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VDDESVAASPHKAKRGELRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRKKTAELFEGIEI VPPKLIAYRGSDFAELDVEAVLRRNPQVVLVDELAHTNTPGSKNTKRWQDIEELLDAGITVITTVNVQHL ESLNDVVTQITGIEQQEKVPDEVVRAADQVELVDITPEALRRRLAHGNVYAPERVDAALSNYFRRGNLTA LRELALLWLADQVDSALEKYRADNKITDTWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVV QGDGLSGVSGPQMGKVRELAASIGATLHTVVGDGAGGVPAALLDFAREMNATQLVLGTSRRSRWARIFDE GIGATVVQKSGRIDVHMVTHEQAGGESLWARVSPRQRHAVSWLAALAVPGAICAATVLLLDRFLGIGGES AMFFIGVLVVALLGGVAPAALSAVLSGVLLNFFLVEPRHTFTISEPDSAITIVVLLVVAVAVAALVDGAA NRTRESRRAAREAELLALFAGAVLRGADLNTLLERVREAYSQQSVTLVRGEAHGGGVVGCAGSEPCVTVE TADTAIEVGSKDDPEEFWLLLAGRRLDARDRRVLGAVANQAAGLARQRELAEEAGRAEAIARADELRRSL LSAVSHDLRTPLAAAKAAVSSLRSEDVGFSPEDTAELLATVEESIDQLSGLVGNLLDSSRLAAGVVRPEL QPVYLEEAVPRALLGISRGSTGLRAGLDRVKVEVGDTVVMADSGLLERVLANVIDNALRYAPDGPVRVTA GRVADRVLIAVADEGPGVARGAETELFAPFQRLGDQDTSSGVGLGLSVARGFVEAMGGTISATDTPGGGM TVEIDLAAPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4762 | - | - | 100% (850) | osmosensitive K+ channel signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 1e-23 | 33.21% (265) | multi-sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_0884 | - | 3e-21 | 33.20% (244) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1056c | kdpD | 0.0 | 79.38% (839) | sensor protein KDPD |
| M. gilvum PYR-GCK | Mflv_4423 | - | 6e-23 | 33.96% (268) | multi-sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1028c | kdpD | 0.0 | 79.38% (839) | sensor protein KDPD |
| M. leprae Br4923 | MLBr_00774 | mtrB | 4e-21 | 28.57% (329) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3251c | - | 0.0 | 64.03% (834) | sensor protein KdpD |
| M. marinum M | MMAR_0634 | kdpD | 0.0 | 79.95% (838) | two-component system response phosphate sensor kinase, KdpD |
| M. avium 104 | MAV_1170 | - | 0.0 | 75.44% (847) | sensor protein KdpD |
| M. smegmatis MC2 155 | MSMEG_5395 | - | 0.0 | 78.52% (838) | sensor protein KdpD |
| M. thermoresistible (build 8) | TH_4550 | - | 2e-24 | 32.76% (290) | PUTATIVE putative integral membrane sensor signal transduction |
| M. ulcerans Agy99 | MUL_2581 | mtrB | 1e-21 | 29.31% (331) | two component sensory transduction histidine kinase MtrB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK MNWAQTPLGPTSEWPQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRN
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VTLGRKYPWALGRPASEVWAEIWDDIGPRIERVLSTGVATWDTSLLLFLE
Mb1056c|M.bovis_AF2122/97 ------------------MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIY
Rv1028c|M.tuberculosis_H37Rv ------------------MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIY
MMAR_0634|M.marinum_M -----------------------------------MTPDYPRKRGELRIY
MAV_1170|M.avium_104 ---------------------------------MTDVRDHHPKRGELRIY
Mvan_4762|M.vanbaalenii_PYR-1 -----------------------------MDDESVAASPHKAKRGELRIY
MSMEG_5395|M.smegmatis_MC2_155 -----------------------------MTTRASNAS----KRGELRIY
MAB_3251c|M.abscessus_ATCC_199 ------------------------------------MPDGLRARGTLRIY
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK RSGYTEESYHTFSYSPLRDDDGAVVGMLCVVSEDTLQVIGERRMATLRDL
Mb1056c|M.bovis_AF2122/97 LGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIE--
