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MSEHTTGTGTTEKQPELRRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVGGAAWLPFLVAFAIATITAF SYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMCSGITSASTASRAFAANFFTGVGVEDAPKAGVL ILALVFMAALAAINFRGVGESVKLNVILTIVEITGLVLVILVGLWAFTGGGEVDFSRVVAFETAEDKNTF LAITAATSLAFFAMVGFEDSVNMAEETKDPVRTFPKILLSGLSIAGVVYILVSIVAVALVPVGKLEESDT PLVEVVRAGAPGLPIDTILPFMTMFAVSNTALINMLMASRLIYGMARQHVLPPALGLVHPTRRSPWVAII FTTVIAFGLIAYVSAFASSNAISILGGTTSLLLLSVFAVVNVAVLVLRRDVVRAGGHFTTPTALPVIGFL ASLYLVLPFSGRPVQQYIVAGGLVVIGVVLFFITQLINKQLGIKSGRITDPTHLGSSPD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1611 | - | - | 100% (479) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_4427 | - | 2e-90 | 41.76% (455) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_0187 | - | 4e-29 | 26.70% (442) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-31 | 23.84% (453) | cationic amino acid transport integral membrane protein RocE |
| M. tuberculosis H37Rv | Rv2320c | rocE | 3e-31 | 23.84% (453) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 4e-18 | 24.51% (457) | putative permease |
| M. abscessus ATCC 19977 | MAB_2598 | - | 9e-33 | 25.06% (447) | hypothetical protein MAB_2598 |
| M. marinum M | MMAR_2407 | rocE_1 | 4e-32 | 24.01% (454) | cationic amino acid transport integral membrane protein, |
| M. avium 104 | MAV_2087 | - | 1e-29 | 23.84% (453) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_5848 | - | 0.0 | 78.27% (474) | amino acid permease-associated region |
| M. thermoresistible (build 8) | TH_4382 | - | 0.0 | 74.32% (479) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 4e-29 | 24.45% (458) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_5147 | - | 0.0 | 86.64% (479) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1611|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5147|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5848|M.smegmatis_MC2_155 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MMAR_2407|M.marinum_M --------------------------------------------------
MAB_2598|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_1611|M.gilvum_PYR-GCK -----------------------------------------MSEHTTGTG
Mvan_5147|M.vanbaalenii_PYR-1 -----------------------------------------MSESVAGPR
MSMEG_5848|M.smegmatis_MC2_155 ---------------------------------------------MTNPE
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MMAR_2407|M.marinum_M ---------------------------MAAPTIGLIQQMLRRRPVIGAPV
MAB_2598|M.abscessus_ATCC_1997 -------------------------------------------------M
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mflv_1611|M.gilvum_PYR-GCK TTEKQPELRRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVGGAAWLPFL
Mvan_5147|M.vanbaalenii_PYR-1 SPEKQPELKRVMGPGLLLLFVVGDILGTGVYALVGDVAGEVGGAAWLPFL
MSMEG_5848|M.smegmatis_MC2_155 MVEEQPQLRRVMGPGLLLLFVVGDILGTGVYALTGQVAKEVGGAAWLPFL
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVGDILGTGIYALVGDVAGEVGGAAWLPFL
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAGPGVIVSFI
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVPEAGPGVIVSFI
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVPEAGPAVIVSFI
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVPEAGPAVIVSFL
MMAR_2407|M.marinum_M AHGASDQLKRSIGTFQLTLFGVGATVGTGIFFVLSEAVPEAGPGVVASFV
MAB_2598|M.abscessus_ATCC_1997 SSQQPGALRRELGTFDAVMIGLGSMIGAGIFAALAPAARSAGSALLIGLC
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIKIAGPFAPIAYT
:* :: :. :*:*:: . . .*
Mflv_1611|M.gilvum_PYR-GCK VAFAIATITAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMCS
Mvan_5147|M.vanbaalenii_PYR-1 VAFAIATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFITFLVAFVVMCS
MSMEG_5848|M.smegmatis_MC2_155 VAFLVATVTAFSYLELVTKYPQAAGAALYAHKAFGIHFVTFLVAFIVMCS
TH_4382|M.thermoresistible__bu IAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVMCS
Mb2347c|M.bovis_AF2122/97 IAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEY
Rv2320c|M.tuberculosis_H37Rv IAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEY
MUL_1244|M.ulcerans_Agy99 IAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLEY
MAV_2087|M.avium_104 LAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLEY
MMAR_2407|M.marinum_M IAGIAAGLAAVCYAELASAVPVSGSTYSYAYTTLGELVAMGVAACLLLEY
MAB_2598|M.abscessus_ATCC_1997 VAAVIAYCNATSSARLAAVYPASGGTYVYGRERLGDFWGYLAGWGFVVGK
MLBr_01974|M.leprae_Br4923 LAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAITA
:* * * . ..: * :* :
Mflv_1611|M.gilvum_PYR-GCK GITSASTAS-------RAFAANFFTGVGVEDAPKAG-----------VLI
Mvan_5147|M.vanbaalenii_PYR-1 GITSAATAS-------RAFAANFFEGAGID-ASKLG-----------VVV
MSMEG_5848|M.smegmatis_MC2_155 GITSASTAS-------RFFAANFFTGLHLD-WGKAG-----------VVV
TH_4382|M.thermoresistible__bu GITSASTAS-------RFFAANLEVGLGQE-WGRLG-----------VAG
Mb2347c|M.bovis_AF2122/97 GVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----WVNL
Rv2320c|M.tuberculosis_H37Rv GVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----WVNL
MUL_1244|M.ulcerans_Agy99 GVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPW-DERPGEAAGYLNL
MAV_2087|M.avium_104 GVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPW-DAQPG----YVNL
MMAR_2407|M.marinum_M GVSTAAVAVGWSQYVNKLLDNFFGHHLPQALSAAPWGDASPG----IINL
MAB_2598|M.abscessus_ATCC_1997 TASCAAMALT------------------IGFYAWPG----------HAHA
MLBr_01974|M.leprae_Br4923 SIAWGVLAS-------SFVSTLLRVAFPEKIWADND------ELISVKTL
: . :
Mflv_1611|M.gilvum_PYR-GCK LALVFMAALAAINFRGVGESVKLNVILTIVEITGLVLVILVGLWAFTGG-
Mvan_5147|M.vanbaalenii_PYR-1 LALLFMAALAAVNYRGVGESVRLNVVLTIVEITGLVVVVLVGLWAFTGG-
MSMEG_5848|M.smegmatis_MC2_155 LALLFMALIAAVNFRGVSESVKLNVFLTFIEITGLALVILVGLWAFTGGS
TH_4382|M.thermoresistible__bu VALLFMALLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGG
Mb2347c|M.bovis_AF2122/97 PAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD-
Rv2320c|M.tuberculosis_H37Rv PAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD-
MUL_1244|M.ulcerans_Agy99 PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN-
MAV_2087|M.avium_104 PAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH-
MMAR_2407|M.marinum_M PAVVLVGLCAVLLIRGASESAKVNTIMVLIKLSVLVMFAVIALTAFDAD-
MAB_2598|M.abscessus_ATCC_1997 VAVASVVALTAINYVGVQKSAWLTRVIVAIVLSVLAAIVATAAGSGSVD-
MLBr_01974|M.leprae_Br4923 TFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQH
: : : * . . . : * . . :
Mflv_1611|M.gilvum_PYR-GCK GEVDFSRVVAFETAEDKNT---------FLAITAATSLAFFAMVGFEDSV
Mvan_5147|M.vanbaalenii_PYR-1 ADVDFSRITAFETGEDKNT---------FLAVTAATSLAFFAMVGFEDSV
