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MPNDKLHVIHPLVVVGAGPVGLTAALAARHHQLPVLIVEAEPEDRTRPGSRATYLFQETLDLLESVADGV TAPITEQANNWESLRTTYSGRQIYFKRFPPCRPGKFGAAISQRESEQVLLKRCHEEGVQFRWKTSVTGVH TTSDRVTLTLDDGSRLHASYVIAADGARSAVRRALGIELDGDRSESSFVIVDVAEDPAAPLERTRSFHYR SPAVDGRNVLMVPFAGGWRIDLECRPDEDVRPWQEEPLLSQWVAAVAGPKYASRISWVSTYRFHRSVALS YTDDHARVLLTGEAAHLFPPFGGGRGLNSGVPDAIFGVEAIAKALSDPASARQIINAVATERRLAGIANR DAASSALVHMEARGRLLRLQQRLAALLARWFRRPGEWLDRAPMGPSRPVSARSRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4409 | - | - | 100% (405) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 3e-22 | 28.65% (377) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 6e-19 | 29.28% (321) | hypothetical protein Mvan_2422 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 2e-08 | 29.65% (172) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5009 | - | 2e-25 | 29.61% (385) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0561c | - | 2e-08 | 29.65% (172) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 3e-05 | 26.63% (169) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3775c | - | 3e-54 | 35.93% (398) | putative monooxygenase |
| M. marinum M | MMAR_4271 | - | 2e-21 | 31.17% (308) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 6e-20 | 28.07% (374) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_1699 | - | 3e-27 | 29.70% (394) | pentachlorophenol 4-monooxygenase |
| M. thermoresistible (build 8) | TH_4641 | - | 2e-23 | 28.22% (365) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0663 | - | 2e-07 | 28.40% (169) | FAD-linked oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4409|M.vanbaalenii_PYR-1 --------MPNDKLHVIHPLVVVGAGPVGLTAALAARHHQLPVLIVEAE-
MAB_3775c|M.abscessus_ATCC_199 MAHLAAVSADARRDITDDAVVIVGGGPVGLLAATVLARQGIRVVVLEAAG
Mflv_5009|M.gilvum_PYR-GCK -----------MPGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAA
TH_4641|M.thermoresistible__bu -----------MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAP
MSMEG_1699|M.smegmatis_MC2_155 -------------MTIATDVLIVGAGPVGLAAAMVLTQQGRDVTVVDGQA
MMAR_4271|M.marinum_M --------------MADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRV
MAV_2736|M.avium_104 ----MRGVRFSERSVRGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRA
Mb0576c|M.bovis_AF2122/97 -----------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTAT
Rv0561c|M.tuberculosis_H37Rv -----------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTAT
MUL_0663|M.ulcerans_Agy99 -------METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAG
MLBr_02276|M.leprae_Br4923 -----------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVC
:::.*.**.* * * :::
Mvan_4409|M.vanbaalenii_PYR-1 PEDRTRPGSRATYLFQETLDLLESVADGVTAPITEQANNWESLRTTYSGR
MAB_3775c|M.abscessus_ATCC_199 SKERQRHRNCATFVGHSTLRRYDRVAPGLGKRLRESALAVHGVQTFYQGR
Mflv_5009|M.gilvum_PYR-GCK GPATT---SRANFLHARGSEVLD--RMGALGTLPQESLRALRITNYLGDR
TH_4641|M.thermoresistible__bu APATT---SRANFLHARGSEVLD--RLGALGGLPERSVRAMQITTHLGGE
MSMEG_1699|M.smegmatis_MC2_155 EGANT---SRAAVVHARTLELLE--PYGVVDDLVNRGVHTPAFTIRDRDE
MMAR_4271|M.marinum_M SQDLVG--SRAGGLHSRTIEVLD--QRGIADRFLAQGTATQVAR------
MAV_2736|M.avium_104 DQQLIG--SRAGGLHARTLEILD--QRGIVDRFLAEGQVAQVAG------
Mb0576c|M.bovis_AF2122/97 FPRDKPCGDGLTPRAVAELHQLG-LGKWLADHIRHRGLRMSGFGG-----
Rv0561c|M.tuberculosis_H37Rv FPRDKPCGDGLTPRAVAELHQLG-LGKWLADHIRHRGLRMSGFGG-----
MUL_0663|M.ulcerans_Agy99 FPRDKACGDGLTPRAIAELQQLG-LGEWLAGRIQHRGLRMSGFGG-----
MLBr_02276|M.leprae_Br4923 FPRDKACGDGLTPRAVAELKRLG-LDDWLNTRIRHRGLRMSGFGG-----
. : .