Rv1028c|M.tuberculosis_H37Rv LGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIE--
MMAR_0634|M.marinum_M LGAAPGVGKTFAMLGEAQRRLERGTDVVAAVVETHGRKRTAELLEGIE--
MAV_1170|M.avium_104 LGAAPGVGKTYSMLGEAHRRLERGTDLVAGVVETHGRAKTAELLEGIE--
Mvan_4762|M.vanbaalenii_PYR-1 LGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRKKTAELFEGIE--
MSMEG_5395|M.smegmatis_MC2_155 LGAAPGVGKTYAMLGEAHRRLDRGTDLVAAVVETHGRKNTAELLAGIE--
MAB_3251c|M.abscessus_ATCC_199 LGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDGLE--
MLBr_00774|M.leprae_Br4923 ------------MIFSSRRRIRG---------------------------
MUL_2581|M.ulcerans_Agy99 ------------MIWGSRRRMRG---------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GSDPSVVRTEGEILSFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGI
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK TGDHPAAPDVLTGADGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREP
Mb1056c|M.bovis_AF2122/97 -------------MIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAH
Rv1028c|M.tuberculosis_H37Rv -------------MIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAH
MMAR_0634|M.marinum_M -------------RIPPKFIEYRGSRFAELDVEAVLRRQPQVVLVDELAH
MAV_1170|M.avium_104 -------------IIPPRYIEYRGGRFPELDVPAVLARHPQVVLVDELAH
Mvan_4762|M.vanbaalenii_PYR-1 -------------IVPPKLIAYRGSDFAELDVEAVLRRNPQVVLVDELAH
MSMEG_5395|M.smegmatis_MC2_155 -------------VIPPRYIEYRGGRFPELDVPAVLDRKPQVVLVDELAH
MAB_3251c|M.abscessus_ATCC_199 -------------LIPPKEMVHRGTAMYELDVDAVLERRPALVLIDEMAH
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK PRQVLIVPLLQQGAAPTGFLVAGLNRYRVLDDAYRGFVALVAGHIAAGIG
Mb1056c|M.bovis_AF2122/97 TNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
Rv1028c|M.tuberculosis_H37Rv TNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
MMAR_0634|M.marinum_M TNTPGSKNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQQ
MAV_1170|M.avium_104 TNTPGSKNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQK
Mvan_4762|M.vanbaalenii_PYR-1 TNTPGSKNTKRWQDIEELLDAGITVITTVNVQHLESLNDVVTQITGIEQQ
MSMEG_5395|M.smegmatis_MC2_155 TNTPGSKNAKRWQDVDELLNAGITVISTVNVQHLDSLNDVVAAITGIEQQ
MAB_3251c|M.abscessus_ATCC_199 TNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQR
MLBr_00774|M.leprae_Br4923 ----------RWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALT-----
MUL_2581|M.ulcerans_Agy99 ----------RWGRSGPMTRGLSALSRAVGVAWRRSLQLRVVALT-----
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK LSRSYRTQQMRAEELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRA
Mb1056c|M.bovis_AF2122/97 EKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAA--------------
Rv1028c|M.tuberculosis_H37Rv EKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAA--------------
MMAR_0634|M.marinum_M EKVPDEIVRAAEQVELVDITPEALRRRLAHGNVYAA--------------
MAV_1170|M.avium_104 ETVPDSVVRQASQVELIDITPEALRRRLSHGNVYAP--------------
Mvan_4762|M.vanbaalenii_PYR-1 EKVPDEVVRAADQVELVDITPEALRRRLAHGNVYAP--------------
MSMEG_5395|M.smegmatis_MC2_155 ETVPDEVVRSADQIELVDITPEALRRRLSHGNVYAP--------------
MAB_3251c|M.abscessus_ATCC_199 ETVPDAVVRRAEQVELVDITPEALRRRMVHGNVYAP--------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK DTLGDAARQELDVVWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGA
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VTAELASVFRSAIERAGLVFDVDCPPLGEEAYVDLDMWEKVIFNLLSNAL
