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SSPGGSTLDRRLGVFDTVTIGLGSMIGAGIFVALAPAAAAAGSGLLIGLAVAAVVAVCNAMSSARLAARY PQSGGTYVYGRERLGPFWGHAAGWSFIVGKTASCAAMALTVGFYAWPEYANAVAVASVVALTAVGYAGVQ RSAALTRIIVALVLAVLAMVVVVLLGFGGADTSRLALGDDVTVYGVLQAAGLLFFAFAGYARIATLGEEV RDPARTIPRAVALALVIALMVYAVVAVAVVSELGVAGLASATAPLSDAVRAAGFPGLTPVVNVGAAIAAL GALLALLLGVSRTTLAMARDRYLPAGLAAVHPKHGTPHHAEVAVGLVVAVVAAFVDLRGAIGFSSFGVLL YYAIANASAWTLGARLIPAIGLVGCLVLAFTLPLTSVLAGAAVVLVGMIAYTIGGTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0718 | - | - | 100% (408) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 9e-36 | 26.36% (459) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_5147 | - | 3e-30 | 26.91% (431) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 1e-155 | 72.64% (402) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0187 | - | 0.0 | 83.25% (400) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 1e-155 | 72.64% (402) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 2e-17 | 24.49% (437) | putative permease |
| M. abscessus ATCC 19977 | MAB_2598 | - | 1e-151 | 68.29% (410) | hypothetical protein MAB_2598 |
| M. marinum M | MMAR_3621 | rocE | 1e-40 | 28.82% (451) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 3e-36 | 27.99% (443) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_0812 | - | 1e-168 | 76.49% (404) | amino acid transporter |
| M. thermoresistible (build 8) | TH_3126 | - | 5e-93 | 68.34% (259) | PUTATIVE putative amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-41 | 28.38% (451) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0812|M.smegmatis_MC2_155 --------------------------------------------------
TH_3126|M.thermoresistible__bu --------------------------------------------------
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2022c|M.bovis_AF2122/97 --------------------------------------------MRRPLD
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------MRRPLD
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------MSSQQ-
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------MSSPGG
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0812|M.smegmatis_MC2_155 --------------------------------------------MSTPGG
TH_3126|M.thermoresistible__bu --------------------------------------------------
MMAR_3621|M.marinum_M ---------------------------MPATSIRLREQMLRRRPVGGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAGSGLLLGLA
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAYAAGSGLLLGLA
MAB_2598|M.abscessus_ATCC_1997 ----PGALRRELGTFDAVMIGLGSMIGAGIFAALAPAARSAGSALLIGLC
Mvan_0718|M.vanbaalenii_PYR-1 S-----TLDRRLGVFDTVTIGLGSMIGAGIFVALAPAAAAAGSGLLIGLA
Mflv_0187|M.gilvum_PYR-GCK -------MRRRLGTFDTVTLGLGSMIGAGIFVALAPAAAAAGTGLLVGLA
MSMEG_0812|M.smegmatis_MC2_155 -------LQRRLGTFDAVTIGLGSMIGAGIFAAIGPAAAAAGSGLLIGLA
TH_3126|M.thermoresistible__bu -------LPRRLGTLDAVTIGLGAMIGAGIFVALGPAAAAAGPWLLAGLG
MMAR_3621|M.marinum_M AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVPEAGPAVIVSFI
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVPEAGPAVIVSFI
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVPEAGPAVIVSFL
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAGPFAPIAYT
:* . . :*:.: :*:*** . . . **. .