Mvan_4409|M.vanbaalenii_PYR-1 QIYFK------RFP-PCRPGKFGAAISQRESEQVLLKRCHEEGVQFRWKT
MAB_3775c|M.abscessus_ATCC_199 PVFVMSSYAPSRIPGPWNPAAWGMSLSQRTIEDETLTEALELGVEYHPGT
Mflv_5009|M.gilvum_PYR-GCK PLATLEFGD----PGMRTAAP-PMVVSQAKVEAALRARLADLDVEPEWGR
TH_4641|M.thermoresistible__bu PVMRMQFGD----PGMRTAAP-PMVISQAEVEAALRNRLAELGGRVELDC
MSMEG_1699|M.smegmatis_MC2_155 LLVEVPFG------RLPTAYPYTLMISQADTEAFLLKRLEALGGKVIRPA
MMAR_4271|M.marinum_M -FAAIPLDI----SDFPTRHNYGLALWQNRIERILAEWVAELRVRIYRGC
MAV_2736|M.avium_104 -FAQIRLDI----SDFPTRHPYGLALWQNHIERILADWVGELGVPIYRGH
Mb0576c|M.bovis_AF2122/97 -EVEVDWPG-------PSFPSYGSAVARLELDDRIRKVAEDTGARMLLGA
Rv0561c|M.tuberculosis_H37Rv -EVEVDWPG-------PSFPSYGSAVARLELDDRIRKVAEDTGARMLLGA
MUL_0663|M.ulcerans_Agy99 -EVEIGWPG-------PSFPAYSSAVARLELDDRIRKVAEESGARMLLGT
MLBr_02276|M.leprae_Br4923 -EVEVDWPG-------PSFPSTSSAVPRLELDDRIRKVAENSGARMLLGT
: : :
Mvan_4409|M.vanbaalenii_PYR-1 SVTGVHTTSDR--VTLTLDDGSRLHASYVIAADGARSAVRRALGIELDGD
MAB_3775c|M.abscessus_ATCC_199 AVTDISTDHTG--ARLMLASGERVRASYVIAADGTKSAIRQALRIGMSER
Mflv_5009|M.gilvum_PYR-GCK KVIDVREDADG--VVADLADGARVRGQWLVGCDGTTSVVRRQTGIEFPGV
TH_4641|M.thermoresistible__bu PLTGLRQDAST--VTAGIGGGGELRGRWLVGCDGTGSSTRKSVGIGYPGA
MSMEG_1699|M.smegmatis_MC2_155 TVTSVTQHGTH--AMVTFEDGQRIRARYVVGADGMHSTVREAARIPFSGS
MMAR_4271|M.marinum_M EVTDITQDDNG--VDLTLSDGPPLRADYVVGCDGGRSLVRRAVGIDFPGW
MAV_2736|M.avium_104 RIATCTQDDTG--VDVVASDGRTLRGQYLVGCDGGRSVIRKAAGIDFPGW
Mb0576c|M.bovis_AF2122/97 KAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRE
Rv0561c|M.tuberculosis_H37Rv KAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRE
MUL_0663|M.ulcerans_Agy99 KAVAAHHDSSRRVVSLTLADRTEVACRQLIVADGARSSLGRKLGRRWHQE
MLBr_02276|M.leprae_Br4923 KAVSVYHDSSRRAASVTLADGTEVGCRQLIIADGARSPLGRKLGRSWHQK
. . : :: .** * .