Mb1056c|M.bovis_AF2122/97 ---------------------------------------ERVDAALSNYF
Rv1028c|M.tuberculosis_H37Rv ---------------------------------------ERVDAALSNYF
MMAR_0634|M.marinum_M ---------------------------------------ERVDAALANYF
MAV_1170|M.avium_104 ---------------------------------------DRIDAALSNYF
Mvan_4762|M.vanbaalenii_PYR-1 ---------------------------------------ERVDAALSNYF
MSMEG_5395|M.smegmatis_MC2_155 ---------------------------------------ERIDAALSNYF
MAB_3251c|M.abscessus_ATCC_199 ---------------------------------------EKVGSALSNYF
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK KFTFEGSVSVTARRDGRGAVITVSDTGTGVPADEMPRLFERFHRIENTRA
Mb1056c|M.bovis_AF2122/97 RTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGG
Rv1028c|M.tuberculosis_H37Rv RTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGG
MMAR_0634|M.marinum_M RTGNLTALRELALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGG
MAV_1170|M.avium_104 RRGNLTALRELALLWLADQVDTALAKYRAENKITDTWEARERVVVAVTGG
Mvan_4762|M.vanbaalenii_PYR-1 RRGNLTALRELALLWLADQVDSALEKYRADNKITDTWEARERVVVAVTGG
MSMEG_5395|M.smegmatis_MC2_155 RRGNLTALRELALLWLADQVDAALAKYRADNKITALWETRERVVVAVTGG
MAB_3251c|M.abscessus_ATCC_199 RTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVVVAVTGG
MLBr_00774|M.leprae_Br4923 -----FGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTG-
MUL_2581|M.ulcerans_Agy99 -----LGLSLAVVMALGFVLTSQVTNRVFDIKVKATIDQIERARNTVSG-
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK RSNEGSGIGLALVKELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPAD
Mb1056c|M.bovis_AF2122/97 PESETLVRRASRIASKSSAELMVVHVIRGDDLAGVSAPQLGRVRELATSL
Rv1028c|M.tuberculosis_H37Rv PESETLVRRASRIASKSSAELMVVHVIRGDGLAGVSAPQLGRVRELATSL
MMAR_0634|M.marinum_M PESETLVRRAFRIASKASAELMVVHLARGDGLSGVAAPQMGKVRELAASL
MAV_1170|M.avium_104 PESETLVRRASRIASKSSAELMVVHVIRGDGLAGLSESRMAKIRELASSL
Mvan_4762|M.vanbaalenii_PYR-1 PESETLVRRASRIASKSSAELMVVHVVQGDGLSGVSGPQMGKVRELAASI
MSMEG_5395|M.smegmatis_MC2_155 TESETLVRRAFRIASKSSAELMVVHVVHGDGLTGISAAQMGKVRELAVSL
MAB_3251c|M.abscessus_ATCC_199 PESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDI
MLBr_00774|M.leprae_Br4923 -------------------------IVNGE-----------ETRSLDSSL
MUL_2581|M.ulcerans_Agy99 -------------------------IVNGE-----------ETRSLDSSL
TH_4550|M.thermoresistible__bu -----------------------------------------------VSL
Mflv_4423|M.gilvum_PYR-GCK AVASQPRERRPGNTVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGT
.
Mb1056c|M.bovis_AF2122/97 GATMHTVVGD----------------------------------------
Rv1028c|M.tuberculosis_H37Rv GATMHTVVGD----------------------------------------
MMAR_0634|M.marinum_M GATVHTVVGD----------------------------------------
MAV_1170|M.avium_104 DASLHTIVGD----------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 GATLHTVVGDG---------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 GATVHTVVGD----------------------------------------
MAB_3251c|M.abscessus_ATCC_199 GASVQAVTGD----------------------------------------
MLBr_00774|M.leprae_Br4923 QLARNTLTSK----------------------------------------
MUL_2581|M.ulcerans_Agy99 QLARNTLTSK----------------------------------------
TH_4550|M.thermoresistible__bu RGRITIMSAA----------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GTLARVLVADDNADMREYLGRLLRSDGYAVEAVVDGWQALEAIRAEPPDL
: .
