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TNPEMVEEQPQLRRVMGPGLLLLFVVGDILGTGVYALTGQVAKEVGGAAWLPFLVAFLVATVTAFSYLEL VTKYPQAAGAALYAHKAFGIHFVTFLVAFIVMCSGITSASTASRFFAANFFTGLHLDWGKAGVVVLALLF MALIAAVNFRGVSESVKLNVFLTFIEITGLALVILVGLWAFTGGSADIDFSRVVAFDTPSDKGVFLAVST ATSLAFFAMVGFEDSVNMAEETKDPVRIFPKMLLTGLGIAGLVYVVVSIVAVALVPVGVLAGSETPLVEV VKAGAPGLPIETILPFISMFAVSNTALINMLMASRLIYGMARQRVLPPVLGSVHPRRLTPWVAILFTTLI AFGLIFYVSAFANSSAIAVLGGTTSLLLLAVFAVVNIAVLVLRRDLREKGTHFKTPTVLPVIGFIASTYL VLPFSGRPAQQYILAGILIAIGIVLFGITTIINRRLGISSKAQIDPTHLTDAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5848 | - | - | 100% (474) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_6727 | - | 3e-87 | 42.66% (443) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_1838 | - | 2e-30 | 25.30% (498) | cationic amino acid transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 1e-31 | 25.76% (427) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1611 | - | 0.0 | 78.27% (474) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 1e-31 | 25.76% (427) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 8e-19 | 24.88% (430) | putative permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 3e-34 | 25.82% (457) | cationic amino acid transport integral membrane protein |
| M. marinum M | MMAR_2407 | rocE_1 | 1e-35 | 25.77% (454) | cationic amino acid transport integral membrane protein, |
| M. avium 104 | MAV_2087 | - | 4e-30 | 25.93% (432) | amino acid transporter |
| M. thermoresistible (build 8) | TH_4382 | - | 0.0 | 77.20% (478) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_2597 | - | 1e-30 | 25.26% (475) | cationic amino acid transport integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_5147 | - | 0.0 | 78.51% (470) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1611|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5147|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5848|M.smegmatis_MC2_155 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MMAR_2407|M.marinum_M --------------------------------------------------
MAB_3842|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_2597|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_1611|M.gilvum_PYR-GCK -----------------------------MSEHTTGTGT-----------
Mvan_5147|M.vanbaalenii_PYR-1 -----------------------------MSESVAGPRS-----------
MSMEG_5848|M.smegmatis_MC2_155 ---------------------------------MTNPEM-----------
TH_4382|M.thermoresistible__bu ---------------------------------MSGTRT-----------
Mb2347c|M.bovis_AF2122/97 ---------------MPTTSMSLRELMLRRRPVSGAPVA-----------
Rv2320c|M.tuberculosis_H37Rv ---------------MPTTSMSLRELMLRRRPVSGAPVA-----------
MAV_2087|M.avium_104 -------------------------------------MA-----------
MMAR_2407|M.marinum_M ---------------MAAPTIGLIQQMLRRRPVIGAPVA-----------
MAB_3842|M.abscessus_ATCC_1997 ---------------MAPSSPSLAQQLLRRRPTSGAPTA-----------
MUL_2597|M.ulcerans_Agy99 ----------------------MAGGLRTKSVEQSIADT-----------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mflv_1611|M.gilvum_PYR-GCK -TEKQPELRRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVG-GAAWLPF
Mvan_5147|M.vanbaalenii_PYR-1 -PEKQPELKRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVG-GAAWLPF
MSMEG_5848|M.smegmatis_MC2_155 -VEEQPQLRRVMGPGLLLLFVVGDILGTGVYALTGQVAKEVG-GAAWLPF
TH_4382|M.thermoresistible__bu -EQAQPELRRVLGPGLLLLFIVGDILGTGIYALVGDVAGEVG-GAAWLPF
Mb2347c|M.bovis_AF2122/97 -SGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAG-PGVIVSF
Rv2320c|M.tuberculosis_H37Rv -SGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAG-PGVIVSF
MAV_2087|M.avium_104 -PGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVPEAG-PAVIVSF
MMAR_2407|M.marinum_M -HGASDQLKRSIGTFQLTLFGVGATVGTGIFFVLSEAVPEAG-PGVVASF
MAB_3842|M.abscessus_ATCC_1997 -HGAGGHLKQSMGTFQLTMIGVGATVGTGIFFILAESVPKAG-PAVMASF
MUL_2597|M.ulcerans_Agy99 -DEPETRLRKDLTWRDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAG-PFAPIAY
. : : :: :. :*:*:: .. .:
Mflv_1611|M.gilvum_PYR-GCK LVAFAIATITAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMC
Mvan_5147|M.vanbaalenii_PYR-1 LVAFAIATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMC
MSMEG_5848|M.smegmatis_MC2_155 LVAFLVATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFVTFLVAFIVMC
TH_4382|M.thermoresistible__bu LIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVMC
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MMAR_2407|M.marinum_M VIAGIAAGLAAVCYAELASAVPVSGSTYSYAYTTLGELVAMGVAACLLLE
MAB_3842|M.abscessus_ATCC_1997 LVAGLAAGLAALCYAELASAVPVSGSSFSYAYTTLGELAAMVVAACLLLE
MUL_2597|M.ulcerans_Agy99 LIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWVIGWNLVLE
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
:* . : *. : .. ..: : ::* : :
Mflv_1611|M.gilvum_PYR-GCK SGITSASTAS-----------RAFAANFFTGVGVEDAPKAG-------VL
Mvan_5147|M.vanbaalenii_PYR-1 SGITSAATAS-----------RAFAANFFEGAGID-ASKLG-------VV
MSMEG_5848|M.smegmatis_MC2_155 SGITSASTAS-----------RFFAANFFTGLHLD-WGKAG-------VV
TH_4382|M.thermoresistible__bu SGITSASTAS-----------RFFAANLEVGLGQE-WGRLG-------VA
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----WVN
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPW-DAQPG----YVN
MMAR_2407|M.marinum_M YGVSTAAVAVGWSQYVNKLLDNFFGHHLPQALSAAPWGDASPG----IIN
MAB_3842|M.abscessus_ATCC_1997 YGVSAAAVAVGWSQYLDKLLVNLFGWHLPHAISAAPWDSADPAAPHPWLN
MUL_2597|M.ulcerans_Agy99 LAIGAAVVAKGWSSYLG----TVFGFSGGTADFGSIR-----------LD
MLBr_01974|M.leprae_Br4923 ASIAWGVLAS-----------SFVSTLLRVAFPEKIWADNDELIS--VKT
.: . : ..
Mflv_1611|M.gilvum_PYR-GCK ILALVFMAALAAINFRGVGESVKLNVILTIVEITGLVLVILVGLWAFTGG
Mvan_5147|M.vanbaalenii_PYR-1 VLALLFMAALAAVNYRGVGESVRLNVVLTIVEITGLVVVVLVGLWAFTGG
MSMEG_5848|M.smegmatis_MC2_155 VLALLFMALIAAVNFRGVSESVKLNVFLTFIEITGLALVILVGLWAFTGG
TH_4382|M.thermoresistible__bu GVALLFMALLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGG
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
MMAR_2407|M.marinum_M LPAVVLVGLCAVLLIRGASESAKVNTIMVLIKLSVLVMFAVIALTAFDAD
MAB_3842|M.abscessus_ATCC_1997 LPAVLLIIMCAILLIRGTSESALVNTVMVLLKLAVLSVFAIIAFTAFHAG
MUL_2597|M.ulcerans_Agy99 WGALLSVSIVSLLVAYGTKLSSRFSAVVTTIKVAVVILVVVVGAFYVKAA
MLBr_01974|M.leprae_Br4923 LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ
:: : : * . . . :: : :. .
Mflv_1611|M.gilvum_PYR-GCK -GEVDFSRVVAFETAE-------------------DKNTFLAITAATSLA
Mvan_5147|M.vanbaalenii_PYR-1 -ADVDFSRITAFETGE-------------------DKNTFLAVTAATSLA
MSMEG_5848|M.smegmatis_MC2_155 SADIDFSRVVAFDTPS-------------------DKGVFLAVSTATSLA
TH_4382|M.thermoresistible__bu GADVDFTRVVAFETTT-------------------DKSVFLAVSAATSLA
Mb2347c|M.bovis_AF2122/97 ----HLKDFVP--------------------------FGVAGIGSAAGTI
Rv2320c|M.tuberculosis_H37Rv ----HLKDFVP--------------------------FGVAGIGSAAGTI
MAV_2087|M.avium_104 ----HLDDFAP--------------------------FGVAGVGTAAGTI
MMAR_2407|M.marinum_M ----RFAEFAP--------------------------FGVAGIGAAAGTI
MAB_3842|M.abscessus_ATCC_1997 ----NFSDFAP--------------------------FGVSGIGAAAGTI
MUL_2597|M.ulcerans_Agy99 ----NYSPFIPEPEAGPEGRGADQSLLSLLTGAPGSHYGWYGVLAGASIV
MLBr_01974|M.leprae_Br4923 HVNNYVTSRSAYQPTTYSLLG----------VTEIGKSTAASMTLATIVA
. .: .:
Mflv_1611|M.gilvum_PYR-GCK FFAMVGFEDSVNMAEETKDPVRTFPKILLSGLSIAGVVYILVSIVAVALV
Mvan_5147|M.vanbaalenii_PYR-1 FFAMVGFEDSVNMAEETKDPVNTFPKILLSGLSIAGVVYVLISIVAVALV
MSMEG_5848|M.smegmatis_MC2_155 FFAMVGFEDSVNMAEETKDPVRIFPKMLLTGLGIAGLVYVVVSIVAVALV
TH_4382|M.thermoresistible__bu FFAMVGFEDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALV
Mb2347c|M.bovis_AF2122/97 FFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQ
Rv2320c|M.tuberculosis_H37Rv FFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQ
MAV_2087|M.avium_104 FFSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQ
MMAR_2407|M.marinum_M FFSYIGLDAVSTAGDEVKNPQKTMPLAIMAALVTVTTVYVVVTVAALGAQ
MAB_3842|M.abscessus_ATCC_1997 FFTYVGLDTVSTAGEEVKDPQRTMPRALIAALLIVTAFYLVVALAALGAQ
MUL_2597|M.ulcerans_Agy99 FFAFIGFDIVATMAEETKHPQRDVPRGILVSLGVVTLLYVAVSIVLSGMV
MLBr_01974|M.leprae_Br4923 LYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLG
::: *:: . .:* * .* : : . .*: :.
