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STTQPTSDARGRNEGDGFYDFHDKDDAAHLHALGYKSEFKRDMSPWANFSLGFTYLSPVVGIYTLFAFAL ATGGPPMIWSLVIVGVGQLLVALTFSEIVAQFPVAGGVYPWARRLWGRRYAWMTGWVYLVALLVTIASVA YGSGPFIAATFGIDATVNNVIAFSLLLLAVATAINFMGTKVLAKAAIIGFSAEIIGALVVGGWLLIAHRE HNIGIIFDSFGAGGDGDYMWAFAAAALIGLYQYYGFEACGDVAEEVPDPGRLIPKAMRRTIYIGGAAATF VCLSLILAVADIPAVIAGEDTDPVSTVLGEAFGPVGSKIILVIVLISFLSCAMSLQAAASRLAYSYGRDE MIMGSSLLKKFSPTRHVPPYALLLAAVVPAVIIVGSKFSTDAITKIISFAALGIYIGFQMVVLAALRARL KGWVPSGKYSLGKWGLAVNIAALVYGVTAMINMAWPRTPDAPWYDNWIVALSAAVVIGIGLVYMVVHPLH DKSTAPYADAIPTK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1845 | - | - | 100% (505) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0043 | - | 4e-76 | 34.22% (453) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_4517 | - | 4e-49 | 26.74% (460) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3281c | - | 5e-17 | 22.71% (480) | cationic amino acid transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0800 | - | 4e-73 | 34.90% (447) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv3253c | - | 5e-17 | 22.71% (480) | cationic amino acid transport integral membrane protein |
| M. leprae Br4923 | MLBr_01304 | ansP1 | 3e-15 | 23.36% (411) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 3e-62 | 30.74% (501) | putative amino-acid permease |
| M. marinum M | MMAR_0869 | - | 9e-23 | 24.14% (435) | amino acid permease |
| M. avium 104 | MAV_4216 | - | 6e-17 | 23.87% (486) | cationic amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_6701 | - | 0.0 | 86.60% (500) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-16 | 22.67% (450) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2597 | - | 5e-17 | 23.92% (393) | cationic amino acid transport integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1845|M.vanbaalenii_PYR-1 -----MSTTQ-PTSDARGRNEGDGFYDFHDKDDAAHLHALGYKSEFKRDM
MSMEG_6701|M.smegmatis_MC2_155 -----MSISKSPVSPSEGAHASD--------SDAAHLDKLGYKSEFKRDM
Mflv_0800|M.gilvum_PYR-GCK -----MSSLVSPAEQ---------------------------QPQLRREF
Mb3281c|M.bovis_AF2122/97 -----MAGRRRMKSVEQSIADTD-----------------EPTTRLRKDL
Rv3253c|M.tuberculosis_H37Rv -----MAGRRRMKSVEQSIADTD-----------------EPTTRLRKDL
MUL_2597|M.ulcerans_Agy99 -----MAGGLRTKSVEQSIADTD-----------------EPETRLRKDL
MAV_4216|M.avium_104 -----MASRWRTKSVEQSIADTD-----------------EPDTRLRKDL
TH_0471|M.thermoresistible__bu -----MTDRLRVKSVEQSIADTD-----------------EPDSRLRKDL
