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VSELDRSDSEDLAQFGYKQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTWPIAVIGQ LAVAFVLGALASRIPVTGYHYQWMSRLANPILGWIIGWISFTFLAVVVCAVDYTIASTILPVLLNYESTA TIAWVMTAAVLLLQALLVAFSTPWAERVNNGLVTLELIGMVALTVLLLVVAAVRGDMDFANLFSKGAVPA DGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETHDPERVVPRAMWQAVLASGVLGFVFLIAVTL AAGDPVALAESGTPIADVIDKTLGSAVATLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQQWH QISPRFHTPLKATLLYFCLAQLILAIFARSETALFTLFGAATLLPAVMYASTVVLYLVKRKSLPSNGKFD LGRWEAPILVVAVVWLAFELALFRDASFKEAWSYVIVMVAVGAAYLAYLLIRHGKESLSMPDMHSIDAEL RE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3928 | - | - | 100% (492) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_4517 | - | 3e-56 | 32.69% (465) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0043 | - | 5e-42 | 29.00% (462) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 9e-18 | 26.25% (461) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_2651 | - | 0.0 | 94.03% (486) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 1e-17 | 26.25% (461) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 1e-13 | 21.93% (342) | putative permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 8e-58 | 34.56% (463) | putative amino-acid permease |
| M. marinum M | MMAR_0869 | - | 6e-26 | 24.84% (463) | amino acid permease |
| M. avium 104 | MAV_2087 | - | 2e-17 | 25.77% (392) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_2184 | - | 6e-54 | 33.11% (453) | amino acid permease |
| M. thermoresistible (build 8) | TH_4382 | - | 6e-15 | 24.62% (459) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 7e-21 | 26.53% (490) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3928|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2651|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4090|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2184|M.smegmatis_MC2_155 --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mvan_3928|M.vanbaalenii_PYR-1 ---------------------------------MSELDR----SDSEDLA
Mflv_2651|M.gilvum_PYR-GCK ---------------------------------MSALPTGDGSADAAELA
MAB_4090|M.abscessus_ATCC_1997 ------------------------MNASTATGTAAPSAAISAASDSDDLA
MSMEG_2184|M.smegmatis_MC2_155 ---------------------------MTSSATAPGPDVADPSGDHRDLA
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
MMAR_0869|M.marinum_M -----------------------------------------------MAV
TH_4382|M.thermoresistible__bu ---------------------------------------------MSGTR
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mvan_3928|M.vanbaalenii_PYR-1 QFGYKQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTW
Mflv_2651|M.gilvum_PYR-GCK QFGYTQSLERRTGKFASFAVAFAFVSIATGIFTTYGSVLNSSGPVGIWTW
MAB_4090|M.abscessus_ATCC_1997 AFGYKPQLHRSLGKFASFAAGFSFVSILTTIFQLFAFGFSFGGPAFFWTW
MSMEG_2184|M.smegmatis_MC2_155 EFGYDQQLHRRLGRFESFAAGFSFVSILTTIFQLFGLGFGFGGPAFFWTW
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVPEAGPGVIVSF
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVG-ATIGTGIFFVLAQAVPEAGPGVIVSF
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVG-STVGTGIFFVLAEAVPEAGPAVIVSF
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVG-STIGTGIFFVMSQAVPEAGPAVIVSF
MMAR_0869|M.marinum_M TTGARSELQKALGQRSAVLFGLAYMTPII-VLGIFGVIAERSKGASAGSY
TH_4382|M.thermoresistible__bu TEQAQPELRRVLGPGLLLLFIVG-DILGTGIYALVGDVAGEVGGAAWLPF
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGIN-SIIGAGIFMTPGEVIKIAGPFAPIAY
* . : . .:
Mvan_3928|M.vanbaalenii_PYR-1 PIAVIGQLAVAFVLGALASRIPVTGYHYQWMSRLANPILGWIIGWISFTF
Mflv_2651|M.gilvum_PYR-GCK PIAVIGQLAVAFVLGALASRIPVTGYHYQWMSRLANPVLGWIIGWISFTF
MAB_4090|M.abscessus_ATCC_1997 PIVFLGQYMVALNFAELAARYPISGAIYQWARRLGGAAVGWFAGWFMIIA
MSMEG_2184|M.smegmatis_MC2_155 PAVFVGQFLVALCFAELAARYPISGAIYQWSRRMGGEVIGWFGGWFMILA
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MMAR_0869|M.marinum_M LLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVLLD
TH_4382|M.thermoresistible__bu LIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVMC
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
. : * . . : . .
