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SESVAGPRSPEKQPELKRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVGGAAWLPFLVAFAIATVTAFS YLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMCSGITSAATASRAFAANFFEGAGIDASKLGVVVL ALLFMAALAAVNYRGVGESVRLNVVLTIVEITGLVVVVLVGLWAFTGGADVDFSRITAFETGEDKNTFLA VTAATSLAFFAMVGFEDSVNMAEETKDPVNTFPKILLSGLSIAGVVYVLISIVAVALVPVGRLEESDTPL VEVVRAGAPGLPIDAILPFMTMFAVSNTALINMLMASRLIYGMARQHVLPPVLGTVHPTRRSPWVAILFT TLIAFGLIIYVSTFASSNAIAVLGGTTSLLLLAVFAVVNVAVLALRRDVREAGGHFKTPTALPVIGFLAS LFLVTPLSGRPAQQYIVAATLVAIGVVLFFVTQLINRQLGIRDGHITDPTRLGSGTD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5147 | - | - | 100% (478) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0718 | - | 3e-30 | 26.91% (431) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 2e-28 | 21.38% (491) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 4e-30 | 27.03% (455) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1611 | - | 0.0 | 86.64% (479) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 4e-30 | 27.03% (455) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 1e-15 | 23.36% (441) | putative permease |
| M. abscessus ATCC 19977 | MAB_2598 | - | 2e-32 | 24.94% (441) | hypothetical protein MAB_2598 |
| M. marinum M | MMAR_2407 | rocE_1 | 1e-32 | 23.87% (465) | cationic amino acid transport integral membrane protein, |
| M. avium 104 | MAV_2087 | - | 7e-27 | 23.76% (463) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_5848 | - | 0.0 | 78.51% (470) | amino acid permease-associated region |
| M. thermoresistible (build 8) | TH_4382 | - | 0.0 | 75.32% (474) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_2597 | - | 3e-28 | 23.92% (485) | cationic amino acid transport integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5147|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1611|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5848|M.smegmatis_MC2_155 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MMAR_2407|M.marinum_M --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MUL_2597|M.ulcerans_Agy99 --------------------------------------------------
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mvan_5147|M.vanbaalenii_PYR-1 -----------------------------------------MSESVAGPR
Mflv_1611|M.gilvum_PYR-GCK -----------------------------------------MSEHTTGTG
MSMEG_5848|M.smegmatis_MC2_155 ---------------------------------------------MTNPE
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MMAR_2407|M.marinum_M ---------------------------MAAPTIGLIQQMLRRRPVIGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MUL_2597|M.ulcerans_Agy99 ----------------------------------MAGGLRTKSVEQSIAD
Mb2022c|M.bovis_AF2122/97 --------------------------------------------MRRPLD
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------MRRPLD
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------MSSQQ-
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mvan_5147|M.vanbaalenii_PYR-1 SPEKQPELKRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVG-GAAWLPF
Mflv_1611|M.gilvum_PYR-GCK TTEKQPELRRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVG-GAAWLPF
MSMEG_5848|M.smegmatis_MC2_155 MVEEQPQLRRVMGPGLLLLFVVGDILGTGVYALTGQVAKEVG-GAAWLPF
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVGDILGTGIYALVGDVAGEVG-GAAWLPF
MMAR_2407|M.marinum_M AHGASDQLKRSIGTFQLTLFGVGATVGTGIFFVLSEAVPEAG-PGVVASF
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVPEAG-PAVIVSF
MUL_2597|M.ulcerans_Agy99 TDEPETRLRKDLTWRDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISF
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAG-SGLLLGL
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAG-SGLLLGL
MAB_2598|M.abscessus_ATCC_1997 ----PGALRRELGTFDAVMIGLGSMIGAGIFAALAPAARSAG-SALLIGL
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAG-PFAPIAY
: :: :. :*:*:: . .
Mvan_5147|M.vanbaalenii_PYR-1 LVAFAIATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMC
Mflv_1611|M.gilvum_PYR-GCK LVAFAIATITAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMC
MSMEG_5848|M.smegmatis_MC2_155 LVAFLVATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFVTFLVAFIVMC
TH_4382|M.thermoresistible__bu LIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVMC
MMAR_2407|M.marinum_M VIAGIAAGLAAVCYAELASAVPVSGSTYSYAYTTLG-ELVAMGVAACLLL
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLG-EVVAMGVAACLLL
MUL_2597|M.ulcerans_Agy99 LIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFG-EFLAWVIGWNLVL
Mb2022c|M.bovis_AF2122/97 AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLG-DFWGYLAGWGFVV
Rv1999c|M.tuberculosis_H37Rv AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLG-DFWGYLAGWGFVV
MAB_2598|M.abscessus_ATCC_1997 CVAAVIAYCNATSSARLAAVYPASGGTYVYGRERLG-DFWGYLAGWGFVV
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFG-HRIGIYVGVTHAI
:* . * . ..: : :* . .
