For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NWAQTPLGPTSEWPQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRNVTLGRKYPWALGRPASEVWAE IWDDIGPRIERVLSTGVATWDTSLLLFLERSGYTEESYHTFSYSPLRDDDGAVVGMLCVVSEDTLQVIGE RRMATLRDLGSDPSVVRTEGEILSFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGITGDHPAAPDVL TGADGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREPPRQVLIVPLLQQGAAPTGFLVAGLNRYRVLD DAYRGFVALVAGHIAAGIGLSRSYRTQQMRAEELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRAD TLGDAARQELDVVWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGAVTAELASVFRSAIERAGLVFD VDCPPLGEEAYVDLDMWEKVIFNLLSNALKFTFEGSVSVTARRDGRGAVITVSDTGTGVPADEMPRLFER FHRIENTRARSNEGSGIGLALVKELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPADAVASQPRERRP GNTVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGTGTLARVLVADDNADMREYLGRLLRSDGYAVE AVVDGWQALEAIRAEPPDLVISDVMMPRLDGLGLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGAD DYLVKPFAAAELLARVRANIQLARLREGHARWRTALVDSLQEAFFVCDEHGAVVEINPAFTEILGYDSTG LPYPLMHPWWPLKGSDAEANRRVEEAFGSFMRDPHGTLTEVPVTHRDGHRLYVTVTFSHADDPETGRDVI VGTLRDVTAERYIVQRESALASLNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWPDEPDGEHESDA PSLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDAGAAGVALRHPRGVLVLYVELPEQRLFTAEDD TLLTVLAGRLGQGLQRVHQIDQQRETALALQHAILGPSLSSAFAVRYQPATRPLQVGGDWYDVVDLEDGR IGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAARLPGARCTTAFCAVLDPRIGEV VYSCAGHPPPIMVTADRTTELLEGARATPLGLKNPPHRTEARVTMPARATLLLYTDGLVERRRESIDDGI ARATDVVQGNRATDLDQLANVIMARLAPADGYHDDVALLLYRQPEPLDLDFPADVAELAGSRTVLRGWLD SAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLRAVALPDRVQLTIIDTGSWKAPDDVPALHRGR GIALMKALMQDVTIDSQTTGTTVHMNTRIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4423 | - | - | 100% (1361) | multi-sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_4521 | - | e-169 | 60.60% (500) | putative GAF sensor protein |
| M. gilvum PYR-GCK | Mflv_1000 | - | 2e-31 | 28.47% (418) | multi-sensor hybrid histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 2e-48 | 33.50% (406) | hypothetical protein Mb1399c |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-48 | 33.50% (406) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_02440 | - | 9e-26 | 29.26% (229) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 5e-27 | 31.98% (247) | sensor histidine kinase |
| M. marinum M | MMAR_0738 | - | 1e-135 | 42.13% (750) | two-component sensor and regulator |
| M. avium 104 | MAV_2108 | - | 1e-175 | 62.20% (500) | stage II sporulation protein E (SpoIIE) |
| M. smegmatis MC2 155 | MSMEG_0936 | senX3 | 1e-26 | 29.26% (229) | sensor histidine kinase SenX3 |
| M. thermoresistible (build 8) | TH_2781 | - | 1e-110 | 37.43% (708) | PUTATIVE stage II sporulation protein E (SpoIIE) |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 1e-48 | 33.51% (388) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 0.0 | 77.66% (1361) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4423|M.gilvum_PYR-GCK ------------------------------------MNWAQTPLGPTSEW
