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VKVHHLNCGTIRPTGVGTMVCHVLLVESADGLVLVDTGFGTHDCEDPNRFGRIRSRFIRPNFDRGETALN QIRQLGFRRSDVRHVVVTHFDADHIGGLADFPDALVHVTTTEAFGAMRSPSIQERIRFRPPQWAHGPRIV EHDIDGEAWRGFAAAKELTQIGPGFVLVSLPGHTRGHACVAVDAGHRWLLHAGDSFYHPGTLAGAPPVPK WTARLEMLVASDKQKVKQNHVRLAELYRRQDPDLMILCSHDVTLYEQARATAQT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | - | 100% (264) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2949 | - | 4e-09 | 27.13% (188) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 2e-92 | 60.69% (262) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 1e-109 | 70.57% (265) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv2300c | - | 2e-92 | 60.69% (262) | hypothetical protein Rv2300c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4947 | - | 2e-07 | 25.31% (245) | Beta-lactamase-like protein |
| M. marinum M | MMAR_3523 | - | 5e-92 | 61.78% (259) | hypothetical protein MMAR_3523 |
| M. avium 104 | MAV_4762 | - | 7e-05 | 28.48% (151) | metallo-beta-lactamase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 5e-10 | 28.57% (189) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 5e-09 | 28.72% (188) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 3e-88 | 59.85% (259) | hypothetical protein MUL_2742 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5078|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
TH_0195|M.thermoresistible__bu --------------------------MSTTAVRPVA-HPEHDELVPSRYA
MAB_4947|M.abscessus_ATCC_1997 ------------------------MFSAAVRTFTVGDATVTQLTELDVWP
MAV_4762|M.avium_104 --------------------------------------------------
Mvan_5078|M.vanbaalenii_PYR-1 MKVHHLNCGTIRPTGVGT-MVCHVLLVESADGLVLVDTGFGTHDCED-PN
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
MMAR_3523|M.marinum_M MKVHHLNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MAB_4947|M.abscessus_ATCC_1997 IKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTII
MAV_4762|M.avium_104 ---MAELVQVTDAVHLARGDAVNWTLVADDTGVMLVDAGYPGD-------
. .
Mvan_5078|M.vanbaalenii_PYR-1 RFGRIRS-----------RFIRPNFD----RGETALNQIRQLGFRRSDVR
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFE----RTETAAEQLAHLGYRLSDVR
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFL----QAETAARQIEQLGYRTSDVR
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFL----QAETAARQIEQLGYRTSDVR
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALL----QNETAVHQIERLGYRPSDVR
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALL----QNETAVHQIERLGYRPSDVR
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFP----RAGRTVARLEAAGIDPSAVT
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFP----RAGRLAHRMQAAGIEPAAVT
MAB_4947|M.abscessus_ATCC_1997 VVDTCSGN----------HKNRPLFADLHMLNTDYLTRLEQSGYSPEAVD
MAV_4762|M.avium_104 -------------------------------REDVLGSLAELGYGPGDVR
: * *
Mvan_5078|M.vanbaalenii_PYR-1 HVVVTHFDADHIGGLADFPDALVHVTTTEAFGAMRSP--------SIQER
Mflv_1675|M.gilvum_PYR-GCK HIIVTHFDADHIGGLADFPDAQVHVTAQEVLSAMKSP--------SVQNR
Mb2322c|M.bovis_AF2122/97 HIVLTHFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRER
Rv2300c|M.tuberculosis_H37Rv HIVLTHFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRER
MMAR_3523|M.marinum_M HVVLTHFDFDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRER
MUL_2742|M.ulcerans_Agy99 HIVLTHFDSDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRER
MSMEG_3427|M.smegmatis_MC2_155 DVVLTHLHMDHIGGLLSHGLKERLRPDLRIHVASAEA--------NFWES
TH_0195|M.thermoresistible__bu DVVLTHLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEA--------EFWAA
MAB_4947|M.abscessus_ATCC_1997 IVVNTHLHLDHCG----WNTRLVEGTWRPTFPAATYL--------FHHTE
MAV_4762|M.avium_104 AIVLTHAHIDHLGTAIWLASEHGIPVYCHADEVGHAKREYLEQVSIVDVA
:: ** . ** * .