MAB_4090|M.abscessus_ATCC_1997 MNASTATGTAAPSAAISAASDSD------------DLAAFGYKPQLHRSL
MMAR_0869|M.marinum_M -----MAVTT------------------------------GARSELQKAL
MLBr_01304|M.leprae_Br4923 -----MATLAESPEPKSGASRAG---------------VLGEEAGYHKGL
: . :: :
Mvan_1845|M.vanbaalenii_PYR-1 SPWANFSLGFTYLSPVVGIYTLFAFALATGGPPMIWSLVIVGVGQLLVAL
MSMEG_6701|M.smegmatis_MC2_155 SPWANFSLGFTYLSPVVGIYTLFAYALATGGPPMIWSLVIVGVGQLLVAL
Mflv_0800|M.gilvum_PYR-GCK SLGSAFAFAFAFISPIVALYGIFGLALSAAGPSFWWGFGLVFAGQFLVAL
Mb3281c|M.bovis_AF2122/97 TWWDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAAL
Rv3253c|M.tuberculosis_H37Rv TWWDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAAL
MUL_2597|M.ulcerans_Agy99 TWRDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISFLIAAGTCALAAL
MAV_4216|M.avium_104 TWWDLVVFGVAVVIGAGIFTVTASTTGDITGPAIWVSFVIAAGTCALAAL
TH_0471|M.thermoresistible__bu SWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSFIIAAIACGLAAL
MAB_4090|M.abscessus_ATCC_1997 GKFASFAAGFSFVSILTTIFQLFAFGFSFGGPAFFWTWPIVFLGQYMVAL
MMAR_0869|M.marinum_M GQRSAVLFGLAYMTPIIVLGIFGVIAERSKG-ASAGSYLLATVAMLFTAQ
MLBr_01304|M.leprae_Br4923 KPRQLQMIGIGGAIGTGLFLGAGG-RLAKAGPGLFLVYAVCGVFVFLILR
.. : * : :
Mvan_1845|M.vanbaalenii_PYR-1 TFSEIVAQFPVAGGVYPWARRLWGRRYAWMTGWVYLVALLVTIASVAYGS
MSMEG_6701|M.smegmatis_MC2_155 VFSEVVAQFPVAGGVYPWARRLWGRKYAWMTGWVYLVALLVTIASVTYGS
Mflv_0800|M.gilvum_PYR-GCK VFATLVSRWPLEGSIYQWSRRLLGTAYGWFAGWVYMWTLVIAMATVALGA
Mb3281c|M.bovis_AF2122/97 CYAEFASTLPVAGSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGW
Rv3253c|M.tuberculosis_H37Rv CYAEFASTLPVAGSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGW
MUL_2597|M.ulcerans_Agy99 CYAEFASTLPVAGSAYTFSYATFGEFLAWVIGWNLVLELAIGAAVVAKGW
MAV_4216|M.avium_104 CYAEFASTLPVAGSAYTFSYATFGEFLAWIIGWNLLLELAIGAAVVAKGW
TH_0471|M.thermoresistible__bu CYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGW
MAB_4090|M.abscessus_ATCC_1997 NFAELAARYPISGAIYQWARRLGGAAVGWFAGWFMIIAQIVTASAAAIAL
MMAR_0869|M.marinum_M SYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVLLDYLFLPLVIWLIG
MLBr_01304|M.leprae_Br4923 ALGELVLHRPSSGSFVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAI
. .. * *. : . .:. ** . .
Mvan_1845|M.vanbaalenii_PYR-1 GPFIAATFGID-----------ATVN-NVIAFSLLLLAVATAINFMGTKV
MSMEG_6701|M.smegmatis_MC2_155 GPFIAATFGIE-----------ATVN-NTIAFALVLLALATIINFMGTKV
Mflv_0800|M.gilvum_PYR-GCK AGFTANIVGIE-----------EPSGGTLALIALVILLAGTAVNLIGRQA