Mb1056c|M.bovis_AF2122/97 ------------DVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGA
Rv1028c|M.tuberculosis_H37Rv ------------DVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGA
MMAR_0634|M.marinum_M ------------DVPTALLDFAREMNATQLVLGTSRRSRWARVLDEGIGA
MAV_1170|M.avium_104 ------------EVPAALLEFAREMNATQLVIGTSRRSRWARLFEEGIGP
Mvan_4762|M.vanbaalenii_PYR-1 ----------AGGVPAALLDFAREMNATQLVLGTSRRSRWARIFDEGIGA
MSMEG_5395|M.smegmatis_MC2_155 ------------DVPTALLDFARDINATQLVLGTSRRSRWARMFDEGIGA
MAB_3251c|M.abscessus_ATCC_199 ------------DVPQTLLDFARGVNATQLVLGTSRRSRWARILDEGVAA
MLBr_00774|M.leprae_Br4923 ------------TDPTSGAGLVGAFDAVLIVPGDGPR--------TATTA
MUL_2581|M.ulcerans_Agy99 ------------TDPASGAGQAGAFDAVLMVPGDGPR--------AASAA
TH_4550|M.thermoresistible__bu -------------VSCAAAALLLAITYALVDLQLSRR-----------GP
Mflv_4423|M.gilvum_PYR-GCK VISDVMMPRLDGLGLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGA
: . : . .
Mb1056c|M.bovis_AF2122/97 RTVQESGGIDVHMVTHPAASRASGWSRVSP--RERHIASWLAALVVPSVI
Rv1028c|M.tuberculosis_H37Rv RTVQEPGGIDVHMVTHPAASRASGWSRVSP--RERHIASWLAALVVPSVI
MMAR_0634|M.marinum_M TVVQQSGPIDVHMVTHQEAGRPARWSWLWP--REHHLVSWLAAVVVPSLI
MAV_1170|M.avium_104 RIVELSGKIDVHLVTHEESKRGFRASSLAP--RERRVASWLAALIVPSVI
Mvan_4762|M.vanbaalenii_PYR-1 TVVQKSGRIDVHMVTHEQAGGESLWARVSP--RQRHAVSWLAALAVPGAI
MSMEG_5395|M.smegmatis_MC2_155 TVVQQSQKIDVHMVTHEAAKRGFRWSSTSP--RQRHAASWAAALMVPSLI
MAB_3251c|M.abscessus_ATCC_199 AVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGRKRLIINWLAAILVP-PA
MLBr_00774|M.leprae_Br4923 GPVDQVPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIG-----------
MUL_2581|M.ulcerans_Agy99 GPVDQVPSALRGFVKAGQAAYQYAIVHTDGFSGPALIVG-----------
TH_4550|M.thermoresistible__bu VVMRRSPPDTAPAEPTGPEVSG----------------------------
Mflv_4423|M.gilvum_PYR-GCK DDYLVKPFAAAELLARVRANIQLARLREGHARWRTALVDSLQEAFFVCDE
Mb1056c|M.bovis_AF2122/97 CAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNY
Rv1028c|M.tuberculosis_H37Rv CAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNY
MMAR_0634|M.marinum_M CALTVAWLDRFLAVGGESALFVIGVLVVALLGGVAPAALSAVLSGLLLNY
MAV_1170|M.avium_104 CAVTVTWLDPYLDTGGESALFFVGVLLVGLLGGIAPAALSAVLSGLLLNY
Mvan_4762|M.vanbaalenii_PYR-1 CAATVLLLDRFLGIGGESAMFFIGVLVVALLGGVAPAALSAVLSGVLLNF
MSMEG_5395|M.smegmatis_MC2_155 CAFSVAILDPFLDVGGKSALFFVGVLVVALLGGVAPAALSAVLSGLLLNY
MAB_3251c|M.abscessus_ATCC_199 TALFIHFFDTAFGVGSKSALFLIAVLGVSLLGGVSTALVSAVISGLLLNF
MLBr_00774|M.leprae_Br4923 ----------------------------------TPTSSQVTNLELYLIF
MUL_2581|M.ulcerans_Agy99 ----------------------------------TPTSSRVANLELYLIF
TH_4550|M.thermoresistible__bu --------------------------------------VAAWMDRHRAEL