Mb2022c|M.bovis_AF2122/97 VAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVGK
Rv1999c|M.tuberculosis_H37Rv VAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVGK
MAB_2598|M.abscessus_ATCC_1997 VAAVIAYCNATSSARLAAVYPASGGTYVYGRERLGDFWGYLAGWGFVVGK
Mvan_0718|M.vanbaalenii_PYR-1 VAAVVAVCNAMSSARLAARYPQSGGTYVYGRERLGPFWGHAAGWSFIVGK
Mflv_0187|M.gilvum_PYR-GCK VAALIAVCNAMSSARLAARYPESGGTYVYGRERLGPFWGHTAGWSFIVGK
MSMEG_0812|M.smegmatis_MC2_155 LAAVVAYCNATSSARLAAIYPQSGGTYVYGRERLGEFWGYLAGWSFAVGK
TH_3126|M.thermoresistible__bu IAAAVAYCNATASARLAARYPQSGGTYVYGRERLGAFWGYTAGFSFVVGK
MMAR_3621|M.marinum_M IAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLEY
MUL_1244|M.ulcerans_Agy99 IAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLEY
MAV_2087|M.avium_104 LAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLEY
MLBr_01974|M.leprae_Br4923 LAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAITA
:*. * * * * .*.:* * :* . .. :
Mb2022c|M.bovis_AF2122/97 TASCAAMALTVG---------FYVWPAQAHAVAVAVVVALTAVNY-----
Rv1999c|M.tuberculosis_H37Rv TASCAAMALTVG---------FYVWPAQAHAVAVAVVVALTAVNY-----
MAB_2598|M.abscessus_ATCC_1997 TASCAAMALTIG---------FYAWPGHAHAVAVASVVALTAINY-----
Mvan_0718|M.vanbaalenii_PYR-1 TASCAAMALTVG---------FYAWPEYANAVAVASVVALTAVGY-----
Mflv_0187|M.gilvum_PYR-GCK TASCAAMALTVG---------YYVWPAYANAVAVGSVVALTAVSY-----
MSMEG_0812|M.smegmatis_MC2_155 TASCAAMALTVG---------SYAWPEHANAVAVGAVVALTAVNY-----
TH_3126|M.thermoresistible__bu TASCAAMALTIG---------FYLWPGHAHAIAVAAVVALTALTY-----
MMAR_3621|M.marinum_M GVATAAVAVGWS---------GYVNKLLHNVFGFQLPQALSEAPWDERPG
MUL_1244|M.ulcerans_Agy99 GVATAAVAVGLS---------GYVNKLLHNVFGFQLPQALSEAPWDERPG
MAV_2087|M.avium_104 GVATAAVSVNWS---------GYLNKLLSNVVGFQLPHALSAAPWDAQPG
MLBr_01974|M.leprae_Br4923 SIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAVLLAIN
: ..:: . ... *
Mb2022c|M.bovis_AF2122/97 ----------------------AGIQKSAWLTRSIVAVVLVVLTAVVVAA
Rv1999c|M.tuberculosis_H37Rv ----------------------AGIQKSAWLTRSIVAVVLVVLTAVVVAA
MAB_2598|M.abscessus_ATCC_1997 ----------------------VGVQKSAWLTRVIVAIVLSVLAAIVATA
Mvan_0718|M.vanbaalenii_PYR-1 ----------------------AGVQRSAALTRIIVALVLAVLAMVVVVL
Mflv_0187|M.gilvum_PYR-GCK ----------------------AGVQRSATLTRVIVALVLGVLAMVVVVV
MSMEG_0812|M.smegmatis_MC2_155 ----------------------VGVQKSAVLTRVIVAVVLAILATVVVLL
TH_3126|M.thermoresistible__bu ----------------------LGIEKSALLTRLVVAGVLGVLTAVVVLV
MMAR_3621|M.marinum_M EAAGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILA
MUL_1244|M.ulcerans_Agy99 EAAGYLNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILA
MAV_2087|M.avium_104 ----YVNLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILA
MLBr_01974|M.leprae_Br4923 ------------IFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHV
* . . : * : .
