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MDSSVWDERYASVEHPWGSTPPCALMARYAALRPGRAIDLACGDGRNARYLAESGWDVEAVDFSPVAIEV AKGVDDSENISYTVGDVRNWQPEKRADLVVISFLHLPIDELVAVIATAATWLRPGGHLLYLGHALENFVY GVGGPADPAILPGLADLARASQGLRVVEMAHLLRPQGDRQAVDVLLHVQPWDPDQGWPPQAPGQAATAVT DTESK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4027 | - | - | 100% (215) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 7e-12 | 31.85% (135) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_5314 | - | 6e-10 | 33.58% (137) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 3e-08 | 40.00% (80) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_2895 | - | 5e-14 | 34.33% (134) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0294 | tam | 3e-08 | 40.00% (80) | trans-aconitate methyltransferase tam |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3178 | - | 3e-21 | 35.95% (153) | hypothetical protein MAB_3178 |
| M. marinum M | MMAR_2640 | - | 4e-09 | 42.17% (83) | methyltransferase |
| M. avium 104 | MAV_2216 | cheR | 2e-16 | 36.84% (133) | CheR methyltransferase SAM binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 2e-15 | 36.30% (135) | methyltransferase |
| M. thermoresistible (build 8) | TH_0144 | - | 2e-12 | 33.33% (120) | methyltransferase |
| M. ulcerans Agy99 | MUL_3115 | - | 2e-09 | 37.38% (107) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------------------------
Rv0294|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M -------------------------MSRTAERADRLSIRYPVCSPTAQVR
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0302|M.bovis_AF2122/97 --------------------------------MWDPDVYLAFSGHRNRPF
Rv0294|M.tuberculosis_H37Rv --------------------------------MWDPDVYLAFSGHRNRPF
Mvan_4027|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2216|M.avium_104 ---MDTSCEPGE---AGRFWEERYRGA--ERVWSGRVNPRLAELAADLP-
TH_0144|M.thermoresistible__bu -------------------------------MWSGRVNARLAEVAGELP-
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYGER--EQIWSGRVNPQLEKVASDLP-
Mflv_2895|M.gilvum_PYR-GCK ---MTD---------VKQHWEERYSQR--DRIWSGHVNRWLAEVAAPLK-
MAB_3178|M.abscessus_ATCC_1997 ---MHDHNNPPS---DEKSWDEFYQSH--DALWSGNANPQLVAEISSLP-
MMAR_2640|M.marinum_M RSCRGRRMVARVAESDRRRWDRRYASLGPAAVSAARPPALLQAHLKLVPT
MUL_3115|M.ulcerans_Agy99 --------MARVAESDRRRWDRRYASLGPAAVSAVRPPALLQAHLKLVPA
Mb0302|M.bovis_AF2122/97 YELVSRVGLERARRVVDLGCGPGHLTRYLARRWPGAVIEALDSSPEMVA-
Rv0294|M.tuberculosis_H37Rv YELVSRVGLERARRVVDLGCGPGHLTRYLARRWPGAVIEALDSSPEMVA-
Mvan_4027|M.vanbaalenii_PYR-1 --------------MDSSVWDERYASV--EHPWGSTPPCALMARYAALR-
* :
MAV_2216|M.avium_104 AGRALDLGCGEGADALWLAQRGWTVLAVDISATALRRAAEAAASR--KLL
TH_0144|M.thermoresistible__bu PGRALDVGCGEGADAMWLAERGWQVTAVDISQTALDRAAAEAASR--GLT
MSMEG_4303|M.smegmatis_MC2_155 AGHALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRR--GVA
Mflv_2895|M.gilvum_PYR-GCK PGRALDLGCGEGGDTLWLAEHGWEVVGVDISDTALRRAAEEADKR--GLA