Mvan_3928|M.vanbaalenii_PYR-1 LAVVVCAVDYTIASTILPVLLNYEST-----------ATIAWVMTAAVLL
Mflv_2651|M.gilvum_PYR-GCK LAVVVCAVDYTIASTILPVLLNYEST-----------ATIAWVMTAVVLL
MAB_4090|M.abscessus_ATCC_1997 QIVTASAAAIALQVVLPTVWSGFQLIGTDSSLTSVSGASNAVLLGSLLLV
MSMEG_2184|M.smegmatis_MC2_155 QIVTASAAAIALQVVLPTIWPGFQIIGDDPALTSASGATNAVLLGTVLLV
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVNL
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVNL
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLNL
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVNL
MMAR_0869|M.marinum_M YLFLPLVIWLIGGSYLQDRFP----------------TVPFWTWIVGFAA
TH_4382|M.thermoresistible__bu SGITSASTASRFFAANLEVGLGQEWG-----------RLGVAGVALLFMA
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWADND-----ELISVKTLTFLVFIA
. .
Mvan_3928|M.vanbaalenii_PYR-1 LQALLVAFSTPWAERVNNGLVTLELIGMVALTVL-LLVVAAVRGD-MDFA
Mflv_2651|M.gilvum_PYR-GCK LQALLVAFSTPWAERVNNGLVTLELIGMVALTAL-LLVVAAVRGD-MDFS
MAB_4090|M.abscessus_ATCC_1997 ATTAINAVGVNWMSRINSIGVTCEIVGVVAVVGM-LFGHAERG-----PS
MSMEG_2184|M.smegmatis_MC2_155 VTTTINCLGVKWMSRVNSAGVVCEIVGVIAVIGV-FFTHAQRG-----PQ
Mb2347c|M.bovis_AF2122/97 PAVILIGLCALLLIRGASESARVNAIMVLIKLGV-LGMFMIIA------F
Rv2320c|M.tuberculosis_H37Rv PAVILIGLCALLLIRGASESARVNAIMVLIKLGV-LGMFMIIA------F
MUL_1244|M.ulcerans_Agy99 PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGV-LGMFVILA------L
MAV_2087|M.avium_104 PAVMLIGMCALLLIRGASESAKVNAIMVMVKLGV-LVVFGILA------F
MMAR_0869|M.marinum_M LTTVLNLIGLKVADRANFILMTFQLLILAFFVAL-TIGYLVGD-----SR
TH_4382|M.thermoresistible__bu LLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFTGGGAD-VDFT
MLBr_01974|M.leprae_Br4923 VLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTS
: : :
Mvan_3928|M.vanbaalenii_PYR-1 NLFSKGAVPADGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETH
Mflv_2651|M.gilvum_PYR-GCK NLFSKGAVPSEGFWSFGDWTSAGPWMLGFLLGAFTIVGFESAANLAEETH
MAB_4090|M.abscessus_ATCC_1997 VVLHTGDAG--SGYPWAFLAAG-------LMAAYVLVGFGSASELAEETR
MSMEG_2184|M.smegmatis_MC2_155 VVFDTGHAGGQPGYIWAWIVSG-------LMAAYVMVGFGSAGELAEETR
Mb2347c|M.bovis_AF2122/97 SAYSADHLKDFVPFGVAGIGSAAG------TIFFSYIGLDAVSTAGDEVK
Rv2320c|M.tuberculosis_H37Rv SAYSADHLKDFVPFGVAGIGSAAG------TIFFSYIGLDAVSTAGDEVK
MUL_1244|M.ulcerans_Agy99 TAYDTNHLKDFAPFGVAGVGAAAG------TIFFSFIGLDAVSTAGEEVR
MAV_2087|M.avium_104 TAFDMHHLDDFAPFGVAGVGTAAG------TIFFSYIGLDAVSTAGDEVT
MMAR_0869|M.marinum_M SLLSLTPFTGNGGFTAITAGAA--------VAAYSFLGFDAVSTLTEETH
TH_4382|M.thermoresistible__bu RVVAFETTTDKSVFLAVSAATS--------LAFFAMVGFEDSVNMAEETR
MLBr_01974|M.leprae_Br4923 RSAYQPTTYSLLGVTEIGKSTAASMTLATIVALYAFTGFESIANAAEEMN
:. : *: :*
Mvan_3928|M.vanbaalenii_PYR-1 DPERVVPRAMWQAVLASGVLGFVFLIAVTLAAGDPVALAESGTPIADVID