Mflv_4423|M.gilvum_PYR-GCK HGAVVEINPAFTEILGYDSTGLPYPLMHPWWPLKGSDAEANRRVEEAFGS
Mb1056c|M.bovis_AF2122/97 FLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAV-------LVDGAASRTRE
Rv1028c|M.tuberculosis_H37Rv FLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAV-------LVDGAASRTRE
MMAR_0634|M.marinum_M FLIEPRYTFTIADPDNAVTTLVLLVVAVAVAA-------LVDNAAKRSRE
MAV_1170|M.avium_104 YLIAPRHSFTIAEPNSAITELVLLLIAVAVAV-------LVDFAAKRTRE
Mvan_4762|M.vanbaalenii_PYR-1 FLVEPRHTFTISEPDSAITIVVLLVVAVAVAA-------LVDGAANRTRE
MSMEG_5395|M.smegmatis_MC2_155 FLTSPRHTFTMSDPDSALTIVVLLAVAVAVAA-------LVDGAAKRARE
MAB_3251c|M.abscessus_ATCC_199 LFVAPRYSFTIGETDNALTILMMMVTAVAVAA-------LVDAAATRARQ
MLBr_00774|M.leprae_Br4923 PLKNEQATVTLVRGTMATGGMVLLVLLSGIAL-------LVSRQVVVP--
MUL_2581|M.ulcerans_Agy99 PLANEQATITLVRGTMATGSLVLLVLLAGIAL-------LISRQVVVP--
TH_4550|M.thermoresistible__bu QEAATNSLLLYGAVAMAAVTALAAVVAWLVAG-------RVLSPLHRVTA
Mflv_4423|M.gilvum_PYR-GCK FMRDPHGTLTEVPVTHRDGHRLYVTVTFSHADDPETGRDVIVGTLRDVTA
. : * :
Mb1056c|M.bovis_AF2122/97 ARRASQEAELLALFAGSVLRGADLATLLQRVRETYS--------------
Rv1028c|M.tuberculosis_H37Rv ARRASQEAELLALFAGSVLRGADLATLLQRVRETYS--------------
MMAR_0634|M.marinum_M AGRASREAELLALFAGSVLRGADLEALLEKVRETYS--------------
MAV_1170|M.avium_104 ARRASQEAELLTLFAGSVLRGADLETLLERVRETYA--------------
Mvan_4762|M.vanbaalenii_PYR-1 SRRAAREAELLALFAGAVLRGADLNTLLERVREAYS--------------
MSMEG_5395|M.smegmatis_MC2_155 ARHASREAELLALFAGSVLRGADLTALLERVRETYA--------------
MAB_3251c|M.abscessus_ATCC_199 ARRASREAELLALFAGGVLVNSDLSALLERVRTTYN--------------
MLBr_00774|M.leprae_Br4923 VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFN--------------
MUL_2581|M.ulcerans_Agy99 VRSASRIAERFAEGHLSERMPVRGEDDMARLALSFN--------------
TH_4550|M.thermoresistible__bu TARRISRAPALSSGLRERIQLAGPADEVKDLADTFD--------------
Mflv_4423|M.gilvum_PYR-GCK ERYIVQRESALASLNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWP
:: : :
Mb1056c|M.bovis_AF2122/97 -------------------------------QRAVTMLR----VRQGAST
Rv1028c|M.tuberculosis_H37Rv -------------------------------QRAVTMLR----VRQGAST
MMAR_0634|M.marinum_M -------------------------------QRAVSILR----IEAGTSQ
MAV_1170|M.avium_104 -------------------------------QRSVSMLRESEDARAGGTK
Mvan_4762|M.vanbaalenii_PYR-1 -------------------------------QQSVTLVR------GEAHG
MSMEG_5395|M.smegmatis_MC2_155 -------------------------------QRAVSLLR------ETSDG
MAB_3251c|M.abscessus_ATCC_199 -------------------------------QTAVSLLC---------AE
MLBr_00774|M.leprae_Br4923 -------------------------------DMAESLSR-----------
MUL_2581|M.ulcerans_Agy99 -------------------------------DMAESLSR-----------
TH_4550|M.thermoresistible__bu -------------------------------QMLCRLDR-----------
