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MFHSGTHKVKETAMKAMVYHGDGKASWDDVPDAVLVDPTDAVVRVDAVTICGTDLHILRGHVPTVDRGRI LGHEAVGTVTAIGSGVRQLAVGDRVLISCISSCGSCRYCRRTSYGQCSGGGGWILGNRIDGTQAEFVRVP FADNSTHRVPDGVSDENMITLADLLPTGYEVGAINGRVRPADTVVVVGAGPIGLAAIMTSQLFSPSRIVA IDLADSRLDAARKFGADIVINPDRLDPVAAIADLTGGLGVDAAMEAVGTAATFELAVQLVRPGGHVANIG VHGGPATLHLEDIWIRNLTITTGLVDTYSTPTLVDLVAAHRLDTSALVTHRYPLDEFERAYHEFSNAGET GALKVLLTQN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4901 | - | - | 100% (360) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1380 | - | e-143 | 69.57% (345) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1841 | - | 8e-51 | 37.17% (339) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 5e-31 | 33.43% (341) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_4997 | - | 1e-143 | 70.43% (345) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 3e-45 | 34.13% (334) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-31 | 32.66% (346) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-29 | 28.74% (334) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_2790 | - | 7e-45 | 32.95% (346) | dehydrogenase |
| M. avium 104 | MAV_2804 | - | 6e-49 | 36.53% (334) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0671 | - | 8e-52 | 36.51% (367) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_2319 | - | 8e-37 | 36.59% (246) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. ulcerans Agy99 | MUL_2962 | - | 8e-43 | 32.08% (346) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4901|M.vanbaalenii_PYR-1 MFHSGTHKVKETAMKAMVYHGDGKASWDDVPDAVLVDPTDAVVRVDAVTI
Mflv_4997|M.gilvum_PYR-GCK -------------MQAMVYTGPGQRSWQTVPDPVLVDATDAIVRVDTVTI
MMAR_2790|M.marinum_M -------------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGI
MUL_2962|M.ulcerans_Agy99 -------------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGI
Rv1895|M.tuberculosis_H37Rv -------------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGI
MAV_2804|M.avium_104 -------------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGI
MSMEG_0671|M.smegmatis_MC2_155 -------------MRAMVYRGPYKIRLEDKPIPAIEHPNDAIVRVTKAAI
Mb2283|M.bovis_AF2122/97 ---------MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGV
MLBr_01784|M.leprae_Br4923 ---------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGV
MAB_2084|M.abscessus_ATCC_1997 -----------MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGL
TH_2319|M.thermoresistible__bu ----------------VTWHGRRKVSVDTVPDPAIMEPTDAIIRVTSTNI
. . .:: : :
Mvan_4901|M.vanbaalenii_PYR-1 CGTDLHILRGHVPTVDRGRILGHEAVGTVTAIGSGVRQLAVGDRVLISCI
Mflv_4997|M.gilvum_PYR-GCK CGTDLHILKGDVPEVESGRILGHEAVGTVTAIGSAVQTLSVGDRVLVSCI
MMAR_2790|M.marinum_M CGSDLHFYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSV
MUL_2962|M.ulcerans_Agy99 CGSDLHFYEGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSV
Rv1895|M.tuberculosis_H37Rv CGSDLHFYEGEYPFTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSV
MAV_2804|M.avium_104 CGSDLHFYEADFPMPDP-IALGHEAIGTVVEAGPQVRNVKVGDQVMVSSV
MSMEG_0671|M.smegmatis_MC2_155 CGSDLHLYHGMMPDTRVGTTFGHEFIGVVEKVGPSVQNLSVGDRVMVPFN
Mb2283|M.bovis_AF2122/97 CHTDLTYREGGINDEYP-FLLGHEAAGIIEAVGPGVTAVEPGDFVILNWR
MLBr_01784|M.leprae_Br4923 CHTDLTYREGGINDRYP-FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWR
MAB_2084|M.abscessus_ATCC_1997 CHSDEHLVTGDLPIPLP-VVGGHEGAGTVVECGEGVEDLSEGDSVILTFL
TH_2319|M.thermoresistible__bu CGSDLHLYEVLSAFMSPGDILGHEAMGVVEEVGPEVGALQAGDRVVIPFN
* :* *** * : * * : ** *::
Mvan_4901|M.vanbaalenii_PYR-1 SSCGSCRYCRRTSYGQCSGGGG-----------WILG-----NRIDGTQA
Mflv_4997|M.gilvum_PYR-GCK SSCGACRYCRQGHYGQCLGGGG-----------WILG-----HLIDGTQA