Mvan_5078|M.vanbaalenii_PYR-1 IRFRPPQWAHGPRIVEHDIDG---EAWRG-FAAAKELTQIGPGFVLVSLP
Mflv_1675|M.gilvum_PYR-GCK IRFQPSQWAHGPRIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLP
Mb2322c|M.bovis_AF2122/97 LRYRRGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP
Rv2300c|M.tuberculosis_H37Rv LRYRRGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP
MMAR_3523|M.marinum_M VRYRSVQWAHGPKLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMP
MUL_2742|M.ulcerans_Agy99 VRYRSVQWAHGPKLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMP
MSMEG_3427|M.smegmatis_MC2_155 PDFSHTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTG
TH_0195|M.thermoresistible__bu PDFSRTAMPHPVPDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTG
MAB_4947|M.abscessus_ATCC_1997 LKYIRAQWESAPIDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYG
MAV_4762|M.avium_104 LRIWRPRWAKWTAHVVR-SGGLIRDGIPTAQPLTAEVAAGLPGRPTPVFS
: . : *
Mvan_5078|M.vanbaalenii_PYR-1 ----------GHTRGHACVAVDAGHRWLLHAGDSFYHPG-TLAG--APPV
Mflv_1675|M.gilvum_PYR-GCK ----------GHTEGHACVAVDAGHRWLLHAGDAFYHHS-EIDGGGPPPM
Mb2322c|M.bovis_AF2122/97 ----------GHTRGHAAVAVDAGHRWVLHCGDAFYHRG-TLDG--RFRV
Rv2300c|M.tuberculosis_H37Rv ----------GHTRGHAAVAVDAGHRWVLHCGDAFYHRG-TLDG--RFRV
MMAR_3523|M.marinum_M ----------GHTRGHAAVAVDAGDRWILHCGDAFYHVG-TLDG--QSKV
MUL_2742|M.ulcerans_Agy99 ----------GHTRGHAAVAVDAGDRWILHCGDAFYHVG-TLDG--QSKV
MSMEG_3427|M.smegmatis_MC2_155 ----------GHTPGHSVVRLASGEDRLTFAGDAVFAPG-FDNPQWHNGF
TH_0195|M.thermoresistible__bu ----------GHTPGHSIVRLESGKDRLTFAGDAVFQVG-FDNPQWHNGF
MAB_4947|M.abscessus_ATCC_1997 STHIRALDAGGHTPGHVAIEVRAADTGLLIAGDALHHPMQAQFPDLPFYA
MAV_4762|M.avium_104 P---------GHTNGHCSYLIDG----VLVSGDALITGHPLLRHRGPQLL
*** ** : . : .**:.
Mvan_5078|M.vanbaalenii_PYR-1 PKWTARLEMLVASDKQKVKQNHVRLAELYRRQDPDLMILCSHDVTLYEQA
Mflv_1675|M.gilvum_PYR-GCK PASLRAFEMAVAADRKMVLDNHSRLTELYRRQDPDLLIVCSHDRKLYEHA
Mb2322c|M.bovis_AF2122/97 PFVMRAEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLA
Rv2300c|M.tuberculosis_H37Rv PFVMRAEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLA
MMAR_3523|M.marinum_M PFVLRSQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYALA
MUL_2742|M.ulcerans_Agy99 PFVLRSQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYAVA
MSMEG_3427|M.smegmatis_MC2_155 EHDPEESVRVRVELLRELAATGESLVATHLP-FPSVCHVAAAGDAFRCVP
TH_0195|M.thermoresistible__bu EHDPEEAARVRVRLLQEIAASGETLVATHLP-FPSLCRVAPRGEAFRFVP
MAB_4947|M.abscessus_ATCC_1997 DADPAQAVATRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGS
MAV_4762|M.avium_104 PAIFSYSQRDCIRTLSALALLDTEVLLPGHGDVWRGPIKEATDAALALAT
: . .
Mvan_5078|M.vanbaalenii_PYR-1 RATAQT
Mflv_1675|M.gilvum_PYR-GCK KATAGD
Mb2322c|M.bovis_AF2122/97 RDTA--
Rv2300c|M.tuberculosis_H37Rv RDTA--
MMAR_3523|M.marinum_M KDLS--
MUL_2742|M.ulcerans_Agy99 KDLS--
MSMEG_3427|M.smegmatis_MC2_155 AVWDY-
TH_0195|M.thermoresistible__bu TVWDH-
MAB_4947|M.abscessus_ATCC_1997 RAID--
MAV_4762|M.avium_104 GR----