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TDAISPPTHSEQRQPALSDEDAKLAELGYRQKLDRSVGTLASFAIGFATISATTAVFTGFGAGYFTAGAP FVWTLLLAGAVFALWAFIAADLTAKLPLAGYSYQWVSRINGPDLAWFTGFIALMGWVCGMTGVGFILSGY LGGLLGWSMTQTTQILLAIAVVFVCVLINIYGVRFATMVNNIGVSLELVITVGATALVAIIAFSAPENHQ PISALFTGGQAGDKDSYMLAWLAAALGPFFGLIGVESGADVAEETKDARRVVPKTMFYALVTSIVIEFLM YVVYVLAIKDPSAVQANSAAPIEEIITQQAGPAVTKVVVAIALTNILACLLANILVATRLTYSMARDNML PFSHVWRHVSPKSKAPTYAVVGLGFLSTVLLLSALVNEKAFNYIIGIASLLFFFVYILQTIGLLVGYRRG TIPAAEPGTFDLGRFRLPLYVTALSVFLGVAVALLLLPQFATNKWVFLGIVVLAAVWWATGLKSRLSRGD AGADYAKTHGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4517 | - | - | 100% (502) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_3928 | - | 3e-56 | 32.69% (465) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_1845 | - | 4e-49 | 26.74% (460) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-20 | 24.53% (477) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_2651 | - | 2e-57 | 31.30% (492) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 4e-20 | 24.53% (477) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01304 | ansP1 | 3e-08 | 21.23% (438) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 6e-46 | 29.27% (451) | putative amino-acid permease |
| M. marinum M | MMAR_2052 | - | 5e-28 | 27.15% (442) | amino acid transporter |
| M. avium 104 | MAV_2087 | - | 1e-19 | 23.72% (489) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_6701 | - | 3e-52 | 27.72% (487) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 2e-16 | 24.22% (351) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 6e-18 | 25.81% (496) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 ---MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLTMFGVG-
Rv2320c|M.tuberculosis_H37Rv ---MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLTMFGVG-
MUL_1244|M.ulcerans_Agy99 ---MPATSIRLREQMLRRRPAGGAPVAEGAAGSLKRSFGTFELTMFGVG-
MAV_2087|M.avium_104 -------------------------MAPGTADHLRRGIGTFQLTMFGVG-
MMAR_2052|M.marinum_M --------------MSEGPQRRAEAAPATLAASALRPRNVLAIAVSAIS-
Mvan_4517|M.vanbaalenii_PYR-1 MTDAISPPTHSEQRQPALSDEDAKLAELGYRQKLDRSVGTLASFAIGFAT
Mflv_2651|M.gilvum_PYR-GCK ---------MSALPTGDGSADAAELAQFGYTQSLERRTGKFASFAVAFAF
MAB_4090|M.abscessus_ATCC_1997 MNASTATGTAAPSAAISAASDSDDLAAFGYKPQLHRSLGKFASFAAGFSF
MSMEG_6701|M.smegmatis_MC2_155 -MSISKSPVSPSEGAHASDSDAAHLDKLGYKSEFKRDMSPWANFSLGFTY
TH_4382|M.thermoresistible__bu ---------------------MSGTRTEQAQPELRRVLGPGLLLLFIVG-
MLBr_01304|M.leprae_Br4923 --------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIG-
: .