Mflv_4423|M.gilvum_PYR-GCK DEPDGEHESDAPSLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDA
: :
Mb1056c|M.bovis_AF2122/97 GETVACVGTNPCRDVDSADTAIEVG----DDEFWMLMAGRKLAARDRRVL
Rv1028c|M.tuberculosis_H37Rv GETVACVGTNPCRDVDSADTAIEVG----DDEFWMLMAGRKLAARDRRVL
MMAR_0634|M.marinum_M GAIVSCVGEDPCVDVDTADTAIDVG----DDEFWMLMAGRKLLARDRRVL
MAV_1170|M.avium_104 TQVVACVGRDPCVSVDAADTAIEVGGPD-SSEFQMLLAGRKLSARDRRVL
Mvan_4762|M.vanbaalenii_PYR-1 GGVVGCAGSEPCVTVETADTAIEVGSKDDPEEFWLLLAGRRLDARDRRVL
MSMEG_5395|M.smegmatis_MC2_155 ATIVDCVGQDPCDRVAAADTAVEAG-----DEFWLLLSGRELPARDRRVL
MAB_3251c|M.abscessus_ATCC_199 GPAVASVGEDPPTRESEADSVFRVD----DGAYALALNGPPVPSSDARVL
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
MUL_2581|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GAAGVALRHPRGVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQ
Mb1056c|M.bovis_AF2122/97 TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLS------------
Rv1028c|M.tuberculosis_H37Rv TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLS------------
MMAR_0634|M.marinum_M TAVAKQAAGLIKQRELADEAGKAQAIEQADQLRRALLS------------
MAV_1170|M.avium_104 SAVARQAAGLIRQRELAEEASRTEAIVRADELRRSLLS------------
Mvan_4762|M.vanbaalenii_PYR-1 GAVANQAAGLARQRELAEEAGRAEAIARADELRRSLLS------------
MSMEG_5395|M.smegmatis_MC2_155 GAVANQAAGLVRQRELTEEAAKANAIAKADELSRSLLS------------
MAB_3251c|M.abscessus_ATCC_199 QVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLS------------
MLBr_00774|M.leprae_Br4923 ---------------------QITQLEEFGNLQRRFTS------------
MUL_2581|M.ulcerans_Agy99 ---------------------QITQLEEFGNLQRRFTS------------
TH_4550|M.thermoresistible__bu ----------------------------AFAGQRRFVG------------
Mflv_4423|M.gilvum_PYR-GCK IDQQRETALALQHAILGPSLSSAFAVRYQPATRPLQVGGDWYDVVDLEDG
.
Mb1056c|M.bovis_AF2122/97 --------------AVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELL
Rv1028c|M.tuberculosis_H37Rv --------------AVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELL
MMAR_0634|M.marinum_M --------------AVSHDLRTPLAAAKAAVSSLRSDDVDFSADDMGELL
MAV_1170|M.avium_104 --------------AVSHDLRTPLAAAKVAVSSLRAEDVAFSPTDTAELL
Mvan_4762|M.vanbaalenii_PYR-1 --------------AVSHDLRTPLAAAKAAVSSLRSEDVGFSPEDTAELL
MSMEG_5395|M.smegmatis_MC2_155 --------------AVSHDLRTPLAAAKAAASSLRSCDIDFSAEDTAELL
MAB_3251c|M.abscessus_ATCC_199 --------------AVSHDLRTPLAAVKAAVSSLRSPDIEFSPEDTAELL
MLBr_00774|M.leprae_Br4923 --------------DVSHELRTPLTTVRMAADLIYDHSSDLDP-TLRRST
MUL_2581|M.ulcerans_Agy99 --------------DVSHELRTPLTTVRMAADLIYDHSADLDP-TLRRST
TH_4550|M.thermoresistible__bu --------------DASHELRTPVAVSRAMIELAMRR--NPGSPELIRLG
Mflv_4423|M.gilvum_PYR-GCK RIGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAAR
.: : :. : ..
