGAYSFTFVGELG------WQSASNLAHSTLWST MLBr_01974|M.leprae_Br4923 THAITASIAWGVLASSFVSTLLRVAFP--------EKIWADNDELISVKT :. . :: . Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH TH_0471|M.thermoresistible__bu WGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA MAB_4206|M.abscessus_ATCC_1997 ISTVALLAIATYISSRGITTSEKVQYVLVGFQMIVLVLFAVVAIVKAPG- MSMEG_1625|M.smegmatis_MC2_155 LTTLVFIALATWVSSRGITTSEHVQYVLVGFQMTVLLAFAITAVIHVGAG MMAR_2609|M.marinum_M ASTLVFIAGATWVSSRGIQTSERVQGLLVIFQMTVILGFGVVAIIGAVRG Mflv_4853|M.gilvum_PYR-GCK ALGCFFIIAMTLVSARGIVVSERVQNVLIAIQFGVLITVSIIALVRVFSG Mvan_1574|M.vanbaalenii_PYR-1 ALGCFFIISMTLVSARGIVVSERVQNVLIAIQFGVLITVSVIALIRVFTG MUL_2787|M.ulcerans_Agy99 VAGVAWIVVMTCICYRGTDVSARMQYVLLSVELVVLVALAAVALARVYTN MLBr_01974|M.leprae_Br4923 LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ : : * . :. .: . . Mb2347c|M.bovis_AF2122/97 HLKDFVP---------------------------FGVAGIGSAAGTIFFS Rv2320c|M.tuberculosis_H37Rv HLKDFVP---------------------------FGVAGIGSAAGTIFFS MAV_2087|M.avium_104 HLDDFAP---------------------------FGVAGVGTAAGTIFFS TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA MAB_4206|M.abscessus_ATCC_1997 --AAGHLDFDLD-------------WFNPMTGLTLSA--FVIGLVGSIFA MSMEG_1625|M.smegmatis_MC2_155 N-APEGLAFDLD-------------WFNPFTNLAFGA--FVIGVTGSIFA MMAR_2609|M.marinum_M H-GPANLSFDFN-------------WFDPFSGLAMGA--FVIGVTGSIFS Mflv_4853|M.gilvum_PYR-GCK TAGAQAVMPEVS-------------WLWP-SGLDVSS--IAAAVILCIFI Mvan_1574|M.vanbaalenii_PYR-1 TAGAQAISPQLS-------------WLWP-SGLDVSS--IAAAVILCIFI MUL_2787|M.ulcerans_Agy99 HGDVGSLRPSLS-------------WLWP-SGLDFGTQ-MAPALLITIFI MLBr_01974|M.leprae_Br4923 HVNNYVTSRSAYQP-------TTYSLLGVTEIGKSTAASMTLATIVALYA . . :: Mb2347c|M.bovis_AF2122/97 YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ Rv2320c|M.tuberculosis_H37Rv YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQ TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYT MAB_4206|M.abscessus_ATCC_1997 FWGWDTCLTLGEESKDPTKVPGRAGLLCVLSILLTYLLVAVAVMMFAGIG MSMEG_1625|M.smegmatis_MC2_155 FWGWDTCLTLGEESKDPTKVPGRAGLLCVTTILLTYLLVAVAVMMYAGVG MMAR_2609|M.marinum_M FWGWDTCLTLGEECTDPKKVPGRAGVLCVVSILLTYLLVSVAMMMYAGVG Mflv_4853|M.gilvum_PYR-GCK YWGWDACLAVGEETKDPGKTPGIAALITTVILVCTYVLVAYALQSFAGFS Mvan_1574|M.vanbaalenii_PYR-1 YWGWDACLAVGEETKDPGRTPGIAALVTTVILVCTYVLVAFALQSFAGFS MUL_2787|M.ulcerans_Agy99 YWGFDTAVACNDETDDPGRTLGRAAVISTFLLLATYAVVTVASIAFAGVG MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLG--- : * : :* * : . : * . . Mb2347c|M.bovis_AF2122/97 D----FAEQ-ETAGLAIILDN-----VTHGEWASTILAAGAVVSIFTVTL