For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RAMVYRGPYKIRLEDKPIPAIEHPNDAIVRVTKAAICGSDLHLYHGMMPDTRVGTTFGHEFIGVVEKVGP SVQNLSVGDRVMVPFNIFCGSCYFCARGLYSNCHNVNPNATAVGGIYGYSHTCGGYDGGQAEFVRVPFAD VGPSIIPDRLDDEDALLLTDALATGYFGAQLGNIAEGDTVVVFGAGPVGLFAAKSAWLMGAGRVIVIDHL EYRLEKARTFAHAETINFVDCDDIVVKMKRTTDHLGADVAIDAAGAEADGNFLQHVTATKLKLQGGSPIA LNWAIDSVRKGGTVSVVGAYGPMFSAVKFGDAFNKGLTLRMNQCPVKREWPRLLSHIKNGYLKPNDIVTH RIPLEHIAEGYHIFSAKLDDCIKPIIVPTAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0671 | - | - | 100% (382) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6616 | - | 7e-59 | 34.94% (395) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 2e-30 | 34.90% (255) | 5-exo-alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 2e-31 | 34.51% (255) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3148 | - | 0.0 | 82.28% (378) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 5e-51 | 35.79% (380) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-25 | 28.93% (363) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 1e-26 | 29.07% (344) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_2790 | - | 7e-49 | 34.83% (379) | dehydrogenase |
| M. avium 104 | MAV_4101 | - | 3e-60 | 37.22% (395) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_2319 | - | 1e-47 | 39.53% (258) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. ulcerans Agy99 | MUL_2962 | - | 1e-47 | 34.30% (379) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4749 | - | 6e-61 | 36.71% (395) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv -----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFY
MMAR_2790|M.marinum_M -----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGSDLHFY
MUL_2962|M.ulcerans_Agy99 -----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLHFY
MSMEG_0671|M.smegmatis_MC2_155 -----MRAMVYRGPYKIRLEDKPIPAIEHPNDAIVRVTKAAICGSDLHLY
Mflv_3148|M.gilvum_PYR-GCK -----MKAMTYRGPYKVRVEEKDVPSLEHPNDAIVRVQRAAICGSDLHLY
MAV_4101|M.avium_104 -----MKAVTWHGKRDVRVDSVPDPKIEQPTDAIIEVTSTNICGSDLHLY
Mvan_4749|M.vanbaalenii_PYR-1 -----MRAVTWHGRRDVRVDSVPDPKIEEPTDAIIEVTSTNICGSDLHLY
TH_2319|M.thermoresistible__bu --------VTWHGRRKVSVDTVPDPAIMEPTDAIIRVTSTNICGSDLHLY
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDP-GPGEAVVDVTACGVCHTDLTYR
MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDP-GPGEVVVKVQACGVCHTDLTYR
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv EGEYPFTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPG
MMAR_2790|M.marinum_M EGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGACAG
MUL_2962|M.ulcerans_Agy99 EGEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGACAG
MSMEG_0671|M.smegmatis_MC2_155 HGMMPDTRVGTTFGHEFIGVVEKVGPSVQNLSVGDRVMVPFNIFCGSCYF
Mflv_3148|M.gilvum_PYR-GCK HGLMPDTRVGHTFGHEFIGTVHEVGSSVQNLQPGDRVMVPFNIFCGSCYF
MAV_4101|M.avium_104 EILGAFMKPGDILGHEPMGVVREVGTETGDLRVGDRVVIPFQICCGSCYM
Mvan_4749|M.vanbaalenii_PYR-1 EVLGAFMNEGDILGHEPMGVVREVGSAVSNLAVGDRVVIPFQISCGHCFM
TH_2319|M.thermoresistible__bu EVLSAFMSPGDILGHEAMGVVEEVGPEVGALQAGDRVVIPFNISCGTCWM
MLBr_01784|M.leprae_Br4923 EGGINDRYP-FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRA
MAB_1869c|M.abscessus_ATCC_199 EGGINDEFP-FLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVCRA
Mb1929|M.bovis_AF2122/97 -------------M---IFGA---------GVLGGAQADLLAVPAADFQV
Rv1895|M.tuberculosis_H37Rv CETHDPVMCFSGPM---IFGA---------GVLGGAQADLLAVPAADFQV
MMAR_2790|M.marinum_M CATRDPAMCVSGPQ---IFGS---------GALGGAQADLLAVPAADFQV
MUL_2962|M.ulcerans_Agy99 CATRDPAMCVSGPQ---IFGS---------GALGGAQADLLAVPATDFQV
MSMEG_0671|M.smegmatis_MC2_155 CARGLYSNCHNVNPNATAVGG-IYGYSHTCGGYDGGQAEFVRVPFADVGP
Mflv_3148|M.gilvum_PYR-GCK CARGLYSNCHNVNPNATAVGG-IYGYSHTCGGYDGGQAEFVRVPFADVGP
MAV_4101|M.avium_104 CGQQLYTQCETTQVRDQGMGAALFGYSELYGEVPGGQAELLRVPQAQFTH
Mvan_4749|M.vanbaalenii_PYR-1 CDRKLYTQCETTQVRDQGMGAALFGYSELYGSVPGGQAEYLRVPQAQFTH
TH_2319|M.thermoresistible__bu CAQGLQSQCETTQNRDQGTGAALFGYSKLYGEVAGGQAEYLRVPQAQYTH
MLBr_01784|M.leprae_Br4923 CKRGRPSYCFDTFN--AQQKMTLIDGTELTPALGIGAFADKTLVHSGQCT
MAB_1869c|M.abscessus_ATCC_199 CKRGRPQYCFDTFN--AAQKMTLTDGTELTPALGIGAFIEKTLVHAGQCT
. : :
Mb1929|M.bovis_AF2122/97 LKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLCAL
Rv1895|M.tuberculosis_H37Rv LKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLCAL
MMAR_2790|M.marinum_M LKIPAAITTEQALLLTDNLATGWAAARRADILFGATVAVIGLGAVGLCAV
MUL_2962|M.ulcerans_Agy99 LKIPAAITTEQALLLTDNLATGWAAARRADIPFGATVAVIGLGAVGLCAV
MSMEG_0671|M.smegmatis_MC2_155 SIIPDRLDDEDALLLTDALATGYFGAQLGNIAEGDTVVVFGAGPVGLFAA
Mflv_3148|M.gilvum_PYR-GCK VLIPDWLGDDDALMLTDALPTGYFGAQLGDIVEGDTVIVFGAGPVGLYAA
MAV_4101|M.avium_104 IKVPVGPPDSRFVYLSDVLPTAWQAVAYADIPDGGTVAVLGLGPIGDMAS
Mvan_4749|M.vanbaalenii_PYR-1 IKVPDGPPDSRFVYLSDVLPTAWQAVAYADVPDGGTVTVLGLGPIGDMAA
TH_2319|M.thermoresistible__bu ITVPHDGPDDRYVYLSDVLPTAWQGVEYAAVPDGGTLVVLGLGPIGSMAC
MLBr_01784|M.leprae_Br4923 KVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAI
MAB_1869c|M.abscessus_ATCC_199 KVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDAAI
* : . :. . . : . :: *:* * :* *
Mb1929|M.bovis_AF2122/97 RSAFIHGAATVFAVDRVKGRLQRAATWG---------ATPIPSPAAETIL