MAB_3178|M.abscessus_ATCC_1997 PRTALDAGCGEGGDAIWLAQHGWQVTGMDFAHTALRRAADNAVKVDPELA
MMAR_2640|M.marinum_M AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
MUL_3115|M.ulcerans_Agy99 AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
Mb0302|M.bovis_AF2122/97 AAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPEHSDLLVRWVDELA
Rv0294|M.tuberculosis_H37Rv AAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPEHSDLLVRWVDELA
Mvan_4027|M.vanbaalenii_PYR-1 PGRAIDLACGDGRNARYLAESGWDVEAVDFSPVAIEVAKGVDDSE-----
. . . * : .. . * : : :
MAV_2216|M.avium_104 ARIDFQRHDLNESFPEGM-FDLISAQYFHSPVHLDRDAVLRRAATRVKPG
TH_0144|M.thermoresistible__bu --IDFQRHELPATFPDGQ-FELVSAHFLHSEVELDRVRILRRAAEAVVPG
MSMEG_4303|M.smegmatis_MC2_155 DRITFERHDLSESFPDGE-FDLVSAQFLHSTVRLERPRILSTAARAIRPG
Mflv_2895|M.gilvum_PYR-GCK DRVQLRQTDLSASFPDGV-FDLVSAQFLQSMVHLDRERIFAAAARAVAPG
MAB_3178|M.abscessus_ATCC_1997 NRISWTQADLTAWQPNRQ-FDLVTSHFMHLPTNL-REPVFAALAAAVAPG
MMAR_2640|M.marinum_M ARCCFDVVDLDDGLPDGPPVDVIVCHNFR------DRRLDAAIIDRLAPG
MUL_3115|M.ulcerans_Agy99 ARCRFDVVDLDDGLPDGPPVDLIVCHNFR------DRRLDAAIIERLAPG
Mb0302|M.bovis_AF2122/97 P-GSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQSPA
Rv0294|M.tuberculosis_H37Rv P-GSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGAVVQSPA
Mvan_4027|M.vanbaalenii_PYR-1 -NISYTVGDVRNWQPEKR-ADLVVISFLHLPID-ELVAVIATAATWLRPG
:: : . *.
MAV_2216|M.avium_104 --GVLLIVDHGAAPPWAQHDGHH----FPGVEEVLGS------LRLDPDG
TH_0144|M.thermoresistible__bu --GLLLIVDHGAPPPWAPDHVHEFE--FPSAQEVVES------LQLPEGQ
MSMEG_4303|M.smegmatis_MC2_155 --GHLVIVDHGKMPPNATRVPHDHP--FPSAEEVLAG------LDLPASE
Mflv_2895|M.gilvum_PYR-GCK --GVLIVVDHAAAPPWAPPEVHEHR--FSTVDEVLAT------IDLGEGS
MAB_3178|M.abscessus_ATCC_1997 --GTLLIVGHHPSDMQAAIGRPDLPDWYFTAEDIADT------LNPKE--
MMAR_2640|M.marinum_M --GLVALVALSEVG------------------AAAGT------YRAAPGE
MUL_3115|M.ulcerans_Agy99 --GLVALVALSEVG------------------AAAGT------YRAAPGE
Mb0302|M.bovis_AF2122/97 YYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDES
Rv0294|M.tuberculosis_H37Rv YYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDES
Mvan_4027|M.vanbaalenii_PYR-1 --GHLLYLGHALENFVYGVGGPADPAILPGLADLARASQGLRVVEMAHLL
. :
MAV_2216|M.avium_104 WTRLRAEAAGRE----MTGPNGEVGTLMDNIMMLRRTEQAYAAS-
TH_0144|M.thermoresistible__bu WELLRAEPVKRD----AVGPDGQQGTLIDNVIMLRRR--------
MSMEG_4303|M.smegmatis_MC2_155 WERVRVEAVHRE----ATGPDGQPMPMVDNVMVLRRTS-------
Mflv_2895|M.gilvum_PYR-GCK WERLRADVVERD----AIGPDGEAGVLRDNLIVVRRCA-------
MAB_3178|M.abscessus_ATCC_1997 WTIIVAESRSRK----FTR-DDEEFDIADTVLRAERKPTTESA--
MMAR_2640|M.marinum_M LSAAFAELDPIA----AGEGDGRAWLLARA---------------
MUL_3115|M.ulcerans_Agy99 LSTAFAELDPIA----AGEGDGRAWLLARA---------------
Mb0302|M.bovis_AF2122/97 WQQFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG
Rv0294|M.tuberculosis_H37Rv WQQFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG
Mvan_4027|M.vanbaalenii_PYR-1 RPQGDRQAVDVLLHVQPWDPDQGWPPQAPGQAATAVTDTESK---
: :