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AHLAAVSADARRDITDDAVVIVGGGPVGLLAATVLARQGIRVVVLEAAGSKERQRHRNCATFVGHSTLRR YDRVAPGLGKRLRESALAVHGVQTFYQGRPVFVMSSYAPSRIPGPWNPAAWGMSLSQRTIEDETLTEALE LGVEYHPGTAVTDISTDHTGARLMLASGERVRASYVIAADGTKSAIRQALRIGMSERPPSPSCVVIDVEP HPDGTTVDLPVQIQYHHPDLGGRHAIRLPYPDGLRLDVQFLPKDEAPPTTEQVRSWVTALTRDQWYADHI RSVEVHQTIQGVAASYTDVNRRVLLAGEAAHQFAPLGGRSLNSGVADAIVAAEAIAEALSEPSDLAAAWL AINRSARERRRSGVRNRMLSVRAQRVLDGSDVSMRARRTMAAKSAPHVWIAGAWLTAGLVRPTAIPHISR SGVTWS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3775c | - | - | 100% (427) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_0857 | - | 2e-21 | 28.30% (318) | hypothetical protein MAB_0857 |
| M. abscessus ATCC 19977 | MAB_3483 | - | 1e-18 | 28.87% (336) | hypothetical protein MAB_3483 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_5009 | - | 2e-18 | 29.60% (321) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_02276 | - | 9e-08 | 23.86% (415) | putative FAD-linked oxidoreductase |
| M. marinum M | MMAR_4271 | - | 7e-23 | 29.31% (331) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 3e-20 | 28.70% (324) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_1699 | - | 6e-23 | 29.37% (412) | pentachlorophenol 4-monooxygenase |
| M. thermoresistible (build 8) | TH_1880 | - | 9e-17 | 27.58% (330) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_0979 | - | 1e-10 | 26.84% (354) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4409 | - | 3e-54 | 35.93% (398) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3775c|M.abscessus_ATCC_199 MAHLAAVSADARRDITDDAVVIVGGGPVGLLAATVLARQGIRVVVLEAAG
Mvan_4409|M.vanbaalenii_PYR-1 --------MPNDKLHVIHPLVVVGAGPVGLTAALAARHHQLPVLIVEAE-
Mflv_5009|M.gilvum_PYR-GCK -----------MPGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDA--
MSMEG_1699|M.smegmatis_MC2_155 -------------MTIATDVLIVGAGPVGLAAAMVLTQQGRDVTVVDG--
MMAR_4271|M.marinum_M --------------MADHAVVVVGAGPTGLMLAGELALAGVDVAVVERR-
MAV_2736|M.avium_104 ----MRGVRFSERSVRGHAVLVAGAGPTGLMLAGELGLAGVDVALVERR-
TH_1880|M.thermoresistible__bu ----------------VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEK--
MUL_0979|M.ulcerans_Agy99 ------------MTTYDTDVLVVGGGPGGLATALNARKRGLSVIVADPR-
MLBr_02276|M.leprae_Br4923 -----------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDS--
:::.*.** * * * : :
MAB_3775c|M.abscessus_ATCC_199 SKERQRHRNCATFVGHSTLRRYDRV--APGLGKRLRESALAVHGVQTFYQ
Mvan_4409|M.vanbaalenii_PYR-1 PEDRTRPGSRATYLFQETLDLLESV--ADGVTAPITEQANNWESLRTTYS
Mflv_5009|M.gilvum_PYR-GCK -AAGPATTSRANFLHARGSEVLD----RMGALGTLPQESLRALRITNYLG
MSMEG_1699|M.smegmatis_MC2_155 -QAEGANTSRAAVVHARTLELLE----PYGVVDDLVNRGVHTPAFTIRDR
MMAR_4271|M.marinum_M -VSQDLVGSRAGGLHSRTIEVLD----QRGIADRFLAQGTATQVAR----
MAV_2736|M.avium_104 -ADQQLIGSRAGGLHARTLEILD----QRGIVDRFLAEGQVAQVAG----
TH_1880|M.thermoresistible__bu -NSEPPAHVRSLGLHVRSIEMLD----QRGLLDRFLAHGQRHPVGGF---
MUL_0979|M.ulcerans_Agy99 --ESPIDKACGEGLMPGGLAELKSL--DVDPAG-VPFQGIAYVSQQ----
MLBr_02276|M.leprae_Br4923 -VCFPRDKACGDGLTPRAVAELKRLGLDDWLNTRIRHRGLRMSGFG----
. : . . .
