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SEGPQRRAEAAPATLAASALRPRNVLAIAVSAISPTTSVFLIYGDGLQIAGTGVVWAFVIGSAIAVCMAL CYAEVGSVFPSAGGAYTIVRRAIGPVAGGVTSVLFLLLGVVSTAAILVAAATYLSSLIGAAVPVRWLALG MMALITALSIGKIAPASWVVAAMLALELAVIIVFTVVAFAHASAVTKPFTQPVTAGPGGALVGVGIAGIF AAVGPALFAFNGYDWPLYFSEETAGSRRAIPHAVVLSAVLAVVVECVAVIAATLAIRDIPAAITDGSAVE FLARQMMGPAGATVLVAGVVVAMFDTGLAANLGYARVYYAAARDGMLPRRLQPLFGRLSTRSRVPVHGFL FLFLGNGLLCVFMSLPKLITFTGVVIAIVYLLVALSAIVCRLRDRDLVRPFRMPLWPLPPLLAVVGVVVT LATQEVKDLAIGAGLAAAAALGYRIARRRLPARLGGDPVTGRSTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2052 | - | - | 100% (466) | amino acid transporter |
| M. marinum M | MMAR_2407 | rocE_1 | 2e-36 | 28.15% (405) | cationic amino acid transport integral membrane protein, |
| M. marinum M | MMAR_3621 | rocE | 3e-31 | 26.04% (407) | cationic amino acid transport integral membrane protein RocE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 6e-40 | 27.59% (464) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_3442 | - | 7e-28 | 26.91% (405) | ethanolamine transproter |
| M. tuberculosis H37Rv | Rv2320c | rocE | 6e-40 | 27.59% (464) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 4e-13 | 22.98% (409) | putative permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 3e-37 | 26.59% (425) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_2087 | - | 4e-35 | 26.94% (412) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1412 | - | 7e-32 | 27.32% (410) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 4e-21 | 25.32% (395) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 5e-31 | 25.51% (443) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_3196 | - | 1e-30 | 28.68% (394) | ethanolamine transproter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3442|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3196|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MAB_3842|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1412|M.smegmatis_MC2_155 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MMAR_2052|M.marinum_M --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_3442|M.gilvum_PYR-GCK ---------------------------MRGVEEHRESESYLQKRQLKSG-
Mvan_3196|M.vanbaalenii_PYR-1 -----------------MSGEAHSTHTTRGVEAHRESDAYLQKRQLKKG-
Mb2347c|M.bovis_AF2122/97 ---------------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKR--
Rv2320c|M.tuberculosis_H37Rv ---------------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKR--
MUL_1244|M.ulcerans_Agy99 ---------------MPATSIRLREQMLRRRPAGGAPVAEGAAGSLKR--
MAV_2087|M.avium_104 -------------------------------------MAPGTADHLRR--
MAB_3842|M.abscessus_ATCC_1997 ---------------MAPSSPSLAQQLLRRRPTSGAPTAHGAGGHLKQ--
MSMEG_1412|M.smegmatis_MC2_155 ---------------MSAPPTSMAGQMMRRRPVIGAPVAHGASDHLKR--
TH_0471|M.thermoresistible__bu ----------------------MTDRLRVKSVEQSIADTDEPDSRLRK--
MMAR_2052|M.marinum_M ------------------------------MSEGPQRRAEAAPATLAAS-
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
: *
Mflv_3442|M.gilvum_PYR-GCK ----------SAGWILLAGLGVSYVIS-GDYSGWNFGLGQGGFGGLAIAA
Mvan_3196|M.vanbaalenii_PYR-1 ----------SAGWILLAGLGISYVVS-GDYSGWNFGLGQGGFGGLAIAA
Mb2347c|M.bovis_AF2122/97 ----------SFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
Rv2320c|M.tuberculosis_H37Rv ----------SFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
MUL_1244|M.ulcerans_Agy99 ----------SFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
MAV_2087|M.avium_104 ----------GIGTFQLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSF
MAB_3842|M.abscessus_ATCC_1997 ----------SMGTFQLTMIGVGATVGTGIFFILAESVP-KAGPAVMASF
MSMEG_1412|M.smegmatis_MC2_155 ----------SIGTFQLTLFGVGATVGTGIFLVLQEAVP-EAGPAVLVSF
TH_0471|M.thermoresistible__bu ----------DLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
MMAR_2052|M.marinum_M ----------ALRPRNVLAIAVSAISPTTSVFLIYGDGLQIAGTGVVWAF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK-IAGPFAPIAY
: :.:. :
Mflv_3442|M.gilvum_PYR-GCK VIIAAMYLAMVLGMAEMSSALPAAGGGYTFARRALGPWGGFATGTAILIE
Mvan_3196|M.vanbaalenii_PYR-1 VVIAAMYLAMVLGMAEMSSALPAAGGGYTFARRALGPWGGFATGTAILIE
