For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SALPTGDGSADAAELAQFGYTQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTWPIAV IGQLAVAFVLGALASRIPVTGYHYQWMSRLANPVLGWIIGWISFTFLAVVVCAVDYTIASTILPVLLNYE STATIAWVMTAVVLLLQALLVAFSTPWAERVNNGLVTLELIGMVALTALLLVVAAVRGDMDFSNLFSKGA VPSEGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETHDPERVVPRAMWQAVLASGVLGFVFLVA VTLAAGDPVALAESGTPIADVIDRTLGSAVATLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQ QWNQISPRFHTPLKATVLYFCLAQLILAIFAHSETALFTLFGAATLLPAVMYASTVVLYLIKRKSLPNNH KFDLGAWEVPILVVAVVWLAFELALFRDAAFKEAWLYVLVMVAIGAAYLAYLLIRRGSKGLSMPDMHSID AELRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2651 | - | - | 100% (496) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_3084 | - | 3e-58 | 30.04% (496) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_0800 | - | 7e-40 | 29.28% (461) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 5e-19 | 26.71% (468) | cationic amino acid transport integral membrane protein RocE |
| M. tuberculosis H37Rv | Rv2320c | rocE | 5e-19 | 26.71% (468) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 4e-13 | 21.05% (342) | putative permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 1e-55 | 33.53% (504) | putative amino-acid permease |
| M. marinum M | MMAR_0869 | - | 1e-25 | 25.00% (460) | amino acid permease |
| M. avium 104 | MAV_2087 | - | 1e-17 | 25.76% (396) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_2184 | - | 1e-54 | 32.39% (457) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 1e-15 | 24.24% (458) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 6e-22 | 27.09% (502) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_3928 | - | 0.0 | 94.03% (486) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2651|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3928|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4090|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2184|M.smegmatis_MC2_155 --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mflv_2651|M.gilvum_PYR-GCK ---------------------------------MSALPTGDGSADAAELA
Mvan_3928|M.vanbaalenii_PYR-1 ---------------------------------MSELDR----SDSEDLA
MAB_4090|M.abscessus_ATCC_1997 ------------------------MNASTATGTAAPSAAISAASDSDDLA
MSMEG_2184|M.smegmatis_MC2_155 ---------------------------MTSSATAPGPDVADPSGDHRDLA
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MMAR_0869|M.marinum_M -----------------------------------------------MAV
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mflv_2651|M.gilvum_PYR-GCK QFGYTQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTW
Mvan_3928|M.vanbaalenii_PYR-1 QFGYKQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTW
MAB_4090|M.abscessus_ATCC_1997 AFGYKPQLHRSLGKFASFAAGFSFVSILTTIFQLFAFGFSFGGPAFFWTW
MSMEG_2184|M.smegmatis_MC2_155 EFGYDQQLHRRLGRFESFAAGFSFVSILTTIFQLFGLGFGFGGPAFFWTW
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVPEAGPGVIVSF
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVPEAGPGVIVSF
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVG-STVGTGIFFVLAEAVPEAGPAVIVSF
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVG-STIGTGIFFVMSQAVPEAGPAVIVSF
MMAR_0869|M.marinum_M TTGARSELQKALGQRSAVLFGLAYMTPII-VLGIFGVIAERSKGASAGSY
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVG-DILGTGIYALVGDVAGEVGGAAWLPF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN-SIIGAGIFMTPGEVIKIAGPFAPIAY
* . : . .:
Mflv_2651|M.gilvum_PYR-GCK PIAVIGQLAVAFVLGALASRIPVTGYHYQWMSRLANPVLGWIIGWISFTF
Mvan_3928|M.vanbaalenii_PYR-1 PIAVIGQLAVAFVLGALASRIPVTGYHYQWMSRLANPILGWIIGWISFTF
MAB_4090|M.abscessus_ATCC_1997 PIVFLGQYMVALNFAELAARYPISGAIYQWARRLGGAAVGWFAGWFMIIA
MSMEG_2184|M.smegmatis_MC2_155 PAVFVGQFLVALCFAELAARYPISGAIYQWSRRMGGEVIGWFGGWFMILA
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MMAR_0869|M.marinum_M LLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVLLD
TH_4382|M.thermoresistible__bu LIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVMC
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
. : * . . : . .