Rv2320c|M.tuberculosis_H37Rv D----FAEQ-ETAGLAIILDN-----VTHGEWASTILAAGAVVSIFTVTL MAV_2087|M.avium_104 D----FGGQ-QEAGLATILDH-----VTHGSWASTILAAGAVISIFSVTL TH_0471|M.thermoresistible__bu E----LRAAGENANLATAFA------ANGIDWAAKVISIGALAGLTTVVI MAB_4206|M.abscessus_ATCC_1997 DTDLGLANENNKDNVFGALA-----NPVLGSWFGPLLLLAIFASAIASLQ MSMEG_1625|M.smegmatis_MC2_155 ETGLGLGNPENSENVFGALA-----DPVLGSWGGPLLFLAVLASSVASLQ MMAR_2609|M.marinum_M SQGLGLGNPDNSENVFGALA-----RPVLGPWGSQLLFLGILASTLSSLQ Mflv_4853|M.gilvum_PYR-GCK EVGIGLNNPNNTDDVLTVLG-----EPVAGAIAASALLLTVSVSALSSTQ Mvan_1574|M.vanbaalenii_PYR-1 EVGIGLNNPNNTDDVLTVLG-----KPVAGAIAASALLLTVSVSALSSTQ MUL_2787|M.ulcerans_Agy99 VDGIGLGNPDNSNDVFAAVGPALFGDGVLGKIGLLLLSASILTSASASTQ MLBr_01974|M.leprae_Br4923 --SDKIVATNHTVKLAAAVG---------NNTFRTIIVVGALVSMFGINV : . : . : . Mb2347c|M.bovis_AF2122/97 VTMYGQTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAF Rv2320c|M.tuberculosis_H37Rv VTMYGQTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAF MAV_2087|M.avium_104 VTMYGITRILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAAF TH_0471|M.thermoresistible__bu VLVLGQTRVLFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAIAASV MAB_4206|M.abscessus_ATCC_1997 TTSLPAARTMLAMGTYGAFPKRFASVSPRFLTPTFSTVVAGVVTAAFYTI MSMEG_1625|M.smegmatis_MC2_155 TTFLPAARAMLAMGAYGAFPKRFSHVHPRFLVPSFSTLIAGIVTGVFYTV MMAR_2609|M.marinum_M TTFLPASRCMLAMGAYRAFPQRFSAVSSRFQVPLFSTIAAAIASGAFYTL Mflv_4853|M.gilvum_PYR-GCK TTILPTARGTLSMAVYEAIPRRFASVHPRYMTPAFGTIVMGISALFFYLV Mvan_1574|M.vanbaalenii_PYR-1 TTILPTARGTLSMAVYEAIPKRFANVHPRYMTPAFGTIVMGLSALFFYLV MUL_2787|M.ulcerans_Agy99 TTILPTARTTLSMAVYKALPASFAKIHPRYLTPTVSTIAMGAVSILFYVL MLBr_01974|M.leprae_Br4923 AASFGAPRLWTALSDGRILPTRLS-SKNRFGVPIVAFGITAFLTLAFPLS . .* ::. :* :: * .* . Mb2347c|M.bovis_AF2122/97 IPLDS----LADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFK-VPGYP Rv2320c|M.tuberculosis_H37Rv IPLDS----LADMVSIGTLTAFSVVAVGVIVLRVREPDLPRGFK-VPGYP MAV_2087|M.avium_104 IPLQN----LADMVSIGTLTAFVVVSVGVIVLRVREPDLPRGFR-VPGYP TH_0471|M.thermoresistible__bu FPVGN----LEEMVNIGTLFAFALVSAGVIVLRRTRPDLKRGFR-VPFVP MAB_4206|M.abscessus_ATCC_1997 VSLLSDRTLLDTIAALGIMICWYYGITAFACVWYFRAELFQNAHNLVYKF MSMEG_1625|M.smegmatis_MC2_155 VSLLSEYALLDTIAALGIMICWYYGITAFACIWYFRRELFTDAHNIVFKF MMAR_2609|M.marinum_M ARLLSERTLLDTIAALGMLVCWYYGITAFACMWYFRKELFTSLRNVVFKF Mflv_4853|M.gilvum_PYR-GCK LKMLSENALLDSVASLGLAVAFYYGITAFACVWYFRRTLFSSARNLFFRG Mvan_1574|M.vanbaalenii_PYR-1 LKALSENALLDSVASLGLAVAFYYGITAFACVWYFRRTLFESTRNLFFRG MUL_2787|M.ulcerans_Agy99 FTLVSRNLLSALIGSVGLVIAFYYGLTGYACAHYYRATLTKSLRNFVMRG