Mvan_1931|M.vanbaalenii_PYR-1 --------MTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRW
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M MSANAAAPGTPNRQPLPEDLQAAIALGGEMGRRFAEFDWAHHRLGPPGDW
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK PQSLQTAANILLSSRFPMWMAWGPDLTFFCNDAYRNVTLGRKYPWALGRP
Mvan_1931|M.vanbaalenii_PYR-1 PQSLLTAASILLSSRFPMWMAWGPELTFFCNDAYRRDTLGRKYPWALGRP
MAV_2108|M.avium_104 -----------MHTRLDELMAARDQLEQLVR-------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M APEVRAAVAMTLTSRFPIVLWLSPTDLFLMYNDAYAQILGDKHPAALGSA
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ASEVWAEIWDDIGPRIERVLSTGVATWDTSLLLFLERSGYTEESYHTFSY
Mvan_1931|M.vanbaalenii_PYR-1 ASEVWAEIWDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTFSY
MAV_2108|M.avium_104 ---VIAEIGSDLDLDVT---------------------------------
TH_2781|M.thermoresistible__bu ---MSPDFGARYA-------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M GKAVWPEIWTAIGPMLAGVVATGKATWSTDLMLLLMTAGVPQERYFTFTY
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK SPLRDDDGAVVGMLCVVSEDTLQVIGERRMATLRDLGSDPSVVRTEGEIL
Mvan_1931|M.vanbaalenii_PYR-1 SPLRDDDGRVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDIL
MAV_2108|M.avium_104 -------------LRRVLKAAMELTG-ARYAVLSSRASD-------GGLL
TH_2781|M.thermoresistible__bu ---------------AALAAYLEDSSERRLAVAHDLGRQ-----------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M SPIISG-GAVPAIFCAVIETTQRVLSDRRLHLLNAVASAVLETHTIDDAI
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK SFVDRQLAQNLRDLPFTLTYLFDDDGSAHLAGMSGITGDHPAAPDVLTGA
Mvan_1931|M.vanbaalenii_PYR-1 RFADEQLGHNLRDLPFTLTYLFDGDGSARLAGTSGIAPEHPAVPTRLSAD
MAV_2108|M.avium_104 SFVHAGL---------------DADTARQLG-------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M GAAVTACAAQPADLPFIAVYVAADGADAGAGRHRITLRGATPSVLPVLPQ
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK DGELWPVGPPAGGETVLLEVDTAPYPAMPTGDWREPPRQVLIVPLL-QQG
Mvan_1931|M.vanbaalenii_PYR-1 GGGIWPVAEPARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLL-HQG
MAV_2108|M.avium_104 ---ELAVGDGLRIDDVSVDPRSAHLSAHDP-----PLRALLGIPIT-VRA
TH_2781|M.thermoresistible__bu ---------ALLGRISVLQIVEDHVRLVDELSRRQPVDTDTALQFL-LQA
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M LLAELTDWDMASRSRESAHVVGELARVIPGICEVFTDDCPTQALVLPLSE
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AAPTGFLVAGLNRYRVLDDAYRGFVALVAGHIAAGIGLSRSYRTQQMRAE
Mvan_1931|M.vanbaalenii_PYR-1 GSPSGFLVVGLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAE
MAV_2108|M.avium_104 ANFGNLYLADDRQGRVFTDSQEGAVRAMATAAAAAIDNARLFERERESAK
TH_2781|M.thermoresistible__bu LAAVDVAVRGYLEG------------------------TRRYEQQRARAE
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 -------------------------------------------------M
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M GSTPGAVVIGISPRRPLDALYRGFCQLLVDQLSAALASVVSYERQRQRAD