Mflv_2651|M.gilvum_PYR-GCK LAVVVCAVDYTIASTILPVLLNYEST-----------ATIAWVMTAVVLL
Mvan_3928|M.vanbaalenii_PYR-1 LAVVVCAVDYTIASTILPVLLNYEST-----------ATIAWVMTAAVLL
MAB_4090|M.abscessus_ATCC_1997 QIVTASAAAIALQVVLPTVWSGFQLIGTDSSLTSVSGASNAVLLGSLLLV
MSMEG_2184|M.smegmatis_MC2_155 QIVTASAAAIALQVVLPTIWPGFQIIGDDPALTSASGATNAVLLGTVLLV
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVNL
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVNL
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLNL
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVNL
MMAR_0869|M.marinum_M YLFLPLVIWLIGGSYLQDRFP----------------TVPFWTWIVGFAA
TH_4382|M.thermoresistible__bu SGITSASTASRFFAANLEVGLGQEWG-----------RLGVAGVALLFMA
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADND-----ELISVKTLTFLVFIA
. .
Mflv_2651|M.gilvum_PYR-GCK LQALLVAFSTPWAERVNNGLVTLELIGMVALTAL-LLVVAAVRGD-MDFS
Mvan_3928|M.vanbaalenii_PYR-1 LQALLVAFSTPWAERVNNGLVTLELIGMVALTVL-LLVVAAVRGD-MDFA
MAB_4090|M.abscessus_ATCC_1997 ATTAINAVGVNWMSRINSIGVTCEIVGVVAVVGM-LFGHAERG-----PS
MSMEG_2184|M.smegmatis_MC2_155 VTTTINCLGVKWMSRVNSAGVVCEIVGVIAVIGV-FFTHAQRG-----PQ
Mb2347c|M.bovis_AF2122/97 PAVILIGLCALLLIRGASESARVNAIMVLIKLGV-LGMFMIIA------F
Rv2320c|M.tuberculosis_H37Rv PAVILIGLCALLLIRGASESARVNAIMVLIKLGV-LGMFMIIA------F
MUL_1244|M.ulcerans_Agy99 PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGV-LGMFVILA------L
MAV_2087|M.avium_104 PAVMLIGMCALLLIRGASESAKVNAIMVMVKLGV-LVVFGILA------F
MMAR_0869|M.marinum_M LTTVLNLIGLKVADRANFILMTFQLLILAFFVAL-TIGYLVGD-----SR
TH_4382|M.thermoresistible__bu LLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGAD-VDFT
MLBr_01974|M.leprae_Br4923 VLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTS
: : :
Mflv_2651|M.gilvum_PYR-GCK NLFSKGAVPSEGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETH
Mvan_3928|M.vanbaalenii_PYR-1 NLFSKGAVPADGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETH
MAB_4090|M.abscessus_ATCC_1997 VVLHTGDAG--SGYPWAFLAAG-------LMAAYVLVGFGSASELAEETR
MSMEG_2184|M.smegmatis_MC2_155 VVFDTGHAGGQPGYIWAWIVSG-------LMAAYVMVGFGSAGELAEETR
Mb2347c|M.bovis_AF2122/97 SAYSADHLKDFVPFGVAGIGSAAG------TIFFSYIGLDAVSTAGDEVK
Rv2320c|M.tuberculosis_H37Rv SAYSADHLKDFVPFGVAGIGSAAG------TIFFSYIGLDAVSTAGDEVK
MUL_1244|M.ulcerans_Agy99 TAYDTNHLKDFAPFGVAGVGAAAG------TIFFSFIGLDAVSTAGEEVR
MAV_2087|M.avium_104 TAFDMHHLDDFAPFGVAGVGTAAG------TIFFSYIGLDAVSTAGDEVT
MMAR_0869|M.marinum_M SLLSLTPFTGNGGFTAITAGAA--------VAAYSFLGFDAVSTLTEETH
TH_4382|M.thermoresistible__bu RVVAFETTTDKSVFLAVSAATS--------LAFFAMVGFEDSVNMAEETR
MLBr_01974|M.leprae_Br4923 RSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMN
:. : *: :*
Mflv_2651|M.gilvum_PYR-GCK DPERVVPRAMWQAVLASGVLGFVFLVAVTLAAGDPVALAESGTPIADVID
Mvan_3928|M.vanbaalenii_PYR-1 DPERVVPRAMWQAVLASGVLGFVFLIAVTLAAGDPVALAESGTPIADVID