Mvan_5147|M.vanbaalenii_PYR-1 SGITSAATASRAFAANFFEGAGID----------------ASKLGVVVLA
Mflv_1611|M.gilvum_PYR-GCK SGITSASTASRAFAANFFTGVGVED---------------APKAGVLILA
MSMEG_5848|M.smegmatis_MC2_155 SGITSASTASRFFAANFFTGLHLD----------------WGKAGVVVLA
TH_4382|M.thermoresistible__bu SGITSASTASRFFAANLEVGLGQE----------------WGRLGVAGVA
MMAR_2407|M.marinum_M EYGVSTAAVAVGWSQYVNKLLDNFFGHHLPQALSAAPWGDASPGIINLPA
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPW-DAQPGYVNLPA
MUL_2597|M.ulcerans_Agy99 ELAIGAAVVAKGWSSYLGTVFG-----------FSGGTADFGSIRLDWGA
Mb2022c|M.bovis_AF2122/97 GKTASCAAMALTVGFYV------------------------WPAQAHAVA
Rv1999c|M.tuberculosis_H37Rv GKTASCAAMALTVGFYV------------------------WPAQAHAVA
MAB_2598|M.abscessus_ATCC_1997 GKTASCAAMALTIGFYA------------------------WPGHAHAVA
MLBr_01974|M.leprae_Br4923 TASIAWGVLASSFVSTLLRVAFPEKIWAD---------NDELISVKTLTF
. .. :
Mvan_5147|M.vanbaalenii_PYR-1 LLFMAALAAVNYRGVGESVRLNVVLTIVEITGLVVVVLVGLWAFTGG-AD
Mflv_1611|M.gilvum_PYR-GCK LVFMAALAAINFRGVGESVKLNVILTIVEITGLVLVILVGLWAFTGG-GE
MSMEG_5848|M.smegmatis_MC2_155 LLFMALIAAVNFRGVSESVKLNVFLTFIEITGLALVILVGLWAFTGGSAD
TH_4382|M.thermoresistible__bu LLFMALLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGAD
MMAR_2407|M.marinum_M VVLVGLCAVLLIRGASESAKVNTIMVLIKLSVLVMFAVIALTAFDADRFA
MAV_2087|M.avium_104 VMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMHHLD
MUL_2597|M.ulcerans_Agy99 LLSVSIVSLLVAYGTKLSSRFSAVVTTIKVAVVILVVVVGAFYVKAANYS
Mb2022c|M.bovis_AF2122/97 VAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGAADPAR
Rv1999c|M.tuberculosis_H37Rv VAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGAADPAR
MAB_2598|M.abscessus_ATCC_1997 VASVVALTAINYVGVQKSAWLTRVIVAIVLSVLAAIVATAAGSGSVDIAA
MLBr_01974|M.leprae_Br4923 LVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVN
: : : * . . : : . .
