For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MFARCRTAAHAGAMTHSPDAAALAEEWDERYTSLADRIPDGTPSAVLIETAEKLTPGAALDIGCGVGSDA IWLAAQGWKSTALDVSRVALDRATERGRRAGVDVNWVCSRLEDLPLPPGGFDLVTAHYPALLHSPGADAE RTLLAAVAPGGTLLVVHHADIDVDLAKAHGFDPADYLSHDDVIELLGEEWEVSVEKRRPRDVPAGIDGQH THDDIVLARRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5314 | - | - | 100% (221) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 2e-19 | 34.30% (207) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4027 | - | 6e-10 | 33.58% (137) | methyltransferase type 12 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1412c | - | 1e-11 | 39.81% (103) | putative transferase |
| M. gilvum PYR-GCK | Mflv_2895 | - | 1e-21 | 44.68% (141) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1377c | - | 1e-11 | 39.81% (103) | putative transferase |
| M. leprae Br4923 | MLBr_01723 | - | 9e-08 | 28.28% (145) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_3178 | - | 4e-23 | 33.66% (202) | hypothetical protein MAB_3178 |
| M. marinum M | MMAR_2640 | - | 3e-12 | 32.14% (140) | methyltransferase |
| M. avium 104 | MAV_2216 | cheR | 1e-18 | 41.30% (138) | CheR methyltransferase SAM binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 2e-19 | 34.45% (209) | methyltransferase |
| M. thermoresistible (build 8) | TH_0144 | - | 2e-22 | 37.89% (190) | methyltransferase |
| M. ulcerans Agy99 | MUL_3115 | - | 4e-12 | 31.65% (139) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 -------------------------------------------MFARCRT
MMAR_2640|M.marinum_M -------------------------MSRTAERADRLSIRYPVCSPTAQVR
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 ----------------------MTRSTEISANAVPNPHATAEQVAAARKD
Mb1412c|M.bovis_AF2122/97 -----MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWV
Rv1377c|M.tuberculosis_H37Rv -----MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWV
MAV_2216|M.avium_104 ---MDTSCEPGE---AGRFWEERYR-GAERVWSGRVNPRLAELAADLPA-
TH_0144|M.thermoresistible__bu ------------------------------MWSGRVNARLAEVAGELPP-
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYG-EREQIWSGRVNPQLEKVASDLPA-
Mflv_2895|M.gilvum_PYR-GCK ---MTD---------VKQHWEERYS-QRDRIWSGHVNRWLAEVAAPLKP-
MAB_3178|M.abscessus_ATCC_1997 ---MHDHNNPPS---DEKSWDEFYQ-SHDALWSGNANPQLVAEISSLPP-
Mvan_5314|M.vanbaalenii_PYR-1 AAHAGAMTHSPDAAALAEEWDERYTSLADRIPDGTPSAVLIETAEKLTP-
MMAR_2640|M.marinum_M RSCRGRRMVARVAESDRRRWDRRYASLGPAAVSAARPPALLQAHLKLVPT
MUL_3115|M.ulcerans_Agy99 --------MARVAESDRRRWDRRYASLGPAAVSAVRPPALLQAHLKLVPA
MLBr_01723|M.leprae_Br4923 SKLAQVLYHDWEAENYDEKWSISYDQRCVDYVRHCFDAIVPDELFTELP-
Mb1412c|M.bovis_AF2122/97 HGDVLDIGCGLGDNAIYLARNGYQVTG--LDISPTALTTAKRRASDAG--
Rv1377c|M.tuberculosis_H37Rv HGDVLDIGCGLGDNAIYLARNGYQVTG--LDISPTALTTAKRRASDAG--
MAV_2216|M.avium_104 -GRALDLGCGEGADALWLAQRGWTVLA--VDISATALRRAAEAAASR--K
TH_0144|M.thermoresistible__bu -GRALDVGCGEGADAMWLAERGWQVTA--VDISQTALDRAAAEAASR--G
MSMEG_4303|M.smegmatis_MC2_155 -GHALDLGCGEGGDAVWLAERGWRVTA--VDISHTALSRAAAEAGRR--G
Mflv_2895|M.gilvum_PYR-GCK -GRALDLGCGEGGDTLWLAEHGWEVVG--VDISDTALRRAAEEADKR--G
MAB_3178|M.abscessus_ATCC_1997 -RTALDAGCGEGGDAIWLAQHGWQVTG--MDFAHTALRRAADNAVKVDPE
Mvan_5314|M.vanbaalenii_PYR-1 -GAALDIGCGVGSDAIWLAAQGWKSTA--LDVSRVALDRATERGRRAG--
MMAR_2640|M.marinum_M AGRALDLGCGQGLGAVWLARRGLDVLG--LDISPVAIAQARDLAERS--G
MUL_3115|M.ulcerans_Agy99 AGRALDLGCGQGLGAVWLARRGLDVLG--LDISPVAIAQARDLAERS--G
MLBr_01723|M.leprae_Br4923 YDCALELGCGTGFFLLNLIQSGVARRGSVTDLSPGMVKIATRNGQSLG--
.*: *** * : * * . *.: : * .