Mb3281c|M.bovis_AF2122/97 SSYLGTVFGFGNGT-------GHLGSLQLDWGALVIVTLVATLIALGTKL
Rv3253c|M.tuberculosis_H37Rv SSYLGTVFGFGNGT-------GHLGSLQLDWGALVIVTLVATLIALGTKL
MUL_2597|M.ulcerans_Agy99 SSYLGTVFGFSGGT-------ADFGSIRLDWGALLSVSIVSLLVAYGTKL
MAV_4216|M.avium_104 SSYLGTVFGFSGGT-------VKFGAAQLDWGALVIVGGVATLIALGTKL
TH_0471|M.thermoresistible__bu SSYLGEVFEFAGAT-------TRLGPITLDWGALLIIGFVTVLLATGTKL
MAB_4090|M.abscessus_ATCC_1997 QVVLPTVWSGFQLIGTDSSLTSVSGASNAVLLGSLLLVATTAINAVGVNW
MMAR_0869|M.marinum_M GSYLQDRFPTVP----------------FWTWIVGFAALTTVLNLIGLKV
MLBr_01304|M.leprae_Br4923 ATYLHRWTIFTALP--------------QWTLALLALAVVLVMNLISVEW
: . :
Mvan_1845|M.vanbaalenii_PYR-1 LAKAAIIG---FSAEIIGALVVGGWLLIA---HREHNIGIIFDSFGAG--
MSMEG_6701|M.smegmatis_MC2_155 LAKAAIIG---FTAEIIGALVVGGWLLIA---HREHNLGVIFDSFGAG--
Mflv_0800|M.gilvum_PYR-GCK LKIFMIGS---IIAEVIGSVVLGTWLLIF---HRQNSISVLFEGGGAD--
Mb3281c|M.bovis_AF2122/97 SSRFSAVVTAIKVSVVVLVVVVGAFYIRA---ANYSPFIPEPEVQHHG-G
Rv3253c|M.tuberculosis_H37Rv SSRFSAVVTAIKVSVVVLVVVVGAFYIRA---ANYSPFIPEPEVQHHG-G
MUL_2597|M.ulcerans_Agy99 SSRFSAVVTTIKVAVVILVVVVGAFYVKA---ANYSPFIPEPEAGPEG-R
MAV_4216|M.avium_104 SSRFSAVITGIKVSVVVFVVVVGVFYIKR---ANYSPFIPKPEAGGQA-K
TH_0471|M.thermoresistible__bu SANVSLAITVIKVGVVLLVVIVGAFFIKA---ANYTPFIPPAEAGGEAGR
MAB_4090|M.abscessus_ATCC_1997 MSRINSIG---VTCEIVGVVAVVGMLFGH---AERGPSVVLHTGDAGS--
MMAR_0869|M.marinum_M ADRANFILMTFQLLILAFFVALTIGYLVG---DSRSLLSLTPFTGNGG--
MLBr_01304|M.leprae_Br4923 FGELEFWAALIKVCALMAFLVVGTIFLGGRYPVDGHNTGLSLWTSHGG--
: : : .
Mvan_1845|M.vanbaalenii_PYR-1 ------------GDG--DYMWAFAAAALIGLYQYYGFEACGDVAEEVPDP
MSMEG_6701|M.smegmatis_MC2_155 ------------GDG--SYLWAFAAAALIGVYQYYGFEACGDVAEEVRDP
Mflv_0800|M.gilvum_PYR-GCK ------------VDLGAYLGGPFLLAVAFIGWSFVGFESAGSIAEEVHNP
Mb3281c|M.bovis_AF2122/97 GLDQSVFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRP
Rv3253c|M.tuberculosis_H37Rv GLDQSVFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRP
MUL_2597|M.ulcerans_Agy99 GADQSLLSLLTGAPGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKHP
MAV_4216|M.avium_104 GIDQSVLSLLTGAHTSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKHP
TH_0471|M.thermoresistible__bu SLDQSLFSLITGAEGSSYGWYGLLAGASIVFFAFIGFDIIATTAEETKNP
MAB_4090|M.abscessus_ATCC_1997 -----------------GYPWAFLAAGLMAAYVLVGFGSASELAEETRNP
MMAR_0869|M.marinum_M -------------------FTAITAGAAVAAYSFLGFDAVSTLTEETHDA
MLBr_01304|M.leprae_Br4923 --------------LFPTGVAPLIVVSSGVMFAYAAVELVGTAAGETVEP
. : .. . : *. .