Mvan_4409|M.vanbaalenii_PYR-1 RSESSFVIVDVAEDP-AAPLERTRSFHYRSPAVDGRNVLMVPFAGGWRID
MAB_3775c|M.abscessus_ATCC_199 PPSPSCVVIDVEPHPDGTTVDLPVQIQYHHPDLGGRHAIRLPYPDGLRLD
Mflv_5009|M.gilvum_PYR-GCK RLSERFLLADIHLDWAVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLF
TH_4641|M.thermoresistible__bu RLSERFLLADVYLDWRLDRSGTTGWIHPDGMVGAMPMP-----DGLWRII
MSMEG_1699|M.smegmatis_MC2_155 TYAESFVLADVRLSGGIPTKEVILYFSPAGLVVVAPLP-----DGIHRIV
MMAR_4271|M.marinum_M DPTTSSLIAEVEVAVGSESGPNLGEVRHDALGVHGFTRLPD--GGPLRVV
MAV_2736|M.avium_104 EATTSYLLAEAEMDWRTGQPPQWG-IHHDSLGVHALSETEP--AGGVRVL
Mb0576c|M.bovis_AF2122/97 TVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVN
Rv0561c|M.tuberculosis_H37Rv TVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVN
MUL_0663|M.ulcerans_Agy99 TVYGVAARGYLTTARSEDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVN
MLBr_02276|M.leprae_Br4923 TVYGVAARGYLTTPRSDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVN
. .:
Mvan_4409|M.vanbaalenii_PYR-1 LECRPDEDVRPWQEEPLLSQWVAAVAGPKY----ASRISWVSTYRFHRSV
MAB_3775c|M.abscessus_ATCC_199 VQFLP-KDEAPPTTEQVRSWVTALTRDQWY----ADHIRSVEVHQTIQGV
Mflv_5009|M.gilvum_PYR-GCK VYDPSLDRKPTDSEILDRISELVPYRTGRR--VKIGDAEWLSMFTVHRRL
TH_4641|M.thermoresistible__bu AYDPGPG--DLDQGALER---LLYERTGHR--VKVTGTVWQSEFRVHRRL
MSMEG_1699|M.smegmatis_MC2_155 ATVDAQQAQAHPDAAFVQG--LLDERGPHASPAAVRDVVWSSRFRVHHRV
MMAR_4271|M.marinum_M VTERQLDAGGEPSLGDLSAALTAVYGTDYG----IHSPTWISRFTDLTRQ
MAV_2736|M.avium_104 VTERQLRSAAEPNLDDLRQALIAVYRTDYG----IHSPRWISRFTDAARQ
Mb0576c|M.bovis_AF2122/97 IGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGG
Rv0561c|M.tuberculosis_H37Rv IGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGG
MUL_0663|M.ulcerans_Agy99 IGVGGLSTTKRPADLALRPLMSYYTDLRRDEWGFTGQPRAVASALLPMGG
MLBr_02276|M.leprae_Br4923 IGVGALSTSKRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGG
Mvan_4409|M.vanbaalenii_PYR-1 ALSYTDDHARVLLTGEAAHLFPPFGGGRGLNSGVPDAIFGVEAIAKALSD
MAB_3775c|M.abscessus_ATCC_199 AASYTDVNRRVLLAGEAAHQFAPLGG-RSLNSGVADAIVAAEAIAEALSE
Mflv_5009|M.gilvum_PYR-GCK ADTYRRG--RVLIAGDAAHVHAPFGG-QGMLTGIGDAENVGFKLALVVRG
TH_4641|M.thermoresistible__bu ADTYRRG--RVFIAGDAAHAHAPFGG-QGMLTGLGDAENLAFKLALVIRG
MSMEG_1699|M.smegmatis_MC2_155 ADTFRAN--RILLAGDAAHVHSPAGG-QGMNLGIEDAVMLAGALSEVLDG
MMAR_4271|M.marinum_M AATYRQG--RVLIAGDAAHVHDPVGG-QGLNTGVQDAVNLGWKLAQVVNR
MAV_2736|M.avium_104 AARYRDR--RVLLAGDAAHIHHPVGG-QGLNTGVQDAVNLGWKLALVVGG
Mb0576c|M.bovis_AF2122/97 AVSGVAG-SNWMLIGDAAACVNPLNG-----EGIDYGLETGRLAAELLDS
Rv0561c|M.tuberculosis_H37Rv AVSGVAG-SNWMLIGDAAACVNPLNG-----EGIDYGLETGRLAAELLDS
MUL_0663|M.ulcerans_Agy99 AVSGVAG-PNWMLIGDAAACVNPLNG-----EGIDYGLDTGRLAAELLDS
MLBr_02276|M.leprae_Br4923 AVSGVAG-PNWMLIGDAAACVNPLNG-----EGIDYGLETGRLAAELLDL
* . :: *:** * .* *: . : :
Mvan_4409|M.vanbaalenii_PYR-1 P---ASARQIINAVATERRLAGIANRDAASSALVHMEARGRLLRLQQRLA
MAB_3775c|M.abscessus_ATCC_199 PSDLAAAWLAINRSARERRRSGVRNRMLSVRAQRVLDGSDVSMRARRTMA
Mflv_5009|M.gilvum_PYR-GCK L----AADDLLDTYEAERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRV
TH_4641|M.thermoresistible__bu Y----AGPALLDTYEAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRV
MSMEG_1699|M.smegmatis_MC2_155 -----APDTALDDYAADRRRTAQKIVAATGRLTDLATAS-ARKRPLRNRI
MMAR_4271|M.marinum_M R----SPESLLDTYHAERHPVAARVLRTTMAQVALRRLD-YRKKALSDTI
MAV_2736|M.avium_104 A----SPPALLDTYHAERHPVGERVLRNAIAQMALLRPD-ERTRALRDLV
Mb0576c|M.bovis_AF2122/97 R----DLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRST
Rv0561c|M.tuberculosis_H37Rv R----DLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRST
MUL_0663|M.ulcerans_Agy99 P----DLSQLWPSLLQAHYGRGFSVARRLALLLTYQRFLPTTGPVAMRST
MLBr_02276|M.leprae_Br4923 R----DLSYVWPSLLQQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRST
: .