MMAR_2790|M.marinum_M AGCGACAGCATRDPAMCVSGPQ------------IFG----SGALGGAQA
MUL_2962|M.ulcerans_Agy99 AGCGACAGCATRDPAMCVSGPQ------------IFG----SGALGGAQA
Rv1895|M.tuberculosis_H37Rv AGCGVCPGCETHDPVMCFSGPM------------IFG----AGVLGGAQA
MAV_2804|M.avium_104 AGCGSCAGCATRDPVLCHSGFQ------------IFG----GGVLGGAQA
MSMEG_0671|M.smegmatis_MC2_155 IFCGSCYFCARGLYSNCHNVNPNAT-----AVGGIYGYSHTCGGYDGGQA
Mb2283|M.bovis_AF2122/97 AVCGQCRACKRGRPRYCFDTFNAEQ-----KMTLTDG--TELTAALGIGA
MLBr_01784|M.leprae_Br4923 AVCGQCRACKRGRPSYCFDTFNAQQ-----KMTLIDG--TELTPALGIGA
MAB_2084|M.abscessus_ATCC_1997 PSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQMCLLGT
TH_2319|M.thermoresistible__bu ISCGTCWMCAQGLQSQCETTQNRDQG----TGAALFGYSKLYGEVAGGQA
** * * * . :
Mvan_4901|M.vanbaalenii_PYR-1 EFVRVPFADNSTHRVPDGVSDENMITLADLLPTGYEVGAINGRVRPADTV
Mflv_4997|M.gilvum_PYR-GCK EYVRVPFADNSTHKVPAGVSDEQMIVLADILPTSYEVGVLAGRVGPGDVV
MMAR_2790|M.marinum_M DLLAVPAADFQVLKIPAAITTEQALLLTDNLATGWAA-ARRADILFGATV
MUL_2962|M.ulcerans_Agy99 DLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAA-ARRADIPFGATV
Rv1895|M.tuberculosis_H37Rv DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAA-AQRADISFGSAV
MAV_2804|M.avium_104 DLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAA-AQRADIPFGGTV
MSMEG_0671|M.smegmatis_MC2_155 EFVRVPFADVGPSIIPDRLDDEDALLLTDALATGYFG-AQLGNIAEGDTV
Mb2283|M.bovis_AF2122/97 FADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTV
MLBr_01784|M.leprae_Br4923 FADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTV
MAB_2084|M.abscessus_ATCC_1997 FSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTV
TH_2319|M.thermoresistible__bu EYLRVPQAQYTHITVPHDGPDDRYVYLSDVLPTAWQG-VEYAAVPDGGTL
. . : : : :. . : .:
Mvan_4901|M.vanbaalenii_PYR-1 VVVGAGPIGLAAIMTSQLFSPSRIVAIDLADSRLDAARKFG-ADIVINPD
Mflv_4997|M.gilvum_PYR-GCK AIVGAGPIGLAAVLTAKLYSPSHIVVIDVADTRLEAAKKLG-ADVTVNSR
MMAR_2790|M.marinum_M AVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRASEWG-ATAVASPA
MUL_2962|M.ulcerans_Agy99 AVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWG-ATAVASPA
Rv1895|M.tuberculosis_H37Rv AVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWG-ATPIPSPA
MAV_2804|M.avium_104 AVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARWG-ATPLKAPA
MSMEG_0671|M.smegmatis_MC2_155 VVFGAGPVGLFAAKSAWLMGAGRVIVIDHLEYRLEKARTFAHAETINFVD
Mb2283|M.bovis_AF2122/97 AVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFG-ATHTVNAR
MLBr_01784|M.leprae_Br4923 AVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFG-ATHTVNAL
MAB_2084|M.abscessus_ATCC_1997 VVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFG--ATHTAAS
TH_2319|M.thermoresistible__bu VVLGLGPIGSMACRIAAHRGNCRVIGVDRVPERIEKVRPYC--ADVLNVD
.:.* * :* * : . :. :* : .
Mvan_4901|M.vanbaalenii_PYR-1 RLDPVAAIADLTGGLGVDAAMEAVGTAAT---------------------
Mflv_4997|M.gilvum_PYR-GCK SRRPRDVIDELTGGLGADVVMEAVGLPET---------------------
MMAR_2790|M.marinum_M AEAIVAATGGR----GADSVIDAVGTDAS---------------------
MUL_2962|M.ulcerans_Agy99 AEAIVAATSGR----GADSVIDAVDTDAS---------------------
Rv1895|M.tuberculosis_H37Rv AETILAATRGR----GADSVIDAVGTDAS---------------------
MAV_2804|M.avium_104 LEAILAATGGR----GADAVIDAVATDAS---------------------
MSMEG_0671|M.smegmatis_MC2_155 CDDIVVKMKRTTDHLGADVAIDAAGAEADGNFLQHVTATKLKLQGGSPIA
Mb2283|M.bovis_AF2122/97 EVDVVQAIGGLTDGFGADVVIDAVGRPET---------------------
MLBr_01784|M.leprae_Br4923 ELEVVKTIQDLTSGFGVDVVIDTVGRPET---------------------
MAB_2084|M.abscessus_ATCC_1997 MDEAWSLVSDMTRGKLADVCILTTDVAEG-------------------SY
TH_2319|M.thermoresistible__bu TDDVEAAVREQTGGXXVQTPPDPRRQSADCEN----HADQHGRPEHPPEE
.: .