Mb2347c|M.bovis_AF2122/97 ATIGTGIFFVLAQAVPEAGPGVIVSFIIAGIAAGLAAICYAELASAVPIS
Rv2320c|M.tuberculosis_H37Rv ATIGTGIFFVLAQAVPEAGPGVIVSFIIAGIAAGLAAICYAELASAVPIS
MUL_1244|M.ulcerans_Agy99 STVGTGIFFVLAEAVPEAGPAVIVSFIIAGVAAGLAAICCAELASAVPVS
MAV_2087|M.avium_104 STIGTGIFFVMSQAVPEAGPAVIVSFLLAGVAAGLAAVCYAELASAVPVS
MMAR_2052|M.marinum_M PTT--SVFLIYGDGLQIAGTGVVWAFVIGSAIAVCMALCYAEVGSVFPSA
Mvan_4517|M.vanbaalenii_PYR-1 ISATTAVFTGFGAGYFTAGAPFVWTLLLAGAVFALWAFIAADLTAKLPLA
Mflv_2651|M.gilvum_PYR-GCK VSIATGIFTTYGSVLNSSGPVGIWTWPIAVIGQLAVAFVLGALASRIPVT
MAB_4090|M.abscessus_ATCC_1997 VSILTTIFQLFAFGFSFGGPAFFWTWPIVFLGQYMVALNFAELAARYPIS
MSMEG_6701|M.smegmatis_MC2_155 LSPVVGIYTLFAYALATGGPPMIWSLVIVGVGQLLVALVFSEVVAQFPVA
TH_4382|M.thermoresistible__bu DILGTGIYALVGDVAGEVGGAAWLPFLIAFLIATVTAFSYLELVTKYPQA
MLBr_01304|M.leprae_Br4923 GAIGTGLFLGAGGRLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSS
:: . * : : * :
Mb2347c|M.bovis_AF2122/97 GSAYSYAYTTLGEA-VAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNL
Rv2320c|M.tuberculosis_H37Rv GSAYSYAYTTLGEA-VAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNL
MUL_1244|M.ulcerans_Agy99 GSSYSYAYATLGEA-VAMGVASCLLLEYGVATAAVAVGLSGYVNKLLHNV
MAV_2087|M.avium_104 GSSYSYAYTTLGEV-VAMGVAACLLLEYGVATAAVSVNWSGYLNKLLSNV
MMAR_2052|M.marinum_M GGAYTIVRRAIGPV-AGGVTSVLFLLLGVVSTAAILVAAATYLSSLIGAA
Mvan_4517|M.vanbaalenii_PYR-1 GYSYQWVSRINGPD-LAWFTGFIALMGWVCGMTGVGFILSGYLGGLLGWS
Mflv_2651|M.gilvum_PYR-GCK GYHYQWMSRLANPV-LGWIIGWISFTFLAVVVCAVDYTIASTILPVLLNY
MAB_4090|M.abscessus_ATCC_1997 GAIYQWARRLGGAA-VGWFAGWFMIIAQIVTASAAAIALQVVLPTVWSGF
MSMEG_6701|M.smegmatis_MC2_155 GGVYPWARRLWGRK-YAWMTGWVYLVALLVTIASVTYGSGPFIAATFGIE
TH_4382|M.thermoresistible__bu AGAALYVHKAFGIQFVTFLVAFIVMCSGITSASTASRFFAANLEVGLGQE
MLBr_01304|M.leprae_Br4923 GSFVSYAREFFGEK-AAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT
. . . : :
Mb2347c|M.bovis_AF2122/97 FGFQMPHVLSAAPWDTHPG----WVNLPAVILIGLCALLLIRGASESARV
Rv2320c|M.tuberculosis_H37Rv FGFQMPHVLSAAPWDTHPG----WVNLPAVILIGLCALLLIRGASESARV
MUL_1244|M.ulcerans_Agy99 FGFQLPQALSEAPWDERPGEAAGYLNLPAIILIGLCALLLIRGVSESAKV
MAV_2087|M.avium_104 VGFQLPHALSAAPWDAQPG----YVNLPAVMLIGMCALLLIRGASESAKV
MMAR_2052|M.marinum_M VPVRWLALGMMA-----------LITALSIGKIAPASWVVAAMLALELAV