MAB_4090|M.abscessus_ATCC_1997 NPRRVAPRTILSAIVVSAIGGALMILGALMAAPSLTDGQLATGGLPYVLD
MSMEG_2184|M.smegmatis_MC2_155 NPRRVAPRTIRLALSVSALGGGLMILGALMAAPSLTDGRLATEGLPYVLD
Mb2347c|M.bovis_AF2122/97 DPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILD
Rv2320c|M.tuberculosis_H37Rv DPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILD
MUL_1244|M.ulcerans_Agy99 NPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQEEAGLATILD
MAV_2087|M.avium_104 NPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQQEAGLATILD
MMAR_0869|M.marinum_M DAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSSFP--DADSLSEGVA
TH_4382|M.thermoresistible__bu DPVVIFPRALLTGLGIAGAVYVVVAIVAVALVP-VGTLQASDVPLVEVVK
MLBr_01974|M.leprae_Br4923 TPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATNHTVKLAAAVG
. *::: . : :
Mflv_2651|M.gilvum_PYR-GCK RTLGSAVA-TLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQQW
Mvan_3928|M.vanbaalenii_PYR-1 KTLGSAVA-TLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQQW
MAB_4090|M.abscessus_ATCC_1997 SKLASPFG-TLLLIDVAIAVFVCTLAIQTAASRLMFSMARDGKLPFSAVL
MSMEG_2184|M.smegmatis_MC2_155 TVLSSPWG-TVLLIDVCIAITICTLAIQTAASRLMFSMARDGRLPASAIL
Mb2347c|M.bovis_AF2122/97 NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
Rv2320c|M.tuberculosis_H37Rv NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
MUL_1244|M.ulcerans_Agy99 NVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
MAV_2087|M.avium_104 HVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP--PRF
MMAR_0869|M.marinum_M RTIGGNLFAAVFLAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLP-RRVF
TH_4382|M.thermoresistible__bu AGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRVLP--PVL
MLBr_01974|M.leprae_Br4923 ----NNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILP---TR
. :: .. : *: .:. :*
Mflv_2651|M.gilvum_PYR-GCK NQISPRFHTPLKATVLYFCLAQLILAIFAHSETALFTLFG---AATLLPA
Mvan_3928|M.vanbaalenii_PYR-1 HQISPRFHTPLKATLLYFCLAQLILAIFARSETALFTLFG---AATLLPA
MAB_4090|M.abscessus_ATCC_1997 SHVNPRTGTPIAPAVVVGVCCVLILAVNFGNAALFTSLCS---VCIALIY
MSMEG_2184|M.smegmatis_MC2_155 AKVNGRTGTPIWPSVLIGVLCIAVLLVNVGNSAIFATLAS---VCIILIY
Mb2347c|M.bovis_AF2122/97 AKVNPRTMTPVHNTVIVAIFASTLAAFIP--LDSLADMVS---IGTLTAF
Rv2320c|M.tuberculosis_H37Rv AKVNPRTMTPVHNTVIVAIFASTLAAFIP--LDSLADMVS---IGTLTAF
MUL_1244|M.ulcerans_Agy99 AAVHPRFQTPVSNTVVVAIAAAVLAALVP--LNRLADMVS---IGTLTAF
MAV_2087|M.avium_104 ARVNPRTMTPVNNTVIVAVAAATLAAFIP--LQNLADMVS---IGTLTAF
MMAR_0869|M.marinum_M GVVSAKFHTPMFNIMLTGAVGMAAILLSV---ATSTSFIN---FGAFTAF
TH_4382|M.thermoresistible__bu GSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADSTAIAVLGGTTSLLLLA
MLBr_01974|M.leprae_Br4923 LSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAV---IARFIQF
: .* .
