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VDVGRSTEGRPIQLGLGYNAAQFTLLVVVNALVGGMLGQERTVLPLLGEQEFGLRAYTAGLSFILVFGLA KAATNYFAGTLSDRFGRKPVLVAGWVVAVPVPLLLIWAPSWSWVLAANVLLGVSQGLTWSTTVVMKIDLV GPARRGFAMGLNEAAGYGAVAVTALATGYLAEAYGLRPAPFLLGLAFAALGLGLSAVFVRETHGHARLEA ATHVARADGRHDHLHDQLTNREVFLQTSFRERALSSASQGGLVNNLNDGLAWGLFPILFASAGLSVGRIG VLAALYPAVWGVGQLVTGALSDRWGRKWMIAGGMWLQAIALAMIANGDDFAVWAVAAVALGAGTALVYPT LLAAIGDVAHPAWRARAVGTYRLWRDGGFAVGALVAGVVADVLGVRAAVWTVAALTAASGLVVALRMYET HPGPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5862 | - | - | 100% (425) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 2e-17 | 26.13% (398) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_1167 | - | 2e-13 | 26.82% (343) | protein of unknown function DUF894, DitE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0865 | - | 6e-08 | 30.57% (157) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4405 | - | 7e-17 | 26.30% (403) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0842 | - | 6e-08 | 30.57% (157) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3302 | - | 3e-12 | 24.22% (417) | major facilitator transporter |
| M. marinum M | MMAR_0690 | - | 6e-19 | 28.00% (375) | putative transport protein |
| M. avium 104 | MAV_3974 | - | 1e-15 | 24.23% (355) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2137 | - | 3e-15 | 25.19% (397) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_2446 | - | 4e-11 | 25.33% (375) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_4961 | - | 2e-13 | 28.85% (357) | intergral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4405|M.gilvum_PYR-GCK -----------------------MSST-KEGDCPTT-KQRLPREVW---V
MSMEG_2137|M.smegmatis_MC2_155 -----------------------MSSCPAEGDCSAPEKPKLPGEVW---V
MAV_3974|M.avium_104 --------------------------------------------------
Mb0865|M.bovis_AF2122/97 ------------------------MRYTGPERCSGDGQVRAAGDRYSTVI
Rv0842|M.tuberculosis_H37Rv ------------------------MRYTGPERCSGDGQVRAAGDRYSTVI
MMAR_0690|M.marinum_M -----------------------------MTDSSRRVVLAAVG-------
Mvan_5862|M.vanbaalenii_PYR-1 -------------------------MDVGRSTEGRPIQLGLGYNAAQFTL
MAB_3302|M.abscessus_ATCC_1997 -----------------------MVTMVHVDEVGTARRWAMLAIALG---
MUL_4961|M.ulcerans_Agy99 -------------------------MTSGSAPQWLTRNLRVLS-------
TH_2446|M.thermoresistible__bu VQPYAHPPGSALLNAVTLLDAPVAPHHDDDSAVTPQARTALWASLVGTTI