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MAB_3842|M.abscessus_ATCC_1997 LVAGLAAGLAALCYAELASAVPVSGSSFSYAYTTLGELAAMVVAACLLLE
MSMEG_1412|M.smegmatis_MC2_155 VLAGVAAGLSALCYAEMASAVPVSGSTYSYAYTTMGEFVAMGVAACLLLE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
MMAR_2052|M.marinum_M VIGSAIAVCMALCYAEVGSVFPSAGGAYTIVRRAIGPVAGGVTSVLFLLL
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
: . .: * .. . *. :: ::* . . :
Mflv_3442|M.gilvum_PYR-GCK YAIAPAAIATFIGAYVESLNLFGITDGWWVYLAAYALFIG----------
Mvan_3196|M.vanbaalenii_PYR-1 YSIAPAAIATFIGAYVESLGLFGITDGWWVYLAAYAIFIG----------
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWSGYVN--KLLSNLFGFQMPHVLSAAPWD-THPG----W
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWSGYVN--KLLSNLFGFQMPHVLSAAPWD-THPG----W
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVN--KLLHNVFGFQLPQALSEAPWD-ERPGEAAGY
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLN--KLLSNVVGFQLPHALSAAPWD-AQPG----Y
MAB_3842|M.abscessus_ATCC_1997 YGVSAAAVAVGWSQYLD--KLLVNLFGWHLPHAISAAPWDSADPAAPHPW
MSMEG_1412|M.smegmatis_MC2_155 YGVSMSATSIGWGGYLN--QLLDDVFGFRIPQALTSAPWG-ENPG----I
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWSSYLG--EVFE-FAGATTRLGPITLDWG----------
MMAR_2052|M.marinum_M GVVSTAAILVAAATYLS--SLIGAAVPVRWLALGMMALIT----------
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTF----------
:: .. : .
Mflv_3442|M.gilvum_PYR-GCK --------------IHLAGVGEALKVMFVITVIALIGIVVFAVAAIPQFD
Mvan_3196|M.vanbaalenii_PYR-1 --------------IHLSGVGEALKVMFVITAIALVGLVVFAVAAIPHFD
Mb2347c|M.bovis_AF2122/97 VNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYS
Rv2320c|M.tuberculosis_H37Rv VNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYS
MUL_1244|M.ulcerans_Agy99 LNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYD
MAV_2087|M.avium_104 VNLPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFD
MAB_3842|M.abscessus_ATCC_1997 LNLPAVLLIIMCAILLIRGTSESALVNTVMVLLKLAVLSVFAIIAFTAFH
MSMEG_1412|M.smegmatis_MC2_155 MNLTATLLIVMCGLLLIRGASESALVNTIMVIIKLAVLALFVAVAFTAFT
TH_0471|M.thermoresistible__bu ----ALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIK
MMAR_2052|M.marinum_M -------------ALSIGKIAPASWVVAAMLALELAVIIVFTVVAFAHAS
MLBr_01974|M.leprae_Br4923 -----LVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTII
: . : : :. .
Mflv_3442|M.gilvum_PYR-GCK SANLTDIAVTDAAG----------------ASPLLPFGLLGIWAAIPFAI
Mvan_3196|M.vanbaalenii_PYR-1 STNLTDIAVTDAAG----------------ASALLPFGLLGIWAAIPFAI
Mb2347c|M.bovis_AF2122/97 ADHLKDFVP---------------------------FGVAGIGSAAGTIF
Rv2320c|M.tuberculosis_H37Rv ADHLKDFVP---------------------------FGVAGIGSAAGTIF
MUL_1244|M.ulcerans_Agy99 TNHLKDFAP---------------------------FGVAGVGAAAGTIF
MAV_2087|M.avium_104 MHHLDDFAP---------------------------FGVAGVGTAAGTIF
MAB_3842|M.abscessus_ATCC_1997 AGNFSDFAP---------------------------FGVSGIGAAAGTIF
MSMEG_1412|M.smegmatis_MC2_155 TDHFAGFWD---------------------------KGFAGITAAAGSIF
TH_0471|M.thermoresistible__bu AANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVF
MMAR_2052|M.marinum_M AVTKPFTQPVTAGP----------------GGALVGVGIAGIFAAVGPAL
MLBr_01974|M.leprae_Br4923 TQHVNNYVTSRSAYQPTTYSLLG-------VTEIGKSTAASMTLATIVAL
.: . :
Mflv_3442|M.gilvum_PYR-GCK WFFLAIEGVPLAAEEAEEPERNMPKGIIAGMAVLLVTCVTVLVLTTGAG-
Mvan_3196|M.vanbaalenii_PYR-1 WFFLAIEGVPLAAEETAEPERNVPKGIIAGMAVLLVTCVTVLVLTTGAG-
Mb2347c|M.bovis_AF2122/97 FSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQP
Rv2320c|M.tuberculosis_H37Rv FSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQP
MUL_1244|M.ulcerans_Agy99 FSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQP
MAV_2087|M.avium_104 FSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQP
MAB_3842|M.abscessus_ATCC_1997 FTYVGLDTVSTAGEEVKDPQRTMPRALIAALLIVTAFYLVVALAALGAQP
MSMEG_1412|M.smegmatis_MC2_155 FTFIGLDAVSTAGDEVKNPQKTMPRAILGALVVVASVYILVAFAGLGTQS
TH_0471|M.thermoresistible__bu FAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVH
MMAR_2052|M.marinum_M FAFNGYDWPLYFSEETAGSRRAIPHAVVLSAVLAVVVECVAVIAATLAIR
MLBr_01974|M.leprae_Br4923 YAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLG-
: : . : .:* . : :.:.: . .