Mflv_2651|M.gilvum_PYR-GCK VMYASTVVLYLIK--------------RKSLPNNHKFDLGAWEVPILVVA
Mvan_3928|M.vanbaalenii_PYR-1 VMYASTVVLYLVK--------------RKSLPSNGKFDLGRWEAPILVVA
MAB_4090|M.abscessus_ATCC_1997 LAYLMVTTPLLLRRLGIGGSTWDANLGQTDADGRKLFSLGRCGLPINILA
MSMEG_2184|M.smegmatis_MC2_155 LAYLMVTAPLLYRRFKG----WPAQRNQVDAEGLPLFSLGRFGIVVNVLA
Mb2347c|M.bovis_AF2122/97 SVVAVGVIVLRVR--------------EPDLPRGFKVPGYPVTPVLSVLA
Rv2320c|M.tuberculosis_H37Rv SVVAVGVIVLRVR--------------EPDLPRGFKVPGYPVTPVLSVLA
MUL_1244|M.ulcerans_Agy99 IVVSVGVIILRVR--------------EPALPRGFWVPGYPVTPILSILA
MAV_2087|M.avium_104 VVVSVGVIVLRVR--------------EPDLPRGFRVPGYPVTPVLSIMA
MMAR_0869|M.marinum_M TLVNVSVVVYFVR------------------ERGAGLPRWRYLVLPVIGA
TH_4382|M.thermoresistible__bu VFAMVNVAVLVLR---------------RDESRDPVVARRHFRTPTFLPV
MLBr_01974|M.leprae_Br4923 IIVPIALFALARS---------------RTTNSVYVKRNVFTDKVLPITA
: .
Mflv_2651|M.gilvum_PYR-GCK VVW---LAFELALFRDAAFKEAWLYVLVMVAIGAAYLAYLLIRRGSKGLS
Mvan_3928|M.vanbaalenii_PYR-1 VVW---LAFELALFRDASFKEAWSYVIVMVAVGAAYLAYLLIRHGKESLS
MAB_4090|M.abscessus_ATCC_1997 VGYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPICIIAVLLAG--LVAYP
MSMEG_2184|M.smegmatis_MC2_155 VLYGAVMIVNLGWPRAEIFNPTGEYPVLQWAGPLSIAATVLLG--ALCFP
Mb2347c|M.bovis_AF2122/97 CGY---ILASLHWYTWLAFSG---------WVAVAVIFYLMWGRHHSALN
Rv2320c|M.tuberculosis_H37Rv CGY---ILASLHWYTWLAFSG---------WVAVAVIFYLMWGRHHSALN
MUL_1244|M.ulcerans_Agy99 CGY---LLYSLHWYTWIAFGG---------WVGIALIFYLFWGRHHSRLN
MAV_2087|M.avium_104 CGY---ILASLHWYTWIAFSG---------WVLLALIFYFVWGRHHSALN
MMAR_0869|M.marinum_M AVD---IYLLAHLASDALIVG-------LSWAAIGFLYLLWLTRGLTRQP
TH_4382|M.thermoresistible__bu VGFVASLYLVTPLSGRPAQQYLLS--VVLIVIGVLLFGVTMAINRQLGIP
MLBr_01974|M.leprae_Br4923 VVVSAGLMVSFDYRSIFLTRGGPN------YFSISLIAITFIGIPAVAYL
:
Mflv_2651|M.gilvum_PYR-GCK MPDMHSIDAELRE--
Mvan_3928|M.vanbaalenii_PYR-1 MPDMHSIDAELRE--
MAB_4090|M.abscessus_ATCC_1997 RHTASTTEETVR---
MSMEG_2184|M.smegmatis_MC2_155 RGKTHPKPVTIGA--
Mb2347c|M.bovis_AF2122/97 EEVP-----------
Rv2320c|M.tuberculosis_H37Rv EEVP-----------
MUL_1244|M.ulcerans_Agy99 APALHDNPTGEER--
MAV_2087|M.avium_104 DAAVD--PSGQER--
MMAR_0869|M.marinum_M PDLAGAAERG-----
TH_4382|M.thermoresistible__bu TRAVGDPAKMVLPPD
MLBr_01974|M.leprae_Br4923 HYYRTSGIK------