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ELAELDRAKTTFFSNISHEFRTPLTLILDPVSELRRADTLGDAARQELDV
Mvan_1931|M.vanbaalenii_PYR-1 ELAELDRVKTTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDV
MAV_2108|M.avium_104 WTKASREITTALLS--GDPQTGPLQLIVNRALELAGAEQAILLVPREPES
TH_2781|M.thermoresistible__bu GLAGRDTFRSALVN-----AMQEAFFVMDRTGSVIDINEAFAEITG----
Mb1399c|M.bovis_AF2122/97 -----------------------MAAEMDWDKTVGAAEDVR---------
Rv1364c|M.tuberculosis_H37Rv -----------------------MAAEMDWDKTVGAAEDVR---------
MUL_3853|M.ulcerans_Agy99 LLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVR---------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ALAELDRAKTAFLTNVSHEFRTPLTLLLGPVEDALADAGGDTVLADRLDT
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VWRNGLRLNKLVNTLLDFSRIEAGRTQAHYQPVDLGAVTAELASVFRSAI
Mvan_1931|M.vanbaalenii_PYR-1 VWRNGLRLTKLVNTLLDFSRIEAGRTQARYQPVDLGALTAELASMFRSAV
MAV_2108|M.avium_104 PGR-------------EADTLVVSATAGRYASQVIGRQVPMDGSTTGGVA
TH_2781|M.thermoresistible__bu ---------------------YDGHDLPYRWPHPWVVDEPRADEDLLELL
Mb1399c|M.bovis_AF2122/97 ------------------------RIFEHIPAILVGLEGPDHRFVAVNAA
Rv1364c|M.tuberculosis_H37Rv ------------------------RIFEHIPAILVGLEGPDHRFVAVNAA
MUL_3853|M.ulcerans_Agy99 ------------------------RIFENVPTMLVGLEGPEHRFVAANAA
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ARRNARRLQRMVDSLLAFSRIEAGRATARLVCTDVGTLTSHIASSFTELC
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ERAGLVFDVDCPPLGEEAYVDLDMWEKVIFNLLSNALKFTFEGSVSVTAR
Mvan_1931|M.vanbaalenii_PYR-1 ERAGLTFDIDCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRVR
MAV_2108|M.avium_104 RRG--------------------------LPLITDSFQYPIEGFTDVGER
TH_2781|M.thermoresistible__bu QHG-----------------------------------------------
Mb1399c|M.bovis_AF2122/97 YRG-----------------------------------------------
Rv1364c|M.tuberculosis_H37Rv YRG-----------------------------------------------
MUL_3853|M.ulcerans_Agy99 YRR-----------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ARAGLDLALDCAPALADVDPG--MWETIVLNLLSNAVKYTMKGSIAVEVR
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK RDGRGAVITVSDTGTGVPADEMPRLFERFHRIENTRARSNEGSGIGLALV
Mvan_1931|M.vanbaalenii_PYR-1 RDGHQAVVVVADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALV
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M SEAAHCRLVVRDTGTGIAPADLQRLFERFYRAENAGGRSAEGSGIGLSLV
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK KELVGLHGGTIEADSAESRGTTFTIRLPWGAGHLPADAVASQPRERRPGN
Mvan_1931|M.vanbaalenii_PYR-1 KELIGLHGGTIVADSAEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAG
MAV_2108|M.avium_104 --------------------SAIVIPLIADGAVLGVIAVAR---------
TH_2781|M.thermoresistible__bu -------------------RVQLERQIRHRSGHLAWVAISVN--------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M RGLVELQRGTVHIDSEPGRGTAVTIRLPRSPTGAAADQSPAALLDETN--
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK TVDAYVEEALRWTPDGVREYVAESAQPTTGPEKPIGTGTLARVLVADDNA