Mflv_1611|M.gilvum_PYR-GCK PVGKLEESD-TPLVEVVRAGAPG--LPIDTILPFMTMFAVSNTALINMLM
Mvan_5147|M.vanbaalenii_PYR-1 PVGRLEESD-TPLVEVVRAGAPG--LPIDAILPFMTMFAVSNTALINMLM
MSMEG_5848|M.smegmatis_MC2_155 PVGVLAGSE-TPLVEVVKAGAPG--LPIETILPFISMFAVSNTALINMLM
TH_4382|M.thermoresistible__bu PVGTLQASD-VPLVEVVKAGAPG--LPIEELLPWISMFAVSNTALINMLM
Mb2347c|M.bovis_AF2122/97 PWQDFAEQETAGLAIILDNVTHG--EWASTILAAGAVVSIFTVTLVTMYG
Rv2320c|M.tuberculosis_H37Rv PWQDFAEQETAGLAIILDNVTHG--EWASTILAAGAVVSIFTVTLVTMYG
MAV_2087|M.avium_104 PWQDFGGQQEAGLATILDHVTHG--SWASTILAAGAVISIFSVTLVTMYG
MMAR_2407|M.marinum_M PWRDFEGQQ-AGLATVLDRVVSG--HYWGSVLAAGAVISIFSVTLVVLYG
MAB_3842|M.abscessus_ATCC_1997 PWKEFEGQS-AGLALILDKVTGS--TSASTFLAAGAVISIFSITLVSMYG
MUL_2597|M.ulcerans_Agy99 SYTQLRTVSGGGHANLATAFKANGVYWASGIISVGALAGLTTVVMVLMLG
MLBr_01974|M.leprae_Br4923 SDKIVATNHTVKLAAAVGNNTFR------TIIVVGALVSMFGINVAASFG
. . . .: :: .: :
Mflv_1611|M.gilvum_PYR-GCK ASRLIYGMARQHVLPPALGLVHPTRRSPWVAIIFTTVIAFGLIAYVSAFA
Mvan_5147|M.vanbaalenii_PYR-1 ASRLIYGMARQHVLPPVLGTVHPTRRSPWVAILFTTLIAFGLIIYVSTFA
MSMEG_5848|M.smegmatis_MC2_155 ASRLIYGMARQRVLPPVLGSVHPRRLTPWVAILFTTLIAFGLIFYVSAFA
TH_4382|M.thermoresistible__bu ASRLIYGMARQRVLPPVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFA
Mb2347c|M.bovis_AF2122/97 QTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFAS-------TLA
Rv2320c|M.tuberculosis_H37Rv QTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFAS-------TLA
MAV_2087|M.avium_104 ITRILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAA-------TLA
MMAR_2407|M.marinum_M QTRILFAMGRDGLLPPVFAKVRPPNMTPVYNTIIVAVVIC-------ILA
MAB_3842|M.abscessus_ATCC_1997 QTRILFAIGRDGLLPSVFAQVNPRTLTPVNNTIIVAVVVG-------FMA
MUL_2597|M.ulcerans_Agy99 QCRVLFAMARDGLLPRQLAKTGAR-GTPVRITVLVAVVVG-------ATA
MLBr_01974|M.leprae_Br4923 APRLWTALSDGRILPTRLS-SKNRFGVPIVAFGITAFLTLAFP-----LS
*: .:. :** :. * :.:. :
Mflv_1611|M.gilvum_PYR-GCK SSNAISILGGTTSLLLLSVFAVVNVAVLVLRRDVVR----AGGHFTTP--
Mvan_5147|M.vanbaalenii_PYR-1 SSNAIAVLGGTTSLLLLAVFAVVNVAVLALRRDVRE----AGGHFKTP--
MSMEG_5848|M.smegmatis_MC2_155 NSSAIAVLGGTTSLLLLAVFAVVNIAVLVLRRDLRE----KGTHFKTP--