Mflv_4405|M.gilvum_PYR-GCK LVVANVVVALGYGVVAPVLPQYARH-FGVSIAAATF-VITAFAVMRLVGA
MSMEG_2137|M.smegmatis_MC2_155 LIVANAVIALGYGVVAPVLPQYARH-FGVSISAATF-VITAFALMRLCFA
MAV_3974|M.avium_104 ------MVALGYGVISPALPTFARS-FGVSIKAVTF-LVTVFSLSRLCFA
Mb0865|M.bovis_AF2122/97 WLLGGNLLVRSAGFGYPFLAYHVAG-RGHGAGAVGA-VVAAYGLGWAVGQ
Rv0842|M.tuberculosis_H37Rv WLLGGNLLVRSAGFGYPFLAYHVAG-RGHGAGAVGA-VVAAYGLGWAVGQ
MMAR_0690|M.marinum_M --FTFFIDMLVYGIVVPVLPRLAKP-AGLEFLGVGV-VFACYGLAYFVLT
Mvan_5862|M.vanbaalenii_PYR-1 LVVVNALVGGMLGQERTVLPLLGEQEFGLRAYTAGLSFILVFGLAKAATN
MAB_3302|M.abscessus_ATCC_1997 --STAGANVFINGVAFLIPALHAER--GLDLANAGL-LSAMPSFGMVLTL
MUL_4961|M.ulcerans_Agy99 --LVSLLQDAASELLYPLLPIYLATVLGAPPSVVGA-VEGAAEGAASLTK
TH_2446|M.thermoresistible__bu EWYDFFLYATAAGLVFNHAFFPDQS--TFVGTMLSFATFAVGFVVRPIGG
Mflv_4405|M.gilvum_PYR-GCK PPAGFLVQRLGERRVYTSGLIIVAVSTGACAFAETYWQL--------LLF
MSMEG_2137|M.smegmatis_MC2_155 PATGMLIQRLGERRIYVNGLVIVALSTGACAFAQTYWQL--------LLF
MAV_3974|M.avium_104 PISGLLTERLGERRIYIGGLLIVAVSTAACAFSQAYWQL--------MLC
Mb0865|M.bovis_AF2122/97 LLCGWLVDRVGARVTLVSTMLVAAAVLVLMAGLHTVPGL--------LVG
Rv0842|M.tuberculosis_H37Rv LLCGWLVDRVGARVTLVSTMLVAAAVLVLMAGLHTVPGL--------LVG
MMAR_0690|M.marinum_M PVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGL--------VTC
Mvan_5862|M.vanbaalenii_PYR-1 YFAGTLSDRFGRKPVLVAGWVVAVPVPLLLIWAPSWSWV--------LAA
MAB_3302|M.abscessus_ATCC_1997 IAWGALIDKFGERIALVSGLALTAVAAFAAAESPSLTVT--------GAF
MUL_4961|M.ulcerans_Agy99 IVSGPLGDRFARRPLIASGYGMAALGKLIVAAAGAWPGV--------LAG
TH_2446|M.thermoresistible__bu VVFGHVGDRIGRKRTLALTMVLMGGATALMGVLPTAAQIGALAPILLLLL
* : :: . : : :
Mflv_4405|M.gilvum_PYR-GCK RSLGGVGSAMFTVSALGLMIRISPADARGRVAG--LFSSGFMIGSVGGPI
MSMEG_2137|M.smegmatis_MC2_155 RSLGGIGSTMFFVSALGLMIRISPEDARGRVAG--MFSSAFLVGSVGGPV
MAV_3974|M.avium_104 RVFSGVGSTMFYVSALGLMIHISPADARGRIAG--LFTTSFMVGAVGGPA
Mb0865|M.bovis_AF2122/97 AMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIGAAITGG
Rv0842|M.tuberculosis_H37Rv AMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIGAAITGG
MMAR_0690|M.marinum_M RVLQGGAAAATWVAGYATLVEIFPREQRGRAVG--LASIGTALGALLGPA
Mvan_5862|M.vanbaalenii_PYR-1 NVLLGVSQGLTWSTTVVMKIDLVGPARRGFAMG-LNEAAGYGAVAVTALA
MAB_3302|M.abscessus_ATCC_1997 LLLGGAAAAACNSASGRVVVGWFPPHQRGTVMG--IRQMAQPLGVAAGAL
MUL_4961|M.ulcerans_Agy99 RVVDRLGKGLRGAPRDALLVDGVDPAQRGRAFG--FHRTMDTLGAVIGPL
TH_2446|M.thermoresistible__bu RIVQGFALGGEWAGAVLLAVEHGPPRRRGLCGS--IPQIGLALGLALGTG
. * .