Mflv_2651|M.gilvum_PYR-GCK DPERVVPRAMWQAVLASGVLGFVFLVAVTLAAGDPVALAESGTPIADVID
MAB_4090|M.abscessus_ATCC_1997 NPRRVAPRTILSAIVVSAIGGALMILGALMAAPSLTDGQLATGGLPYVLD
MSMEG_2184|M.smegmatis_MC2_155 NPRRVAPRTIRLALSVSALGGGLMILGALMAAPSLTDGRLATEGLPYVLD
Mb2347c|M.bovis_AF2122/97 DPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILD
Rv2320c|M.tuberculosis_H37Rv DPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILD
MUL_1244|M.ulcerans_Agy99 NPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQEEAGLATILD
MAV_2087|M.avium_104 NPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQQEAGLATILD
MMAR_0869|M.marinum_M DAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSSFP--DADSLSEGVA
TH_4382|M.thermoresistible__bu DPVVIFPRALLTGLGIAGAVYVVVAIVAVALVP-VGTLQASDVPLVEVVK
MLBr_01974|M.leprae_Br4923 TPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKIVATNHTVKLAAAVG
. *::: . : :
Mvan_3928|M.vanbaalenii_PYR-1 KTLGSAVA-TLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQQW
Mflv_2651|M.gilvum_PYR-GCK RTLGSAVA-TLLLLMVVLAIFACGLVIMITGVRLTWAMSRDERFPGWQQW
MAB_4090|M.abscessus_ATCC_1997 SKLASPFG-TLLLIDVAIAVFVCTLAIQTAASRLMFSMARDGKLPFSAVL
MSMEG_2184|M.smegmatis_MC2_155 TVLSSPWG-TVLLIDVCIAITICTLAIQTAASRLMFSMARDGRLPASAIL
Mb2347c|M.bovis_AF2122/97 NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
Rv2320c|M.tuberculosis_H37Rv NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
MUL_1244|M.ulcerans_Agy99 NVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP--ARF
MAV_2087|M.avium_104 HVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP--PRF
MMAR_0869|M.marinum_M RTIGGNLFAAVFLAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLP-RRVF
TH_4382|M.thermoresistible__bu AGAPGLPIEELLPWISMFAVSNTALINMLMASRLIYGMARQRVLP--PVL
MLBr_01974|M.leprae_Br4923 ----NNTFRTIIVVGALVSMFGINVAASFGAPRLWTALSDGRILP---TR
. :: .. : *: .:. :*
Mvan_3928|M.vanbaalenii_PYR-1 HQISPRFHTPLKATLLYFCLAQLILAIFARSETALFTLFG---AATLLPA
Mflv_2651|M.gilvum_PYR-GCK NQISPRFHTPLKATVLYFCLAQLILAIFAHSETALFTLFG---AATLLPA
MAB_4090|M.abscessus_ATCC_1997 SHVNPRTGTPIAPAVVVGVCCVLILAVNFGNAALFTSLCS---VCIALIY
MSMEG_2184|M.smegmatis_MC2_155 AKVNGRTGTPIWPSVLIGVLCIAVLLVNVGNSAIFATLAS---VCIILIY
Mb2347c|M.bovis_AF2122/97 AKVNPRTMTPVHNTVIVAIFASTLAAFIP--LDSLADMVS---IGTLTAF
Rv2320c|M.tuberculosis_H37Rv AKVNPRTMTPVHNTVIVAIFASTLAAFIP--LDSLADMVS---IGTLTAF
MUL_1244|M.ulcerans_Agy99 AAVHPRFQTPVSNTVVVAIAAAVLAALVP--LNRLADMVS---IGTLTAF
MAV_2087|M.avium_104 ARVNPRTMTPVNNTVIVAVAAATLAAFIP--LQNLADMVS---IGTLTAF
MMAR_0869|M.marinum_M GVVSAKFHTPMFNIMLTGAVGMAAILLSV---ATSTSFIN---FGAFTAF
TH_4382|M.thermoresistible__bu GSVHPRRRTPWVAIIFTTLIAFGLIFYVTAFADSTAIAVLGGTTSLLLLA
MLBr_01974|M.leprae_Br4923 LSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSLNLTGLAV---IARFIQF
: .* .