TH_4382|M.thermoresistible__bu DSTAIAVLGGTTSLLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTP--
Mb2347c|M.bovis_AF2122/97 AFIPLDSLADMVSIGTLTAFSVVAVGVIVLRVREPD----LPRGFKVPGY
Rv2320c|M.tuberculosis_H37Rv AFIPLDSLADMVSIGTLTAFSVVAVGVIVLRVREPD----LPRGFKVPGY
MAV_2087|M.avium_104 AFIPLQNLADMVSIGTLTAFVVVSVGVIVLRVREPD----LPRGFRVPGY
MMAR_2407|M.marinum_M GFVPLSYLADVVSIGTLVAFIVVSVGVVILRVREPD----LPRGFKVPLY
MAB_3842|M.abscessus_ATCC_1997 AFVPLDSLANMVSIGTLTAFIVVSIGVIILRVREPE----LPRAFRVPGY
MUL_2597|M.ulcerans_Agy99 SVFPITKLEEMVNVGTLFAFVLVSAGVIVLRKKRPD----LERGFRAPWV
MLBr_01974|M.leprae_Br4923 LRFDSLNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTD--
* . : : * :* .:. * . .
Mflv_1611|M.gilvum_PYR-GCK TALPVIGFLASLYLVLPFSGRPVQQYIVAGGLVVIGVVLFFITQLINKQL
Mvan_5147|M.vanbaalenii_PYR-1 TALPVIGFLASLFLVTPLSGRPAQQYIVAATLVAIGVVLFFVTQLINRQL
MSMEG_5848|M.smegmatis_MC2_155 TVLPVIGFIASTYLVLPFSGRPAQQYILAGILIAIGIVLFGITTIINRRL
TH_4382|M.thermoresistible__bu TFLPVVGFVASLYLVTPLSGRPAQQYLLSVVLIVIGVLLFGVTMAINRQL
Mb2347c|M.bovis_AF2122/97 PVTPVLSVLACGYILASLH---WYTWLAFSGWVAVAVIFYLMWGRHHSAL
Rv2320c|M.tuberculosis_H37Rv PVTPVLSVLACGYILASLH---WYTWLAFSGWVAVAVIFYLMWGRHHSAL
MAV_2087|M.avium_104 PVTPVLSIMACGYILASLH---WYTWIAFSGWVLLALIFYFVWGRHHSAL
MMAR_2407|M.marinum_M PVTPVLSVLACGYILFSLP---WYTWLAFSIWVSVVLVFYFVWGRHHSAL
MAB_3842|M.abscessus_ATCC_1997 PVTPVLSVIACGYILFSLP---WITWIAFGAWVAIVLVFYLVWGRHHSAL
MUL_2597|M.ulcerans_Agy99 PVLPIASLCACLWLMLNLT---ALTWIRFGVWLLVGTVIYVGYGRKHSMV
MLBr_01974|M.leprae_Br4923 KVLPITAVVVSAGLMVSFDYR--SIFLTRGGPNYFSISLIAITFIGIPAV
*: .. .. :: : :: . : :
Mflv_1611|M.gilvum_PYR-GCK GIKSGRITDPTHLGSSPD--------
Mvan_5147|M.vanbaalenii_PYR-1 GIRDGHITDPTRLGSGTD--------
MSMEG_5848|M.smegmatis_MC2_155 GISSKAQIDPTHLTDAP---------
TH_4382|M.thermoresistible__bu GIPTRAVGDPAKMVLPPD--------
Mb2347c|M.bovis_AF2122/97 NEEVP---------------------
Rv2320c|M.tuberculosis_H37Rv NEEVP---------------------
MAV_2087|M.avium_104 NDAAVDPSGQER--------------
MMAR_2407|M.marinum_M NDGGDGVIGAMPADAGDSDVLAQRDH
MAB_3842|M.abscessus_ATCC_1997 NDLPSDPAELSEKEPV----------
MUL_2597|M.ulcerans_Agy99 GRRQLAEAAMDK--------------
MLBr_01974|M.leprae_Br4923 AYLHYYRTSGIK--------------