Rv1895|M.tuberculosis_H37Rv RSAFIHGAATVFAVDRVKGRLQRAATWG---------ATPIPSPAAETIL
MMAR_2790|M.marinum_M RSALAQGAATVFAVDRVQGRLQRASEWG---------ATAVASPAAEAIV
MUL_2962|M.ulcerans_Agy99 RSALAQGAATVFAVDRVQGRLQRAAEWG---------ATAVASPAAEAIV
MSMEG_0671|M.smegmatis_MC2_155 KSAWLMGAGRVIVIDHLEYRLEKARTFAHAETINFVDCDDIVVKMKRTTD
Mflv_3148|M.gilvum_PYR-GCK KSAWLMGAGRVLVVDHLDYRLKKAESFAHAETYNFVEYDDIVVEMKKATG
MAV_4101|M.avium_104 RIADHLG-YRVIAVDLVPERLG--RAAQRGIHT--IDLARLDAGLGDAIR
Mvan_4749|M.vanbaalenii_PYR-1 RIAQHLG-YQVFAVDLVPERLD--RAIARGIHT--IDASIVDGSVGDEVR
TH_2319|M.thermoresistible__bu RIAAHRGNCRVIGVDRVPERIEKVRPYCADVLN--VDTDDVEAAVREQTG
MLBr_01784|M.leprae_Br4923 SGAALVGANRIIAVDIDDTKLEWARTFGATHTVN----ALEL-EVVKTIQ
MAB_1869c|M.abscessus_ATCC_199 AGARLAGARKIIAIDTDDTKLAWAKDFGATDTIN----ARKVDDVVTAIQ
* * :: :* ::
Mb1929|M.bovis_AF2122/97 AATRGRGADSVIDAVGTDASMSDALN------------------------
Rv1895|M.tuberculosis_H37Rv AATRGRGADSVIDAVGTDASMSDALN------------------------
MMAR_2790|M.marinum_M AATGGRGADSVIDAVGTDASMTDALN------------------------
MUL_2962|M.ulcerans_Agy99 AATSGRGADSVIDAVDTDASMTDALN------------------------
MSMEG_0671|M.smegmatis_MC2_155 HLG----ADVAIDAAGAEADGNFLQHVTATKLKLQ---------------
Mflv_3148|M.gilvum_PYR-GCK YLG----ADVVIDAVGAEADGNALMHVTSAKLKLQ---------------
MAV_4101|M.avium_104 DLTDGRGADSVIDAVGMEAHGSPAAKLAQQVAGVLPDALGKR------LM
Mvan_4749|M.vanbaalenii_PYR-1 RLTGGRGSDSVIDAVGMEAHGSPVAKFAQQATALLPDAVAKP------MM
TH_2319|M.thermoresistible__bu GXXVQTPPDPRRQSADCENHADQHGRPEHPPEELHHQADDQRQRRHERDA
MLBr_01784|M.leprae_Br4923 DLTSGFGVDVVIDTVGRPETWKQAFY------------------------
MAB_1869c|M.abscessus_ATCC_199 ELTDEFGADVVIDAVGRPETWKQAFY------------------------
* ::..
Mb1929|M.bovis_AF2122/97 ---------------------AVRPGGTVSVVG-----------------
Rv1895|M.tuberculosis_H37Rv ---------------------AVRPGGTVSVVG-----------------
MMAR_2790|M.marinum_M ---------------------AVRAGGTVSVVG-----------------
MUL_2962|M.ulcerans_Agy99 ---------------------AVRAGGTVSVVG-----------------
MSMEG_0671|M.smegmatis_MC2_155 ---GGSPIALNW------AIDSVRKGGTVSVVG-------------AYG-
Mflv_3148|M.gilvum_PYR-GCK ---GGSPVALNW------AIDSVRKGGTVSVVG-------------AYG-
MAV_4101|M.avium_104 QTAGVDRLSALY-----SAIDAVRRGGTISLIG-------------VYG-
Mvan_4749|M.vanbaalenii_PYR-1 QKAGVDRLDALY-----TAIDCVRRGGTLSLIG-------------VYG-
TH_2319|M.thermoresistible__bu ATAGSPPLPSPWPDRTTTHRHTWRRLGGMELLRDVVVLLHIVGFAVTFGA
MLBr_01784|M.leprae_Br4923 ---------------------ARDLAGTVVLVG-----------------
MAB_1869c|M.abscessus_ATCC_199 ---------------------ARDLAGTVVLVG-----------------
* : ::