Mflv_3442|M.gilvum_PYR-GCK ------GAAAMSESGNPLVEALGDSTWATVVNYIG-LAGLIASFFSIIYA
Mvan_3196|M.vanbaalenii_PYR-1 ------GAAAMSESGNPLVEALGDSGWAKVVNYIG-LAGLIASFFSIIYA
Mb2347c|M.bovis_AF2122/97 WQDF--AEQETAGLAIILDNVTHG-EWASTILAAGAVVSIFTVTLVTMYG
Rv2320c|M.tuberculosis_H37Rv WQDF--AEQETAGLAIILDNVTHG-EWASTILAAGAVVSIFTVTLVTMYG
MUL_1244|M.ulcerans_Agy99 WQMF--AGQEEAGLATILDNVTHS-AWASTVLAMGAVISIFTVTLVTMYG
MAV_2087|M.avium_104 WQDF--GGQQEAGLATILDHVTHG-SWASTILAAGAVISIFSVTLVTMYG
MAB_3842|M.abscessus_ATCC_1997 WKEF--EGQ-SAGLALILDKVTGS-TSASTFLAAGAVISIFSITLVSMYG
MSMEG_1412|M.smegmatis_MC2_155 ADEFGSEEQSEAGLAVILTNILHGQTWASTILSFGAVISIFSVTLVVMYG
TH_0471|M.thermoresistible__bu YTELR-AAGENANLATAFA--ANGIDWAAKVISIGALAGLTTVVIVLVLG
MMAR_2052|M.marinum_M DIP---AAITDGSAVEFLARQMMG-PAGATVLVAGVVVAMFDTGLAANLG
MLBr_01974|M.leprae_Br4923 ------SDKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFG
. . . * : .: . .
Mflv_3442|M.gilvum_PYR-GCK YSRQLFALSRAGYLP----KILSVTNRR-KAPTLALLVPGVIGFCLSLIG
Mvan_3196|M.vanbaalenii_PYR-1 YSRQLFALSRAGYLP----TVLSVTNSR-KAPTLALIVPGVIGFLLSLIG
Mb2347c|M.bovis_AF2122/97 QTRILFAMGRDGLLP----ARFAKVNPRTMTPVHNTVIVAIFASTLAAFI
Rv2320c|M.tuberculosis_H37Rv QTRILFAMGRDGLLP----ARFAKVNPRTMTPVHNTVIVAIFASTLAAFI
MUL_1244|M.ulcerans_Agy99 QTRILFAMGRDGLLP----ARFAAVHPRFQTPVSNTVVVAIAAAVLAALV
MAV_2087|M.avium_104 ITRILFAMGRDGLLP----PRFARVNPRTMTPVNNTVIVAVAAATLAAFI
MAB_3842|M.abscessus_ATCC_1997 QTRILFAIGRDGLLP----SVFAQVNPRTLTPVNNTIIVAVVVGFMAAFV
MSMEG_1412|M.smegmatis_MC2_155 QTRILFAMGRDGLLP----SMFARVNSHTMTPINNTIVVALVTGTLAGFV
TH_0471|M.thermoresistible__bu QTRVLFAMSRDGLLP----RPLSKTGPR-GTPVRITVLVGALVAIAASVF
MMAR_2052|M.marinum_M YARVYYAAARDGMLPRRLQPLFGRLSTRSRVPVHGFLFLFLGNGLLCVFM
MLBr_01974|M.leprae_Br4923 APRLWTALSDGRILP-----TRLSSKNRFGVPIVAFGITAFLTLAFPLSL
.* * . ** : .* .