MAB_3775c|M.abscessus_ATCC_199 GRPVFVMSSYAPSRIPGPWNPAAWGMSLSQRTIEDETLTEALELGVEYHP
Mvan_4409|M.vanbaalenii_PYR-1 GRQIYFK------RFP-PCRPGKFGAAISQRESEQVLLKRCHEEGVQFRW
Mflv_5009|M.gilvum_PYR-GCK DR----PLATLEFGDPGMRTAAP-PMVVSQAKVEAALRARLADLDVEPEW
MSMEG_1699|M.smegmatis_MC2_155 DE----LLVEVPFG--RLPTAYPYTLMISQADTEAFLLKRLEALGGKVIR
MMAR_4271|M.marinum_M -------FAAIPLDISDFPTRHNYGLALWQNRIERILAEWVAELRVRIYR
MAV_2736|M.avium_104 -------FAQIRLDISDFPTRHPYGLALWQNHIERILADWVGELGVPIYR
TH_1880|M.thermoresistible__bu -------FAAIAKPPAELDTAHGYVLGIRQPVTDRLLAEWAAERGAVIRR
MUL_0979|M.ulcerans_Agy99 -------------RRAEARFRTGPGRGVRRTTVHATLAARAKEQDAEWIR
MLBr_02276|M.leprae_Br4923 --------GEVEVDWPGPSFPST-SSAVPRLELDDRIRKVAENSGARMLL
: : .
MAB_3775c|M.abscessus_ATCC_199 GTAVTDISTDHT--GARLMLASGERVRASYVIAADGTKSAIRQALRIGMS
Mvan_4409|M.vanbaalenii_PYR-1 KTSVTGVHTTSD--RVTLTLDDGSRLHASYVIAADGARSAVRRALGIELD
Mflv_5009|M.gilvum_PYR-GCK GRKVIDVREDAD--GVVADLADGARVRGQWLVGCDGTTSVVRRQTGIEFP
MSMEG_1699|M.smegmatis_MC2_155 PATVTSVTQHGT--HAMVTFEDGQRIRARYVVGADGMHSTVREAARIPFS
MMAR_4271|M.marinum_M GCEVTDITQDDN--GVDLTLSDGPPLRADYVVGCDGGRSLVRRAVGIDFP
MAV_2736|M.avium_104 GHRIATCTQDDT--GVDVVASDGRTLRGQYLVGCDGGRSVIRKAAGIDFP
TH_1880|M.thermoresistible__bu GCAVVGLDQDAA--GITVELADGSVQRARYLVGCDGGRSTVRKLAGIGFP
MUL_0979|M.ulcerans_Agy99 -TRVTDVVQDAH--GVTAAG-----VRAKWLVAADGLHSAVRRAVGITAT
MLBr_02276|M.leprae_Br4923 GTKAVSVYHDSSRRAASVTLADGTEVGCRQLIIADGARSPLGRKLGRSWH
:: .** * : .
