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VTPDYPRKRGELRIYLGAAPGVGKTFAMLGEAQRRLERGTDVVAAVVETHGRKRTAELLEGIERIPPKFI EYRGSRFAELDVEAVLRRQPQVVLVDELAHTNTPGSKNPKRWQDVEELLDAGITVISTVNVQHLESLNDV VAQITGIEQQEKVPDEIVRAAEQVELVDITPEALRRRLAHGNVYAAERVDAALANYFRTGNLTALRELAL LWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRAFRIASKASAELMVVHLARGDGLS GVAAPQMGKVRELAASLGATVHTVVGDDVPTALLDFAREMNATQLVLGTSRRSRWARVLDEGIGATVVQQ SGPIDVHMVTHQEAGRPARWSWLWPREHHLVSWLAAVVVPSLICALTVAWLDRFLAVGGESALFVIGVLV VALLGGVAPAALSAVLSGLLLNYFLIEPRYTFTIADPDNAVTTLVLLVVAVAVAALVDNAAKRSREAGRA SREAELLALFAGSVLRGADLEALLEKVRETYSQRAVSILRIEAGTSQGAIVSCVGEDPCVDVDTADTAID VGDDEFWMLMAGRKLLARDRRVLTAVAKQAAGLIKQRELADEAGKAQAIEQADQLRRALLSAVSHDLRTP LAAAKAAVSSLRSDDVDFSADDMGELLATIEESVDQLTALVGNLLDSSRLAAGVVRPQLRRVYLEETVQR ALLGISRGATGYGRSGLDRVKVEVGGAVAIADAGLLERVLANLIDNGLRYAPDSPVRVYAGRVGDRVLIN VADEGPGIPRGAEEQMFAPFQRLGDRDNRIGVGLGLSVAKGFVEAMGGTISATDTPGGGLTVVVDLAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0634 | kdpD | - | 100% (839) | two-component system response phosphate sensor kinase, KdpD |
| M. marinum M | MMAR_4941 | phoR | 4e-21 | 32.86% (280) | two-component system response phosphate sensor kinase, PhoR |
| M. marinum M | MMAR_1300 | mtrB | 7e-20 | 32.89% (225) | two-component sensory transduction histidine kinase MtrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1056c | kdpD | 0.0 | 82.43% (831) | sensor protein KDPD |
| M. gilvum PYR-GCK | Mflv_4423 | - | 5e-20 | 31.47% (251) | multi-sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1028c | kdpD | 0.0 | 82.43% (831) | sensor protein KDPD |
| M. leprae Br4923 | MLBr_00774 | mtrB | 5e-19 | 32.00% (225) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3251c | - | 0.0 | 64.64% (840) | sensor protein KdpD |
| M. avium 104 | MAV_1170 | - | 0.0 | 76.48% (842) | sensor protein KdpD |
| M. smegmatis MC2 155 | MSMEG_5395 | - | 0.0 | 80.14% (831) | sensor protein KdpD |
| M. thermoresistible (build 8) | TH_4550 | - | 6e-20 | 30.93% (291) | PUTATIVE putative integral membrane sensor signal transduction |
| M. ulcerans Agy99 | MUL_0464 | phoR | 2e-21 | 32.86% (280) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_4762 | - | 0.0 | 79.95% (838) | osmosensitive K+ channel signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK MNWAQTPLGPTSEWPQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRN
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VTLGRKYPWALGRPASEVWAEIWDDIGPRIERVLSTGVATWDTSLLLFLE
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK RSGYTEESYHTFSYSPLRDDDGAVVGMLCVVSEDTLQVIGERRMATLRDL
Mb1056c|M.bovis_AF2122/97 -----------------------------MTLLFADLCAIFTPYRWMIEH
Rv1028c|M.tuberculosis_H37Rv -----------------------------MTLLFADLCAIFTPYRWMIEH
MMAR_0634|M.marinum_M ----------------------------------------------MTPD
Mvan_4762|M.vanbaalenii_PYR-1 ----------------------------------------MDDESVAASP
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------MTTRAS
MAV_1170|M.avium_104 --------------------------------------------MTDVRD
MAB_3251c|M.abscessus_ATCC_199 -----------------------------------------------MPD
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GSDPSVVRTEGEILSFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGI
Mb1056c|M.bovis_AF2122/97 VTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNK
Rv1028c|M.tuberculosis_H37Rv VTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNK
MMAR_0634|M.marinum_M YPRKRGELRIYLGAAPGVGKTFAMLGEAQRRLERGTDVVAAVVETHGRKR
Mvan_4762|M.vanbaalenii_PYR-1 HKAKRGELRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRKK
MSMEG_5395|M.smegmatis_MC2_155 NASKRGELRIYLGAAPGVGKTYAMLGEAHRRLDRGTDLVAAVVETHGRKN
MAV_1170|M.avium_104 HHPKRGELRIYLGAAPGVGKTYSMLGEAHRRLERGTDLVAGVVETHGRAK
MAB_3251c|M.abscessus_ATCC_199 GLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSK
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 -----------------------MIFSSRRRIRG----------RWGRSG
Mflv_4423|M.gilvum_PYR-GCK TGDHPAAPDVLTGADGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREP
Mb1056c|M.bovis_AF2122/97 TAKLLEG----IEMIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAH
Rv1028c|M.tuberculosis_H37Rv TAKLLEG----IEMIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAH
MMAR_0634|M.marinum_M TAELLEG----IERIPPKFIEYRGSRFAELDVEAVLRRQPQVVLVDELAH
Mvan_4762|M.vanbaalenii_PYR-1 TAELFEG----IEIVPPKLIAYRGSDFAELDVEAVLRRNPQVVLVDELAH
MSMEG_5395|M.smegmatis_MC2_155 TAELLAG----IEVIPPRYIEYRGGRFPELDVPAVLDRKPQVVLVDELAH
MAV_1170|M.avium_104 TAELLEG----IEIIPPRYIEYRGGRFPELDVPAVLARHPQVVLVDELAH
MAB_3251c|M.abscessus_ATCC_199 TAELLDG----LELIPPKEMVHRGTAMYELDVDAVLERRPALVLIDEMAH
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 -------------------MAERLPRAVQLRVGLVAATLALVLCG-----
MLBr_00774|M.leprae_Br4923 PMMRGMG----ALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTS
Mflv_4423|M.gilvum_PYR-GCK PRQVLIVPLLQQGAAPTGFLVAGLNRYRVLDDAYRGFVALVAGHIAAGIG
Mb1056c|M.bovis_AF2122/97 TNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
Rv1028c|M.tuberculosis_H37Rv TNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQK
MMAR_0634|M.marinum_M TNTPGSKNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQQ
Mvan_4762|M.vanbaalenii_PYR-1 TNTPGSKNTKRWQDIEELLDAGITVITTVNVQHLESLNDVVTQITGIEQQ
MSMEG_5395|M.smegmatis_MC2_155 TNTPGSKNAKRWQDVDELLNAGITVISTVNVQHLDSLNDVVAAITGIEQQ
MAV_1170|M.avium_104 TNTPGSKNPKRWQDVEELLDAGITVISTVNVQHLESLNDVVAQITGIEQK
MAB_3251c|M.abscessus_ATCC_199 TNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQR
TH_4550|M.thermoresistible__bu --------------------------------------------VSLRGR
MUL_0464|M.ulcerans_Agy99 -----------------LLASGVAVTSILRHSLVSRIDSTLLEASRTWAQ
MLBr_00774|M.leprae_Br4923 QLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSLQLARNTLTS
Mflv_4423|M.gilvum_PYR-GCK LSRSYRTQQMRAEELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRA
Mb1056c|M.bovis_AF2122/97 EKIPDEIVRAADQVE------------LVDITPEALRRRLAHGNVYAAER
Rv1028c|M.tuberculosis_H37Rv EKIPDEIVRAADQVE------------LVDITPEALRRRLAHGNVYAAER
MMAR_0634|M.marinum_M EKVPDEIVRAAEQVE------------LVDITPEALRRRLAHGNVYAAER
Mvan_4762|M.vanbaalenii_PYR-1 EKVPDEVVRAADQVE------------LVDITPEALRRRLAHGNVYAPER
MSMEG_5395|M.smegmatis_MC2_155 ETVPDEVVRSADQIE------------LVDITPEALRRRLSHGNVYAPER
MAV_1170|M.avium_104 ETVPDSVVRQASQVE------------LIDITPEALRRRLSHGNVYAPDR
MAB_3251c|M.abscessus_ATCC_199 ETVPDAVVRRAEQVE------------LVDITPEALRRRMVHGNVYAPEK
TH_4550|M.thermoresistible__bu ITIMSAAVSCAAAAL------------LLAITYALVDLQLSR--------
MUL_0464|M.ulcerans_Agy99 ASWRHSMPSVEGPDP------------ARPPSKFYVRSISPDGR------
MLBr_00774|M.leprae_Br4923 KTDPTSGAGLVGAFD------------AVLIVPGDGPR------------
Mflv_4423|M.gilvum_PYR-GCK DTLGDAARQELDVVWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGA
.
Mb1056c|M.bovis_AF2122/97 VDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARE
Rv1028c|M.tuberculosis_H37Rv VDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARE
MMAR_0634|M.marinum_M VDAALANYFRTGNLTALRELALLWLADQVDAALEKYRADKKITATWEARE
Mvan_4762|M.vanbaalenii_PYR-1 VDAALSNYFRRGNLTALRELALLWLADQVDSALEKYRADNKITDTWEARE
MSMEG_5395|M.smegmatis_MC2_155 IDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNKITALWETRE
MAV_1170|M.avium_104 IDAALSNYFRRGNLTALRELALLWLADQVDTALAKYRAENKITDTWEARE
MAB_3251c|M.abscessus_ATCC_199 VGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARE
TH_4550|M.thermoresistible__bu -----------------RGPVVMRRSPPDTAPAEPTGPEVSGVAAWMDRH
MUL_0464|M.ulcerans_Agy99 ---AMTAINDRNAEPALPADNDVGSDPTTLPSVNGSNIEWRAVSVHGPQG
MLBr_00774|M.leprae_Br4923 --------------TATTAGPVDQVPNSLRGFIKAGQAAYQYATVHTEGF
Mflv_4423|M.gilvum_PYR-GCK VTAELASVFRSAIERAGLVFDVDCPPLGEEAYVDLDMWEKVIFNLLSNAL
Mb1056c|M.bovis_AF2122/97 RVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVSAPQLG
Rv1028c|M.tuberculosis_H37Rv RVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGVSAPQLG
MMAR_0634|M.marinum_M RVVVAVTGGPESETLVRRAFRIASKASAELMVVHLARGDGLSGVAAPQMG
Mvan_4762|M.vanbaalenii_PYR-1 RVVVAVTGGPESETLVRRASRIASKSSAELMVVHVVQGDGLSGVSGPQMG
MSMEG_5395|M.smegmatis_MC2_155 RVVVAVTGGTESETLVRRAFRIASKSSAELMVVHVVHGDGLTGISAAQMG
MAV_1170|M.avium_104 RVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGLSESRMA
MAB_3251c|M.abscessus_ATCC_199 RVVVAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMT
TH_4550|M.thermoresistible__bu RAELQEAATN--SLLLYGAVAMAAVTALAAVVAWLVAG------------
MUL_0464|M.ulcerans_Agy99 GLTTVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAG------------
MLBr_00774|M.leprae_Br4923 SGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATG-------
Mflv_4423|M.gilvum_PYR-GCK KFTFEGSVSVTARRDGRGAVITVSDTGTGVPADEMPRLFERFHRIENTRA
.
Mb1056c|M.bovis_AF2122/97 RVRELATSLGATMHTVVGD----------DVPTALLDFAREMNATQLVVG
Rv1028c|M.tuberculosis_H37Rv RVRELATSLGATMHTVVGD----------DVPTALLDFAREMNATQLVVG
MMAR_0634|M.marinum_M KVRELAASLGATVHTVVGD----------DVPTALLDFAREMNATQLVLG
Mvan_4762|M.vanbaalenii_PYR-1 KVRELAASIGATLHTVVGDG-------AGGVPAALLDFAREMNATQLVLG
MSMEG_5395|M.smegmatis_MC2_155 KVRELAVSLGATVHTVVGD----------DVPTALLDFARDINATQLVLG
MAV_1170|M.avium_104 KIRELASSLDASLHTIVGD----------EVPAALLEFAREMNATQLVIG
MAB_3251c|M.abscessus_ATCC_199 RVRRLANDIGASVQAVTGD----------DVPQTLLDFARGVNATQLVLG
TH_4550|M.thermoresistible__bu ---------------------------------------RVLSPLHRVTA
MUL_0464|M.ulcerans_Agy99 ---------------------------------------FAVVQRSLRPL
MLBr_00774|M.leprae_Br4923 ----------------------------------------GMVLLVLLSG
Mflv_4423|M.gilvum_PYR-GCK RSNEGSGIGLALVKELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPAD
Mb1056c|M.bovis_AF2122/97 TSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSP--R
Rv1028c|M.tuberculosis_H37Rv TSRRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSP--R
MMAR_0634|M.marinum_M TSRRSRWARVLDEGIGATVVQQSGPIDVHMVTHQEAGRPARWSWLWP--R
Mvan_4762|M.vanbaalenii_PYR-1 TSRRSRWARIFDEGIGATVVQKSGRIDVHMVTHEQAGGESLWARVSP--R
MSMEG_5395|M.smegmatis_MC2_155 TSRRSRWARMFDEGIGATVVQQSQKIDVHMVTHEAAKRGFRWSSTSP--R
MAV_1170|M.avium_104 TSRRSRWARLFEEGIGPRIVELSGKIDVHLVTHEESKRGFRASSLAP--R
MAB_3251c|M.abscessus_ATCC_199 TSRRSRWARILDEGVAAAVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGR
TH_4550|M.thermoresistible__bu TARRISRAPALSSGLRERIQLAGPADEVKDLADT----------------
MUL_0464|M.ulcerans_Agy99 SEVEQTAAAIASGQLDRRVPERDPRTEVGQLSLA----------------
MLBr_00774|M.leprae_Br4923 IALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRG--------------
Mflv_4423|M.gilvum_PYR-GCK AVASQPRERRPGNTVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGT
Mb1056c|M.bovis_AF2122/97 ERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGG
Rv1028c|M.tuberculosis_H37Rv ERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGG
MMAR_0634|M.marinum_M EHHLVSWLAAVVVPSLICALTVAWLDRFLAVGGESALFVIGVLVVALLGG
Mvan_4762|M.vanbaalenii_PYR-1 QRHAVSWLAALAVPGAICAATVLLLDRFLGIGGESAMFFIGVLVVALLGG
MSMEG_5395|M.smegmatis_MC2_155 QRHAASWAAALMVPSLICAFSVAILDPFLDVGGKSALFFVGVLVVALLGG
MAV_1170|M.avium_104 ERRVASWLAALIVPSVICAVTVTWLDPYLDTGGESALFFVGVLLVGLLGG
MAB_3251c|M.abscessus_ATCC_199 KRLIINWLAAILVP-PATALFIHFFDTAFGVGSKSALFLIAVLGVSLLGG
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GTLARVLVADDNADMREYLGRLLRSDGYAVEAVVDGWQALEAIRAEPPDL
Mb1056c|M.bovis_AF2122/97 VAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVL
Rv1028c|M.tuberculosis_H37Rv VAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVL
MMAR_0634|M.marinum_M VAPAALSAVLSGLLLNYFLIEPRYTFTIADPDNAVTTLVLLVVAVAVAAL
Mvan_4762|M.vanbaalenii_PYR-1 VAPAALSAVLSGVLLNFFLVEPRHTFTISEPDSAITIVVLLVVAVAVAAL
MSMEG_5395|M.smegmatis_MC2_155 VAPAALSAVLSGLLLNYFLTSPRHTFTMSDPDSALTIVVLLAVAVAVAAL
MAV_1170|M.avium_104 IAPAALSAVLSGLLLNYYLIAPRHSFTIAEPNSAITELVLLLIAVAVAVL
MAB_3251c|M.abscessus_ATCC_199 VSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAAL
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VISDVMMPRLDGLGLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGA
Mb1056c|M.bovis_AF2122/97 VDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAV
Rv1028c|M.tuberculosis_H37Rv VDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAV
MMAR_0634|M.marinum_M VDNAAKRSREAGRASREAELLALFAGSVLRGADLEALLEKVRETYSQRAV
Mvan_4762|M.vanbaalenii_PYR-1 VDGAANRTRESRRAAREAELLALFAGAVLRGADLNTLLERVREAYSQQSV
MSMEG_5395|M.smegmatis_MC2_155 VDGAAKRAREARHASREAELLALFAGSVLRGADLTALLERVRETYAQRAV
MAV_1170|M.avium_104 VDFAAKRTREARRASQEAELLTLFAGSVLRGADLETLLERVRETYAQRSV
MAB_3251c|M.abscessus_ATCC_199 VDAAATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAV
TH_4550|M.thermoresistible__bu ---------------------------------FDQMLCRLDRAFAGQ--
MUL_0464|M.ulcerans_Agy99 ---------------------------------MNGMLSQIQVALAASED
MLBr_00774|M.leprae_Br4923 ----------------------------------EDDMARLAVSFNDMAE
Mflv_4423|M.gilvum_PYR-GCK DDYLVKPFAAAELLARVRANIQLARLREGHARWRTALVDSLQEAFFVCDE
: : :
Mb1056c|M.bovis_AF2122/97 TMLR------------------------------VRQGASTGETVACVGT
Rv1028c|M.tuberculosis_H37Rv TMLR------------------------------VRQGASTGETVACVGT
MMAR_0634|M.marinum_M SILR------------------------------IEAGTSQGAIVSCVGE
Mvan_4762|M.vanbaalenii_PYR-1 TLVR------------------------------GEAHG--GGVVGCAGS
MSMEG_5395|M.smegmatis_MC2_155 SLLR------------------------------ETSDG--ATIVDCVGQ
MAV_1170|M.avium_104 SMLRESE--------------------------DARAGGTKTQVVACVGR
MAB_3251c|M.abscessus_ATCC_199 SLLC-----------------------------------AEGPAVASVGE
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 SAEK----------------------------------------------
MLBr_00774|M.leprae_Br4923 SLSR----------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK HGAVVEINPAFTEILGYDSTGLPYPLMHPWWPLKGSDAEANRRVEEAFGS
Mb1056c|M.bovis_AF2122/97 NPCRDVDSADTAIEVGD----DEFWMLMAGRKLAARDRRVLTAVATQAAG
Rv1028c|M.tuberculosis_H37Rv NPCRDVDSADTAIEVGD----DEFWMLMAGRKLAARDRRVLTAVATQAAG
MMAR_0634|M.marinum_M DPCVDVDTADTAIDVGD----DEFWMLMAGRKLLARDRRVLTAVAKQAAG
Mvan_4762|M.vanbaalenii_PYR-1 EPCVTVETADTAIEVGSKDDPEEFWLLLAGRRLDARDRRVLGAVANQAAG
MSMEG_5395|M.smegmatis_MC2_155 DPCDRVAAADTAVEAGD-----EFWLLLSGRELPARDRRVLGAVANQAAG
MAV_1170|M.avium_104 DPCVSVDAADTAIEVGGPDS-SEFQMLLAGRKLSARDRRVLSAVARQAAG
MAB_3251c|M.abscessus_ATCC_199 DPPTRESEADSVFRVDDG----AYALALNGPPVPSSDARVLQVVAGTAVG
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK FMRDPHGTLTEVPVTHRDGHRLYVTVTFSHADDPETGRDVIVGTLRDVTA
Mb1056c|M.bovis_AF2122/97 LVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLR
Rv1028c|M.tuberculosis_H37Rv LVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLR
MMAR_0634|M.marinum_M LIKQRELADEAGKAQAIEQADQLRRALLSAVSHDLRTPLAAAKAAVSSLR
Mvan_4762|M.vanbaalenii_PYR-1 LARQRELAEEAGRAEAIARADELRRSLLSAVSHDLRTPLAAAKAAVSSLR
MSMEG_5395|M.smegmatis_MC2_155 LVRQRELTEEAAKANAIAKADELSRSLLSAVSHDLRTPLAAAKAAASSLR
MAV_1170|M.avium_104 LIRQRELAEEASRTEAIVRADELRRSLLSAVSHDLRTPLAAAKVAVSSLR
MAB_3251c|M.abscessus_ATCC_199 LVRSARLAEEASQASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLR
TH_4550|M.thermoresistible__bu ------------------------RRFVGDASHELRTPVAVSRAMIELAM
MUL_0464|M.ulcerans_Agy99 ----------------ARSSEERMRRFITDASHELRTPLTTIRGFAELYR
MLBr_00774|M.leprae_Br4923 ------------QITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIY
Mflv_4423|M.gilvum_PYR-GCK ERYIVQRESALASLNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWP
.:.:: : :. :
Mb1056c|M.bovis_AF2122/97 TEDVAFSPEDTAELLATIEESIDQ----------LTALVANLLDSSRLAA
Rv1028c|M.tuberculosis_H37Rv TEDVAFSPEDTAELLATIEESIDQ----------LTALVANLLDSSRLAA
MMAR_0634|M.marinum_M SDDVDFSADDMGELLATIEESVDQ----------LTALVGNLLDSSRLAA
Mvan_4762|M.vanbaalenii_PYR-1 SEDVGFSPEDTAELLATVEESIDQ----------LSGLVGNLLDSSRLAA
MSMEG_5395|M.smegmatis_MC2_155 SCDIDFSAEDTAELLATIEESVDA----------LTALVGNLLDSSRLAA
MAV_1170|M.avium_104 AEDVAFSPTDTAELLATIEESIDQ----------LTALVGNLLDSSRLAA
MAB_3251c|M.abscessus_ATCC_199 SPDIEFSPEDTAELLATVEESADQ----------LTALVGNLLDSSRLAA
TH_4550|M.thermoresistible__bu RRNPGSP--ELIRLGTDLLEVNER----------LERLITGLLALTNAEN
MUL_0464|M.ulcerans_Agy99 QG----AARDVAMLLSRIESEASR----------MGLLVDDLLTLARLDV
MLBr_00774|M.leprae_Br4923 DHSSDLDP-TLRRSTELMVSELDR----------FETLLNDLLEISRHDA
Mflv_4423|M.gilvum_PYR-GCK DEPDGEHESDAPSLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDA
: **
Mb1056c|M.bovis_AF2122/97 G-------------VIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDR
Rv1028c|M.tuberculosis_H37Rv G-------------VIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDR
MMAR_0634|M.marinum_M G-------------VVRPQLRRVYLEETVQRALLGISRGATGYGRSGLDR
Mvan_4762|M.vanbaalenii_PYR-1 G-------------VVRPELQPVYLEEAVPRALLGISRGSTGL-RAGLDR
MSMEG_5395|M.smegmatis_MC2_155 G-------------VIHPELRPVYLEETVQRALLGIRRGPTGYGRSAVDR
MAV_1170|M.avium_104 G-------------AIHPDLRRVYLEEAVQRALVSIGKGATGFFRSAIDR
MAB_3251c|M.abscessus_ATCC_199 G-------------VVKPRAVPVYVDEIAQRALLGATE-------NDRKR
TH_4550|M.thermoresistible__bu G-------------VID--AHTVDLADVAGHAAAQLAG----TARARSVE
MUL_0464|M.ulcerans_Agy99 QRP-----------LERNRVDLLVLAADAVHDARAIDR-----KRAITVE
MLBr_00774|M.leprae_Br4923 G-------------VAELSVEAVDLRVMVNNALGNVGH--LAEEAGIELL
Mflv_4423|M.gilvum_PYR-GCK GAAGVALRHPRGVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQ
:
Mb1056c|M.bovis_AF2122/97 VKVDVGDAVAMADAGL-------------------------------LER
Rv1028c|M.tuberculosis_H37Rv VKVDVGDAVAMADAGL-------------------------------LER
MMAR_0634|M.marinum_M VKVEVGGAVAIADAGL-------------------------------LER
Mvan_4762|M.vanbaalenii_PYR-1 VKVEVGDTVVMADSGL-------------------------------LER
MSMEG_5395|M.smegmatis_MC2_155 VKVEVGDSVALADGGL-------------------------------LER
MAV_1170|M.avium_104 VKVDVGDAMVMADAGL-------------------------------LER
MAB_3251c|M.abscessus_ATCC_199 VHLDLGGAVVRADPGL-------------------------------LER
TH_4550|M.thermoresistible__bu VDTTLSEAVTRGDATL-------------------------------LER
MUL_0464|M.ulcerans_Agy99 VLEGPGTPEVLGDEPR-------------------------------LRQ
MLBr_00774|M.leprae_Br4923 VDMPVDEVIAEVDARR-------------------------------VER
Mflv_4423|M.gilvum_PYR-GCK IDQQRETALALQHAILGPSLSSAFAVRYQPATRPLQVGGDWYDVVDLEDG
: . .
Mb1056c|M.bovis_AF2122/97 VLANLIDNALRYAPDCVVRVNAGR-----------VRERVLINVIDEGPG
Rv1028c|M.tuberculosis_H37Rv VLANLIDNALRYAPDCVVRVNAGR-----------VRERVLINVIDEGPG
MMAR_0634|M.marinum_M VLANLIDNGLRYAPDSPVRVYAGR-----------VGDRVLINVADEGPG
Mvan_4762|M.vanbaalenii_PYR-1 VLANVIDNALRYAPDGPVRVTAGR-----------VADRVLIAVADEGPG
MSMEG_5395|M.smegmatis_MC2_155 VLANLIDNALRYAPDGLIRVTAGR-----------VANKVLIAVVDEGPG
MAV_1170|M.avium_104 VLANLIDNALRYAPNCVVRVNAGQ-----------VGDRVLINVIDEGPG
MAB_3251c|M.abscessus_ATCC_199 VLANLVDNALRYS-QGEVRVSHEE-----------VDDRTLVIVADHGKG
TH_4550|M.thermoresistible__bu LAHNLIENAVKYSGDDSPRVVVTTGSL--------SDSQVFLRVSNNGEP
MUL_0464|M.ulcerans_Agy99 VLSNLVGNALQHTPDSADVTVRVG--T--------AGENAVLEVADKGPG
MLBr_00774|M.leprae_Br4923 ILRNLIANAIDHSEHKPVRIRMAA-----------DEDTVAVTVRDYGIG
Mflv_4423|M.gilvum_PYR-GCK RIGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAAR
:: : : : . : .
Mb1056c|M.bovis_AF2122/97 VPRGTEEQLFAPFQRP--GDHDNTTG-----VGLGMSVARGFVEAMGGTI
Rv1028c|M.tuberculosis_H37Rv VPRGTEEQLFAPFQRP--GDHDNTTG-----VGLGMSVARGFVEAMGGTI
MMAR_0634|M.marinum_M IPRGAEEQMFAPFQRL--GDRDNRIG-----VGLGLSVAKGFVEAMGGTI
Mvan_4762|M.vanbaalenii_PYR-1 VARGAETELFAPFQRL--GDQDTSSG-----VGLGLSVARGFVEAMGGTI
MSMEG_5395|M.smegmatis_MC2_155 IPRGAEDALFAPFQRL--GDTNTTTG-----VGLGLSVAKGFVEAMGGTI
MAV_1170|M.avium_104 IPHGAEEQIFEAFQRL--GDHDNTTG-----VGLGMSVARGFVEAMGGTI
MAB_3251c|M.abscessus_ATCC_199 LEASKRGAAFDAFQRL--GDRDNTVG-----VGLGLSVVKGFVEAMEGTV
TH_4550|M.thermoresistible__bu IRDEDLPTLFEPFRRL--TRDTRASG-----AGLGLSIAAAIVQAHQGTI
MUL_0464|M.ulcerans_Agy99 MPAEDAARVFERFYRTDSSRARASGG-----TGLGLSIVHSLVKAHGGDV
MLBr_00774|M.leprae_Br4923 LRPGEEKLVFSRFWRSDPSRVRRSGG-----TGLGLAISIEDARLHQGRL
Mflv_4423|M.gilvum_PYR-GCK LPGARCTTAFCAVLDPRIGEVVYSCAGHPPPIMVTADRTTELLEGARATP
: * . . : . .
Mb1056c|M.bovis_AF2122/97 SATDTPGGGLTVVIDLAAPEDRP---------------------------
Rv1028c|M.tuberculosis_H37Rv SATDTPGGGLTVVIDLAAPEDRP---------------------------
MMAR_0634|M.marinum_M SATDTPGGGLTVVVDLAAA-------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 SATDTPGGGMTVEIDLAAPR------------------------------
MSMEG_5395|M.smegmatis_MC2_155 SAGDTPGGGLTVEIELAVPA------------------------------
MAV_1170|M.avium_104 TATDTPGGGLTVMVDMAAPQSEGAA-------------------------
MAB_3251c|M.abscessus_ATCC_199 NATDTAGGGLTMIVDLPSAGSAPTGAIR----------------------
TH_4550|M.thermoresistible__bu EATARPDGGLTVEVVLPAPAAARP--------------------------
MUL_0464|M.ulcerans_Agy99 TLTTAPGEGCCFRVTLPRVSEAAVELTEPVS-------------------
MLBr_00774|M.leprae_Br4923 EAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGT
Mflv_4423|M.gilvum_PYR-GCK LGLKNPPHRTEARVTMPARATLLLYTDGLVERRRESIDDGIARATDVVQG
. : :.
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 QRQRLREHAERSR-------------------------------------
Mflv_4423|M.gilvum_PYR-GCK NRATDLDQLANVIMARLAPADGYHDDVALLLYRQPEPLDLDFPADVAELA
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GSRTVLRGWLDSAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLR
Mb1056c|M.bovis_AF2122/97 --------------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5395|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00774|M.leprae_Br4923 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AVALPDRVQLTIIDTGSWKAPDDVPALHRGRGIALMKALMQDVTIDSQTT
Mb1056c|M.bovis_AF2122/97 -----------
Rv1028c|M.tuberculosis_H37Rv -----------
MMAR_0634|M.marinum_M -----------
Mvan_4762|M.vanbaalenii_PYR-1 -----------
MSMEG_5395|M.smegmatis_MC2_155 -----------
MAV_1170|M.avium_104 -----------
MAB_3251c|M.abscessus_ATCC_199 -----------
TH_4550|M.thermoresistible__bu -----------
MUL_0464|M.ulcerans_Agy99 -----------
MLBr_00774|M.leprae_Br4923 -----------
Mflv_4423|M.gilvum_PYR-GCK GTTVHMNTRIA