MLBr_01974|M.leprae_Br4923 LRFDSLN--LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTD . : :. : . . : Mb2347c|M.bovis_AF2122/97 VTPVLS--VLACGYILASLH--------------------WYTWLAFSGW Rv2320c|M.tuberculosis_H37Rv VTPVLS--VLACGYILASLH--------------------WYTWLAFSGW MAV_2087|M.avium_104 VTPVLS--IMACGYILASLH--------------------WYTWIAFSGW TH_0471|M.thermoresistible__bu WLPLAA--IAACLWLMLNLT--------------------GLTWVRFLGW MAB_4206|M.abscessus_ATCC_1997 LFPLLGGLMLAAVFVISVQES----MDPEKTGSGASIGGIGLVFYLGFGI MSMEG_1625|M.smegmatis_MC2_155 LFPLIGGLVLAAVFGFSLKES----MDPE-NGSGAELGGIGLVFYIGFGI MMAR_2609|M.marinum_M LCPLLGGMMLLLVFVVSVRES----MDPR-HGSGASIAGVGLVFYLGFGI Mflv_4853|M.gilvum_PYR-GCK VFPLLGGLSMLAAFAISAKD------MIQPDYGHTAFGSIGGVFVLGVGM Mvan_1574|M.vanbaalenii_PYR-1 VFPLLGGLSMLAAFTISAKD------MIQPDYGYTAFGPVGGVFVLGVGM MUL_2787|M.ulcerans_Agy99 VVPLTGGVVLTVVFIFGLIEYAKRDWLVENGHNVTIFG-FGAVAVVGVGS MLBr_01974|M.leprae_Br4923 KVLPITAVVVSAGLMVSFDYR--------------------SIFLTRGGP . * Mb2347c|M.bovis_AF2122/97 VAVAVIFYLMWGRHHSALN--------------EEVP------------- Rv2320c|M.tuberculosis_H37Rv VAVAVIFYLMWGRHHSALN--------------EEVP------------- MAV_2087|M.avium_104 VLLALIFYFVWGRHHSALN--------------DAAVDPSGQER------ TH_0471|M.thermoresistible__bu MALGLVLYFFYGRHHSMLG--------------RGMTDISARRTG----- MAB_4206|M.abscessus_ATCC_1997 LAFGALLMGIMRWYQPA--FFRGELLT------MDTPPLRE--------- MSMEG_1625|M.smegmatis_MC2_155 LLLGAVLMLVMRTRSPE--FFRGETLS------RNTPVIPG--------- MMAR_2609|M.marinum_M LSLGAVLMVVMRVRQPG--FFLGHTLT------PSTPALTDDAAIATASH Mflv_4853|M.gilvum_PYR-GCK LVLGIPLMLACFAFGTKR-FFRGETLN-------ADTAVKVPDTF----- Mvan_1574|M.vanbaalenii_PYR-1 LVLGIPLMLACFAFGTKR-FFRGETLN-------ADTEVKVPDTF----- MUL_2787|M.ulcerans_Agy99 MLLGVVVMLIWWAISPG--FFRGRTLRRHSADLLLEPAVSPPAHLALPDS MLBr_01974|M.leprae_Br4923 NYFSISLIAITFIGIPAVAYLHY----------YRTSGIK---------- .. . . Mb2347c|M.bovis_AF2122/97 ------------------------------------- Rv2320c|M.tuberculosis_H37Rv ------------------------------------- MAV_2087|M.avium_104 ------------------------------------- TH_0471|M.thermoresistible__bu ------------------------------------- MAB_4206|M.abscessus_ATCC_1997 ------------------------------------- MSMEG_1625|M.smegmatis_MC2_155 ------------------------------------- MMAR_2609|M.marinum_M PDAGPDQHH---------------------------- Mflv_4853|M.gilvum_PYR-GCK ------------------------------------- Mvan_1574|M.vanbaalenii_PYR-1 ------------------------------------- MUL_2787|M.ulcerans_Agy99 GDMQTVIAADLSNLPAGETAVNPQTGQHLTKDTSGAS MLBr_01974|M.leprae_Br4923 -------------------------------------