Mvan_1845|M.vanbaalenii_PYR-1 GRLIPKAMRRTIYIGGAAATFVCLSLILAVADIPAVIAGEDTDPVSTVLG
MSMEG_6701|M.smegmatis_MC2_155 GRLIPKAMRRTIYIGGAAATFVCLSLVLAVADIPAVIAGEDVDPVSTVLT
Mflv_0800|M.gilvum_PYR-GCK RRDLPKAVLFSIAFIALVVGYSALAIILAIPDLDAVAEGAVADPVYDTLT
Mb3281c|M.bovis_AF2122/97 QRDVPRGILASLGVVTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAF
Rv3253c|M.tuberculosis_H37Rv QRDVPRGILASLGVVTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAF
MUL_2597|M.ulcerans_Agy99 QRDVPRGILVSLGVVTLLYVAVSIVLSGMVSYTQLRTVSGGGHANLATAF
MAV_4216|M.avium_104 QRDVPRGILASLGIVTLLYVAVAVVLSGMVSYTQLKTMPGRGQANLATAF
TH_0471|M.thermoresistible__bu QRDVARGIMATLGIVTVLYVAVSLVLTGMVHYTELRAAG--ENANLATAF
MAB_4090|M.abscessus_ATCC_1997 RRVAPRTILSAIVVSAIG---GALMILGALMAAPSLTDGQLATGGLPYVL
MMAR_0869|M.marinum_M ERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSSFPDADSLSEGVAR---
MLBr_01304|M.leprae_Br4923 KKIMPRAINSVIARIAIFYVGSVILLALLLPYSAFKASE----SPFVTFF
: .: : :
Mvan_1845|M.vanbaalenii_PYR-1 EAFGP-VGSKIILVIVLISFLSCAMSLQAAASRLAYSYGRDEMIMGSSLL
MSMEG_6701|M.smegmatis_MC2_155 EAFGP-IGSKVILVIVLLSFLSCAMSLQAAASRLAYSYGRDGMIMGSSLL
Mflv_0800|M.gilvum_PYR-GCK TALGA-GIAKPVQVMFVIGFLASFLALQTSASRVIWAYSRDGALPAAGTL
Mb3281c|M.bovis_AF2122/97 QANGVYWASGIISVGALAGLTTVVMVLMLGQCRVLFAMARDGLVP-----
Rv3253c|M.tuberculosis_H37Rv QANGVYWASGIISVGALAGLTTVVMVLMLGQCRVLFAMARDGLVP-----
MUL_2597|M.ulcerans_Agy99 KANGVYWASGIISVGALAGLTTVVMVLMLGQCRVLFAMARDGLLP-----
MAV_4216|M.avium_104 TANGIHWASKIISIGALAGLTTVVMVLMLGQCRVLFAMARDGLLP-----
TH_0471|M.thermoresistible__bu AANGIDWAAKVISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLP-----
MAB_4090|M.abscessus_ATCC_1997 DSKLASPFGTLLLIDVAIAVFVCTLAIQTAASRLMFSMARDGKLPFSAVL
MMAR_0869|M.marinum_M -TIGGNLFAAVFLAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLPR----
MLBr_01304|M.leprae_Br4923 SKVGFYGAGDLMNIVVLTAALSSLNAGLYATGRVMHSIAINGSGPK--FT
. . . . *: : . :
Mvan_1845|M.vanbaalenii_PYR-1 KKFSPTRHVPPYALLLAAVVPAVIIVGSKFSTDAITKIISFAALGIYIGF
MSMEG_6701|M.smegmatis_MC2_155 KKFSASRHVPPYALILAAIVPAMIIIGSKVSTDAITKIISFAAFGIYLGF
Mflv_0800|M.gilvum_PYR-GCK VQLRGKARIPVAAILVTTVIGAALFLLSIVAGDIYSLMVNFTAGGFYLAF
Mb3281c|M.bovis_AF2122/97 ---RQLAKTGSRGTPVRVTVLVAVLVATTASVFPITKLEEMVNVGTLFAF
Rv3253c|M.tuberculosis_H37Rv ---RQLAKTGSRGTPVRVTVLVAVLVATTASVFPITKLEEMVNVGTLFAF
MUL_2597|M.ulcerans_Agy99 ---RQLAKTGARGTPVRITVLVAVVVGATASVFPITKLEEMVNVGTLFAF
MAV_4216|M.avium_104 ---RALAKTGSRGTPVRITVLVALVVAVTASVFPITKLEEMVNVGTLFAF
TH_0471|M.thermoresistible__bu ---RPLSKTGPRGTPVRITVLVGALVAIAASVFPVGNLEEMVNIGTLFAF
MAB_4090|M.abscessus_ATCC_1997 SHVNPRTGTPIAPAVVVGVCCVLILAVNFGNAALFTSLCSVCIALIYLAY