Mvan_3928|M.vanbaalenii_PYR-1 VMYASTVVLYLVK--------------RKSLPSNGKFDLGRWEAPILVVA
Mflv_2651|M.gilvum_PYR-GCK VMYASTVVLYLIK--------------RKSLPNNHKFDLGAWEVPILVVA
MAB_4090|M.abscessus_ATCC_1997 LAYLMVTTPLLLRRLGIGGSTWDANLGQTDADGRKLFSLGRCGLPINILA
MSMEG_2184|M.smegmatis_MC2_155 LAYLMVTAPLLYRRFKG----WPAQRNQVDAEGLPLFSLGRFGIVVNVLA
Mb2347c|M.bovis_AF2122/97 SVVAVGVIVLRVR--------------EPDLPRGFKVPGYPVTPVLSVLA
Rv2320c|M.tuberculosis_H37Rv SVVAVGVIVLRVR--------------EPDLPRGFKVPGYPVTPVLSVLA
MUL_1244|M.ulcerans_Agy99 IVVSVGVIILRVR--------------EPALPRGFWVPGYPVTPILSILA
MAV_2087|M.avium_104 VVVSVGVIVLRVR--------------EPDLPRGFRVPGYPVTPVLSIMA
MMAR_0869|M.marinum_M TLVNVSVVVYFVR------------------ERGAGLPRWRYLVLPVIGA
TH_4382|M.thermoresistible__bu VFAMVNVAVLVLR---------------RDESRDPVVARRHFRTPTFLPV
MLBr_01974|M.leprae_Br4923 IIVPIALFALARS---------------RTTNSVYVKRNVFTDKVLPITA
: .
Mvan_3928|M.vanbaalenii_PYR-1 VVW---LAFELALFRDASFKEAWSYVIVMVAVGAAYLAYLLIRHGKESLS
Mflv_2651|M.gilvum_PYR-GCK VVW---LAFELALFRDAAFKEAWLYVLVMVAIGAAYLAYLLIRRGSKGLS
MAB_4090|M.abscessus_ATCC_1997 VGYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPICIIAVLLAG--LVAYP
MSMEG_2184|M.smegmatis_MC2_155 VLYGAVMIVNLGWPRAEIFNPTGEYPVLQWAGPLSIAATVLLG--ALCFP
Mb2347c|M.bovis_AF2122/97 CGY---ILASLHWYTWLAFSG---------WVAVAVIFYLMWGRHHSALN
Rv2320c|M.tuberculosis_H37Rv CGY---ILASLHWYTWLAFSG---------WVAVAVIFYLMWGRHHSALN
MUL_1244|M.ulcerans_Agy99 CGY---LLYSLHWYTWIAFGG---------WVGIALIFYLFWGRHHSRLN
MAV_2087|M.avium_104 CGY---ILASLHWYTWIAFSG---------WVLLALIFYFVWGRHHSALN
MMAR_0869|M.marinum_M AVD---IYLLAHLASDALIVG-------LSWAAIGFLYLLWLTRGLTRQP
TH_4382|M.thermoresistible__bu VGFVASLYLVTPLSGRPAQQYLLS--VVLIVIGVLLFGVTMAINRQLGIP
MLBr_01974|M.leprae_Br4923 VVVSAGLMVSFDYRSIFLTRGGPN------YFSISLIAITFIGIPAVAYL
:
Mvan_3928|M.vanbaalenii_PYR-1 MPDMHSIDAELRE--
Mflv_2651|M.gilvum_PYR-GCK MPDMHSIDAELRE--
MAB_4090|M.abscessus_ATCC_1997 RHTASTTEETVR---
MSMEG_2184|M.smegmatis_MC2_155 RGKTHPKPVTIGA--
Mb2347c|M.bovis_AF2122/97 EEVP-----------
Rv2320c|M.tuberculosis_H37Rv EEVP-----------
MUL_1244|M.ulcerans_Agy99 APALHDNPTGEER--
MAV_2087|M.avium_104 DAAVD--PSGQER--
MMAR_0869|M.marinum_M PDLAGAAERG-----
TH_4382|M.thermoresistible__bu TRAVGDPAKMVLPPD
MLBr_01974|M.leprae_Br4923 HYYRTSGIK------