Mflv_3442|M.gilvum_PYR-GCK QGA--LLLNMAVFGAAVSYVLMMVSHIVLRRRAPE--MHRPYRTPGGVFT
Mvan_3196|M.vanbaalenii_PYR-1 QGA--LLLNMAVFGAALSYVLMMVSHIVLRRREPD--MPRPYRTPGGVVT
Mb2347c|M.bovis_AF2122/97 PLD--SLADMVSIGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVT
Rv2320c|M.tuberculosis_H37Rv PLD--SLADMVSIGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVT
MUL_1244|M.ulcerans_Agy99 PLN--RLADMVSIGTLTAFIVVSVGVIILRVREPA--LPRGFWVPGYPVT
MAV_2087|M.avium_104 PLQ--NLADMVSIGTLTAFVVVSVGVIVLRVREPD--LPRGFRVPGYPVT
MAB_3842|M.abscessus_ATCC_1997 PLD--SLANMVSIGTLTAFIVVSIGVIILRVREPE--LPRAFRVPGYPVT
MSMEG_1412|M.smegmatis_MC2_155 PLD--YLWDLVSIGTLVAFIVVSAGVVLLRVREPD--LPRSFKVPGYPVT
TH_0471|M.thermoresistible__bu PVG--NLEEMVNIGTLFAFALVSAGVIVLRRTRPD--LKRGFRVPFVPWL
MMAR_2052|M.marinum_M SLP--KLITFTGVVIAIVYLLVALSAIVCRLRDRD--LVRPFRMPLWPLP
MLBr_01974|M.leprae_Br4923 RFDSLNLTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVL
* :. . : :: . . :
Mflv_3442|M.gilvum_PYR-GCK TGFALVIAVLAVIATFLVDYVAALG---CLLVFAAFMAYFGLYSRHHLVA
Mvan_3196|M.vanbaalenii_PYR-1 TGFALVIAVLAVIATFLVDSVAALC---CLVVFAAFMAYFGIYSRHHLVA
Mb2347c|M.bovis_AF2122/97 PVLSVLACGYILASLHWYTWLAFSG---WVAVAVIFYLMWG---RHHSAL
Rv2320c|M.tuberculosis_H37Rv PVLSVLACGYILASLHWYTWLAFSG---WVAVAVIFYLMWG---RHHSAL
MUL_1244|M.ulcerans_Agy99 PILSILACGYLLYSLHWYTWIAFGG---WVGIALIFYLFWG---RHHSRL
MAV_2087|M.avium_104 PVLSIMACGYILASLHWYTWIAFSG---WVLLALIFYFVWG---RHHSAL
MAB_3842|M.abscessus_ATCC_1997 PVLSVIACGYILFSLPWITWIAFGA---WVAIVLVFYLVWG---RHHSAL
MSMEG_1412|M.smegmatis_MC2_155 PVLSIIACLFVLYGLPAVTWLWFSV---WVGAVLLFYLLWG---RRHSAL
TH_0471|M.thermoresistible__bu PLAAIAACLWLMLNLTGLTWVRFLG---WMALGLVLYFFYG---RHHSML
MMAR_2052|M.marinum_M PLLAVVGVVVTLATQEVKDLAIGAG---LAAAAALGYRIAR--RRLPARL
MLBr_01974|M.leprae_Br4923 PITAVVVSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIG----IPAVA
. :: :
Mflv_3442|M.gilvum_PYR-GCK NSPDEEFAALASAEDELR---------
Mvan_3196|M.vanbaalenii_PYR-1 NSPDEEFAALAAAEGELK---------
Mb2347c|M.bovis_AF2122/97 N---EEVP-------------------
Rv2320c|M.tuberculosis_H37Rv N---EEVP-------------------
MUL_1244|M.ulcerans_Agy99 N---APALHDNPTGEER----------
MAV_2087|M.avium_104 N---DAAVD--PSGQER----------
MAB_3842|M.abscessus_ATCC_1997 N---DLPSDPAELSEKEPV--------
MSMEG_1412|M.smegmatis_MC2_155 NDGGDGYIPGAAAGEDDVMTGHPEDRA
TH_0471|M.thermoresistible__bu G---RGMTDISARRTG-----------
MMAR_2052|M.marinum_M G--GDPVTGRSTP--------------
MLBr_01974|M.leprae_Br4923 YLHYYRTSGIK----------------