Mvan_1931|M.vanbaalenii_PYR-1 GADAYVEEALRWIPADT-EADDESAHAPTGS----VTAASARVLVADDNA
MAV_2108|M.avium_104 ----------------------DPQQPPFGN-------------------
TH_2781|M.thermoresistible__bu --------------------VVNPNGT-----------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ----------------PYVEEASQWLVSSPAQVQAAPEQPRQLVLIADDN
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK DMREYLGRLLRSDGYAVEAVVDGWQALEAIRAEPPDLVISDVMMPRLDGL
Mvan_1931|M.vanbaalenii_PYR-1 DMREYLTRLLRSDGYRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGL
MAV_2108|M.avium_104 -----------------------------------------------DYL
TH_2781|M.thermoresistible__bu -----------------------------------------------AFV
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ADMRAHLHRVLSPHWETVLVADGESALNATRSLHPDLVVTDVMMPGLDGF
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GLVAELRADRRTAAVPVLLLSARAGQEASISGLQAGADDYLVKPFAAAEL
Mvan_1931|M.vanbaalenii_PYR-1 GLVAELRADRRTAATPVLLLSARAGQQESISGLRAGADDYLVKPFAAAEL
MAV_2108|M.avium_104 DLVSDF---ARHAAIALALAAGRQH-------------------------
TH_2781|M.thermoresistible__bu GTMRDITAAHKAAARESALTR-----------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M EFIAAIRADPVLAATPVLMLSARAGAEAVSDGFAGGADDYLLKPFRSQEL
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK LARVRANIQLARLREGHARWRTALVDSLQEAFFVCDEHGAVVEINPAFTE
Mvan_1931|M.vanbaalenii_PYR-1 LARVRTNVELARLRHHHAQWRTALVDSLQEAFFVCDADGAVIEINPAFTE
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M VERVTSRLAAVARERTRQGLAARLMQLDAALQATDSVAG-----------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ILGYDSTGLPYPLMHPWWPLKGSDAEANRRVEEAFGSFMRDPHGTLTEVP
Mvan_1931|M.vanbaalenii_PYR-1 ILGYDRAGLPYRPMHPWWPSADNDPDAHRQVAEAFDSLLGNRRGTITAVP
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M --------------------------------------------------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VTHRDGHRLYVTVTFSHADDPETGRDVIVGTLRDVTAERYIVQRESALAS
Mvan_1931|M.vanbaalenii_PYR-1 VTHRDGHRLWVTATFAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALAS
MAV_2108|M.avium_104 -------------------------------------------------A
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 ---------------------------------------------MFSAL
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M ---------------------------------------------ILAAV
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK LNEKLAQADTLDDAVLAAAEEFSSIWSARRVVAATWPD-EPD-GEHESDA
Mvan_1931|M.vanbaalenii_PYR-1 LNESLAQADTLGDAVRAATAEFAAVWRARRVLAVTWPDGYPV-DTETPVD
MAV_2108|M.avium_104 LNQELAQADTVDEAVRAAAEELRRLWRARRVLAVTFPSHTSA-TETAFGP
TH_2781|M.thermoresistible__bu LATAAGVATSVSEVLSIMLDECRPAIDSRRVIAVTWAR------EDAEPT
Mb1399c|M.bovis_AF2122/97 FSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQ------------
Rv1364c|M.tuberculosis_H37Rv FSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQ------------
MUL_3853|M.ulcerans_Agy99 FSPTFTAVGQPAREVYPELESQQIYHMLDRVYETGEPQ------------
MLBr_02440|M.leprae_Br4923 LLAGVLSGLAFVVGIVAGIRLSPRLIERRQRLANEWAG------------