Mvan_4517|M.vanbaalenii_PYR-1 MTQTTQILLAIAVVFVCVL-----INIYGVRFATMVNNIGVSLELVITVG
Mflv_2651|M.gilvum_PYR-GCK ESTATIAWVMTAVVLLLQA----LLVAFSTPWAERVNNGLVTLELIGMVA
MAB_4090|M.abscessus_ATCC_1997 QLIGTDSSLTSVSGASNAVLLGSLLLVATTAINAVGVNWMSRINSIGVTC
MSMEG_6701|M.smegmatis_MC2_155 ATVNNTIAFALVLLALATI-----INFMGTKVLAKAAIIGFTAEIIGALV
TH_4382|M.thermoresistible__bu WGRLGVAGVALLFMALLAM-----VNLRGVGESVRLNVLLTIVEISGLLL
MLBr_01304|M.leprae_Br4923 ALPQWTLALLALAVVLVMN-------LISVEWFGELEFWAALIKVCALMA
Mb2347c|M.bovis_AF2122/97 NAI--MVLIKLGVLGMFMIIAFSAYSADHLKDFVPFG----VAGIGSAAG
Rv2320c|M.tuberculosis_H37Rv NAI--MVLIKLGVLGMFMIIAFSAYSADHLKDFVPFG----VAGIGSAAG
MUL_1244|M.ulcerans_Agy99 NAI--MVLIKLGVLGMFVILALTAYDTNHLKDFAPFG----VAGVGAAAG
MAV_2087|M.avium_104 NAI--MVMVKLGVLVVFGILAFTAFDMHHLDDFAPFG----VAGVGTAAG
MMAR_2052|M.marinum_M IIV--FTVVAFAHASAVTKPFTQPVTAGPGGALVGVG----IAGIFAAVG
Mvan_4517|M.vanbaalenii_PYR-1 ATA--LVAIIAFSAPENHQPISALFTGGQAGDKDSYM----LAWLAAALG
Mflv_2651|M.gilvum_PYR-GCK LTA--LLLVVAAVRGDMDFSNLFSKGAVPSEGFWSFGDWTSAGPWMLGFL
MAB_4090|M.abscessus_ATCC_1997 EIVG-VVAVVGMLFGHAERGPSVVLHTGDAGSGYPWA-------FLAAGL
MSMEG_6701|M.smegmatis_MC2_155 VGG---WLLIAHREHNLGVIFDSFGAGGDGSYLWAFA---------AAAL
TH_4382|M.thermoresistible__bu VIFVGLWAFTGGGADVDFTRVVAFETTTDKSVFLAVS---------AATS
MLBr_01304|M.leprae_Br4923 FLVVGTIFLGGRYPVDGHNTGLSLWTS--HGGLFPTG----VAPLIVVSS
.
Mb2347c|M.bovis_AF2122/97 TIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG
Rv2320c|M.tuberculosis_H37Rv TIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG
MUL_1244|M.ulcerans_Agy99 TIFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALG
MAV_2087|M.avium_104 TIFFSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALG
MMAR_2052|M.marinum_M PALFAFNGYDWPLYFSEETAGSRRAIPHAVVLSAVLAVVVECVAVIAAT-
Mvan_4517|M.vanbaalenii_PYR-1 -PFFGLIGVESGADVAEETKDARRVVPKTMFYALVTSIVIEFLMYVVYVL
Mflv_2651|M.gilvum_PYR-GCK LGAFTIVGFESAANLAEETHDPERVVPRAMWQAVLASGVLGFVFLVAVTL
MAB_4090|M.abscessus_ATCC_1997 MAAYVLVGFGSASELAEETRNPRRVAPRTILSAIVVSAIGGALMILGALM
MSMEG_6701|M.smegmatis_MC2_155 IGVYQYYGFEACGDVAEEVRDPGRLIPKAMRRTIYIGGAAATFVCLSLVL
TH_4382|M.thermoresistible__bu LAFFAMVGFEDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVA
MLBr_01304|M.leprae_Br4923 GVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVILLAL
: . . *. . *::: .