Mvan_4901|M.vanbaalenii_PYR-1 FELAVQLVRPGGHVANIGVHG---GPATLHLEDIWIRNLTIT---TGLVD
Mflv_4997|M.gilvum_PYR-GCK FEESVDLVRPCGHVANIGVHG---APATLHLERIWIKNLTIT---TGLVD
MMAR_2790|M.marinum_M MTDALNAVRAGGTVSVVGVHDL--QPFPLPALTCLLRSITLR---LTIAP
MUL_2962|M.ulcerans_Agy99 MTDALNAVRAGGTVSVVGVHDL--QPFPLPALTCLLRSITLR---LTIAP
Rv1895|M.tuberculosis_H37Rv MSDALNAVRPGGTVSVVGVHDL--QPFPVPALTCLLRSITLR---MTMAP
MAV_2804|M.avium_104 LTEALNAVRPGGTVSVVGVHDM--NPFPLNALGCLIRSITLR---MTTAP
MSMEG_0671|M.smegmatis_MC2_155 LNWAIDSVRKGGTVSVVGAYGP--MFSAVKFGDAFNKGLTLR---MNQCP
Mb2283|M.bovis_AF2122/97 YQQAFYARDLAGTVVLVGVPTPD-MRLDMPLVDFFSHGGALKSSWYGDCL
MLBr_01784|M.leprae_Br4923 WKQAFYARDLAGTVVLVGVPTPD-MRLDMPLLDFFSHGGSLKSSWYGDCL
MAB_2084|M.abscessus_ATCC_1997 TAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSN
TH_2319|M.thermoresistible__bu LHHQADDQRQRRHERDAATAGSPPLPSPWPDRTTTHRHTWRR---LGGME
.
Mvan_4901|M.vanbaalenii_PYR-1 TY-STPTLVDLV-------------------AAHRLDTSALVTHRYPLDE
Mflv_4997|M.gilvum_PYR-GCK TH-STPTLISLV-------------------ANGRLDAATMITHRYPMDE
MMAR_2790|M.marinum_M VQRTWSELIPLL-------------------ESGRLDVDGIFTTSLPLDE
MUL_2962|M.ulcerans_Agy99 VQRTWSELIPLL-------------------ESGRLDVDGIFTTSLPLDE
Rv1895|M.tuberculosis_H37Rv VQRTWPELIPLL-------------------QSGRLDVDGIFTTTLPLDE
MAV_2804|M.avium_104 VQRTWPELIPLL-------------------QSGRLDVDGIFTTTMPLDE
MSMEG_0671|M.smegmatis_MC2_155 VKREWPRLLSHI-------------------KNGYLKPNDIVTHRIPLEH
Mb2283|M.bovis_AF2122/97 PESDFPTLIDLY-------------------LQGRLPLQRFVSERIGLED
MLBr_01784|M.leprae_Br4923 PERDFPTLVDLY-------------------LQGRLPLGKFVSERIGLGD
MAB_2084|M.abscessus_ATCC_1997 APHDIPRLVELY-------------------SAGLLKLDELVTREYSLDQ
TH_2319|M.thermoresistible__bu LLRDVVVLLHIVGFAVTFGAWTAEAVARRFRTTRLMDYGLLLSLITGLAL
*: : :.: :
Mvan_4901|M.vanbaalenii_PYR-1 FERAYHEFSNAGETGALKVLLTQN--------------------------
Mflv_4997|M.gilvum_PYR-GCK FDTAYQVFGDAANSGALKVVLTATS-------------------------
MMAR_2790|M.marinum_M AAKGYSIAGSRSGN-DVKVLLKV---------------------------
MUL_2962|M.ulcerans_Agy99 AAKGYSIAGSRSGN-DVKVLLKV---------------------------
Rv1895|M.tuberculosis_H37Rv AAKGYATARARSGE-ELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADL
MAV_2804|M.avium_104 AAIGYATAGSRSGD-DVKILLKP---------------------------
MSMEG_0671|M.smegmatis_MC2_155 IAEGYHIFSAKLDD-CIKPIIVPTAS------------------------
Mb2283|M.bovis_AF2122/97 VEEAFHKMHGGKVLRSVVML------------------------------
MLBr_01784|M.leprae_Br4923 VEEAFHKIHGGKVLRSVVML------------------------------
MAB_2084|M.abscessus_ATCC_1997 INEGYQDMRSGRNIRGLVRF------------------------------
TH_2319|M.thermoresistible__bu AAPWPAGIVLNYPKIGLKLVLLVALGAVLGIGGAHQRRTGNPVPRPLFVT
:
Mvan_4901|M.vanbaalenii_PYR-1 ----------------
Mflv_4997|M.gilvum_PYR-GCK ----------------
MMAR_2790|M.marinum_M ----------------
MUL_2962|M.ulcerans_Agy99 ----------------
Rv1895|M.tuberculosis_H37Rv QLEGAADGVDGPSMLN
MAV_2804|M.avium_104 ----------------
MSMEG_0671|M.smegmatis_MC2_155 ----------------
Mb2283|M.bovis_AF2122/97 ----------------
MLBr_01784|M.leprae_Br4923 ----------------
MAB_2084|M.abscessus_ATCC_1997 ----------------
TH_2319|M.thermoresistible__bu AGVLSFAAAAVAVLW-