Mflv_4405|M.gilvum_PYR-GCK LGSLTAGFG-LAAPFLIYGAALLVAA------------TVVFVSLRNSAV
MSMEG_2137|M.smegmatis_MC2_155 LGSLTAGLG-LSAPFLIYGAALLVAA------------AVVFISLRHSSL
MAV_3974|M.avium_104 VGGLAAGWG-LTAPFVVYGVAMLGVA------------LVLFLGLRNSAL
Mb0865|M.bovis_AF2122/97 VGGVVAGW--LDTPVLYW---INGIG------------CAIFAGLAGRCI
Rv0842|M.tuberculosis_H37Rv VGGVVAGW--LDTPVLYW---INGIG------------CAIFAGLAGRCI
MMAR_0690|M.marinum_M LGGLAYEASGPHAPFLGAAGLSALAV------------AALAASLPQAAG
Mvan_5862|M.vanbaalenii_PYR-1 TGYLAEAYGLRPAPFLLGLAFAALGLGLSAVFVRETHGHARLEAATHVAR
MAB_3302|M.abscessus_ATCC_1997 VIPRIAEGHGVATALLFPAIVCAVSS------------AVCLVGIIDPPR
MUL_4961|M.ulcerans_Agy99 LGLAGYELFDHQIGPVLYLAVIPAMLS-----------VLLIAWVREPPR
TH_2446|M.thermoresistible__bu VFALLQIALPDDAFLTYGWRIAFLLSIVLVVFG----VVVRLRATETPAF
Mflv_4405|M.gilvum_PYR-GCK VGQADDDVQVPIPFRTVFRHRAYKAALFSN-----FATGWASFGLRIALV
MSMEG_2137|M.smegmatis_MC2_155 AAPAPDDGPK-VTVRTALRNGAYRAALVSN-----LATGWSAFGLRIALV
MAV_3974|M.avium_104 AAPPPPTRST-VTMREALRVRAYQSALLSN-----FATGWSAFGLRMALV
Mb0865|M.bovis_AF2122/97 PADVCRRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFF
Rv0842|M.tuberculosis_H37Rv PADVCRRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFF
MMAR_0690|M.marinum_M GQASGPGMWSGERAFPGLAVPWLVAGLAVG----------LALGAVEATL
Mvan_5862|M.vanbaalenii_PYR-1 ADGRHDHLHDQLTNREVFLQTSFRERALSSAS-QGGLVNNLNDGLAWGLF
MAB_3302|M.abscessus_ATCC_1997 PPRSEAPEEHLANPYRGSRVLWLIHGVSVL--------LVVPQVVVWTFT
MUL_4961|M.ulcerans_Agy99 NLAKAKPASILDGTRRLPRRYWAVVSFLVL----------FSIANFPDAL
TH_2446|M.thermoresistible__bu QRVRDTGDRAAVPLRDVFRPPVLRSTLLGLLS---RWGEGAAFNTWGVFA
Mflv_4405|M.gilvum_PYR-GCK PLFVVEVLGEGPGAAGLALTAFAVGNIAVVIPSGHLSDRLGRRKLLIFG-
MSMEG_2137|M.smegmatis_MC2_155 PLFIAEVFHRGPGIAGLALATFAIGNVGAVIPSGYLSDRVGRRVLLIIG-
MAV_3974|M.avium_104 PLFVSDVMGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVG-
Mb0865|M.bovis_AF2122/97 AAVPMLMSASGLGVGAYGWVQLIN-ALAVVAVTPLLTPWLSKQLALGPRP
Rv0842|M.tuberculosis_H37Rv AAVPMLMSASGLGVGAYGWVQLIN-ALAVVAVTPLLTPWLSKQLALGPRP
MMAR_0690|M.marinum_M PIDLVARFDASGVTVGLLFALTTVAFIVTSQYAGRLSDAGRRAPVLAAG-
Mvan_5862|M.vanbaalenii_PYR-1 PILFASAG-LSVGRIGVLAALYPAVWGVGQLVTGALSDRWGRKWMIAGG-
MAB_3302|M.abscessus_ATCC_1997 LVWLVTDRGWSIGAASVMVTVAQLVGALGRVAAGMWSDRWGSRMRPIRAI
MUL_4961|M.ulcerans_Agy99 LLLRLKQIGFSVVGVIMAYVGYNAVYALASFPVGALADRLGRPVVYAFG-