Mb2022c|M.bovis_AF2122/97 YGSGAADPAR---------LDIGVDAHVWGMLQAAGLLFFAFAGYARIAT
Rv1999c|M.tuberculosis_H37Rv YGSGAADPAR---------LDIGVDAHVWGMLQAAGLLFFAFAGYARIAT
MAB_2598|M.abscessus_ATCC_1997 AGSGSVDIAA---------LDL-TGTSWRGVLQAAGLLFFAFAGYARIAT
Mvan_0718|M.vanbaalenii_PYR-1 LGFGGADTSR---------LALGDDVTVYGVLQAAGLLFFAFAGYARIAT
Mflv_0187|M.gilvum_PYR-GCK FGSGDVDASR---------LALGPDVDAYGVLQAAGLLFFAFAGYARIAT
MSMEG_0812|M.smegmatis_MC2_155 LGSGDADPAR---------LSLGDDVSAVGVLQAAGLLFFAFAGYARIAT
TH_3126|M.thermoresistible__bu LGFGAPAGRV---------AGGGTDIGAGAVLQSAALLFFAFAGYARIAT
MMAR_3621|M.marinum_M LT--AYDTNH---------LKDFAPFGVAGVGAAAGTIFFSFIGLDAVST
MUL_1244|M.ulcerans_Agy99 LT--AYDTNH---------LKDFAPFGVAGVGAAAGTIFFSFIGLDAVST
MAV_2087|M.avium_104 FT--AFDMHH---------LDDFAPFGVAGVGTAAGTIFFSYIGLDAVST
MLBr_01974|M.leprae_Br4923 NNYVTSRSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIAN
.: :: :::: * ::.
Mb2022c|M.bovis_AF2122/97 LGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAP-
Rv1999c|M.tuberculosis_H37Rv LGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAP-
MAB_2598|M.abscessus_ATCC_1997 LGEEVRDPARTIPRAIPIALGIALVVYVVVALAVLITLGPSRLASSAAP-
Mvan_0718|M.vanbaalenii_PYR-1 LGEEVRDPARTIPRAVALALVIALMVYAVVAVAVVSELGVAGLASATAP-
Mflv_0187|M.gilvum_PYR-GCK LGEEVRDPARTIPRAIGLALVIALLTYAVVAVAVLAQLGSTGLATADAP-
MSMEG_0812|M.smegmatis_MC2_155 LGEEVRDPARIIPRAIRIALGLTLVVYAVVAGAVLAVLGGTDLAGATAP-
TH_3126|M.thermoresistible__bu LGEEVRDPARTIRRAIPLALGITLTVYGAVTAAVLVALGSAGLARSPAP-
MMAR_3621|M.marinum_M AGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQEEAG
MUL_1244|M.ulcerans_Agy99 AGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQEEAG
MAV_2087|M.avium_104 AGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQQEAG
MLBr_01974|M.leprae_Br4923 AAEEMNTPDRTLPKAIPLTILTVGVIY-ILALVVAMLLGSDKIVATNHT-
.:*: * : : :*: :: . * :: .. : .
Mb2022c|M.bovis_AF2122/97 -LSEAMRVAGVNWLIPVVQIGAAVAALGSLLALILGVSRTTLAMARDRHL
Rv1999c|M.tuberculosis_H37Rv -LSEAMRVAGVNWLIPVVQIGAAVAALGSLLALILGVSRTTLAMARDRHL
MAB_2598|M.abscessus_ATCC_1997 -LLDAVTAAGAGWMEPVVRIGAVVAATGSLLALILGVSRTTFAMARDRHL
Mvan_0718|M.vanbaalenii_PYR-1 -LSDAVRAAGFPGLTPVVNVGAAIAALGALLALLLGVSRTTLAMARDRYL
Mflv_0187|M.gilvum_PYR-GCK -LADAVRAAGLPALAPVVAVGAALAALGALLALLLGVSRTTLAMARDRHL
MSMEG_0812|M.smegmatis_MC2_155 -LADAVAAVGAGQWQPLVRAGAAIAALGSLLALILGVSRTTLAMARDHHL
TH_3126|M.thermoresistible__bu -VADAVTAAXX---------HGRQQPFGELPG----------AEEVDRGH
MMAR_3621|M.marinum_M LATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLL
MUL_1244|M.ulcerans_Agy99 LATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLL
MAV_2087|M.avium_104 LATILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLL
MLBr_01974|M.leprae_Br4923 --VKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRIL
.. . * .