Mvan_4409|M.vanbaalenii_PYR-1 ALLARWFRRPGEWLDRAPMGP-SRPVSA------------RSRF------
MAB_3775c|M.abscessus_ATCC_199 AKSAPHVWIAGAWLTAGLVRPTAIPHIS------------RSGVTWS---
Mflv_5009|M.gilvum_PYR-GCK APRVFGLPAVQRWTTYTASQLWVSYRNGPLGGR---GSKPRPGDRIDDAP
TH_4641|M.thermoresistible__bu VLPLLALPSVQRRLTYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQR
MSMEG_1699|M.smegmatis_MC2_155 MRAAGSLPAVRRALAWRLSGLDRR--------------------------
MMAR_4271|M.marinum_M S-ELLMMDEPRKRFAAMMSGLDIRYHLG--------GGHPLLGRRMPDLD
MAV_2736|M.avium_104 T-ELLGMDEPRKRFAAMISGLDVRYDLG--------PGHPLLGRRMPDLD
Mb0576c|M.bovis_AF2122/97 ALMNIAVRVMSNLVTDDDRDWVARVWRGG-------GQLSRLVDRRPPFS
Rv0561c|M.tuberculosis_H37Rv ALMNIAVRVMSNLVTDDDRDWVARVWRGG-------GQLSRLVDRRPPFS
MUL_0663|M.ulcerans_Agy99 ALMKVAMRVMANLVTEEDSDWVARLWRGG-------GRASRLIDRRPPFH
MLBr_02276|M.leprae_Br4923 SLITIAVRVMANLVTDDDADWVARVWRSG-------GWASWLVDRRPPFS
.
Mvan_4409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3775c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK CSRPDGTATRLHGELGGRWALLLP-RGVPAVGAAAVRGPAG-YLADHVVT
TH_4641|M.thermoresistible__bu CVRDDGHISRLYEQLGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVG
MSMEG_1699|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4271|M.marinum_M LTTADG-PRRVFTHLHAARPVLLNLAEPGRFDIAGWRHRVLLIDAKYVGV
MAV_2736|M.avium_104 LVTADG-ASRVFALLRNARPVLLNFAGAGRRSVAGWADRVRVVDAKCVAD
Mb0576c|M.bovis_AF2122/97 --------------------------------------------------
Rv0561c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0663|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mvan_4409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3775c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK LHH---DRD---DVMLVRPDAHLAWRGAHDDPTGLDRWLATALHPGGTQ-
TH_4641|M.thermoresistible__bu LRG---AEMRGCDAFLVRPDGHLAWRGR--DATDLADWLKSALTVGRVR-
MSMEG_1699|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4271|M.marinum_M WELPVLGAIAAPAAALIRPDGYVAWVGDDLTDRGLFDALTAWFGRPAVPS
MAV_2736|M.avium_104 WELPVLGRVSAPPAVLIRPDGHVAWAGD-PNDPGLHDALTTWCGPPAAGG
Mb0576c|M.bovis_AF2122/97 --------------------------------------------------
Rv0561c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0663|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mvan_4409|M.vanbaalenii_PYR-1 --------
MAB_3775c|M.abscessus_ATCC_199 --------
Mflv_5009|M.gilvum_PYR-GCK --------
TH_4641|M.thermoresistible__bu --------
MSMEG_1699|M.smegmatis_MC2_155 --------
MMAR_4271|M.marinum_M PRLRASAP
MAV_2736|M.avium_104 --------
Mb0576c|M.bovis_AF2122/97 --------
Rv0561c|M.tuberculosis_H37Rv --------
MUL_0663|M.ulcerans_Agy99 --------
MLBr_02276|M.leprae_Br4923 --------