MSMEG_0936|M.smegmatis_MC2_155 -----MSLLTLIAGVAVGVTVVPRIVARRQRRAAYAAG------------
MMAR_0738|M.marinum_M LHYRLASGDAAAAAIGVVDGDYVRFEYAGAIPAELRDRYHVARLDSPLVG
MAB_3340|M.abscessus_ATCC_1997 -MTRPRYGIGLRLLVVNSLVVLAGIATTSVVAAIVGPP------------
:
Mflv_4423|M.gilvum_PYR-GCK PSLTVVGAPATWDGLPGSARELILTLRRDHLLAPHTSDAG-----AAGVA
Mvan_1931|M.vanbaalenii_PYR-1 PHLVCAGEPARWSDLPAHTRERITALRDDDLLDPDTSTAG-----AAGVA
MAV_2108|M.avium_104 PEVVSVGEPTQWADLPSHMHQALGSLRDGDLLTPNTTQPG-----TAGIA
TH_2781|M.thermoresistible__bu IQVVGDPPASTWADLDESLRTTLLAARDWPPLTVQPVSDAGQNTSRGIVA
Mb1399c|M.bovis_AF2122/97 -------SGSEWRLQTDYDGSGVEERYFDFVVTPRRRADG----------
Rv1364c|M.tuberculosis_H37Rv -------SGSEWRLQTDYDGSGVEERYFDFVVTPRRRADG----------
MUL_3853|M.ulcerans_Agy99 -------SGAEWRLQADFDGSGIDERYFDFLVTPRRREDG----------
MLBr_02440|M.leprae_Br4923 --ITVLQMLQRIIALMPLGAAVVDTYRDVVYLNEQAKELG----------
MSMEG_0936|M.smegmatis_MC2_155 --MTVSQMLQHITSLSPMGVAVVDTFNDVVYSNDRAVELN----------
MMAR_0738|M.marinum_M TDVIHRGEPMLITDTLDLPPRYQHAVQDTAEIVRACVAQP--------LR
MAB_3340|M.abscessus_ATCC_1997 -------MFRRLMDQQVSPGAGNDHPYERAFRDATAMSIG----------
Mflv_4423|M.gilvum_PYR-GCK LRHPRGVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQIDQQRE
Mvan_1931|M.vanbaalenii_PYR-1 LQHPQGVLVIYVELFERRRFTAEDHTLLTVLAGRLGQGLQRVQQIDQQRE
MAV_2108|M.avium_104 LQHPDGVLVVWIDLTDERSFTLEDQTLLTVLAGRLGQGLQRVHQVDQQRE
TH_2781|M.thermoresistible__bu VLSGTPATVLWLEHRVPRPVGIDGRRLINALVGHVSLAVQHVRRFEIARE
Mb1399c|M.bovis_AF2122/97 --SIEGVQLIVDDVTSRVRARQAAEARVEELS----------ERYRNVRD
Rv1364c|M.tuberculosis_H37Rv --SIEGVQLIVDDVTSRVRARQAAEARVEELS----------ERYRNVRD
MUL_3853|M.ulcerans_Agy99 --SIEGVQILFDDVTTRVRARLAAEARVEELS----------ERYRHLRD
MLBr_02440|M.leprae_Br4923 --------LVRDRQLDDQAWRAAQQ------------------ALG-GDD
MSMEG_0936|M.smegmatis_MC2_155 --------VVRDRILDDRAWQAAQR------------------VFETGQD
MMAR_0738|M.marinum_M NADGRVIGVLTLLWPTPRQFDASELEMFTRTAEITQIALDRVRVMTREHR
MAB_3340|M.abscessus_ATCC_1997 -----FAVAVSALAALTLSWYLSHR----------------------VHR
:
Mflv_4423|M.gilvum_PYR-GCK TALALQHAILGPS----LSSAFAVRYQPATRPLQVGGDWYDVVDLEDG-R
Mvan_1931|M.vanbaalenii_PYR-1 TALALQHAILGPA----LSGGFAVRYQPATRPLQVGGDWYDVVDLDDG-R
MAV_2108|M.avium_104 TALALQHAILGPAD---LPNGFAVRYQAATRPLQVGGDWFDIVDLEDG-R
TH_2781|M.thermoresistible__bu SSLTLQRAMLPDIV---PPPGFAVRYEPAVRPLEIGGDWYDVLPLDDH-Q
Mb1399c|M.bovis_AF2122/97 SATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGD--R
Rv1364c|M.tuberculosis_H37Rv SATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGD--R
MUL_3853|M.ulcerans_Agy99 SAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAGGDWFDAVALGD--R
MLBr_02440|M.leprae_Br4923 VEFDLLPGKRPAA------GRSGLSVHGHARLLSEKDRRFAVVFVHD---
MSMEG_0936|M.smegmatis_MC2_155 VEVDLSPLKVANP------GRSGISVRGKVRLLTDDDRRFAVVYIDD---
MMAR_0738|M.marinum_M IAADFQEHLLDLDRGS-TSAVVSAVYQPAGEAMRVGGDWYSVTPLAHPGR
MAB_3340|M.abscessus_ATCC_1997 SATALSQAASAVADG---------NYDIRVPPPRLGKEFDAVAAAFNKMA
: .