Mvan_5147|M.vanbaalenii_PYR-1 VDFSRITAFETGE---------------DKNTFLAVTAATSLAFFAMVGF
Mflv_1611|M.gilvum_PYR-GCK VDFSRVVAFETAE---------------DKNTFLAITAATSLAFFAMVGF
MSMEG_5848|M.smegmatis_MC2_155 IDFSRVVAFDTPS---------------DKGVFLAVSTATSLAFFAMVGF
TH_4382|M.thermoresistible__bu VDFTRVVAFETTT---------------DKSVFLAVSAATSLAFFAMVGF
MMAR_2407|M.marinum_M EFAP--------------------------FGVAGIGAAAGTIFFSYIGL
MAV_2087|M.avium_104 DFAP--------------------------FGVAGVGTAAGTIFFSYIGL
MUL_2597|M.ulcerans_Agy99 PFIPEPEAGPEGRGADQSLLSLLTGAPGSHYGWYGVLAGASIVFFAFIGF
Mb2022c|M.bovis_AF2122/97 LDIG------------------------VDAHVWGMLQAAGLLFFAFAGY
Rv1999c|M.tuberculosis_H37Rv LDIG------------------------VDAHVWGMLQAAGLLFFAFAGY
MAB_2598|M.abscessus_ATCC_1997 LDL-------------------------TGTSWRGVLQAAGLLFFAFAGY
MLBr_01974|M.leprae_Br4923 NYVTSRSAYQPTTYSLLG------VTEIGKSTAASMTLATIVALYAFTGF
.: .: ::: *
Mvan_5147|M.vanbaalenii_PYR-1 EDSVNMAEETKDPVNTFPKILLSGLSIAGVVYVLISIVAVALVPVGRLEE
Mflv_1611|M.gilvum_PYR-GCK EDSVNMAEETKDPVRTFPKILLSGLSIAGVVYILVSIVAVALVPVGKLEE
MSMEG_5848|M.smegmatis_MC2_155 EDSVNMAEETKDPVRIFPKMLLTGLGIAGLVYVVVSIVAVALVPVGVLAG
TH_4382|M.thermoresistible__bu EDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALVPVGTLQA
MMAR_2407|M.marinum_M DAVSTAGDEVKNPQKTMPLAIMAALVTVTTVYVVVTVAALGAQPWRDFEG
MAV_2087|M.avium_104 DAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGG
MUL_2597|M.ulcerans_Agy99 DIVATMAEETKHPQRDVPRGILVSLGVVTLLYVAVSIVLSGMVSYTQLRT
Mb2022c|M.bovis_AF2122/97 ARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLAR
Rv1999c|M.tuberculosis_H37Rv ARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLAR
MAB_2598|M.abscessus_ATCC_1997 ARIATLGEEVRDPARTIPRAIPIALGIALVVYVVVALAVLITLGPSRLAS
MLBr_01974|M.leprae_Br4923 ESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVAT
. .:* * .* : : . :* :. .
Mvan_5147|M.vanbaalenii_PYR-1 SD----TPLVEVVRAGAPGLPIDAILPFMTMFAVSNTALINMLMASRLIY
Mflv_1611|M.gilvum_PYR-GCK SD----TPLVEVVRAGAPGLPIDTILPFMTMFAVSNTALINMLMASRLIY
MSMEG_5848|M.smegmatis_MC2_155 SE----TPLVEVVKAGAPGLPIETILPFISMFAVSNTALINMLMASRLIY
TH_4382|M.thermoresistible__bu SD----VPLVEVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIY
MMAR_2407|M.marinum_M QQ-AGLATVLDRVVSG---HYWGSVLAAGAVISIFSVTLVVLYGQTRILF
MAV_2087|M.avium_104 QQEAGLATILDHVTHG---SWASTILAAGAVISIFSVTLVTMYGITRILF
MUL_2597|M.ulcerans_Agy99 VSGGGHANLATAFKANGV-YWASGIISVGALAGLTTVVMVLMLGQCRVLF
Mb2022c|M.bovis_AF2122/97 AA----APLSEAMRVAGV-NWLIPVVQIGAAVAALGSLLALILGVSRTTL
Rv1999c|M.tuberculosis_H37Rv AA----APLSEAMRVAGV-NWLIPVVQIGAAVAALGSLLALILGVSRTTL
MAB_2598|M.abscessus_ATCC_1997 SA----APLLDAVTAAGA-GWMEPVVRIGAVVAATGSLLALILGVSRTTF
MLBr_01974|M.leprae_Br4923 NH-------TVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWT
. :: : . : *
Mvan_5147|M.vanbaalenii_PYR-1 GMARQHVLPPVLGTVHPTRRSPWVAILFTTLIAFGLIIYVSTFASSNAIA
Mflv_1611|M.gilvum_PYR-GCK GMARQHVLPPALGLVHPTRRSPWVAIIFTTVIAFGLIAYVSAFASSNAIS
MSMEG_5848|M.smegmatis_MC2_155 GMARQRVLPPVLGSVHPRRLTPWVAILFTTLIAFGLIFYVSAFANSSAIA
