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PDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDGLELIPPKEMVH RGTAMYELDVDAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVE QITGIVQRETVPDAVVRRAEQVELVDITPEALRRRMVHGNVYAPEKVGSALSNYFRTGNLTALRELALLW LADQVDAALAKYRSDNRITKTWEARERVVVAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGA STAVMTRVRRLANDIGASVQAVTGDDVPQTLLDFARGVNATQLVLGTSRRSRWARILDEGVAAAVIRDSG AIDVHMVTHGHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHFFDTAFGVGSKSALFLIAVLGV SLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAAATRARQARRAS REAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVGEDPPTRESEADSVFRVDDGAY ALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLSAVSHDLRTPLAAVKA AVSSLRSPDIEFSPEDTAELLATVEESADQLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGAT ENDRKRVHLDLGGAVVRADPGLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRG AAFDAFQRLGDRDNTVGVGLGLSVVKGFVEAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3251c | - | - | 100% (835) | sensor protein KdpD |
| M. abscessus ATCC 19977 | MAB_1721 | - | 2e-21 | 33.33% (219) | putative histidine kinase sensor of two-component system |
| M. abscessus ATCC 19977 | MAB_3340 | - | 4e-17 | 30.20% (245) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1056c | kdpD | 0.0 | 62.60% (837) | sensor protein KDPD |
| M. gilvum PYR-GCK | Mflv_4423 | - | 6e-21 | 31.34% (268) | multi-sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1028c | kdpD | 0.0 | 62.60% (837) | sensor protein KDPD |
| M. leprae Br4923 | MLBr_00175 | - | 2e-20 | 30.57% (314) | putative two-component system sensor kinase |
| M. marinum M | MMAR_0634 | kdpD | 0.0 | 64.64% (840) | two-component system response phosphate sensor kinase, KdpD |
| M. avium 104 | MAV_1170 | - | 0.0 | 61.52% (842) | sensor protein KdpD |
| M. smegmatis MC2 155 | MSMEG_5395 | - | 0.0 | 63.53% (828) | sensor protein KdpD |
| M. thermoresistible (build 8) | TH_2428 | - | 2e-21 | 31.91% (304) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_4700 | mprB | 1e-19 | 29.14% (350) | two component sensor kinase MprB |
| M. vanbaalenii PYR-1 | Mvan_4762 | - | 0.0 | 64.03% (834) | osmosensitive K+ channel signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK MNWAQTPLGPTSEWPQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRN
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VTLGRKYPWALGRPASEVWAEIWDDIGPRIERVLSTGVATWDTSLLLFLE
Mb1056c|M.bovis_AF2122/97 ----------------------------------MTLLFADLCAIFTPYR
Rv1028c|M.tuberculosis_H37Rv ----------------------------------MTLLFADLCAIFTPYR
MAV_1170|M.avium_104 --------------------------------------MTDVRDHHP---
MMAR_0634|M.marinum_M -----------------------------------------MTPDYP---
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------MTTRASNAS---
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------MDDESVAASP--
MAB_3251c|M.abscessus_ATCC_199 -----------------------------------------MPDGLR---
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK RSGYTEESYHTFSYSPLRDDDGAVVGMLCVVSEDTLQVIGERRMATLRDL
Mb1056c|M.bovis_AF2122/97 WMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVET
Rv1028c|M.tuberculosis_H37Rv WMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVET
MAV_1170|M.avium_104 --------KRGELRIYLGAAPGVGKTYSMLGEAHRRLERGTDLVAGVVET
MMAR_0634|M.marinum_M -------RKRGELRIYLGAAPGVGKTFAMLGEAQRRLERGTDVVAAVVET
MSMEG_5395|M.smegmatis_MC2_155 --------KRGELRIYLGAAPGVGKTYAMLGEAHRRLDRGTDLVAAVVET
Mvan_4762|M.vanbaalenii_PYR-1 -----HKAKRGELRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVET
MAB_3251c|M.abscessus_ATCC_199 --------ARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVET
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GSDPSVVRTEGEILSFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGI
Mb1056c|M.bovis_AF2122/97 HGRN-KTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLR---------RH
Rv1028c|M.tuberculosis_H37Rv HGRN-KTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLR---------RH
MAV_1170|M.avium_104 HGRA-KTAELLEGIEIIPPRYIEYRGGRFPELDVPAVLA---------RH
MMAR_0634|M.marinum_M HGRK-RTAELLEGIERIPPKFIEYRGSRFAELDVEAVLR---------RQ
MSMEG_5395|M.smegmatis_MC2_155 HGRK-NTAELLAGIEVIPPRYIEYRGGRFPELDVPAVLD---------RK
Mvan_4762|M.vanbaalenii_PYR-1 HGRK-KTAELFEGIEIVPPKLIAYRGSDFAELDVEAVLR---------RN
MAB_3251c|M.abscessus_ATCC_199 HGRS-KTAELLDGLELIPPKEMVHRGTAMYELDVDAVLE---------RR
MLBr_00175|M.leprae_Br4923 -----MVRFAW-------RRRASLRATSSLSLRWRVMLL---------AM
MUL_4700|M.ulcerans_Agy99 -----MVGFRR-------GPRAPLRATSSLSLRWRVMLL---------AM
TH_2428|M.thermoresistible__bu ------MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLL---------AM
Mflv_4423|M.gilvum_PYR-GCK TGDHPAAPDVLTGADGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREP
* .
