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TDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPATTSRANFLHARGSEVLGRIGALGTLPDESLRA MRITNYLGDRPLVTLEFGDPRMRTAAPPMVISQAKVEASLRSRLADLGAEPQWGNGLAALHRNDDTVVAE LDDGTSVEARWLVGCDGTASTTRKLAGIGFPGVKLTERWLLADLHLDWDLDRGGTTGWIHPGGLLGAMPM PDSSGAHDLWRVFAYDPGHTEKPAESEILERMRQVIPQRSGRRVHVGDPEWLSVFTVHRRLADRYRQGRI LIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDTYEAERRPLATEVLRGTSAVTRVN IAGNPVGRFLRDRVAPKVFGLAPVQRWTTYTASQLWVSYRKGPLGGRGPKPRAGDRIPDVACVRPDGTPS LLHRELSGRWALLAPPDAPAGCADVARRHLGDFVEPLTFDGDEAMLIRPDGHLAWRGDAGDADGVNLWLT RALTTGNAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | - | 100% (500) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 1e-40 | 32.93% (495) | hypothetical protein Mvan_2422 |
| M. vanbaalenii PYR-1 | Mvan_4245 | mhpA | 1e-34 | 33.60% (375) | 3-(3-hydroxyphenyl)propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 2e-07 | 28.49% (179) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5009 | - | 0.0 | 70.20% (500) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0561c | - | 2e-07 | 28.49% (179) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 2e-06 | 26.91% (223) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3483 | - | 1e-50 | 33.07% (505) | hypothetical protein MAB_3483 |
| M. marinum M | MMAR_4271 | - | 5e-47 | 32.29% (511) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 6e-54 | 34.27% (499) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_1499 | - | 0.0 | 72.55% (499) | oxygenase |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-162 | 59.02% (510) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_2358 | - | 4e-11 | 26.09% (368) | FAD-dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5009|M.gilvum_PYR-GCK -------MPGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPAT
MSMEG_1499|M.smegmatis_MC2_155 --------MAATDCDVIVVGAGPTGLTLACSLRLHGLSVRVLDRAAGPAT
Mvan_0779|M.vanbaalenii_PYR-1 ----------MTDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPAT
TH_4641|M.thermoresistible__bu -------MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPAT
MMAR_4271|M.marinum_M ----------MADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDL
MAV_2736|M.avium_104 MRGVRFSERSVRGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQL
MAB_3483|M.abscessus_ATCC_1997 ----------MTEHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHEL
Mb0576c|M.bovis_AF2122/97 -------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRD
Rv0561c|M.tuberculosis_H37Rv -------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRD
MLBr_02276|M.leprae_Br4923 -------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRD
MUL_2358|M.ulcerans_Agy99 -------------MRVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPN
* : *.* .* * * * .::
Mflv_5009|M.gilvum_PYR-GCK T-SRANFLHARGSEVLDRMGALGTLPQESLRALRI-TNYLGDRPLATLEF
MSMEG_1499|M.smegmatis_MC2_155 T-SRANFLHARGSEVLNRIGALGTLPDESLRAMRI-TNYLGDRPVMTLTF
Mvan_0779|M.vanbaalenii_PYR-1 T-SRANFLHARGSEVLGRIGALGTLPDESLRAMRI-TNYLGDRPLVTLEF
TH_4641|M.thermoresistible__bu T-SRANFLHARGSEVLDRLGALGGLPERSVRAMQI-TTHLGGEPVMRMQF
MMAR_4271|M.marinum_M VGSRAGGLHSRTIEVLDQRGIADRFLAQGTATQ------VARFAAIPLDI
MAV_2736|M.avium_104 IGSRAGGLHARTLEILDQRGIVDRFLAEGQVAQ------VAGFAQIRLDI
MAB_3483|M.abscessus_ATCC_1997 DGSRAAGMTSRTLEVLDQRGILDRFTPQGFSAP------VAHFSALLLDM
Mb0576c|M.bovis_AF2122/97 K-PCGDGLTPRAVAELHQLGLGKWLADHIRHRG---LRMSGFGGEVEVDW
Rv0561c|M.tuberculosis_H37Rv K-PCGDGLTPRAVAELHQLGLGKWLADHIRHRG---LRMSGFGGEVEVDW
MLBr_02276|M.leprae_Br4923 K-ACGDGLTPRAVAELKRLGLDDWLNTRIRHRG---LRMSGFGGEVEVDW
MUL_2358|M.ulcerans_Agy99 Q-GAMIDLFGAGYEAADAIGILDAIRDVSYPIGDTGLVDELGRRRAGLPY
: * : :
Mflv_5009|M.gilvum_PYR-GCK GDPGMRTAAPPMVVSQAKVEAALRARLADLDVEPEWGRKVIDVREDADG-
MSMEG_1499|M.smegmatis_MC2_155 GDPGMRTAAPPMVVSQARVEAALRARLAQLGVEPEWGRKVAGVRQAGDR-
Mvan_0779|M.vanbaalenii_PYR-1 GDPRMRTAAPPMVISQAKVEASLRSRLADLGAEPQWGNGLAALHRNDDT-
TH_4641|M.thermoresistible__bu GDPGMRTAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAST-
MMAR_4271|M.marinum_M SDFPTRHNYG-LALWQNRIERILAEWVAELRVRIYRGCEVTDITQDDNG-
MAV_2736|M.avium_104 SDFPTRHPYG-LALWQNHIERILADWVGELGVPIYRGHRIATCTQDDTG-
MAB_3483|M.abscessus_ATCC_1997 TDQPTRHTFG-LALLQYRIERTLSEWVGEHGVPIYRGREVTGFTSSDDA-
Mb0576c|M.bovis_AF2122/97 PGPSFPSYGS--AVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRR
Rv0561c|M.tuberculosis_H37Rv PGPSFPSYGS--AVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRR
MLBr_02276|M.leprae_Br4923 PGPSFPSTSS--AVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRR
MUL_2358|M.ulcerans_Agy99 GRIAKALEDRLCRITRTDLHKVLLDNLP-TNVDLRFGTSVSEVTHGDDR-
: : :. : .
Mflv_5009|M.gilvum_PYR-GCK -VVADLADGARVRGQWLVGCDGTTSVVR-RQTGIEFPGVRLSERFLLADI
MSMEG_1499|M.smegmatis_MC2_155 -VVADLADGAQVSGQWLVGCDGTSSATR-EQVGIPFPGVKLSERFLLADI
Mvan_0779|M.vanbaalenii_PYR-1 -VVAELDDGTSVEARWLVGCDGTASTTR-KLAGIGFPGVKLTERWLLADL
TH_4641|M.thermoresistible__bu -VTAGIGGGGELRGRWLVGCDGTGSSTR-KSVGIGYPGARLSERFLLADV
MMAR_4271|M.marinum_M -VDLTLSDGPPLRADYVVGCDGGRSLVR-RAVGIDFPGWDPTTSSLIAEV
MAV_2736|M.avium_104 -VDVVASDGRTLRGQYLVGCDGGRSVIR-KAAGIDFPGWEATTSYLLAEA
MAB_3483|M.abscessus_ATCC_1997 -VRVELSDGSTLRAQYLVGCDGGRSLTR-KIAGIDFPGWDPSTSCLVADV
Mb0576c|M.bovis_AF2122/97 VVSLTLADGTEVGCRQLIVADGARSPLG-RKLGRRWHRETVYGVAVRGYL
Rv0561c|M.tuberculosis_H37Rv VVSLTLADGTEVGCRQLIVADGARSPLG-RKLGRRWHRETVYGVAVRGYL
MLBr_02276|M.leprae_Br4923 AASVTLADGTEVGCRQLIIADGARSPLG-RKLGRSWHQKTVYGVAARGYL
MUL_2358|M.ulcerans_Agy99 -AVVTLDDGARLDVDLLVGADGIHSTVRALAFGAEVQYLRYLGFHFAAFV
. .* : :: .** * * .