Mflv_4423|M.gilvum_PYR-GCK IGLIVGDCVGHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAARL
Mvan_1931|M.vanbaalenii_PYR-1 IALIVGDCVGHGLAAAAIMGQLRSACRALLLEHPSPAAALSGLDRFAARL
MAV_2108|M.avium_104 VALVVGDCVGHGLASATVMGQVRSACRALLIENPSPAAALAGLDRFAARL
TH_2781|M.thermoresistible__bu IGIIVGDCVGRGLPAAAVMGQLRSSARALLLSGAEPARLLENLDAVAALI
Mb1399c|M.bovis_AF2122/97 LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGYTVVEALEAVDRFHKQV
Rv1364c|M.tuberculosis_H37Rv LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVDRFHKQV
MUL_3853|M.ulcerans_Agy99 LVLIVGDVVGHGVEAAAVMSQLRTALRLQIAAGRSIGEALEALDAFHEHV
MLBr_02440|M.leprae_Br4923 QSDYVRMEAARRDFVANVSHELKTPVGAMALLAEALLASADDAETVSRFA
MSMEG_0936|M.smegmatis_MC2_155 QSEHARMEATRRDFVANVSHELKTPVGAMSVLAEALLASADDPDTVRRFA
MMAR_0738|M.marinum_M IAISVGDVVGHGLAAAIVMSRLRAAVAASALNTAEPADVLGALDKYAATV
MAB_3340|M.abscessus_ATCC_1997 QRLGAVDEARR-QMLADLAHEIRTPVAVLEAYMEAVEDGVQQLDQQTVAT
. . : * : .:::. :
Mflv_4423|M.gilvum_PYR-GCK PGARCTTAFCAVLDPRIG---EVVYSCAGHPPPIMVTADRTTELLEGARA
Mvan_1931|M.vanbaalenii_PYR-1 PGARCTTAFCAVLDPETG---EVVYSCAGHPPPILIGADRSTRLLEEARA
MAV_2108|M.avium_104 PGAQCTTAVCAVLTPDTG---ELVYSSAGHPPPIVVHGDGSTQILDEGHT
TH_2781|M.thermoresistible__bu PDAYCATVLLAVLDTESG---TLRYSNAGHVPALLAGPGPHATVLTDGAS
Mb1399c|M.bovis_AF2122/97 PGSKSATMCVGSLDFTSG---EFQYCTAGHPPPLLVTADASARYVEPTGA
Rv1364c|M.tuberculosis_H37Rv PGSKSATMCVGSLDFTSG---EFQYCTAGHPPPLLVTADASARYVEPTGA
MUL_3853|M.ulcerans_Agy99 PGSNSATLCVGSLDFTTG---EFQYCTAGHPPPLVVTAEAKARYLEPSGA
MLBr_02440|M.leprae_Br4923 EKVLIEANRLGYMVAELI---ELSRLQGAERLPNVTDIDVDIIVSEAIAR
MSMEG_0936|M.smegmatis_MC2_155 EKMVAESHRLADMIGELI---ELSRLQGAERLPDLDAVDVDSIVSEAVSR
MMAR_0738|M.marinum_M PGASCATVAYALIDTTPAGAGAMSYICAGHPYPLVVSPNASPVFLKSGRR
MAB_3340|M.abscessus_ATCC_1997 LRDQTRRLTRFSIDVN-----ALSVAESRTTSIDARSVSPADLVTTAVAA
: . .