TH_2446|M.thermoresistible__bu IAYATTTLGLAKVPVLVAVTAAALLMAVLLPVSGVLTDRFGAKRIYTIG-
. . :
Mflv_4405|M.gilvum_PYR-GCK --LMLAAVSTALVGFTTSLPVFLVAAVIAGAATG---IFVSPQQAAVADV
MSMEG_2137|M.smegmatis_MC2_155 --LTAAGVATAVVGLTDGLTPFLVSALVAGFATG---IFTAPQQAAVADI
MAV_3974|M.avium_104 --LVTSGAATVWLGFVASLPVFLVAAGVVGVVTG---IYMSPLQAAVADI
Mb0865|M.bovis_AF2122/97 DILAGAGVWVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHR
Rv0842|M.tuberculosis_H37Rv DILAGAGVWVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHR
MMAR_0690|M.marinum_M --WVTLGVALAVMGVPSAVGIQAAALVLLGAGLGAMIATIMPALADAMES
Mvan_5862|M.vanbaalenii_PYR-1 --MWLQAIALAMIANGDDFAVWAVAAVALGAGTA----LVYPTLLAAIGD
MAB_3302|M.abscessus_ATCC_1997 AAAASATMALLAVTNQLDWSVSVVVMLVASVITVS----DNGLAYTSIAE
MUL_4961|M.ulcerans_Agy99 --LVLFAVGYLGLGITTDTATAWALIAAYGLFTA----CYDGVGKAWISA
TH_2446|M.thermoresistible__bu ----ITAYALAVFPVFALFGTGEIVFYTLGMLLVFG--VIHALFYGAQGT
.
Mflv_4405|M.gilvum_PYR-GCK VGNKSRGG--PAVATFQMMADFGSIGGSLLVGLIAQYTSYGWAFLVSGII
MSMEG_2137|M.smegmatis_MC2_155 IGNKARGG--TAVATFQMMADVGSIGGSLLVGLIAQYLSFAWAFGISGGM
MAV_3974|M.avium_104 LGNEARAG--LPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVV
Mb0865|M.bovis_AF2122/97 IAPPAHGG--RYHGIWSMAVAASSVAAPILAAFN---LANGGRLVLAATT
Rv0842|M.tuberculosis_H37Rv IAPPAHGG--RYHGIWSMAVAASSVAAPILAAFN---LANGGRLVLAATT
MMAR_0690|M.marinum_M AGGAQRPG--TAAAAYNLAFSAGTVAGGPLAGWMADLRSFQDAAMLIAVV
Mvan_5862|M.vanbaalenii_PYR-1 VAHPAWRA--RAVGTYRLWRDGGFAVGALVAGVVADVLGVRAAVWTVAAL
MAB_3302|M.abscessus_ATCC_1997 IAGPFWSG--RALGAQNTGQLLAAAVAPPIFGAIAAAAGFSAAFAVCALF
MUL_4961|M.ulcerans_Agy99 IVSAELQS--SAQGVFQGLSGFAVLAAGLWAGFLWGVDGRLPLLISGGAG
TH_2446|M.thermoresistible__bu LYASLFPARIRYTGLSTVYQLSGIFASGVTPMILTALIAAAGGAPWLACG
. . . . . .
Mflv_4405|M.gilvum_PYR-GCK LAVAAIGWFFAPETRPTPSTEHTPGRPLGPEAGGEVP-
MSMEG_2137|M.smegmatis_MC2_155 LLLAALCWTFAPETRPRPSAEHTPARPLGPEAGGEVP-
MAV_3974|M.avium_104 LLIAAVGWVMAPETRTATELEADLMAASRTSSRCEQQL
Mb0865|M.bovis_AF2122/97 VTVGFFGAALCLPLARVLAAASCGPLSSKEPSRDSYQ-
Rv0842|M.tuberculosis_H37Rv VTVGFFGAALCLPLARVLAAASCGPLSSKEPSRDSYQ-
MMAR_0690|M.marinum_M TLTCGVLAALVHAAVVRRAVSDA---------------
Mvan_5862|M.vanbaalenii_PYR-1 TAASGLVVALRMYETHPGPR------------------
MAB_3302|M.abscessus_ATCC_1997 PLAAVGLVPVKLERPAP---------------------
MUL_4961|M.ulcerans_Agy99 AVFALALLAAAAGTRRRAR-------------------
TH_2446|M.thermoresistible__bu YLVATALISVVATTALRPAPLHRL--------------