Mflv_5009|M.gilvum_PYR-GCK HLDWAVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDPSLDRKPT
MSMEG_1499|M.smegmatis_MC2_155 HLDWAVDRGGTTGWIHPDGVVGAMPMPSGDGRNDLWRLFVYDPALNRKPS
Mvan_0779|M.vanbaalenii_PYR-1 HLDWDLDRGGTTGWIHPGGLLGAMPMPDSSGAHDLWRVFAYDPGHTEKPA
TH_4641|M.thermoresistible__bu YLDWRLDRSGTTGWIHPDGMVGAMPMPDG-----LWRIIAYDPGPGDLDQ
MMAR_4271|M.marinum_M EVAVGSESGPNLGEVRHDALGVHGFTRLPDG--GPLRVVVTERQLDAGGE
MAV_2736|M.avium_104 EMDWRTGQPPQWG-IHHDSLGVHALSETEPA--GGVRVLVTERQLRSAAE
MAB_3483|M.abscessus_ATCC_1997 QMTEE----PEWGIHRQGAL--HSIFKFEED--GPVRVLVTEAQLGRREE
Mb0576c|M.bovis_AF2122/97 STAYS----------DDPWLTSHLELRSPDGAVLPGYGWIFPLGNGE---
Rv0561c|M.tuberculosis_H37Rv STAYS----------DDPWLTSHLELRSPDGAVLPGYGWIFPLGNGE---
MLBr_02276|M.leprae_Br4923 TTPRS----------DDLWLTSHLELRSPDGAVLPGYGWIFPLGNGE---
MUL_2358|M.ulcerans_Agy99 FDASDMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEPPPD
:
Mflv_5009|M.gilvum_PYR-GCK DSEILDRISELVPYRTGRRVKIGDAEWLSMFTVHRRLADT-YRRGRVLIA
MSMEG_1499|M.smegmatis_MC2_155 DSEILQRIEQIVPYRTGRAITIGQPEWLSMFTVHRRLAQS-YRRGRVLIA
Mvan_0779|M.vanbaalenii_PYR-1 ESEILERMRQVIPQRSGRRVHVGDPEWLSVFTVHRRLADR-YRQGRILIA
TH_4641|M.thermoresistible__bu G-----ALERLLYERTGHRVKVTGTVWQSEFRVHRRLADT-YRRGRVFIA
MMAR_4271|M.marinum_M PS--LGDLSAALTAVYGTDYGIHSPTWISRFTDLTRQAAT-YRQGRVLIA
MAV_2736|M.avium_104 PN--LDDLRQALIAVYRTDYGIHSPRWISRFTDAARQAAR-YRDRRVLLA
MAB_3483|M.abscessus_ATCC_1997 PT--LRDLSEALLSARGTDYGIHSPTWISRFTDVTRQAAT-YRKGRVLLA
Mb0576c|M.bovis_AF2122/97 -----VNIGVGALSTSRRPADLALRPLISYYTDLRRDEWG-FTGQ----P
Rv0561c|M.tuberculosis_H37Rv -----VNIGVGALSTSRRPADLALRPLISYYTDLRRDEWG-FTGQ----P
MLBr_02276|M.leprae_Br4923 -----VNIGVGALSTSKRPADLALRSLISYYTDLRRHEWG-FSGQ----P
MUL_2358|M.ulcerans_Agy99 ARAALRDRFAGMGWLVPEVLERCPPSGDIYFGQVAQVEMPRWSTNRVVLV
: : :
Mflv_5009|M.gilvum_PYR-GCK GDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYEAERR
MSMEG_1499|M.smegmatis_MC2_155 GDAAHAHAPFGGQGMLTGIGDAENLAFKLALVIRGLAADALIDTYEAERR
Mvan_0779|M.vanbaalenii_PYR-1 GDAAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDTYEAERR
TH_4641|M.thermoresistible__bu GDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRGYAGPALLDTYEAERR
MMAR_4271|M.marinum_M GDAAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRRSPESLLDTYHAERH
MAV_2736|M.avium_104 GDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTYHAERH
MAB_3483|M.abscessus_ATCC_1997 GDAAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGTSPENLLDTYHAERH
Mb0576c|M.bovis_AF2122/97 RAVSSALLPMGG--AVSGVAGSNWMLIGDAAACVNPLNGEGID-YGLETG
Rv0561c|M.tuberculosis_H37Rv RAVSSALLPMGG--AVSGVAGSNWMLIGDAAACVNPLNGEGID-YGLETG
MLBr_02276|M.leprae_Br4923 RAVSSALLPMGG--AVSGVAGPNWMLIGDAAACVNPLNGEGID-YGLETG
MUL_2358|M.ulcerans_Agy99 GDACSAGSPLTGPGASLALAGAYVLSEQLRRTS---SVERALDFYERLWS
.. *. * .: .. : . :* *
Mflv_5009|M.gilvum_PYR-GCK PLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTYTAS
MSMEG_1499|M.smegmatis_MC2_155 FLATEVLRGTSAITRVNVASNPVGRFLRDRVATRIFGLPVVQRWTTYTAS
Mvan_0779|M.vanbaalenii_PYR-1 PLATEVLRGTSAVTRVNIAGNPVGRFLRDRVAPKVFGLAPVQRWTTYTAS
TH_4641|M.thermoresistible__bu PLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRLTYQTS
MMAR_4271|M.marinum_M PVAARVLRTTMAQVALRRLDYRKKALS--DTISELLMMDEPRKRFAAMMS
MAV_2736|M.avium_104 PVGERVLRNAIAQMALLRPDERTRALR--DLVTELLGMDEPRKRFAAMIS
MAB_3483|M.abscessus_ATCC_1997 PVAARVLHNTMAQTALIRPGERVDALR--DIMSDLLTLDMPRRRIAAMMS
Mb0576c|M.bovis_AF2122/97 RLAAELLDSRDLAR----------------LWPSLLADRYGRGFSVARRL
Rv0561c|M.tuberculosis_H37Rv RLAAELLDSRDLAR----------------LWPSLLADRYGRGFSVARRL
MLBr_02276|M.leprae_Br4923 RLAAELLDLRDLSY----------------VWPSLLQQHYGRGFSVARRL
MUL_2358|M.ulcerans_Agy99 PTVEEKQESARGLR--------------LDAVAVVLTALDSPRRAALHLA
. :: .