MMAR_0869|M.marinum_M ---RVFGVVSAKFHTPMFNIMLTGAVGMAAILLSVATSTSFINFGAFTAF
MLBr_01304|M.leprae_Br4923 ARMSKXGVPYGGILLAAVICLCGVALNAFNPGQAFEIVLSVAALGIIAGW
.. .:
Mvan_1845|M.vanbaalenii_PYR-1 QMVVLAALRARL-------------KGWVPSGKYSLGKWGLA--VNIAAL
MSMEG_6701|M.smegmatis_MC2_155 QMVVLAALRARL-------------RGWVPSGKYTLGRWGVP--VNIAAL
Mflv_0800|M.gilvum_PYR-GCK LFPLIGFLVVLL-------------RKTWKPGSFSLRAATMP--VAAVAV
Mb3281c|M.bovis_AF2122/97 ILVSAGVVVLRR-------------TRPDLQRGFTAPWVPLLPIAAVCAC
Rv3253c|M.tuberculosis_H37Rv ILVSAGVVVLRR-------------TRPDLQRGFTAPWVPLLPIAAVCAC
MUL_2597|M.ulcerans_Agy99 VLVSAGVIVLRK-------------KRPDLERGFRAPWVPVLPIASLCAC
MAV_4216|M.avium_104 VLVSAGVMVLRR-------------TRPDLERGFKAPWVPVLPIASIGAC
TH_0471|M.thermoresistible__bu ALVSAGVIVLRR-------------TRPDLKRGFRVPFVPWLPLAAIAAC
MAB_4090|M.abscessus_ATCC_1997 LMVTTPLLLRRLGIGGSTWDANLGQTDADGRKLFSLGRCGLP--INILAV
MMAR_0869|M.marinum_M TLVNVSVVVYFVR---------------ERGAGLPRWRYLVLPVIGAAVD
MLBr_01304|M.leprae_Br4923 GTIVLCQLRLHK-------------MAKAGIMRRPRFRMPLAPYSGYLTL
: .
Mvan_1845|M.vanbaalenii_PYR-1 VYGVTAMINMAWPRTPDAPWY--DNWIVALSAAVVIGIGLVYMVVHPLHD
MSMEG_6701|M.smegmatis_MC2_155 VYGITAMVNMAWPRTPDAPWF--DNWIVALSAAVVVVTGLVYMAVHPLHD
Mflv_0800|M.gilvum_PYR-GCK VWAVLQFLNIAWPRVAFEQRY--LDWSVWIGVVVLGIIGAALYASVKSRI
Mb3281c|M.bovis_AF2122/97 LWLMLNLTALTWIR-----------FGIWLVAGTAIYVGYGRRHSAQGLR
Rv3253c|M.tuberculosis_H37Rv LWLMLNLTALTWIR-----------FGIWLVAGTAIYVGYGRRHSAQGLR
MUL_2597|M.ulcerans_Agy99 LWLMLNLTALTWIR-----------FGVWLLVGTVIYVGYGRKHSMVGRR
MAV_4216|M.avium_104 VWLMLNLTALTWVR-----------FGIWLVVGTAIYAGYGYWHSVQGRR
TH_0471|M.thermoresistible__bu LWLMLNLTGLTWVR-----------FLGWMALGLVLYFFYGRHHSMLGRG
MAB_4090|M.abscessus_ATCC_1997 GYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPICIIAVLLAGLVAYPRHT
MMAR_0869|M.marinum_M IYLLAHLASDALIVG-----------LSWAAIGFLYLLWLTRGLTRQPPD
MLBr_01304|M.leprae_Br4923 AFLFAVLVVMAFDKP----------IGTWTVASLIVIVPALIAGWYSIRK
: : :
Mvan_1845|M.vanbaalenii_PYR-1 KSTAPYADAIPTK---------------
MSMEG_6701|M.smegmatis_MC2_155 RSTAPYSDAIPTK---------------
Mflv_0800|M.gilvum_PYR-GCK VAPRDHDEPALADD--------------
Mb3281c|M.bovis_AF2122/97 QARESATRRC------------------
Rv3253c|M.tuberculosis_H37Rv QARESATRRC------------------
MUL_2597|M.ulcerans_Agy99 QLAEAAMDK-------------------
MAV_4216|M.avium_104 DAGEPDRSDALAADPNSPVP--------
TH_0471|M.thermoresistible__bu MTDISARRTG------------------
MAB_4090|M.abscessus_ATCC_1997 ASTTEETVR-------------------
MMAR_0869|M.marinum_M LAGAAERG--------------------
MLBr_01304|M.leprae_Br4923 RVMTIARERMGYTGPFPAIANPPVKSSD