Mb1929|M.bovis_AF2122/97 ---VHDLQPFPLPALTCLLRSITLRMT-MAPVQRTWPELIP---------
Rv1895|M.tuberculosis_H37Rv ---VHDLQPFPVPALTCLLRSITLRMT-MAPVQRTWPELIP---------
MMAR_2790|M.marinum_M ---VHDLQPFPLPALTCLLRSITLRLT-IAPVQRTWSELIP---------
MUL_2962|M.ulcerans_Agy99 ---VHDLQPFPLPALTCLLRSITLRLT-IAPVQRTWSELIP---------
MSMEG_0671|M.smegmatis_MC2_155 ----PMFSAVKFGDAFNKG--LTLRMN-QCPVKREWPRLLS---------
Mflv_3148|M.gilvum_PYR-GCK ----PMFSAVKFGDAMNKG--LTINAN-QCPVKRQWPRLLS---------
MAV_4101|M.avium_104 ----GMADPLPMLTLFDK--QVTLRMG-QANVKRWVDDIMP---------
Mvan_4749|M.vanbaalenii_PYR-1 ----GMADPMPMLTLFDK--QIQVRMG-QANVKKWVDDIMP---------
TH_2319|M.thermoresistible__bu WTAEAVARRFRTTRLMDYGLLLSLITG-LALAAPWPAGIVLNYPKIGLKL
MLBr_01784|M.leprae_Br4923 VPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVD---------
MAB_1869c|M.abscessus_ATCC_199 VPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVS---------
. : . ::
Mb1929|M.bovis_AF2122/97 --LLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELKVLLTP-----
Rv1895|M.tuberculosis_H37Rv --LLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLRPDSRDV
MMAR_2790|M.marinum_M --LLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLKV-----
MUL_2962|M.ulcerans_Agy99 --LLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLKV-----
MSMEG_0671|M.smegmatis_MC2_155 --HIKNGYLKPNDIVTHRIPLEHIAEGYHIFSAKLDDCIKPIIVPTAS--
Mflv_3148|M.gilvum_PYR-GCK --HIQQGYLTPSDIVTHHIPLDEIAEGYHMFSSKLDDCIKPVVVMNTN--
MAV_4101|M.avium_104 --LLTDDDPLGVDDFATHVL--PLERAPHAYEIFQKKQDGAVKVILKP--
Mvan_4749|M.vanbaalenii_PYR-1 --LLTDSDPLGVDTFATHVL--PMEEAPHAYKIFQQKQDGAVKVILQP--
TH_2319|M.thermoresistible__bu VLLVALGAVLGIGGAHQRRTGNPVPRPLFVTAGVLSFAAAAVAVLW----
MLBr_01784|M.leprae_Br4923 --LYLQGRLPLGKFVSERIGLGDVEEAFHKIHG--GKVLRSVVML-----
MAB_1869c|M.abscessus_ATCC_199 --LYQQGRLPLDRFVSERIGIESIEAAFEKMHH--GEVLRSVVVL-----
.
Mb1929|M.bovis_AF2122/97 --------------------------------------
Rv1895|M.tuberculosis_H37Rv LGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
MMAR_2790|M.marinum_M --------------------------------------
MUL_2962|M.ulcerans_Agy99 --------------------------------------
MSMEG_0671|M.smegmatis_MC2_155 --------------------------------------
Mflv_3148|M.gilvum_PYR-GCK --------------------------------------
MAV_4101|M.avium_104 --------------------------------------
Mvan_4749|M.vanbaalenii_PYR-1 --------------------------------------
TH_2319|M.thermoresistible__bu --------------------------------------
MLBr_01784|M.leprae_Br4923 --------------------------------------
MAB_1869c|M.abscessus_ATCC_199 --------------------------------------