MSMEG_5848|M.smegmatis_MC2_155 ADIDFSRVVAFDTPSDKGV---------FLAVSTATSLAFFAMVGFEDSV
TH_4382|M.thermoresistible__bu ADVDFTRVVAFETTTDKSV---------FLAVSAATSLAFFAMVGFEDSV
Mb2347c|M.bovis_AF2122/97 ---HLKDFVPFGVAG----------------IGSAAGTIFFSYIGLDAVS
Rv2320c|M.tuberculosis_H37Rv ---HLKDFVPFGVAG----------------IGSAAGTIFFSYIGLDAVS
MUL_1244|M.ulcerans_Agy99 ---HLKDFAPFGVAG----------------VGAAAGTIFFSFIGLDAVS
MAV_2087|M.avium_104 ---HLDDFAPFGVAG----------------VGTAAGTIFFSYIGLDAVS
MMAR_2407|M.marinum_M ---RFAEFAPFGVAG----------------IGAAAGTIFFSYIGLDAVS
MAB_2598|M.abscessus_ATCC_1997 --IAALDLTGTSWRG----------------VLQAAGLLFFAFAGYARIA
MLBr_01974|M.leprae_Br4923 VNNYVTSRSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIA
: *: ::: *
Mflv_1611|M.gilvum_PYR-GCK NMAEETKDPVRTFPKILLSGLSIAGVVYILVSIVAVALVPVGKLEESD-T
Mvan_5147|M.vanbaalenii_PYR-1 NMAEETKDPVNTFPKILLSGLSIAGVVYVLISIVAVALVPVGRLEESD-T
MSMEG_5848|M.smegmatis_MC2_155 NMAEETKDPVRIFPKMLLTGLGIAGLVYVVVSIVAVALVPVGVLAGSE-T
TH_4382|M.thermoresistible__bu NMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALVPVGTLQASD-V
Mb2347c|M.bovis_AF2122/97 TAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETA
Rv2320c|M.tuberculosis_H37Rv TAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETA
MUL_1244|M.ulcerans_Agy99 TAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQEEA
MAV_2087|M.avium_104 TAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQQEA
MMAR_2407|M.marinum_M TAGDEVKNPQKTMPLAIMAALVTVTTVYVVVTVAALGAQPWRDFEGQQ-A
MAB_2598|M.abscessus_ATCC_1997 TLGEEVRDPARTIPRAIPIALGIALVVYVVVALAVLITLGPSRLASSAAP
MLBr_01974|M.leprae_Br4923 NAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATNHTV
. .:* * .* : : . :*:. ...: . .
Mflv_1611|M.gilvum_PYR-GCK PLVEVVRAGAPGLPIDTILPFMTMFAVSNTALINMLMASRLIYGMARQHV
Mvan_5147|M.vanbaalenii_PYR-1 PLVEVVRAGAPGLPIDAILPFMTMFAVSNTALINMLMASRLIYGMARQHV
MSMEG_5848|M.smegmatis_MC2_155 PLVEVVKAGAPGLPIETILPFISMFAVSNTALINMLMASRLIYGMARQRV
TH_4382|M.thermoresistible__bu PLVEVVKAGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRV
Mb2347c|M.bovis_AF2122/97 GLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGL
Rv2320c|M.tuberculosis_H37Rv GLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGL
MUL_1244|M.ulcerans_Agy99 GLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGL
MAV_2087|M.avium_104 GLATILDHVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGL
MMAR_2407|M.marinum_M GLATVLDRVVSGHYWGSVLAAGAVISIFSVTLVVLYGQTRILFAMGRDGL
MAB_2598|M.abscessus_ATCC_1997 LLDAVTAAGAG--WMEPVVRIGAVVAATGSLLALILGVSRTTFAMARDRH
MLBr_01974|M.leprae_Br4923 KLAAAVG----NNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRI
* :: ::.: : .* .:.
Mflv_1611|M.gilvum_PYR-GCK LPPALGLVHPTRRSPWVAIIFTTVIAFGLIAYVSAFASSNAISILGGTTS
Mvan_5147|M.vanbaalenii_PYR-1 LPPVLGTVHPTRRSPWVAILFTTLIAFGLIIYVSTFASSNAIAVLGGTTS
MSMEG_5848|M.smegmatis_MC2_155 LPPVLGSVHPRRLTPWVAILFTTLIAFGLIFYVSAFANSSAIAVLGGTTS
TH_4382|M.thermoresistible__bu LPPVLGSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADSTAIAVLGGTTS
Mb2347c|M.bovis_AF2122/97 LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP-------LDSLADMVS
Rv2320c|M.tuberculosis_H37Rv LPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP-------LDSLADMVS