Mb2347c|M.bovis_AF2122/97 TQPWQDFAEQ-ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMY
Rv2320c|M.tuberculosis_H37Rv TQPWQDFAEQ-ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMY
MUL_1244|M.ulcerans_Agy99 TQPWQMFAGQ-EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMY
MAV_2087|M.avium_104 TQPWQDFGGQ-QEAGLATILDHVTHGSWASTILAAGAVISIFSVTLVTMY
MMAR_2052|M.marinum_M LAIRDIPAAI-TDGSAVEFLARQMMGPAGATVLVAGVVVAMFDTGLAANL
Mvan_4517|M.vanbaalenii_PYR-1 AIKDPSAVQA-NSAAPIEEIITQQAGPAVTKVVVAIALTNILACLLANIL
Mflv_2651|M.gilvum_PYR-GCK AAGDP-VALA-ESGTPIADVIDRTLGSAVATLLLLMVVLAIFACGLVIMI
MAB_4090|M.abscessus_ATCC_1997 AAPSLTDGQL-ATGGLPYVLDSKLASPFG-TLLLIDVAIAVFVCTLAIQT
MSMEG_6701|M.smegmatis_MC2_155 AVADIPAVIAGEDVDPVSTVLTEAFGPIGSKVILVIVLLSFLSCAMSLQA
TH_4382|M.thermoresistible__bu LVPVGTLQAS--DVPLVEVVKAGAPGLPIEELLPWISMFAVSNTALINML
MLBr_01304|M.leprae_Br4923 LLPYSAFKAS---ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNAGLY
. ::
Mb2347c|M.bovis_AF2122/97 GQTRILFAMGRDGLLP----ARFAKVNPRTMTPVHNTVIVAIFAS--TLA
Rv2320c|M.tuberculosis_H37Rv GQTRILFAMGRDGLLP----ARFAKVNPRTMTPVHNTVIVAIFAS--TLA
MUL_1244|M.ulcerans_Agy99 GQTRILFAMGRDGLLP----ARFAAVHPRFQTPVSNTVVVAIAAA--VLA
MAV_2087|M.avium_104 GITRILFAMGRDGLLP----PRFARVNPRTMTPVNNTVIVAVAAA--TLA
MMAR_2052|M.marinum_M GYARVYYAAARDGMLPRRLQPLFGRLSTRSRVPVHGFLFLFLGNG--LLC
Mvan_4517|M.vanbaalenii_PYR-1 VATRLTYSMARDNMLP--FSHVWRHVSPKSKAPTYAVVGLGFLST--VLL
Mflv_2651|M.gilvum_PYR-GCK TGVRLTWAMSRDERFPG--WQQWNQISPRFHTPLKATVLYFCLAQ--LIL
MAB_4090|M.abscessus_ATCC_1997 AASRLMFSMARDGKLP--FSAVLSHVNPRTGTPIAPAVVVGVCCV--LIL
MSMEG_6701|M.smegmatis_MC2_155 AASRLAYSYGRDGMIMG--SSLLKKFSASRHVPPYALILAAIVPA--MII
TH_4382|M.thermoresistible__bu MASRLIYGMARQRVLP----PVLGSVHPRRRTPWVAIIFTTLIAFGLIFY
MLBr_01304|M.leprae_Br4923 ATGRVMHSIAINGSGP-----KFTARMSKXGVPYGGILLAAVICLC-GVA
*: . . : . .* : .