Mb1056c|M.bovis_AF2122/97 PQVVLVDELAHTNTPGS---------------------------------
Rv1028c|M.tuberculosis_H37Rv PQVVLVDELAHTNTPGS---------------------------------
MAV_1170|M.avium_104 PQVVLVDELAHTNTPGS---------------------------------
MMAR_0634|M.marinum_M PQVVLVDELAHTNTPGS---------------------------------
MSMEG_5395|M.smegmatis_MC2_155 PQVVLVDELAHTNTPGS---------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 PQVVLVDELAHTNTPGS---------------------------------
MAB_3251c|M.abscessus_ATCC_199 PALVLIDEMAHTNVPGS---------------------------------
MLBr_00175|M.leprae_Br4923 SMVAMVVVLMAFAVYVV---------------------------------
MUL_4700|M.ulcerans_Agy99 SMVAMVVVLMSFAVYAV---------------------------------
TH_2428|M.thermoresistible__bu SMVAMVVVLMSIALYAV---------------------------------
Mflv_4423|M.gilvum_PYR-GCK PRQVLIVPLLQQGAAPTGFLVAGLNRYRVLDDAYRGFVALVAGHIAAGIG
. .:: :
Mb1056c|M.bovis_AF2122/97 ------KNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
Rv1028c|M.tuberculosis_H37Rv ------KNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
MAV_1170|M.avium_104 ------KNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQK
MMAR_0634|M.marinum_M ------KNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQQ
MSMEG_5395|M.smegmatis_MC2_155 ------KNAKRWQDVDELLNAGITVISTVNVQHLDSLNDVVAAITGIEQQ
Mvan_4762|M.vanbaalenii_PYR-1 ------KNTKRWQDIEELLDAGITVITTVNVQHLESLNDVVTQITGIEQQ
MAB_3251c|M.abscessus_ATCC_199 ------RNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQR
MLBr_00175|M.leprae_Br4923 ------ISAALYSDIDNQLQSRAQLLIAS---------------------
MUL_4700|M.ulcerans_Agy99 ------ISAALYSDIDNQLQSRAQLLIAS---------------------
TH_2428|M.thermoresistible__bu ------VSRALYNDIDNQLHSRARLLIES---------------------
Mflv_4423|M.gilvum_PYR-GCK LSRSYRTQQMRAEELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRA
. .:: : : .:
Mb1056c|M.bovis_AF2122/97 EKIPDEI-----------------------------VRAADQVELVDITP
Rv1028c|M.tuberculosis_H37Rv EKIPDEI-----------------------------VRAADQVELVDITP
MAV_1170|M.avium_104 ETVPDSV-----------------------------VRQASQVELIDITP
MMAR_0634|M.marinum_M EKVPDEI-----------------------------VRAAEQVELVDITP
MSMEG_5395|M.smegmatis_MC2_155 ETVPDEV-----------------------------VRSADQIELVDITP
Mvan_4762|M.vanbaalenii_PYR-1 EKVPDEV-----------------------------VRAADQVELVDITP
MAB_3251c|M.abscessus_ATCC_199 ETVPDAV-----------------------------VRRAEQVELVDITP
MLBr_00175|M.leprae_Br4923 GSLAADP-----------------------------GKAIEGTAYSDVNA
MUL_4700|M.ulcerans_Agy99 GSLAADP-----------------------------GKAIEGTAYSDVNA
TH_2428|M.thermoresistible__bu GSLAADP-----------------------------GRAIEGTAYSDVNA
Mflv_4423|M.gilvum_PYR-GCK DTLGDAARQELDVVWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGA
.: : *: .
Mb1056c|M.bovis_AF2122/97 EALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAAL
Rv1028c|M.tuberculosis_H37Rv EALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAAL
MAV_1170|M.avium_104 EALRRRLSHGNVYAPDRIDAALSNYFRRGNLTALRELALLWLADQVDTAL
MMAR_0634|M.marinum_M EALRRRLAHGNVYAAERVDAALANYFRTGNLTALRELALLWLADQVDAAL
MSMEG_5395|M.smegmatis_MC2_155 EALRRRLSHGNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAAL
Mvan_4762|M.vanbaalenii_PYR-1 EALRRRLAHGNVYAPERVDAALSNYFRRGNLTALRELALLWLADQVDSAL
MAB_3251c|M.abscessus_ATCC_199 EALRRRMVHGNVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAAL
MLBr_00175|M.leprae_Br4923 MLVN---PGHSIYTANQPGQTLP----------------------VGTAE
MUL_4700|M.ulcerans_Agy99 MLVN---PGRSIYTANQPGQTLP----------------------VGAPE
TH_2428|M.thermoresistible__bu MLVN---PGRSIYTANQQGEALP----------------------LGEPE
Mflv_4423|M.gilvum_PYR-GCK VTAELASVFRSAIERAGLVFDVDCPPLGEEAYVDLDMWEKVIFNLLSNAL
. . : :. .
Mb1056c|M.bovis_AF2122/97 EKYRADKKITATWEARERVVVAVTGG------PESETLVRRASRIASKSS
Rv1028c|M.tuberculosis_H37Rv EKYRADKKITATWEARERVVVAVTGG------PESETLVRRASRIASKSS
MAV_1170|M.avium_104 AKYRAENKITDTWEARERVVVAVTGG------PESETLVRRASRIASKSS
MMAR_0634|M.marinum_M EKYRADKKITATWEARERVVVAVTGG------PESETLVRRAFRIASKAS
MSMEG_5395|M.smegmatis_MC2_155 AKYRADNKITALWETRERVVVAVTGG------TESETLVRRAFRIASKSS
Mvan_4762|M.vanbaalenii_PYR-1 EKYRADNKITDTWEARERVVVAVTGG------PESETLVRRASRIASKSS
MAB_3251c|M.abscessus_ATCC_199 AKYRSDNRITKTWEARERVVVAVTGG------PESETLVRRASRIAAKSS
MLBr_00175|M.leprae_Br4923 KAVIRGELFMSQRTASDQRILAIHLP------NDSSLLISKSLRPTEAVM
MUL_4700|M.ulcerans_Agy99 KAVIHGDLFLSRRTVSDQRVLAIHLP------NGSSLLISKSLKPTEAVM
TH_2428|M.thermoresistible__bu RQVLSGELVMSLRTADQQRVLAIHLS------NGSSLLISKSLAPTMEVL
Mflv_4423|M.gilvum_PYR-GCK KFTFEGSVSVTARRDGRGAVITVSDTGTGVPADEMPRLFERFHRIENTRA
. :::: *. :
Mb1056c|M.bovis_AF2122/97 ----------AELMVVHVIRGDDLAGVSAPQLGRVRELATSLGATMHTVV
Rv1028c|M.tuberculosis_H37Rv ----------AELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVV
MAV_1170|M.avium_104 ----------AELMVVHVIRGDGLAGLSESRMAKIRELASSLDASLHTIV
MMAR_0634|M.marinum_M ----------AELMVVHLARGDGLSGVAAPQMGKVRELAASLGATVHTVV
MSMEG_5395|M.smegmatis_MC2_155 ----------AELMVVHVVHGDGLTGISAAQMGKVRELAVSLGATVHTVV
Mvan_4762|M.vanbaalenii_PYR-1 ----------AELMVVHVVQGDGLSGVSGPQMGKVRELAASIGATLHTVV
MAB_3251c|M.abscessus_ATCC_199 ----------AELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASVQAVT
MLBr_00175|M.leprae_Br4923 ----------TKLRWVLLIVG-------------------SLGVAVAAVA
MUL_4700|M.ulcerans_Agy99 ----------TKLRAVLLIVG-------------------GVGVAVAAVA
TH_2428|M.thermoresistible__bu ----------RRLGTVLLIVG-------------------GIGVAVAAIA
Mflv_4423|M.gilvum_PYR-GCK RSNEGSGIGLALVKELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPAD
: : * .. .
Mb1056c|M.bovis_AF2122/97 GD----------DVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGA
Rv1028c|M.tuberculosis_H37Rv GD----------DVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGA
MAV_1170|M.avium_104 GD----------EVPAALLEFAREMNATQLVIGTSRRSRWARLFEEGIGP
MMAR_0634|M.marinum_M GD----------DVPTALLDFAREMNATQLVLGTSRRSRWARVLDEGIGA
MSMEG_5395|M.smegmatis_MC2_155 GD----------DVPTALLDFARDINATQLVLGTSRRSRWARMFDEGIGA
Mvan_4762|M.vanbaalenii_PYR-1 GDGA-------GGVPAALLDFAREMNATQLVLGTSRRSRWARIFDEGIGA
MAB_3251c|M.abscessus_ATCC_199 GD----------DVPQTLLDFARGVNATQLVLGTSRRSRWARILDEGVAA
MLBr_00175|M.leprae_Br4923 GG------------------------------------------------
MUL_4700|M.ulcerans_Agy99 GG------------------------------------------------
TH_2428|M.thermoresistible__bu GG------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AVASQPRERRPGNTVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGT
.
Mb1056c|M.bovis_AF2122/97 RTVQESGGIDVHMVTHPAASRASGWS--RVSP--RERHIASWLAALVVPS
Rv1028c|M.tuberculosis_H37Rv RTVQEPGGIDVHMVTHPAASRASGWS--RVSP--RERHIASWLAALVVPS
MAV_1170|M.avium_104 RIVELSGKIDVHLVTHEESKRGFRAS--SLAP--RERRVASWLAALIVPS
MMAR_0634|M.marinum_M TVVQQSGPIDVHMVTHQEAGRPARWS--WLWP--REHHLVSWLAAVVVPS
MSMEG_5395|M.smegmatis_MC2_155 TVVQQSQKIDVHMVTHEAAKRGFRWS--STSP--RQRHAASWAAALMVPS
Mvan_4762|M.vanbaalenii_PYR-1 TVVQKSGRIDVHMVTHEQAGGESLWA--RVSP--RQRHAVSWLAALAVPG
MAB_3251c|M.abscessus_ATCC_199 AVIRDSGAIDVHMVTHGHTSGRLRSW--SVPQDGRKRLIINWLAAILVP-
MLBr_00175|M.leprae_Br4923 -MVTRAGLRPVGRLT-EAAERVARTD--DLRP------------------
MUL_4700|M.ulcerans_Agy99 -MVTRAGLRPVGRLT-EAAERVARTD--DLRP------------------
TH_2428|M.thermoresistible__bu -MVARAGLRPVSRLT-EAAERVARTD--DLRP------------------
Mflv_4423|M.gilvum_PYR-GCK GTLARVLVADDNADMREYLGRLLRSDGYAVEAVVDGWQALEAIRAEPPDL
:
Mb1056c|M.bovis_AF2122/97 VICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVA-------------
Rv1028c|M.tuberculosis_H37Rv VICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVA-------------
MAV_1170|M.avium_104 VICAVTVTWLDPYLDTGGESALFFVGVLLVGLLGGIA-------------
MMAR_0634|M.marinum_M LICALTVAWLDRFLAVGGESALFVIGVLVVALLGGVA-------------
MSMEG_5395|M.smegmatis_MC2_155 LICAFSVAILDPFLDVGGKSALFFVGVLVVALLGGVA-------------
Mvan_4762|M.vanbaalenii_PYR-1 AICAATVLLLDRFLGIGGESAMFFIGVLVVALLGGVA-------------
MAB_3251c|M.abscessus_ATCC_199 PATALFIHFFDTAFGVGSKSALFLIAVLGVSLLGGVS-------------
MLBr_00175|M.leprae_Br4923 -----------------------------IPVFGSDE-------------
MUL_4700|M.ulcerans_Agy99 -----------------------------IPVFGSDE-------------
TH_2428|M.thermoresistible__bu -----------------------------IPVVGSDE-------------
Mflv_4423|M.gilvum_PYR-GCK VISDVMMPRLDGLGLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGA
: :...
Mb1056c|M.bovis_AF2122/97 ------PAALSALLSGMLLNYFLTEPRY----------------------
Rv1028c|M.tuberculosis_H37Rv ------PAALSALLSGMLLNYFLTEPRY----------------------
MAV_1170|M.avium_104 ------PAALSAVLSGLLLNYYLIAPRH----------------------
MMAR_0634|M.marinum_M ------PAALSAVLSGLLLNYFLIEPRY----------------------
MSMEG_5395|M.smegmatis_MC2_155 ------PAALSAVLSGLLLNYFLTSPRH----------------------
Mvan_4762|M.vanbaalenii_PYR-1 ------PAALSAVLSGVLLNFFLVEPRH----------------------
MAB_3251c|M.abscessus_ATCC_199 ------TALVSAVISGLLLNFLFVAPRY----------------------
MLBr_00175|M.leprae_Br4923 ------LARLTEAFNLMLRALAESRERQ----------------------
MUL_4700|M.ulcerans_Agy99 ------LARLTEAFNLMLRALAESRERQ----------------------
TH_2428|M.thermoresistible__bu ------LARLTEAFNMMLRALAESRERQ----------------------
Mflv_4423|M.gilvum_PYR-GCK DDYLVKPFAAAELLARVRANIQLARLREGHARWRTALVDSLQEAFFVCDE
: : : *
Mb1056c|M.bovis_AF2122/97 -------------------------------------------------T
Rv1028c|M.tuberculosis_H37Rv -------------------------------------------------T
MAV_1170|M.avium_104 -------------------------------------------------S
MMAR_0634|M.marinum_M -------------------------------------------------T
MSMEG_5395|M.smegmatis_MC2_155 -------------------------------------------------T
Mvan_4762|M.vanbaalenii_PYR-1 -------------------------------------------------T
MAB_3251c|M.abscessus_ATCC_199 -------------------------------------------------S
MLBr_00175|M.leprae_Br4923 -------------------------------------------------A
MUL_4700|M.ulcerans_Agy99 -------------------------------------------------A
TH_2428|M.thermoresistible__bu -------------------------------------------------A
Mflv_4423|M.gilvum_PYR-GCK HGAVVEINPAFTEILGYDSTGLPYPLMHPWWPLKGSDAEANRRVEEAFGS
:
Mb1056c|M.bovis_AF2122/97 WTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFA
Rv1028c|M.tuberculosis_H37Rv WTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFA
MAV_1170|M.avium_104 FTIAEPNSAITELVLLLIAVAVAVLVDFAAKRTREARRASQEAELLTLFA
MMAR_0634|M.marinum_M FTIADPDNAVTTLVLLVVAVAVAALVDNAAKRSREAGRASREAELLALFA
MSMEG_5395|M.smegmatis_MC2_155 FTMSDPDSALTIVVLLAVAVAVAALVDGAAKRAREARHASREAELLALFA
Mvan_4762|M.vanbaalenii_PYR-1 FTISEPDSAITIVVLLVVAVAVAALVDGAANRTRESRRAAREAELLALFA
MAB_3251c|M.abscessus_ATCC_199 FTIGETDNALTILMMMVTAVAVAALVDAAATRARQARRASREAELLALFA
MLBr_00175|M.leprae_Br4923 RLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLP-----DQEMADLRA
MUL_4700|M.ulcerans_Agy99 RLVSDAGHELRTPLTSLRTNVELLMASMEPGAPRLP-----EQEMVGLRE
TH_2428|M.thermoresistible__bu RLVADAGHELRTPLTSLRTNVELLMASQQPGAPGLP-----EEEMAGLRA
Mflv_4423|M.gilvum_PYR-GCK FMRDPHGTLTEVPVTHRDGHRLYVTVTFSHADDPETGRDVIVGTLRDVTA
. : . . : :
Mb1056c|M.bovis_AF2122/97 G--SVLRGADLATLLQRVRETYSQRAVTMLR----VRQGASTGETVACVG
Rv1028c|M.tuberculosis_H37Rv G--SVLRGADLATLLQRVRETYSQRAVTMLR----VRQGASTGETVACVG
MAV_1170|M.avium_104 G--SVLRGADLETLLERVRETYAQRSVSMLRESEDARAGGTKTQVVACVG
MMAR_0634|M.marinum_M G--SVLRGADLEALLEKVRETYSQRAVSILR----IEAGTSQGAIVSCVG
MSMEG_5395|M.smegmatis_MC2_155 G--SVLRGADLTALLERVRETYAQRAVSLLR------ETSDGATIVDCVG
Mvan_4762|M.vanbaalenii_PYR-1 G--AVLRGADLNTLLERVREAYSQQSVTLVR------GEAHGGGVVGCAG
MAB_3251c|M.abscessus_ATCC_199 G--GVLVNSDLSALLERVRTTYNQTAVSLLC---------AEGPAVASVG
MLBr_00175|M.leprae_Br4923 D--VLAQIEELSTLVGDLVDLTRDDAGQVVH-------------------
MUL_4700|M.ulcerans_Agy99 D--VVAQIEELSTLVGDLVDLTRGDAGVVVH-------------------
TH_2428|M.thermoresistible__bu D--VIAQIEELSTLVGDLVDLTRDDAGGVIH-------------------
Mflv_4423|M.gilvum_PYR-GCK ERYIVQRESALASLNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWP
: * :* : :
Mb1056c|M.bovis_AF2122/97 TNPCRDVDSADTAIEVG------------DDEFWMLMAGRKLAARDRRVL
Rv1028c|M.tuberculosis_H37Rv TNPCRDVDSADTAIEVG------------DDEFWMLMAGRKLAARDRRVL
MAV_1170|M.avium_104 RDPCVSVDAADTAIEVGGP--------D-SSEFQMLLAGRKLSARDRRVL
MMAR_0634|M.marinum_M EDPCVDVDTADTAIDVG------------DDEFWMLMAGRKLLARDRRVL
MSMEG_5395|M.smegmatis_MC2_155 QDPCDRVAAADTAVEAG-------------DEFWLLLSGRELPARDRRVL
Mvan_4762|M.vanbaalenii_PYR-1 SEPCVTVETADTAIEVGSK--------DDPEEFWLLLAGRRLDARDRRVL
MAB_3251c|M.abscessus_ATCC_199 EDPPTRESEADSVFRVD------------DGAYALALNGPPVPSSDARVL
MLBr_00175|M.leprae_Br4923 -----------------------------------------EPIDMSEVL
MUL_4700|M.ulcerans_Agy99 -----------------------------------------EPVDMAEVV
TH_2428|M.thermoresistible__bu -----------------------------------------EPVDIADVV
Mflv_4423|M.gilvum_PYR-GCK DEPDGEHESDAPSLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDA
Mb1056c|M.bovis_AF2122/97 TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLS------------
Rv1028c|M.tuberculosis_H37Rv TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLS------------
MAV_1170|M.avium_104 SAVARQAAGLIRQRELAEEASRTEAIVRADELRRSLLS------------
MMAR_0634|M.marinum_M TAVAKQAAGLIKQRELADEAGKAQAIEQADQLRRALLS------------
MSMEG_5395|M.smegmatis_MC2_155 GAVANQAAGLVRQRELTEEAAKANAIAKADELSRSLLS------------
Mvan_4762|M.vanbaalenii_PYR-1 GAVANQAAGLARQRELAEEAGRAEAIARADELRRSLLS------------
MAB_3251c|M.abscessus_ATCC_199 QVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLS------------
MLBr_00175|M.leprae_Br4923 YRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLN------------
MUL_4700|M.ulcerans_Agy99 DRSLERVRRRRNDIHFDVDVVGWQVYGDAAGLSRAALN------------
TH_2428|M.thermoresistible__bu DRSLERVRRRRNDIDFDIEVVPWQVYGDAAGLSRAVMN------------
Mflv_4423|M.gilvum_PYR-GCK GAAGVALRHPRGVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQ
: : : :
Mb1056c|M.bovis_AF2122/97 ---------AVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEE
Rv1028c|M.tuberculosis_H37Rv ---------AVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEE
MAV_1170|M.avium_104 ---------AVSHDLRTPLAAAKVAVSSLRAEDVAFSPTDTAELLATIEE
MMAR_0634|M.marinum_M ---------AVSHDLRTPLAAAKAAVSSLRSDDVDFSADDMGELLATIEE
MSMEG_5395|M.smegmatis_MC2_155 ---------AVSHDLRTPLAAAKAAASSLRSCDIDFSAEDTAELLATIEE
Mvan_4762|M.vanbaalenii_PYR-1 ---------AVSHDLRTPLAAAKAAVSSLRSEDVGFSPEDTAELLATVEE
MAB_3251c|M.abscessus_ATCC_199 ---------AVSHDLRTPLAAVKAAVSSLRSPDIEFSPEDTAELLATVEE
MLBr_00175|M.leprae_Br4923 ---------LMDNAAKWSPSGGRVVVT-----------------------
MUL_4700|M.ulcerans_Agy99 ---------LMDNAAKWSPPGGRVGIR-----------------------
TH_2428|M.thermoresistible__bu ---------LLDNAAKWSPSGGRVGVR-----------------------
Mflv_4423|M.gilvum_PYR-GCK IDQQRETALALQHAILGPSLSSAFAVRYQPATRPLQVGGDWYDVVDLEDG
:.: . .
Mb1056c|M.bovis_AF2122/97 SIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGF
Rv1028c|M.tuberculosis_H37Rv SIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGF
MAV_1170|M.avium_104 SIDQLTALVGNLLDSSRLAAGAIHPDLRRVYLEEAVQRALVSIGKGATGF
MMAR_0634|M.marinum_M SVDQLTALVGNLLDSSRLAAGVVRPQLRRVYLEETVQRALLGISRGATGY
MSMEG_5395|M.smegmatis_MC2_155 SVDALTALVGNLLDSSRLAAGVIHPELRPVYLEETVQRALLGIRRGPTGY
Mvan_4762|M.vanbaalenii_PYR-1 SIDQLSGLVGNLLDSSRLAAGVVRPELQPVYLEEAVPRALLGISRGSTGL
MAB_3251c|M.abscessus_ATCC_199 SADQLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATE-----
MLBr_00175|M.leprae_Br4923 -MRQFDPSHVELVVSDYGPG--IPPQERRLVFERFYRSTTARSLPG----
MUL_4700|M.ulcerans_Agy99 -LRQLDPSHAELVVSDNGPG--ISPQERRLVFERFYRSTSARAMPG----
TH_2428|M.thermoresistible__bu -LTQVDPVHAELVVSDHGPG--IPPQERRLVFERFYRSTTARSMPG----
Mflv_4423|M.gilvum_PYR-GCK RIGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAAR
. : : . .:. :
Mb1056c|M.bovis_AF2122/97 YR-----SGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVR
Rv1028c|M.tuberculosis_H37Rv YR-----SGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVR
MAV_1170|M.avium_104 FR-----SAIDRVKVDVGDAMVMADAGLLERVLANLIDNALRYAPNCVVR
MMAR_0634|M.marinum_M GR-----SGLDRVKVEVGGAVAIADAGLLERVLANLIDNGLRYAPDSPVR
MSMEG_5395|M.smegmatis_MC2_155 GR-----SAVDRVKVEVGDSVALADGGLLERVLANLIDNALRYAPDGLIR
Mvan_4762|M.vanbaalenii_PYR-1 -R-----AGLDRVKVEVGDTVVMADSGLLERVLANVIDNALRYAPDGPVR
MAB_3251c|M.abscessus_ATCC_199 -------NDRKRVHLDLGGAVVRADPGLLERVLANLVDNALRYS-QGEVR
MLBr_00175|M.leprae_Br4923 ----------SGLGLAIVKQVVINHGGLLR-----------------VED
MUL_4700|M.ulcerans_Agy99 ----------SGLGLAIVKQVVLNHGGSLR-----------------IED
TH_2428|M.thermoresistible__bu ----------SGLGLAIVKQVVLKHGGTLR-----------------VED
Mflv_4423|M.gilvum_PYR-GCK LPGARCTTAFCAVLDPRIGEVVYSCAGHPPPIMVTADRTTELLEGARATP
: :. *
Mb1056c|M.bovis_AF2122/97 VNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMS
Rv1028c|M.tuberculosis_H37Rv VNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMS
MAV_1170|M.avium_104 VNAGQVGDRVLINVIDEGPGIPHGAEEQIFEAFQRLGDHDNTTGVGLGMS
MMAR_0634|M.marinum_M VYAGRVGDRVLINVADEGPGIPRGAEEQMFAPFQRLGDRDNRIGVGLGLS
MSMEG_5395|M.smegmatis_MC2_155 VTAGRVANKVLIAVVDEGPGIPRGAEDALFAPFQRLGDTNTTTGVGLGLS
Mvan_4762|M.vanbaalenii_PYR-1 VTAGRVADRVLIAVADEGPGVARGAETELFAPFQRLGDQDTSSGVGLGLS
MAB_3251c|M.abscessus_ATCC_199 VSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRLGDRDNTVGVGLGLS
MLBr_00175|M.leprae_Br4923 TAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVS
MUL_4700|M.ulcerans_Agy99 TVPGGQPPGTAICMLLPGRPMPDSAYPAAPDD--------KKTEPVDTRG
TH_2428|M.thermoresistible__bu TVPGGQPPGTSIHVVLPGRPLSGVPPASQEPQ---------PPQHAPGAD
Mflv_4423|M.gilvum_PYR-GCK LGLKNPPHRTEARVTMPARATLLLYTDGLVERRRESIDDGIARATDVVQG
. : . .
Mb1056c|M.bovis_AF2122/97 VARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP--------------
Rv1028c|M.tuberculosis_H37Rv VARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP--------------
MAV_1170|M.avium_104 VARGFVEAMGGTITATDTPGGGLTVMVDMAAPQSEGAA------------
MMAR_0634|M.marinum_M VAKGFVEAMGGTISATDTPGGGLTVVVDLAAA------------------
MSMEG_5395|M.smegmatis_MC2_155 VAKGFVEAMGGTISAGDTPGGGLTVEIELAVPA-----------------
Mvan_4762|M.vanbaalenii_PYR-1 VARGFVEAMGGTISATDTPGGGMTVEIDLAAPR-----------------
MAB_3251c|M.abscessus_ATCC_199 VVKGFVEAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR---------
MLBr_00175|M.leprae_Br4923 GKSANFRDSAHVISVDYQSARAR---------------------------
MUL_4700|M.ulcerans_Agy99 ANGANSRGSANVISVDSQSARAR---------------------------
TH_2428|M.thermoresistible__bu PHAPTQTGNDAVQSVFTAENK-----------------------------
Mflv_4423|M.gilvum_PYR-GCK NRATDLDQLANVIMARLAPADGYHDDVALLLYRQPEPLDLDFPADVAELA
. .
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GSRTVLRGWLDSAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLR
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MUL_4700|M.ulcerans_Agy99 --------------------------------------------------
TH_2428|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AVALPDRVQLTIIDTGSWKAPDDVPALHRGRGIALMKALMQDVTIDSQTT
Mb1056c|M.bovis_AF2122/97 -----------
Rv1028c|M.tuberculosis_H37Rv -----------
MAV_1170|M.avium_104 -----------
MMAR_0634|M.marinum_M -----------
MSMEG_5395|M.smegmatis_MC2_155 -----------
Mvan_4762|M.vanbaalenii_PYR-1 -----------
MAB_3251c|M.abscessus_ATCC_199 -----------
MLBr_00175|M.leprae_Br4923 -----------
MUL_4700|M.ulcerans_Agy99 -----------
TH_2428|M.thermoresistible__bu -----------
Mflv_4423|M.gilvum_PYR-GCK GTTVHMNTRIA