Mb1056c|M.bovis_AF2122/97 ATIEESIDQLTALVAN----------------LLDSSRLAAGVIRPQLRR
Rv1028c|M.tuberculosis_H37Rv ATIEESIDQLTALVAN----------------LLDSSRLAAGVIRPQLRR
MMAR_0634|M.marinum_M ATIEESVDQLTALVGN----------------LLDSSRLAAGVVRPQLRR
MAV_1170|M.avium_104 ATIEESIDQLTALVGN----------------LLDSSRLAAGAIHPDLRR
Mvan_4762|M.vanbaalenii_PYR-1 ATVEESIDQLSGLVGN----------------LLDSSRLAAGVVRPELQP
MSMEG_5395|M.smegmatis_MC2_155 ATIEESVDALTALVGN----------------LLDSSRLAAGVIHPELRP
MAB_3251c|M.abscessus_ATCC_199 ATVEESADQLTALVGN----------------LLDSSRLAAGVVKPRAVP
MLBr_00774|M.leprae_Br4923 ELMVSELDRFETLLND----------------LLEISRHDAGVAELSVEA
MUL_2581|M.ulcerans_Agy99 ELMVNELDRFESLLND----------------LLEISRHDAGVAELSVEA
TH_4550|M.thermoresistible__bu TDLLEVNERLERLITG----------------LLALTNAENGVID--AHT
Mflv_4423|M.gilvum_PYR-GCK LPGARCTTAFCAVLDPRIGEVVYSCAGHPPPIMVTADRTTELLEGARATP
: :: :: .
Mb1056c|M.bovis_AF2122/97 AYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLA
Rv1028c|M.tuberculosis_H37Rv AYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLA
MMAR_0634|M.marinum_M VYLEETVQRALLGISRGATGYGRSGLDRVKVEVGGAVAIADAGLLERVLA
MAV_1170|M.avium_104 VYLEEAVQRALVSIGKGATGFFRSAIDRVKVDVGDAMVMADAGLLERVLA
Mvan_4762|M.vanbaalenii_PYR-1 VYLEEAVPRALLGISRGSTGL-RAGLDRVKVEVGDTVVMADSGLLERVLA
MSMEG_5395|M.smegmatis_MC2_155 VYLEETVQRALLGIRRGPTGYGRSAVDRVKVEVGDSVALADGGLLERVLA
MAB_3251c|M.abscessus_ATCC_199 VYVDEIAQRALLGATE-------NDRKRVHLDLGGAVVRADPGLLERVLA
MLBr_00774|M.leprae_Br4923 VDLRVMVNNALGNVGHLAEEAGIELLVDMPVDE--VIAEVDARRVERILR
MUL_2581|M.ulcerans_Agy99 VDLRTTVNSALGNVGHLAEEAGIELLVEMPDSE--VIAEVDARRVERILR
TH_4550|M.thermoresistible__bu VDLADVAGHAAAQLAG----TARARSVEVDTTLSEAVTRGDATLLERLAH
Mflv_4423|M.gilvum_PYR-GCK LGLKNPPHRTEARVTMPARATLLLYTDGLVERRRESIDDGIARATDVVQG
: : : : : :
Mb1056c|M.bovis_AF2122/97 NLIDNALRYAPDCVVRVNAGR---VRERVLINVIDEGPGVPRGTEEQLFA
Rv1028c|M.tuberculosis_H37Rv NLIDNALRYAPDCVVRVNAGR---VRERVLINVIDEGPGVPRGTEEQLFA
MMAR_0634|M.marinum_M NLIDNGLRYAPDSPVRVYAGR---VGDRVLINVADEGPGIPRGAEEQMFA
MAV_1170|M.avium_104 NLIDNALRYAPNCVVRVNAGQ---VGDRVLINVIDEGPGIPHGAEEQIFE
Mvan_4762|M.vanbaalenii_PYR-1 NVIDNALRYAPDGPVRVTAGR---VADRVLIAVADEGPGVARGAETELFA
MSMEG_5395|M.smegmatis_MC2_155 NLIDNALRYAPDGLIRVTAGR---VANKVLIAVVDEGPGIPRGAEDALFA
MAB_3251c|M.abscessus_ATCC_199 NLVDNALRYS-QGEVRVSHEE---VDDRTLVIVADHGKGLEASKRGAAFD
MLBr_00774|M.leprae_Br4923 NLIANAIDHSEHKPVRIRMAA---DEDTVAVTVRDYGIGLRPGEEKLVFS
MUL_2581|M.ulcerans_Agy99 NLIANAIDHAEHRPVRIRMGA---DEDTVAVTVRDYGVGLRPGEEKLVFS
TH_4550|M.thermoresistible__bu NLIENAVKYSGDDSPRVVVTTGSLSDSQVFLRVSNNGEPIRDEDLPTLFE
Mflv_4423|M.gilvum_PYR-GCK NRATDLDQLANVIMARLAPADGYHDDVALLLYRQPEPLDLDFPADVAELA
* : : *: : : :
Mb1056c|M.bovis_AF2122/97 PFQRPGDH--DNTTG---VGLGMSVARGFVEAMGGTISATDTPGGGLTVV
Rv1028c|M.tuberculosis_H37Rv PFQRPGDH--DNTTG---VGLGMSVARGFVEAMGGTISATDTPGGGLTVV
MMAR_0634|M.marinum_M PFQRLGDR--DNRIG---VGLGLSVAKGFVEAMGGTISATDTPGGGLTVV
MAV_1170|M.avium_104 AFQRLGDH--DNTTG---VGLGMSVARGFVEAMGGTITATDTPGGGLTVM
Mvan_4762|M.vanbaalenii_PYR-1 PFQRLGDQ--DTSSG---VGLGLSVARGFVEAMGGTISATDTPGGGMTVE
MSMEG_5395|M.smegmatis_MC2_155 PFQRLGDT--NTTTG---VGLGLSVAKGFVEAMGGTISAGDTPGGGLTVE
MAB_3251c|M.abscessus_ATCC_199 AFQRLGDR--DNTVG---VGLGLSVVKGFVEAMEGTVNATDTAGGGLTMI
MLBr_00774|M.leprae_Br4923 RFWRSDPSRVRRSGG---TGLGLAISIEDARLHQGRLEAWGEPGQGACFR
MUL_2581|M.ulcerans_Agy99 RFWRADPSRVRRSGG---TGLGLAISVEDARLHQGRLEAWGEPGQGACFR
TH_4550|M.thermoresistible__bu PFRRLTRD--TRASG---AGLGLSIAAAIVQAHQGTIEATARPDGGLTVE
Mflv_4423|M.gilvum_PYR-GCK GSRTVLRGWLDSAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLR
.*.: : . .. .
Mb1056c|M.bovis_AF2122/97 IDLAAPEDRP----------------------------------------
Rv1028c|M.tuberculosis_H37Rv IDLAAPEDRP----------------------------------------
MMAR_0634|M.marinum_M VDLAAA--------------------------------------------
MAV_1170|M.avium_104 VDMAAPQSEGAA--------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 IDLAAPR-------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 IELAVPA-------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 VDLPSAGSAPTGAIR-----------------------------------
MLBr_00774|M.leprae_Br4923 LTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAERSR
MUL_2581|M.ulcerans_Agy99 LTLPLVRGHKVTTSPLPMKPIPQPAAQPN--ALEH-TDRLRPREHAEWSG
TH_4550|M.thermoresistible__bu VVLPAPAAARP---------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AVALPDRVQLTIIDTGSWKAPDDVPALHRGRGIALMKALMQDVTIDSQTT
Mb1056c|M.bovis_AF2122/97 -----------
Rv1028c|M.tuberculosis_H37Rv -----------
MMAR_0634|M.marinum_M -----------
MAV_1170|M.avium_104 -----------
Mvan_4762|M.vanbaalenii_PYR-1 -----------
MSMEG_5395|M.smegmatis_MC2_155 -----------
MAB_3251c|M.abscessus_ATCC_199 -----------
MLBr_00774|M.leprae_Br4923 -----------
MUL_2581|M.ulcerans_Agy99 -----------
TH_4550|M.thermoresistible__bu -----------
Mflv_4423|M.gilvum_PYR-GCK GTTVHMNTRIA