Mb2347c|M.bovis_AF2122/97 AFIPLDS-----LADMVSIGTLTAFSVVAVGVIVLRVR--------EP--
Rv2320c|M.tuberculosis_H37Rv AFIPLDS-----LADMVSIGTLTAFSVVAVGVIVLRVR--------EP--
MUL_1244|M.ulcerans_Agy99 ALVPLNR-----LADMVSIGTLTAFIVVSVGVIILRVR--------EP--
MAV_2087|M.avium_104 AFIPLQN-----LADMVSIGTLTAFVVVSVGVIVLRVR--------EP--
MMAR_2052|M.marinum_M VFMSLPK-----LITFTGVVIAIVYLLVALSAIVCRLR--------DR--
Mvan_4517|M.vanbaalenii_PYR-1 LSALVNEKAFNYIIGIASLLFFFVYILQTIGLLVGYRRGTIP--AAEPGT
Mflv_2651|M.gilvum_PYR-GCK AIFAHSETALFTLFGAATLLPAVMYASTVVLYLIKRKS--------LPNN
MAB_4090|M.abscessus_ATCC_1997 AVNFGNAALFTSLCSVCIALIYLAYLMVTTPLLLRRLGIGGS--TWDANL
MSMEG_6701|M.smegmatis_MC2_155 IGSKVSTDAITKIISFAAFGIYLGFQMVVLAALRARLRG------WVPSG
TH_4382|M.thermoresistible__bu VTAFADSTAIAVLGGTTSLLLLAVFAMVNVAVLVLRRDE--SRDP-----
MLBr_01304|M.leprae_Br4923 LNAFNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAG--------
: : :
Mb2347c|M.bovis_AF2122/97 -----DLPRGFKVPGYPVTP-VLSVLACGYILASLH---WYTWLAFSGWV
Rv2320c|M.tuberculosis_H37Rv -----DLPRGFKVPGYPVTP-VLSVLACGYILASLH---WYTWLAFSGWV
MUL_1244|M.ulcerans_Agy99 -----ALPRGFWVPGYPVTP-ILSILACGYLLYSLH---WYTWIAFGGWV
MAV_2087|M.avium_104 -----DLPRGFRVPGYPVTP-VLSIMACGYILASLH---WYTWIAFSGWV
MMAR_2052|M.marinum_M -----DLVRPFRMPLWPLPP-LLAVVGVVVTLATQE---VKDLAIGAGLA
Mvan_4517|M.vanbaalenii_PYR-1 ----FDLGR-FRLPLYVTALSVFLGVAVALLLLPQF---ATNKWVFLGIV
Mflv_2651|M.gilvum_PYR-GCK ----HKFDLGAWEVPILVVAVVWLAFELALFRDAAF---KEAWLYVLVMV
MAB_4090|M.abscessus_ATCC_1997 GQTDADGRKLFSLGRCGLPINILAVGYGAFMILNLS---WPRPAVFDPTG
MSMEG_6701|M.smegmatis_MC2_155 KYTLGRWGVPVNIAALVYGITAMVNMAWPRTPDAPW---FDNWIVALSAA
TH_4382|M.thermoresistible__bu ----VVARRHFRTPTFLPVVGFVASLYLVTPLSGRP---AQQYLLSVVLI
MLBr_01304|M.leprae_Br4923 ----IMRRPRFRMPLAPYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIV
Mb2347c|M.bovis_AF2122/97 AVAVIFYLMWGRHHSALNEEVP--------------------
Rv2320c|M.tuberculosis_H37Rv AVAVIFYLMWGRHHSALNEEVP--------------------
MUL_1244|M.ulcerans_Agy99 GIALIFYLFWGRHHSRLNAPALHDNPTGEER-----------
MAV_2087|M.avium_104 LLALIFYFVWGRHHSALNDAAVD--PSGQER-----------
MMAR_2052|M.marinum_M AAAALGYRIARRRLPARLGGDPVTGRSTP-------------
Mvan_4517|M.vanbaalenii_PYR-1 VLAAVWWATGLKSRLSRGDAGADYAKTHGV------------
Mflv_2651|M.gilvum_PYR-GCK AIGAAYLAYLLIRRGSKGLSMPDMHSIDAELRE---------
MAB_4090|M.abscessus_ATCC_1997 EHPYLVWMAPICIIAVLLAGLVAYPRHTASTTEETVR-----
MSMEG_6701|M.smegmatis_MC2_155 VVVVTGLVYMAVHPLHDRSTAPYSDAIPTK------------
TH_4382|M.thermoresistible__bu VIGVLLFGVTMAINRQLGIPTRAVGDPAKMVLPPD-------
MLBr_01304|M.leprae_Br4923 IVPALIAGWYSIRKRVMTIARERMGYTGPFPAIANPPVKSSD