Mflv_4423|M.gilvum_PYR-GCK TPLGLKNPP-HRTEARVTMPARATLLLYTDGLVERRRESIDDGIARATDV
Mvan_1931|M.vanbaalenii_PYR-1 TPLGLKNPP-HRTEARETMAPRATLLLYTDGLVERRRESIDDGIARAAGV
MAV_2108|M.avium_104 IALGIRRDW-PRPEARVTIPARATLLLYTDGLVERRRSPLDRGIYRVATV
TH_2781|M.thermoresistible__bu VPLGVQQNR-PRPQVSRQLTPGSTLMLYTDGLVERRDSPIDTGMDRACQV
Mb1399c|M.bovis_AF2122/97 GPLGSGTG---FPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADL
Rv1364c|M.tuberculosis_H37Rv GPLGSGTG---FPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADL
MUL_3853|M.ulcerans_Agy99 GPLGSDTG---FPVRTELIGVGDVVLLYTDGLIERPGRPLGASTAEFADL
MLBr_02440|M.leprae_Br4923 HKVAADTA----AIEVRTDPPSGLRVLGDQTLLVTALANLVSNAIAYSPG
MSMEG_0936|M.smegmatis_MC2_155 HKVAADNS----QISITTDAPTGYRVLGDEGLLVTAIANLVSNAIAYSPN
MMAR_0738|M.marinum_M PPVATRGTDSTDVTARADLPAGSLIIFYTDGLMERAGETLDDGFARLADA
MAB_3340|M.abscessus_ATCC_1997 FAPRYQTKG---VILTSHADDGLPDVWADPERMGQVLSNLLDNALRHTGP
: : : .
Mflv_4423|M.gilvum_PYR-GCK VQ-----------GNRATDLDQLANVIMARLAPADGYHDDVALLLYRQ--
Mvan_1931|M.vanbaalenii_PYR-1 VE-----------DNRATALDELANAVMAGLAPADGYHDDVALLLYRQ--
MAV_2108|M.avium_104 AQ-----------DARGSSLDELATRIMSAVAPSGGYQDDVVLLLYRH--
TH_2781|M.thermoresistible__bu LT-----------AMLDAEPEAVADAMLDTLAPADGYDDDVAIVVYRHT-
Mb1399c|M.bovis_AF2122/97 AASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRA
Rv1364c|M.tuberculosis_H37Rv AASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRA
MUL_3853|M.ulcerans_Agy99 AANITSG-GGFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLLAVQRRA
MLBr_02440|M.leprae_Br4923 GS-----------LVSISRRRRGDNIEIAVTDRGIGIALEDQERVFER--
MSMEG_0936|M.smegmatis_MC2_155 GT-----------DVSISRRKRGGNIEIAVTDRGIGIAKDDQERVFER--
MMAR_0738|M.marinum_M AA-----------DCSAMPVAAVCAELLHRMCPAEGYRDDVVVLALRPSH
MAB_3340|M.abscessus_ATCC_1997 GG-----------QVTVTATATGTGATIAVADTGDGVPAEHLDRLFDR--
: . * :
Mflv_4423|M.gilvum_PYR-GCK --PEPLDLDFPADVAELAGSRTVLRGWLDSAGVPQDQALDVLIAVGEALA
Mvan_1931|M.vanbaalenii_PYR-1 --PAPLDLEFAADVAELAVGREALRGWLDRAGVGAEQSLDVLIATGEALA
MAV_2108|M.avium_104 --PAPLELNFPADVNQLAPARTALRNWLRRVRLDPEQTLNVLVAAGEAVA
TH_2781|M.thermoresistible__bu --FAPLRIELPATPDRLSEVRARLTGWLTAAGAPELLISDIVLAVNEACT
Mb1399c|M.bovis_AF2122/97 P-TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVE
Rv1364c|M.tuberculosis_H37Rv P-TPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVE
MUL_3853|M.ulcerans_Agy99 P-TPPLNITEDATIHAARAIRSRLRQWLSEIGADSGDISDIVHAISEFVE
MLBr_02440|M.leprae_Br4923 ----------------FFRGDKARSRATGGSGLGLAIVKHVAANHNGSIG
MSMEG_0936|M.smegmatis_MC2_155 ----------------FFRVDKARSRATGGTGLGLAIVKHVAANHNGSIR
MMAR_0738|M.marinum_M AGPRSFATVLTAVPAEIPVARRRMAQWLTAIGVDPVRKGAILLATGEAVT
MAB_3340|M.abscessus_ATCC_1997 ----------------FYRADAARDRQHGGAGIGLSIAKALVEAHEGRIE
:
Mflv_4423|M.gilvum_PYR-GCK NAIEHGHRDDPGGRVRLRAVALPD-RVQLTIIDTGSWKAPDDV--PALHR
Mvan_1931|M.vanbaalenii_PYR-1 NAIEHGHREQPRGPVRLRAIALPD-RVHVTVVDSGTWKPPATV--PALHR