Mflv_5009|M.gilvum_PYR-GCK QLWVSYRNGPLGGRGS---KPRPGDRIDDAPCSRPDGTATRLHGELGGRW
MSMEG_1499|M.smegmatis_MC2_155 QLWVSYRKGPLGGHGR---RPRLGDRIGDRPCTRADGAATRLHSELAGRW
Mvan_0779|M.vanbaalenii_PYR-1 QLWVSYRKGPLGGRGP---KPRAGDRIPDVACVRPDGTPSLLHRELSGRW
TH_4641|M.thermoresistible__bu QLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQLGGRW
MMAR_4271|M.marinum_M GLDIRYHLGGG--------HPLLGRRMPDLDLTTADGPRRVFTHLHAARP
MAV_2736|M.avium_104 GLDVRYDLGPG--------HPLLGRRMPDLDLVTADGASRVFALLRNARP
MAB_3483|M.abscessus_ATCC_1997 GLDIHYDLGPG--------HPLLGRRMPDLEVRTAQGPRCVFTLLREGRG
Mb0576c|M.bovis_AF2122/97 ALLLTFP-----------------------RFLPTTGPITMRSTALMN--
Rv0561c|M.tuberculosis_H37Rv ALLLTFP-----------------------RFLPTTGPITMRSTALMN--
MLBr_02276|M.leprae_Br4923 ALLLTFK-----------------------RCLPAIGPSAMRSTSLIT--
MUL_2358|M.ulcerans_Agy99 PADQPIR-------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK ALLLPRG--VPAVG------AAAVRGPAGYLADHVVTLH---HDRDDVML
MSMEG_1499|M.smegmatis_MC2_155 ALLWPRD--APAPG------ASLLAR----LGDFGVTLR---HDGAEAML
Mvan_0779|M.vanbaalenii_PYR-1 ALLAPPD--APAGC------ADVARR---HLGDFVEPLT---FDGDEAML
TH_4641|M.thermoresistible__bu AVLEPGSGRHHREG------PGLLGTAHTFLGEYVVGLRGAEMRGCDAFL
MMAR_4271|M.marinum_M VLLNLAEPGRFDIAGWRHRVLLIDAKYV---GVWELPVLG-AIAAPAAAL
MAV_2736|M.avium_104 VLLNFAGAGRRSVAGWADRVRVVDAKCV---ADWELPVLG-RVSAPPAVL
MAB_3483|M.abscessus_ATCC_1997 VLLNLGTP-ITGASGWSHRVDVVEAEYLDAEGTFELPVIG-MVEAPHAVL
Mb0576c|M.bovis_AF2122/97 ------------------------------------------IAVRVMSN
Rv0561c|M.tuberculosis_H37Rv ------------------------------------------IAVRVMSN
MLBr_02276|M.leprae_Br4923 ------------------------------------------IAVRVMAN
MUL_2358|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK VRPDAHLAWRGAHDDPTGLDRWLATALHPGGTQ---------
MSMEG_1499|M.smegmatis_MC2_155 IRPDAHLAWRGAPDDTAGLDHWLAKALGSGAVR---------
Mvan_0779|M.vanbaalenii_PYR-1 IRPDGHLAWRGDAGDADGVNLWLTRALTTGNAR---------
TH_4641|M.thermoresistible__bu VRPDGHLAWRGR--DATDLADWLKSALTVGRVR---------
MMAR_4271|M.marinum_M IRPDGYVAWVGDDLTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 IRPDGHVAWAGD-PNDPGLHDALTTWCGPPAAGG--------
MAB_3483|M.abscessus_ATCC_1997 IRPDGYVAWVGN-GTTAGLNGALQRWFGPPRYSGGGS-----
Mb0576c|M.bovis_AF2122/97 LVTDDDRDWVARVWRGGGQLSRLVDRRPPFS-----------
Rv0561c|M.tuberculosis_H37Rv LVTDDDRDWVARVWRGGGQLSRLVDRRPPFS-----------
MLBr_02276|M.leprae_Br4923 LVTDDDADWVARVWRSGGWASWLVDRRPPFS-----------
MUL_2358|M.ulcerans_Agy99 ------------------------------------------