MUL_1244|M.ulcerans_Agy99 LPARFAAVHPRFQTPVSNTVVVAIAAAVLAALVP-------LNRLADMVS
MAV_2087|M.avium_104 LPPRFARVNPRTMTPVNNTVIVAVAAATLAAFIP-------LQNLADMVS
MMAR_2407|M.marinum_M LPPVFAKVRPPNMTPVYNTIIVAVVICILAGFVP-------LSYLADVVS
MAB_2598|M.abscessus_ATCC_1997 LPHTLATVHPKYGVPYRAEILVGLVVSVLAATAD-------LRGAIGFSS
MLBr_01974|M.leprae_Br4923 LPTRLSSKN-RFGVPIVAFGITAFLTLAFPLSLR-----FDSLNLTGLAV
** :. . * .. . : .
Mflv_1611|M.gilvum_PYR-GCK LLLLSVFAVVNVAVLVLRRDVVR----AGGHFTTP--TALPVIGFLASLY
Mvan_5147|M.vanbaalenii_PYR-1 LLLLAVFAVVNVAVLALRRDVRE----AGGHFKTP--TALPVIGFLASLF
MSMEG_5848|M.smegmatis_MC2_155 LLLLAVFAVVNIAVLVLRRDLRE----KGTHFKTP--TVLPVIGFIASTY
TH_4382|M.thermoresistible__bu LLLLAVFAMVNVAVLVLRRDESRDPVVARRHFRTP--TFLPVVGFVASLY
Mb2347c|M.bovis_AF2122/97 IGTLTAFSVVAVGVIVLRVREPD----LPRGFKVPGYPVTPVLSVLACGY
Rv2320c|M.tuberculosis_H37Rv IGTLTAFSVVAVGVIVLRVREPD----LPRGFKVPGYPVTPVLSVLACGY
MUL_1244|M.ulcerans_Agy99 IGTLTAFIVVSVGVIILRVREPA----LPRGFWVPGYPVTPILSILACGY
MAV_2087|M.avium_104 IGTLTAFVVVSVGVIVLRVREPD----LPRGFRVPGYPVTPVLSIMACGY
MMAR_2407|M.marinum_M IGTLVAFIVVSVGVVILRVREPD----LPRGFKVPLYPVTPVLSVLACGY
MAB_2598|M.abscessus_ATCC_1997 FAVLVYYAVANASAWTLTPSQGR------------PARIIPAVGLVGCVI
MLBr_01974|M.leprae_Br4923 IARFIQFIIVPIALFALARSRTTN--SVYVKRNVFTDKVLPITAVVVSAG
: : : :. . * * ..: .
Mflv_1611|M.gilvum_PYR-GCK LVLPFSGRPVQQYIVAGGLVVIGVVLFFITQLINKQLGIKSGRITDPTHL
Mvan_5147|M.vanbaalenii_PYR-1 LVTPLSGRPAQQYIVAATLVAIGVVLFFVTQLINRQLGIRDGHITDPTRL
MSMEG_5848|M.smegmatis_MC2_155 LVLPFSGRPAQQYILAGILIAIGIVLFGITTIINRRLGISSKAQIDPTHL
TH_4382|M.thermoresistible__bu LVTPLSGRPAQQYLLSVVLIVIGVLLFGVTMAINRQLGIPTRAVGDPAKM
Mb2347c|M.bovis_AF2122/97 ILASLH---WYTWLAFSGWVAVAVIFYLMWGRHHSALN---EEVP-----
Rv2320c|M.tuberculosis_H37Rv ILASLH---WYTWLAFSGWVAVAVIFYLMWGRHHSALN---EEVP-----
MUL_1244|M.ulcerans_Agy99 LLYSLH---WYTWIAFGGWVGIALIFYLFWGRHHSRLN---APALHDNPT
MAV_2087|M.avium_104 ILASLH---WYTWIAFSGWVLLALIFYFVWGRHHSALN---DAAVD--PS
MMAR_2407|M.marinum_M ILFSLP---WYTWLAFSIWVSVVLVFYFVWGRHHSALNDGGDGVIGAMPA
MAB_2598|M.abscessus_ATCC_1997 VSLALP---LSSVAAGTGVLAVGVIVYALRRVSGPGRRE-----------
MLBr_01974|M.leprae_Br4923 LMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK---
: .: . : :: .
Mflv_1611|M.gilvum_PYR-GCK GSSPD--------
Mvan_5147|M.vanbaalenii_PYR-1 GSGTD--------
MSMEG_5848|M.smegmatis_MC2_155 TDAP---------
TH_4382|M.thermoresistible__bu VLPPD--------
Mb2347c|M.bovis_AF2122/97 -------------
Rv2320c|M.tuberculosis_H37Rv -------------
MUL_1244|M.ulcerans_Agy99 GEER---------
MAV_2087|M.avium_104 GQER---------
MMAR_2407|M.marinum_M DAGDSDVLAQRDH
MAB_2598|M.abscessus_ATCC_1997 -------------
MLBr_01974|M.leprae_Br4923 -------------