Mb2022c|M.bovis_AF2122/97 PRWLAAVHPRFKVPFRAELVVGAVVAALAATADIRGA--IGFSSFGVLVY
Rv1999c|M.tuberculosis_H37Rv PRWLAAVHPRFKVPFRAELVVGAVVAALAATADIRGA--IGFSSFGVLVY
MAB_2598|M.abscessus_ATCC_1997 PHTLATVHPKYGVPYRAEILVGLVVSVLAATADLRGA--IGFSSFAVLVY
Mvan_0718|M.vanbaalenii_PYR-1 PAGLAAVHPKHGTPHHAEVAVGLVVAVVAAFVDLRGA--IGFSSFGVLLY
Mflv_0187|M.gilvum_PYR-GCK PHPLAHVHPGHGTPQRAEVAVGVVVAVVAAVVDVRSA--IGFSSFGVLLY
MSMEG_0812|M.smegmatis_MC2_155 PSALGAVHPRFGVPHRAEVTVGVVVAVLAAVADLRGA--IGFSSFAVLLY
TH_3126|M.thermoresistible__bu PQRIPDAR---RHPGHVEHRS------SPTTCAPR---------------
MMAR_3621|M.marinum_M PARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNRL--ADMVSIGTLTA
MUL_1244|M.ulcerans_Agy99 PARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNRL--ADMVSIGTLTA
MAV_2087|M.avium_104 PPRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQNL--ADMVSIGTLTA
MLBr_01974|M.leprae_Br4923 PTRLSSKN-RFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAVIARFIQ
* : . * .
Mb2022c|M.bovis_AF2122/97 YAIANASALTLGLDEGRPRR----------LIPLVGLIGCVVLAFALPLS
Rv1999c|M.tuberculosis_H37Rv YAIANASALTLGLDEGRPRR----------LIPLVGLIGCVVLAFALPLS
MAB_2598|M.abscessus_ATCC_1997 YAVANASAWTLTPSQGRPAR----------IIPAVGLVGCVIVSLALPLS
Mvan_0718|M.vanbaalenii_PYR-1 YAIANASAWTLG------AR----------LIPAIGLVGCLVLAFTLPLT
Mflv_0187|M.gilvum_PYR-GCK YAVANASAWTLTATPR--AR----------LVPAVGLIGCVVLAFTLPPV
MSMEG_0812|M.smegmatis_MC2_155 YAIANASAATLG------GR----------LVPAVGLVGCLVLAFTLPLS
TH_3126|M.thermoresistible__bu --------------------------------PLTWRTTWAPMPDPQPVT
MMAR_3621|M.marinum_M FIVVSVGVIILRVREPALPRGFWV--PGYPVTPILSILACGYLLYSLHWY
MUL_1244|M.ulcerans_Agy99 FIVVSVGVIILRVREPALPRGFWV--PGYPVTPILSILACGYLLYSLHWY
MAV_2087|M.avium_104 FVVVSVGVIVLRVREPDLPRGFRV--PGYPVTPVLSIMACGYILASLHWY
MLBr_01974|M.leprae_Br4923 FIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVVVSAGLMVSFDYR
* : .
Mb2022c|M.bovis_AF2122/97 SVAAGAA---VLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT
Rv1999c|M.tuberculosis_H37Rv SVAAGAA---VLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT
MAB_2598|M.abscessus_ATCC_1997 SVAAGTG---VLAVGVIVYALRRVSGPGRRE---------------
Mvan_0718|M.vanbaalenii_PYR-1 SVLAGAA---VVLVGMIAYTIGGTR---------------------
Mflv_0187|M.gilvum_PYR-GCK SVLAGAA---VVLVGMLAYTTGGALRRGV-----------------
MSMEG_0812|M.smegmatis_MC2_155 SVLAGLA---VVAAGAVVYGVRRIS---------------------
TH_3126|M.thermoresistible__bu TTRRPS----------------------------------------
MMAR_3621|M.marinum_M TWIAFGG---WVGIALIFYLFWGRHHSRLNAPALHDNPTGEER---
MUL_1244|M.ulcerans_Agy99 TWIAFGG---WVGIALIFYLFWGRHHSRLNAPALHDNPTGEER---
MAV_2087|M.avium_104 TWIAFSG---WVLLALIFYFVWGRHHSALNDAAVD--PSGQER---
MLBr_01974|M.leprae_Br4923 SIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK-------
: