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M. vanbaalenii PYR-1 Mvan_1931 (-)

annotation: multi-sensor signal transduction histidine kinase
coordinates: 2060449 - 2064606
length: 1385

VTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRWPQSLLTAASILLSSRFPMWMAWGPELTF
FCNDAYRRDTLGRKYPWALGRPASEVWAEIWDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTF
SYSPLRDDDGRVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDILRFADEQLGHNLRDLPFTL
TYLFDGDGSARLAGTSGIAPEHPAVPTRLSADGGGIWPVAEPARSESVLVDLDGDSYPSLPTGDWREPPA
QALVVPLLHQGGSPSGFLVVGLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAEELAELDRVK
TTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDVVWRNGLRLTKLVNTLLDFSRIEAGRTQAR
YQPVDLGALTAELASMFRSAVERAGLTFDIDCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRV
RRDGHQAVVVVADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALVKELIGLHGGTIVADSAEGQ
GTAFTIRMPFGAAHLPDDALAPVGDGREAAGGADAYVEEALRWIPADTEADDESAHAPTGSVTAASARVL
VADDNADMREYLTRLLRSDGYRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGLGLVAELRADRRTAA
TPVLLLSARAGQQESISGLRAGADDYLVKPFAAAELLARVRTNVELARLRHHHAQWRTALVDSLQEAFFV
CDADGAVIEINPAFTEILGYDRAGLPYRPMHPWWPSADNDPDAHRQVAEAFDSLLGNRRGTITAVPVTHR
DGHRLWVTATFAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALASLNESLAQADTLGDAVRAATAEFAA
VWRARRVLAVTWPDGYPVDTETPVDPHLVCAGEPARWSDLPAHTRERITALRDDDLLDPDTSTAGAAGVA
LQHPQGVLVIYVELFERRRFTAEDHTLLTVLAGRLGQGLQRVQQIDQQRETALALQHAILGPALSGGFAV
RYQPATRPLQVGGDWYDVVDLDDGRIALIVGDCVGHGLAAAAIMGQLRSACRALLLEHPSPAAALSGLDR
FAARLPGARCTTAFCAVLDPETGEVVYSCAGHPPPILIGADRSTRLLEEARATPLGLKNPPHRTEARETM
APRATLLLYTDGLVERRRESIDDGIARAAGVVEDNRATALDELANAVMAGLAPADGYHDDVALLLYRQPA
PLDLEFAADVAELAVGREALRGWLDRAGVGAEQSLDVLIATGEALANAIEHGHREQPRGPVRLRAIALPD
RVHVTVVDSGTWKPPATVPALHRGRGIALMRALMHDVTIDSQTTGTTVHMNARIV
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_1931--100% (1385)multi-sensor signal transduction histidine kinase
M. vanbaalenii PYR-1Mvan_3797-e-17563.47% (501) putative GAF sensor protein
M. vanbaalenii PYR-1Mvan_5174-2e-2834.24% (257) integral membrane sensor signal transduction histidine kinase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1399c-2e-4834.54% (388) hypothetical protein Mb1399c
M. gilvum PYR-GCKMflv_4423-0.077.66% (1361) multi-sensor signal transduction histidine kinase
M. tuberculosis H37RvRv1364c-1e-4834.54% (388) hypothetical protein Rv1364c
M. leprae Br4923MLBr_00774mtrB1e-2530.54% (239) putative two-component system sensor kinase
M. abscessus ATCC 19977MAB_4048c-4e-2627.05% (329) sensor-like histidine kinase senX3
M. marinum MMMAR_0738-1e-14140.87% (778) two-component sensor and regulator
M. avium 104MAV_2108-0.060.66% (549) stage II sporulation protein E (SpoIIE)
M. smegmatis MC2 155MSMEG_5870-1e-2631.82% (242) sensor histidine kinase PhoR
M. thermoresistible (build 8)TH_2781-1e-11339.59% (634) PUTATIVE stage II sporulation protein E (SpoIIE)
M. ulcerans Agy99MUL_3853rsbU2e-4934.96% (389) regulator of sigma subunit, anti-anti-sigma factor RsbU

CLUSTAL 2.0.9 multiple sequence alignment


Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       --------MTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRW
Mflv_4423|M.gilvum_PYR-GCK          ------------------------------------MNWAQTPLGPTSEW
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               MSANAAAPGTPNRQPLPEDLQAAIALGGEMGRRFAEFDWAHHRLGPPGDW
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       PQSLLTAASILLSSRFPMWMAWGPELTFFCNDAYRRDTLGRKYPWALGRP
Mflv_4423|M.gilvum_PYR-GCK          PQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRNVTLGRKYPWALGRP
MAV_2108|M.avium_104                -----------MHTRLDELMAARDQLEQLVR-------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               APEVRAAVAMTLTSRFPIVLWLSPTDLFLMYNDAYAQILGDKHPAALGSA
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       ASEVWAEIWDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTFSY
Mflv_4423|M.gilvum_PYR-GCK          ASEVWAEIWDDIGPRIERVLSTGVATWDTSLLLFLERSGYTEESYHTFSY
MAV_2108|M.avium_104                ---VIAEIGSDLDLDVT---------------------------------
TH_2781|M.thermoresistible__bu      ---MSPDFGARYA-------------------------------------
MMAR_0738|M.marinum_M               GKAVWPEIWTAIGPMLAGVVATGKATWSTDLMLLLMTAGVPQERYFTFTY
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       SPLRDDDGRVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDIL
Mflv_4423|M.gilvum_PYR-GCK          SPLRDDDGAVVGMLCVVSEDTLQVIGERRMATLRDLGSDPSVVRTEGEIL
MAV_2108|M.avium_104                -------------LRRVLKAAMELTG-ARYAVLSSRASD-------GGLL
TH_2781|M.thermoresistible__bu      ---------------AALAAYLEDSSERRLAVAHDLGRQ-----------
MMAR_0738|M.marinum_M               SPIISG-GAVPAIFCAVIETTQRVLSDRRLHLLNAVASAVLETHTIDDAI
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       RFADEQLGHNLRDLPFTLTYLFDGDGSARLAGTSGIAPEHPAVPTRLSAD
Mflv_4423|M.gilvum_PYR-GCK          SFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGITGDHPAAPDVLTGA
MAV_2108|M.avium_104                SFVHAGL---------------DADTARQLG-------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               GAAVTACAAQPADLPFIAVYVAADGADAGAGRHRITLRGATPSVLPVLPQ
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       GGGIWPVAEPARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLL-HQG
Mflv_4423|M.gilvum_PYR-GCK          DGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREPPRQVLIVPLL-QQG
MAV_2108|M.avium_104                ---ELAVGDGLRIDDVSVDPRSAHLSAHDP-----PLRALLGIPIT-VRA
TH_2781|M.thermoresistible__bu      ---------ALLGRISVLQIVEDHVRLVDELSRRQPVDTDTALQFL-LQA
MMAR_0738|M.marinum_M               LLAELTDWDMASRSRESAHVVGELARVIPGICEVFTDDCPTQALVLPLSE
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           -------------------------------------------------M
Mvan_1931|M.vanbaalenii_PYR-1       GSPSGFLVVGLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAE
Mflv_4423|M.gilvum_PYR-GCK          AAPTGFLVAGLNRYRVLDDAYRGFVALVAGHIAAGIGLSRSYRTQQMRAE
MAV_2108|M.avium_104                ANFGNLYLADDRQGRVFTDSQEGAVRAMATAAAAAIDNARLFERERESAK
TH_2781|M.thermoresistible__bu      LAAVDVAVRGYLEG------------------------TRRYEQQRARAE
MMAR_0738|M.marinum_M               GSTPGAVVIGISPRRPLDALYRGFCQLLVDQLSAALASVVSYERQRQRAD
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          -----------------------------MIFSSRRRIRGRWGRSGPMMR
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           -----------------------MAAEMDWDKTVGAAEDVR---------
Rv1364c|M.tuberculosis_H37Rv        -----------------------MAAEMDWDKTVGAAEDVR---------
MUL_3853|M.ulcerans_Agy99           LLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVR---------
Mvan_1931|M.vanbaalenii_PYR-1       ELAELDRVKTTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDV
Mflv_4423|M.gilvum_PYR-GCK          ELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRADTLGDAARQELDV
MAV_2108|M.avium_104                WTKASREITTALLS--GDPQTGPLQLIVNRALELAGAEQAILLVPREPES
TH_2781|M.thermoresistible__bu      GLAGRDTFRSALVN-----AMQEAFFVMDRTGSVIDINEAFAEITG----
MMAR_0738|M.marinum_M               ALAELDRAKTAFLTNVSHEFRTPLTLLLGPVEDALADAGGDTVLADRLDT
MSMEG_5870|M.smegmatis_MC2_155      ----------------MNRGRRGIPLRVGLVAAALVLVACG---------
MLBr_00774|M.leprae_Br4923          GMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTSQLTSR---
MAB_4048c|M.abscessus_ATCC_199      -----------------MTAASALLVATAALAALAVGAALGVWYSR----
                                                                                      

Mb1399c|M.bovis_AF2122/97           ------------------------RIFEHIPAILVGLEGPDHRFVAVNAA
Rv1364c|M.tuberculosis_H37Rv        ------------------------RIFEHIPAILVGLEGPDHRFVAVNAA
MUL_3853|M.ulcerans_Agy99           ------------------------RIFENVPTMLVGLEGPEHRFVAANAA
Mvan_1931|M.vanbaalenii_PYR-1       VWRNGLRLTKLVNTLLDFSRIEAGRTQARYQPVDLGALTAELASMFRSAV
Mflv_4423|M.gilvum_PYR-GCK          VWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGAVTAELASVFRSAI
MAV_2108|M.avium_104                PGR-------------EADTLVVSATAGRYASQVIGRQVPMDGSTTGGVA
TH_2781|M.thermoresistible__bu      ---------------------YDGHDLPYRWPHPWVVDEPRADEDLLELL
MMAR_0738|M.marinum_M               ARRNARRLQRMVDSLLAFSRIEAGRATARLVCTDVGTLTSHIASSFTELC
MSMEG_5870|M.smegmatis_MC2_155      -----------------------------LLASGIAVTSIMRHTEVSRID
MLBr_00774|M.leprae_Br4923          ----------------------VLDVKVRVAIEQIERARTTVTGIVNGEE
MAB_4048c|M.abscessus_ATCC_199      ------------------------RASTHRNASEVAQTGLTVSQMLERIV
                                                                                      

Mb1399c|M.bovis_AF2122/97           YRG-----------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        YRG-----------------------------------------------
MUL_3853|M.ulcerans_Agy99           YRR-----------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       ERAGLTFDIDCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRVR
Mflv_4423|M.gilvum_PYR-GCK          ERAGLVFDVDCPPLGEEAYVDLDMWEKVIFNLLSNALKFTFEGSVSVTAR
MAV_2108|M.avium_104                RRG--------------------------LPLITDSFQYPIEGFTDVGER
TH_2781|M.thermoresistible__bu      QHG-----------------------------------------------
MMAR_0738|M.marinum_M               ARAGLDLALDCAPALADVDPG--MWETIVLNLLSNAVKYTMKGSIAVEVR
MSMEG_5870|M.smegmatis_MC2_155      QTL-----------------------------------------------
MLBr_00774|M.leprae_Br4923          TRS-----------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      AIS-----------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       RDGHQAVVVVADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALV
Mflv_4423|M.gilvum_PYR-GCK          RDGRGAVITVSDTGTGVPADEMPRLFERFHRIENTRARSNEGSGIGLALV
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               SEAAHCRLVVRDTGTGIAPADLQRLFERFYRAENAGGRSAEGSGIGLSLV
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       KELIGLHGGTIVADSAEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAG
Mflv_4423|M.gilvum_PYR-GCK          KELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPADAVASQPRERRPGN
MAV_2108|M.avium_104                --------------------SAIVIPLIADGAVLGVIAVAR---------
TH_2781|M.thermoresistible__bu      -------------------RVQLERQIRHRSGHLAWVAISVN--------
MMAR_0738|M.marinum_M               RGLVELQRGTVHIDSEPGRGTAVTIRLPRSPTGAAADQSPAALLDETNPY
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       GADAYVEEALRWIPADT-EADDESAHAPTGS----VTAASARVLVADDNA
Mflv_4423|M.gilvum_PYR-GCK          TVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGTGTLARVLVADDNA
MAV_2108|M.avium_104                ----------------------DPQQPPFGN-------------------
TH_2781|M.thermoresistible__bu      --------------------VVNPNGT-----------------------
MMAR_0738|M.marinum_M               VEEASQWLVSSPAQVQAAPEQPRQLVLIADDN------------------
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       DMREYLTRLLRSDGYRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGL
Mflv_4423|M.gilvum_PYR-GCK          DMREYLGRLLRSDGYAVEAVVDGWQALEAIRAEPPDLVISDVMMPRLDGL
MAV_2108|M.avium_104                -----------------------------------------------DYL
TH_2781|M.thermoresistible__bu      -----------------------------------------------AFV
MMAR_0738|M.marinum_M               ADMRAHLHRVLSPHWETVLVADGESALNATRSLHPDLVVTDVMMPGLDGF
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       GLVAELRADRRTAATPVLLLSARAGQQESISGLRAGADDYLVKPFAAAEL
Mflv_4423|M.gilvum_PYR-GCK          GLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGADDYLVKPFAAAEL
MAV_2108|M.avium_104                DLVSDF---ARHAAIALALAAGRQH-------------------------
TH_2781|M.thermoresistible__bu      GTMRDITAAHKAAARESALTR-----------------------------
MMAR_0738|M.marinum_M               EFIAAIRADPVLAATPVLMLSARAGAEAVSDGFAGGADDYLLKPFRSQEL
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       LARVRTNVELARLRHHHAQWRTALVDSLQEAFFVCDADGAVIEINPAFTE
Mflv_4423|M.gilvum_PYR-GCK          LARVRANIQLARLREGHARWRTALVDSLQEAFFVCDEHGAVVEINPAFTE
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               VERVTSRLAAVARERTRQG-------------------------------
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       ILGYDRAGLPYRPMHPWWPSADNDPDAHRQVAEAFDSLLGNRRGTITAVP
Mflv_4423|M.gilvum_PYR-GCK          ILGYDSTGLPYPLMHPWWPLKGSDAEANRRVEEAFGSFMRDPHGTLTEVP
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               --------------------------------------------------
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv        --------------------------------------------------
MUL_3853|M.ulcerans_Agy99           --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1       VTHRDGHRLWVTATFAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALAS
Mflv_4423|M.gilvum_PYR-GCK          VTHRDGHRLYVTVTFSHADDPETGRDVIVGTLRDVTAERYIVQRESALAS
MAV_2108|M.avium_104                -------------------------------------------------A
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               ---------------------------------------LAARLMQLDAA
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           FSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQ------------
Rv1364c|M.tuberculosis_H37Rv        FSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQ------------
MUL_3853|M.ulcerans_Agy99           FSPTFTAVGQPAREVYPELESQQIYHMLDRVYETGEPQ------------
Mvan_1931|M.vanbaalenii_PYR-1       LNESLAQADTLGDAVRAATAEFAAVWRARRVLAVTWPDGYPVDTETPVDP
Mflv_4423|M.gilvum_PYR-GCK          LNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWPD-EPDGEHESDAP
MAV_2108|M.avium_104                LNQELAQADTVDEAVRAAAEELRRLWRARRVLAVTFPSHTSATETAFGPP
TH_2781|M.thermoresistible__bu      LATAAGVATSVSEVLSIMLDECRPAIDSRRVIAVTWAR-----EDAEPTI
MMAR_0738|M.marinum_M               LQATDSVAGILAAVLHYRLASGDAAAAAIGVVDGDYVRFEYAGAIPAELR
MSMEG_5870|M.smegmatis_MC2_155      LDASRSWAQAPRRAPTTPLEGPNPARPPSNFYVRGFDE------------
MLBr_00774|M.leprae_Br4923          LDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDG------------
MAB_4048c|M.abscessus_ATCC_199      -PTGIVVVDKHQDVVLVNARARELGLVRDRQLDG----------------
                                           .                                          

Mb1399c|M.bovis_AF2122/97           ------SGSEWRLQTDYDGSGVEERYFDFVVTPRRRADG-----------
Rv1364c|M.tuberculosis_H37Rv        ------SGSEWRLQTDYDGSGVEERYFDFVVTPRRRADG-----------
MUL_3853|M.ulcerans_Agy99           ------SGAEWRLQADFDGSGIDERYFDFLVTPRRREDG-----------
Mvan_1931|M.vanbaalenii_PYR-1       HLVCAGEPARWSDLPAHTRERITALRDDDLLDPDTSTAG-----------
Mflv_4423|M.gilvum_PYR-GCK          SLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDAG-----------
MAV_2108|M.avium_104                EVVSVGEPTQWADLPSHMHQALGSLRDGDLLTPNTTQPG-----------
TH_2781|M.thermoresistible__bu      QVVGDPPASTWADLDESLRTTLLAARDWPPLTVQPVSDAGQN-------T
MMAR_0738|M.marinum_M               DRYHVARLDSPLVGTDVIHRGEPMLITDTLDLPPRYQHAVQDTAEIVRAC
MSMEG_5870|M.smegmatis_MC2_155      ------DGRTWIAVNDR--EAEPALPENNDVGPVPVTVG-----------
MLBr_00774|M.leprae_Br4923          -----PRTATTAGPVDQVPNSLRGFIKAGQAAYQYATVHT----------
MAB_4048c|M.abscessus_ATCC_199      --------QAWNAAQRTLATGEAVEVDLTTKPRAPGRAG-----------
                                                                                      

Mb1399c|M.bovis_AF2122/97           --------SIEGVQLIVDDVTSRVRARQAAEARVEELS----------ER
Rv1364c|M.tuberculosis_H37Rv        --------SIEGVQLIVDDVTSRVRARQAAEARVEELS----------ER
MUL_3853|M.ulcerans_Agy99           --------SIEGVQILFDDVTTRVRARLAAEARVEELS----------ER
Mvan_1931|M.vanbaalenii_PYR-1       -AAGVALQHPQGVLVIYVELFERRRFTAEDHTLLTVLAGRLGQGLQRVQQ
Mflv_4423|M.gilvum_PYR-GCK          -AAGVALRHPRGVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQ
MAV_2108|M.avium_104                -TAGIALQHPDGVLVVWIDLTDERSFTLEDQTLLTVLAGRLGQGLQRVHQ
TH_2781|M.thermoresistible__bu      SRGIVAVLSGTPATVLWLEHRVPRPVGIDGRRLINALVGHVSLAVQHVRR
MMAR_0738|M.marinum_M               VAQPLRNADGRVIGVLTLLWPTPRQFDASELEMFTRTAEITQIALDRVRV
MSMEG_5870|M.smegmatis_MC2_155      --------SIDKSNVEWRAMTVRGPNGELTTVAIDLSE------------
MLBr_00774|M.leprae_Br4923          --------EGFSGPALIIGTPTSSQVTNLELYLIFPLKN-----------
MAB_4048c|M.abscessus_ATCC_199      ---------------FSLRGHVRRLSDADTRWVVIYVD------------
                                                                     .                

Mb1399c|M.bovis_AF2122/97           YRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALA
Rv1364c|M.tuberculosis_H37Rv        YRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALA
MUL_3853|M.ulcerans_Agy99           YRHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAGGDWFDAVA
Mvan_1931|M.vanbaalenii_PYR-1       IDQQRETALALQHAILGPA----LSGGFAVRYQPATRPLQVGGDWYDVVD
Mflv_4423|M.gilvum_PYR-GCK          IDQQRETALALQHAILGPS----LSSAFAVRYQPATRPLQVGGDWYDVVD
MAV_2108|M.avium_104                VDQQRETALALQHAILGPAD---LPNGFAVRYQAATRPLQVGGDWFDIVD
TH_2781|M.thermoresistible__bu      FEIARESSLTLQRAMLPDIV---PPPGFAVRYEPAVRPLEIGGDWYDVLP
MMAR_0738|M.marinum_M               MTREHRIAADFQEHLLDLDRGS-TSAVVSAVYQPAGEAMRVGGDWYSVTP
MSMEG_5870|M.smegmatis_MC2_155      -VQSSVRALVWSQVGIGAAVLLVLGVVGYVVVHRSLRPLVEVERTAAAIA
MLBr_00774|M.leprae_Br4923          -EQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAERFA
MAB_4048c|M.abscessus_ATCC_199      -DDSEHVRMEATRRDFVANVSHELKTPVGAMGVLAEALLESSDDPETVRH
                                                                                      

Mb1399c|M.bovis_AF2122/97           LGD--RLVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGYTVVEALEAVD
Rv1364c|M.tuberculosis_H37Rv        LGD--RLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVD
MUL_3853|M.ulcerans_Agy99           LGD--RLVLIVGDVVGHGVEAAAVMSQLRTALRLQIAAGRSIGEALEALD
Mvan_1931|M.vanbaalenii_PYR-1       LDDG-RIALIVGDCVGHGLAAAAIMGQLRSACRALLLEHPSPAAALSGLD
Mflv_4423|M.gilvum_PYR-GCK          LEDG-RIGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALD
MAV_2108|M.avium_104                LEDG-RVALVVGDCVGHGLASATVMGQVRSACRALLIENPSPAAALAGLD
TH_2781|M.thermoresistible__bu      LDDH-QIGIIVGDCVGRGLPAAAVMGQLRSSARALLLSGAEPARLLENLD
MMAR_0738|M.marinum_M               LAHPGRIAISVGDVVGHGLAAAIVMSRLRAAVAASALNTAEPADVLGALD
MSMEG_5870|M.smegmatis_MC2_155      AGQLDRRVPERDPRTEVGRLSSALNGMLAQIQRAVAASEASAEQARSSED
MLBr_00774|M.leprae_Br4923          EGHLSERMPVRGE-DDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTS
MAB_4048c|M.abscessus_ATCC_199      FGEQVLAESRRLGNMVTELIALSRLQGAEKLPDLEVVDVDFVVSEALSRS
                                      .                 :                            .

Mb1399c|M.bovis_AF2122/97           RFHKQVPGSKSATMCVGSLDFTSG---EFQYCTAGHPPPLLVTADASARY
Rv1364c|M.tuberculosis_H37Rv        RFHKQVPGSKSATMCVGSLDFTSG---EFQYCTAGHPPPLLVTADASARY
MUL_3853|M.ulcerans_Agy99           AFHEHVPGSNSATLCVGSLDFTTG---EFQYCTAGHPPPLVVTAEAKARY
Mvan_1931|M.vanbaalenii_PYR-1       RFAARLPGARCTTAFCAVLDPETG---EVVYSCAGHPPPILIGADRSTRL
Mflv_4423|M.gilvum_PYR-GCK          RFAARLPGARCTTAFCAVLDPRIG---EVVYSCAGHPPPIMVTADRTTEL
MAV_2108|M.avium_104                RFAARLPGAQCTTAVCAVLTPDTG---ELVYSSAGHPPPIVVHGDGSTQI
TH_2781|M.thermoresistible__bu      AVAALIPDAYCATVLLAVLDTESG---TLRYSNAGHVPALLAGPGPHATV
MMAR_0738|M.marinum_M               KYAATVPGASCATVAYALIDTTPAGAGAMSYICAGHPYPLVVSPNASPVF
MSMEG_5870|M.smegmatis_MC2_155      RMRRFITDAS--HELRTPLTTIRG----------------------FAEL
MLBr_00774|M.leprae_Br4923          DVSHELRTPLTTVRMAADLIYDHS--------------------SDLDPT
MAB_4048c|M.abscessus_ATCC_199      KVAAENADIAVTTDAPSGFEVRGD--------------PTLLITAISNLV
                                                      :                               

Mb1399c|M.bovis_AF2122/97           VEPTGAGPLG-SGTG--FPVRSEVLNIGDAILFYTDGLIERPGRPLEAST
Rv1364c|M.tuberculosis_H37Rv        VEPTGAGPLG-SGTG--FPVRSEVLNIGDAILFYTDGLIERPGRPLEAST
MUL_3853|M.ulcerans_Agy99           LEPSGAGPLG-SDTG--FPVRTELIGVGDVVLLYTDGLIERPGRPLGAST
Mvan_1931|M.vanbaalenii_PYR-1       LEEARATPLG-LKNPPHRTEARETMAPRATLLLYTDGLVERRRESIDDGI
Mflv_4423|M.gilvum_PYR-GCK          LEGARATPLG-LKNPPHRTEARVTMPARATLLLYTDGLVERRRESIDDGI
MAV_2108|M.avium_104                LDEGHTIALG-IRRDWPRPEARVTIPARATLLLYTDGLVERRRSPLDRGI
TH_2781|M.thermoresistible__bu      LTDGASVPLG-VQQNRPRPQVSRQLTPGSTLMLYTDGLVERRDSPIDTGM
MMAR_0738|M.marinum_M               LKSGRRPPVATRGTDSTDVTARADLPAGSLIIFYTDGLMERAGETLDDGF
MSMEG_5870|M.smegmatis_MC2_155      YRQGAARDIEMLMGRIESESRRMGLLVEDLLLLARLDAQRPLERRRVDLL
MLBr_00774|M.leprae_Br4923          LRRSTELMVS-------ELDRFETLLNDLLEISRHDAGVAELSVEAVDLR
MAB_4048c|M.abscessus_ATCC_199      ANAIAYSPQG---SPVSISRRRRGDKVEIAVTDRGIGIAKEHQERVFERF
                                                                                      

Mb1399c|M.bovis_AF2122/97           AEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLL
Rv1364c|M.tuberculosis_H37Rv        AEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLL
MUL_3853|M.ulcerans_Agy99           AEFADLAANITSG-GGFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLL
Mvan_1931|M.vanbaalenii_PYR-1       ARAAGVVE-----------DNRATALDELANAVMAGLAPADGYHDDVALL
Mflv_4423|M.gilvum_PYR-GCK          ARATDVVQ-----------GNRATDLDQLANVIMARLAPADGYHDDVALL
MAV_2108|M.avium_104                YRVATVAQ-----------DARGSSLDELATRIMSAVAPSGGYQDDVVLL
TH_2781|M.thermoresistible__bu      DRACQVLT-----------AMLDAEPEAVADAMLDTLAPADGYDDDVAIV
MMAR_0738|M.marinum_M               ARLADAAA-----------DCSAMPVAAVCAELLHRMCPAEGYRDDVVVL
MSMEG_5870|M.smegmatis_MC2_155      ALATDAVH----------------DAQSIAPKRRVKMEVFDGPGTPEVLG
MLBr_00774|M.leprae_Br4923          VMVNNALG----------------NVGHLAEEAGIELLVDMPVDEVIAEV
MAB_4048c|M.abscessus_ATCC_199      FRVDKARS---------------RDTGGTGLGLAIVKHVAANHNGVIKLW
                                                                                      

Mb1399c|M.bovis_AF2122/97           AMQRRAP-TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHA
Rv1364c|M.tuberculosis_H37Rv        AMQRRAP-TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHA
MUL_3853|M.ulcerans_Agy99           AVQRRAP-TPPLNITEDATIHAARAIRSRLRQWLSEIGADSGDISDIVHA
Mvan_1931|M.vanbaalenii_PYR-1       LYRQ----PAPLDLEFAADVAELAVGREALRGWLDRAGVGAEQSLDVLIA
Mflv_4423|M.gilvum_PYR-GCK          LYRQ----PEPLDLDFPADVAELAGSRTVLRGWLDSAGVPQDQALDVLIA
MAV_2108|M.avium_104                LYRH----PAPLELNFPADVNQLAPARTALRNWLRRVRLDPEQTLNVLVA
TH_2781|M.thermoresistible__bu      VYRHT---FAPLRIELPATPDRLSEVRARLTGWLTAAGAPELLISDIVLA
MMAR_0738|M.marinum_M               ALRPSHAGPRSFATVLTAVPAEIPVARRRMAQWLTAIGVDPVRKGAILLA
MSMEG_5870|M.smegmatis_MC2_155      DEAR-------LRQVIGNLVANAVQHTPETAGITVRVGTDGDNAVLEVCD
MLBr_00774|M.leprae_Br4923          DARR-------VERILRNLIANAIDHSEHKP-VRIRMAADEDTVAVTVRD
MAB_4048c|M.abscessus_ATCC_199      SQPGTGSTFTLSLPVYEDDVDDDDAEDTQADSPTGDTTPRKDATNHPPRP
                                                                                      

Mb1399c|M.bovis_AF2122/97           ISEFVE-NAVEHGYATDVSKGIVVEAALAGDG--NVRASVIDRGQWK--D
Rv1364c|M.tuberculosis_H37Rv        ISEFVE-NAVEHGYATDVSKGIVVAAALAGDG--NVRASVIDRGQWK--D
MUL_3853|M.ulcerans_Agy99           ISEFVE-NAVEHGYSTDVSDGLAVAAALGGDG--KLRVAVIDHGTWK--H
Mvan_1931|M.vanbaalenii_PYR-1       TGEALA-NAIEHGHREQPRGPVRLRAIALPD---RVHVTVVDSGTWK--P
Mflv_4423|M.gilvum_PYR-GCK          VGEALA-NAIEHGHRDDPGGRVRLRAVALPD---RVQLTIIDTGSWK--A
MAV_2108|M.avium_104                AGEAVA-NAIEHGHRHSPQGTIRLGATALGD---QVRLTITDTGTWK--V
TH_2781|M.thermoresistible__bu      VNEACT-NSVEHAYRDREPGPMQVYADLRDG---QIMLQVRDFGTWK--T
MMAR_0738|M.marinum_M               TGEAVT-NAIEHGSGCDAGKTVSVEAFLDQD---AIAVTVSDQGRWTGDS
MSMEG_5870|M.smegmatis_MC2_155      EGPGMS-QEDARRVFERFYRADTSRTRASGGT--GLGLSIVDSLVYA---
MLBr_00774|M.leprae_Br4923          YGIGLR-PGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQG-R
MAB_4048c|M.abscessus_ATCC_199      HGLPASGSSKADGLLTSTSPADGLRIGSSPADGLRIGSSPADGLRIG---
                                     .                                 :     *        

Mb1399c|M.bovis_AF2122/97           HRD-GARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDT
Rv1364c|M.tuberculosis_H37Rv        HRD-GARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDT
MUL_3853|M.ulcerans_Agy99           HRE-GERGRGRGLAMAEALVSETHVSHDGAGTTATVVHRLSRPAQFVTDP
Mvan_1931|M.vanbaalenii_PYR-1       PATVPALHRGRGIALMRALMHDVTIDSQTTGTTVHMNARIV---------
Mflv_4423|M.gilvum_PYR-GCK          PDDVPALHRGRGIALMKALMQDVTIDSQTTGTTVHMNTRIA---------
MAV_2108|M.avium_104                PQATSYPHRGRGIPLMKSLMNDVDIRSDTGGTTVQLSARIT---------
TH_2781|M.thermoresistible__bu      PEPNPRIR-GRGLPMMRAISADVQVDNTRSGTVVELTFTLSGQPALT---
MMAR_0738|M.marinum_M               SASLRSQRRGRGLTLMSGLANRVETVRTPQGTRVVLQFDAATVD------
MSMEG_5870|M.smegmatis_MC2_155      --------HGGTVKVTTALGKGSRFTVSLP-RIADLPARL----------
MLBr_00774|M.leprae_Br4923          LEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHG
MAB_4048c|M.abscessus_ATCC_199      ------SSPADGLRIGSSQVPPSRLREEHKATTREEHVRR----------
                                             .  . :                                   

Mb1399c|M.bovis_AF2122/97           MVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSG
Rv1364c|M.tuberculosis_H37Rv        MVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSG
MUL_3853|M.ulcerans_Agy99           VVSRAPNRPAIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVESRSG
Mvan_1931|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               --------------------------------------------------
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          TQRQRLREHAERSR------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           IAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVL
Rv1364c|M.tuberculosis_H37Rv        IAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVL
MUL_3853|M.ulcerans_Agy99           IASLTIDLSAVTHLGSAGVSALVTARDRARKQGGRCVLMAPPGSPAHHVL
Mvan_1931|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_2108|M.avium_104                --------------------------------------------------
TH_2781|M.thermoresistible__bu      --------------------------------------------------
MMAR_0738|M.marinum_M               --------------------------------------------------
MSMEG_5870|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_00774|M.leprae_Br4923          --------------------------------------------------
MAB_4048c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb1399c|M.bovis_AF2122/97           SLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv        SLVQLPVVGADTEDIFAQE
MUL_3853|M.ulcerans_Agy99           SLVQIPVISGETENVFAED
Mvan_1931|M.vanbaalenii_PYR-1       -------------------
Mflv_4423|M.gilvum_PYR-GCK          -------------------
MAV_2108|M.avium_104                -------------------
TH_2781|M.thermoresistible__bu      -------------------
MMAR_0738|M.marinum_M               -------------------
MSMEG_5870|M.smegmatis_MC2_155      -------------------
MLBr_00774|M.leprae_Br4923          -------------------
MAB_4048c|M.abscessus_ATCC_199      -------------------