MAV_2108|M.avium_104 NAIEHGHRHSPQGTIRLGATALGD-QVRLTITDTGTWKVPQAT--SYPHR
TH_2781|M.thermoresistible__bu NSVEHAYRDREPGPMQVYADLRDG-QIMLQVRDFGTWKTPEPN--PRIR-
Mb1399c|M.bovis_AF2122/97 NAVEHGYATDVSKGIVVEAALAGDGNVRASVIDRGQWKDHRD---GARGR
Rv1364c|M.tuberculosis_H37Rv NAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQWKDHRD---GARGR
MUL_3853|M.ulcerans_Agy99 NAVEHGYSTDVSDGLAVAAALGGDGKLRVAVIDHGTWKHHRE---GERGR
MLBr_02440|M.leprae_Br4923 VWSKPGTGSTFTLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQ--REEEE
MSMEG_0936|M.smegmatis_MC2_155 LWSQPGTGSTFTLSIP----EYPDPESHSDE--------REDQ--RER--
MMAR_0738|M.marinum_M NAIEHGSGCDAGKTVSVEAFLDQD-AIAVTVSDQGRWTGDSSASLRSQRR
MAB_3340|M.abscessus_ATCC_1997 AHS---AGHAAGTTFTVSLPRPSDHPEKAPGQRPG---------------
. .
Mflv_4423|M.gilvum_PYR-GCK GRGIALMKALMQDVTIDSQTTGTTVHMNTRIA------------------
Mvan_1931|M.vanbaalenii_PYR-1 GRGIALMRALMHDVTIDSQTTGTTVHMNARIV------------------
MAV_2108|M.avium_104 GRGIPLMKSLMNDVDIRSDTGGTTVQLSARIT------------------
TH_2781|M.thermoresistible__bu GRGLPMMRAISADVQVDNTRSGTVVELTFTLSGQPALT------------
Mb1399c|M.bovis_AF2122/97 GRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQ
Rv1364c|M.tuberculosis_H37Rv GRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQ
MUL_3853|M.ulcerans_Agy99 GRGLAMAEALVSETHVSHDGAGTTATVVHRLSRPAQFVTDPVVSRAPNRP
MLBr_02440|M.leprae_Br4923 FKSMTPAQAMMQSEVTRGNVNDKCPDCGGRGIAG----------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M GRGLTLMSGLANRVETVRTPQGTRVVLQFDAATVD---------------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 TIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLS
Rv1364c|M.tuberculosis_H37Rv TIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLS
MUL_3853|M.ulcerans_Agy99 AIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVESRSGIASLTIDLS
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M --------------------------------------------------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1931|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2108|M.avium_104 --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVG
Rv1364c|M.tuberculosis_H37Rv AVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVG
MUL_3853|M.ulcerans_Agy99 AVTHLGSAGVSALVTARDRARKQGGRCVLMAPPGSPAHHVLSLVQIPVIS
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
MSMEG_0936|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0738|M.marinum_M --------------------------------------------------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ----------
Mvan_1931|M.vanbaalenii_PYR-1 ----------
MAV_2108|M.avium_104 ----------
TH_2781|M.thermoresistible__bu ----------
Mb1399c|M.bovis_AF2122/97 ADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv ADTEDIFAQE
MUL_3853|M.ulcerans_Agy99 GETENVFAED
MLBr_02440|M.leprae_Br4923 ----------
MSMEG_0936|M.smegmatis_MC2_155 ----------
MMAR_0738|M.marinum_M ----------
MAB_3340|M.abscessus_ATCC_1997 ----------