Mb1412c|M.bovis_AF2122/97 --VDVKFAVGDATKLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRAT
Rv1377c|M.tuberculosis_H37Rv --VDVKFAVGDATKLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRAT
MAV_2216|M.avium_104 LLARIDFQRHDLNES-FPEGMFDLISAQYFHSPVHLDRDAVLRRAATRVK
TH_0144|M.thermoresistible__bu LT--IDFQRHELPAT-FPDGQFELVSAHFLHSEVELDRVRILRRAAEAVV
MSMEG_4303|M.smegmatis_MC2_155 VADRITFERHDLSES-FPDGEFDLVSAQFLHSTVRLERPRILSTAARAIR
Mflv_2895|M.gilvum_PYR-GCK LADRVQLRQTDLSAS-FPDGVFDLVSAQFLQSMVHLDRERIFAAAARAVA
MAB_3178|M.abscessus_ATCC_1997 LANRISWTQADLTAW-QPNRQFDLVTSHFMHLPTNL-REPVFAALAAAVA
Mvan_5314|M.vanbaalenii_PYR-1 --VDVNWVCSRLEDLPLPPGGFDLVTAHYP-ALLHSPGADAERTLLAAVA
MMAR_2640|M.marinum_M VSARCCFDVVDLDDG-LPDG-----PPVDVIVCHNFRDRRLDAAIIDRLA
MUL_3115|M.ulcerans_Agy99 VSARCRFDVVDLDDG-LPDG-----PPVDLIVCHNFRDRRLDAAIIERLA
MLBr_01723|M.leprae_Br4923 --LDINGRVADAEGIPYDDNTFDLVVGHAV--LHHIPDVELSLREVLRVL
Mb1412c|M.bovis_AF2122/97 RPGATLLLSCFSNAMPPDEEWPRS---------------------TVSEQ
Rv1377c|M.tuberculosis_H37Rv RPGATLLLSCFSNAMPPDEEWPRS---------------------TVSEQ
MAV_2216|M.avium_104 -PGGVLLIVDHGAAPPWAQHDGHH-------------------FPGVEEV
TH_0144|M.thermoresistible__bu -PGGLLLIVDHGAPPPWAPDHVHEFE-----------------FPSAQEV
MSMEG_4303|M.smegmatis_MC2_155 -PGGHLVIVDHGKMPPNATRVPHDHP-----------------FPSAEEV
Mflv_2895|M.gilvum_PYR-GCK -PGGVLIVVDHAAAPPWAPPEVHEHR-----------------FSTVDEV
MAB_3178|M.abscessus_ATCC_1997 -PGGTLLIVGHHPSDMQAAIGRPDLPDW---------------YFTAEDI
Mvan_5314|M.vanbaalenii_PYR-1 -PGGTLLVVHHADIDVDLAKAHGFDPAD---------------YLSHDDV
MMAR_2640|M.marinum_M -PGGLVALVALSEVG---------------------------------AA
MUL_3115|M.ulcerans_Agy99 -PGGLVALVALSEVG---------------------------------AA
MLBr_01723|M.leprae_Br4923 KPGGRFVFAGEPTDVGNRYARVFADLTWKVTIRVVQLPGLSAWRRTQVEI
**. . .
Mb1412c|M.bovis_AF2122/97 TLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS------
Rv1377c|M.tuberculosis_H37Rv TLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS------
MAV_2216|M.avium_104 LGSLRLDPDGWTRLRAEAAGREMTGPNGEVGTLMDNIMMLRRTEQAYAAS
TH_0144|M.thermoresistible__bu VESLQLPEGQWELLRAEPVKRDAVGPDGQQGTLIDNVIMLRRR-------
MSMEG_4303|M.smegmatis_MC2_155 LAGLDLPASEWERVRVEAVHREATGPDGQPMPMVDNVMVLRRTS------
Mflv_2895|M.gilvum_PYR-GCK LATIDLGEGSWERLRADVVERDAIGPDGEAGVLRDNLIVVRRCA------
MAB_3178|M.abscessus_ATCC_1997 ADTLNPKE--WTIIVAESRSRKFTR-DDEEFDIADTVLRAERKPTTESA-
Mvan_5314|M.vanbaalenii_PYR-1 IELL---GEEWEVSVEKRRPRDVPAGIDGQHTHDDIVLARRR--------
MMAR_2640|M.marinum_M AGTYRAAPGELSAAFAELDPIAAGEGDGRAWLLARA--------------
MUL_3115|M.ulcerans_Agy99 AGTYRAAPGELSTAFAELDPIAAGEGDGRAWLLARA--------------
MLBr_01723|M.leprae_Br4923 DENSRAAALEWVVDLHTFEPKVLETMATNAGAVQVKTVTEEFTAAMLGWP
Mb1412c|M.bovis_AF2122/97 --------------------------------------------------
Rv1377c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5314|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 LRTFESTMPPSKLGWGWARFAFTSWKTLSWVDANVWRRVIPKSWFYNIII
Mb1412c|M.bovis_AF2122/97 ------
Rv1377c|M.tuberculosis_H37Rv ------
MAV_2216|M.avium_104 ------
TH_0144|M.thermoresistible__bu ------
MSMEG_4303|M.smegmatis_MC2_155 ------
Mflv_2895|M.gilvum_PYR-GCK ------
MAB_3178|M.abscessus_ATCC_1997 ------
Mvan_5314|M.vanbaalenii_PYR-1 ------
MMAR_2640|M.marinum_M ------
MUL_3115|M.ulcerans_Agy99 ------
MLBr_01723|M.leprae_Br4923 TGVKPS