TH_4382|M.thermoresistible__bu GMARQRVLPPVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADSTAIA
MMAR_2407|M.marinum_M AMGRDGLLPPVFAKVRPPNMTPVYNTIIVAVVIC-------ILAGFVPLS
MAV_2087|M.avium_104 AMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAA-------TLAAFIPLQ
MUL_2597|M.ulcerans_Agy99 AMARDGLLPRQLAKTGAR-GTPVRITVLVAVVVG-------ATASVFPIT
Mb2022c|M.bovis_AF2122/97 AMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVA-------ALAATADIR
Rv1999c|M.tuberculosis_H37Rv AMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVA-------ALAATADIR
MAB_2598|M.abscessus_ATCC_1997 AMARDRHLPHTLATVHPKYGVPYRAEILVGLVVS-------VLAATADLR
MLBr_01974|M.leprae_Br4923 ALSDGRILPTRLS-SKNRFGVPIVAFGITAFLTLAFP-----LSLRFDSL
.:. ** :. * .. :
Mvan_5147|M.vanbaalenii_PYR-1 VLGGTTSLLLLAVFAVVNVAVLALRRDVRE----AGGHFKTPTALPVIGF
Mflv_1611|M.gilvum_PYR-GCK ILGGTTSLLLLSVFAVVNVAVLVLRRDVVR----AGGHFTTPTALPVIGF
MSMEG_5848|M.smegmatis_MC2_155 VLGGTTSLLLLAVFAVVNIAVLVLRRDLRE----KGTHFKTPTVLPVIGF
TH_4382|M.thermoresistible__bu VLGGTTSLLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTPTFLPVVGF
MMAR_2407|M.marinum_M YLADVVSIGTLVAFIVVSVGVVILRVREPD--LPRGFKVPLYPVTPVLSV
MAV_2087|M.avium_104 NLADMVSIGTLTAFVVVSVGVIVLRVREPD--LPRGFRVPGYPVTPVLSI
MUL_2597|M.ulcerans_Agy99 KLEEMVNVGTLFAFVLVSAGVIVLRKKRPD--LERGFRAPWVPVLPIASL
Mb2022c|M.bovis_AF2122/97 GAIGFSSFGVLVYYAIANASALTLGLDEGR--PRR--------LIPLVGL
Rv1999c|M.tuberculosis_H37Rv GAIGFSSFGVLVYYAIANASALTLGLDEGR--PRR--------LIPLVGL
MAB_2598|M.abscessus_ATCC_1997 GAIGFSSFAVLVYYAVANASAWTLTPSQGR--PAR--------IIPAVGL
MLBr_01974|M.leprae_Br4923 NLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAV
. : : :. . * * ..
Mvan_5147|M.vanbaalenii_PYR-1 LASLFLVTPLSGRPAQQYIVAATLVAIGVVLFFVTQLINRQLGIRDGHIT
Mflv_1611|M.gilvum_PYR-GCK LASLYLVLPFSGRPVQQYIVAGGLVVIGVVLFFITQLINKQLGIKSGRIT
MSMEG_5848|M.smegmatis_MC2_155 IASTYLVLPFSGRPAQQYILAGILIAIGIVLFGITTIINRRLGISSKAQI
TH_4382|M.thermoresistible__bu VASLYLVTPLSGRPAQQYLLSVVLIVIGVLLFGVTMAINRQLGIPTRAVG
MMAR_2407|M.marinum_M LACGYILFSLP---WYTWLAFSIWVSVVLVFYFVWGRHHSALNDGGDGVI
MAV_2087|M.avium_104 MACGYILASLH---WYTWIAFSGWVLLALIFYFVWGRHHSALND------
MUL_2597|M.ulcerans_Agy99 CACLWLMLNLT---ALTWIRFGVWLLVGTVIYVGYGRKHSMVGR------
Mb2022c|M.bovis_AF2122/97 IGCVVLAFALP---LSSVAAGAAVLGVGVAAYGVRRIITRRARQTDSGDT
Rv1999c|M.tuberculosis_H37Rv IGCVVLAFALP---LSSVAAGAAVLGVGVAAYGVRRIITRRARQTDSGDT
MAB_2598|M.abscessus_ATCC_1997 VGCVIVSLALP---LSSVAAGTGVLAVGVIVYALRRVSGPGRRE------
MLBr_01974|M.leprae_Br4923 VVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSG
. : : . :
Mvan_5147|M.vanbaalenii_PYR-1 DPTRLGSGTD--------
Mflv_1611|M.gilvum_PYR-GCK DPTHLGSSPD--------
MSMEG_5848|M.smegmatis_MC2_155 DPTHLTDAP---------
TH_4382|M.thermoresistible__bu DPAKMVLPPD--------
MMAR_2407|M.marinum_M GAMPADAGDSDVLAQRDH
MAV_2087|M.avium_104 -AAVDPSGQER-------
MUL_2597|M.ulcerans_Agy99 -RQLAEAAMDK-------
Mb2022c|M.bovis_AF2122/97 QRSGHPSAT---------
Rv1999c|M.tuberculosis_H37Rv QRSGHPSAT---------
MAB_2598|M.abscessus_ATCC_1997 ------------------
MLBr_01974|M.leprae_Br4923 IK----------------