MAB_3775c|M.abscessus_ATCC_199 ERPPSPSCVVIDVEPHPDGTTVDLP------VQIQYHHPDLGGRHAIRLP
Mvan_4409|M.vanbaalenii_PYR-1 GDRSESSFVIVDVAEDP-AAPLERT------RSFHYRSPAVDGRNVLMVP
Mflv_5009|M.gilvum_PYR-GCK GVRLSERFLLADIHLDWAVDRAGT-------TGWIHPDGVVGAMPMPSTD
MSMEG_1699|M.smegmatis_MC2_155 GSTYAESFVLADVRLSGGIPTKEV-------ILYFSPAGLVVVAPLPDGI
MMAR_4271|M.marinum_M GWDPTTSSLIAEVEVAVG-SESGP-------NLGEVRHDALGVHGFTRLP
MAV_2736|M.avium_104 GWEATTSYLLAEAEMDWR-TGQPP-------QWG-IHHDSLGVHALSETE
TH_1880|M.thermoresistible__bu GEPARSETLLGEMSLSADPATVAA-------VVAEVRKTQLRFGAMPLG-
MUL_0979|M.ulcerans_Agy99 AGTPRRYGVRRHYRVPAWSEFVEVHWSPWGEAYVTPVEPDLVGVAILSRQ
MLBr_02276|M.leprae_Br4923 QKTVYGVAARGYLTTPRSDDLWLTS------HLELRSPDGAVLPGYGWIF
MAB_3775c|M.abscessus_ATCC_199 YPDGLRLDVQFLP-KDEAP---PTTEQVRSWVTALTRDQWYAD--HIRSV
Mvan_4409|M.vanbaalenii_PYR-1 FAGGWRIDLECRPDEDVRP---WQEEPLLSQWVAAVAGPKYAS--RISWV
Mflv_5009|M.gilvum_PYR-GCK GRDDLWRLFVYDPSLDRKPTDSEILDRISELVPYRTGRRVKIG--DAEWL
MSMEG_1699|M.smegmatis_MC2_155 HR---IVATVDAQQAQAHPDAAFVQGLLDERGPHAS--PAAVR--DVVWS
MMAR_4271|M.marinum_M DGGPLRVVVTERQLDAG---GEPSLGDLSAALTAVYGTDYGIH--SPTWI
MAV_2736|M.avium_104 PAGGVRVLVTERQLRSA---AEPNLDDLRQALIAVYRTDYGIH--SPRWI
TH_1880|M.thermoresistible__bu -DGVYRVIVPAEGVAGDR--AEPTLDEFRRRLKAFAGTDFGAH--TPRWL
MUL_0979|M.ulcerans_Agy99 RPEIDWFPWLAQQLRGASPGAARGCGPLRQVVSRRVAGRVLLVGDAAGYE
MLBr_02276|M.leprae_Br4923 PLGNGEVNIGVGALSTSKRPADLALRSLISYYTDLRRHEWGFSGQPRAVS
.
MAB_3775c|M.abscessus_ATCC_199 EVHQ-TIQGVAASYTDVNRRVLLAGEAAHQFAPLGG-RSLNSGVADAIVA
Mvan_4409|M.vanbaalenii_PYR-1 STYR-FHRSVALSYTDDHARVLLTGEAAHLFPPFGGGRGLNSGVPDAIFG
Mflv_5009|M.gilvum_PYR-GCK SMFT-VHRRLADTYRRG--RVLIAGDAAHVHAPFGG-QGMLTGIGDAENV
MSMEG_1699|M.smegmatis_MC2_155 SRFR-VHHRVADTFRAN--RILLAGDAAHVHSPAGG-QGMNLGIEDAVML
MMAR_4271|M.marinum_M SRFT-DLTRQAATYRQG--RVLIAGDAAHVHDPVGG-QGLNTGVQDAVNL
MAV_2736|M.avium_104 SRFT-DAARQAARYRDR--RVLLAGDAAHIHHPVGG-QGLNTGVQDAVNL
TH_1880|M.thermoresistible__bu SRFG-DATRLAERYRAG--RVFLAGDAAHVHPPAGG-QGLNLGIQDAFNL
MUL_0979|M.ulcerans_Agy99 DALTGEGITLAVKQAAAAVRAIADNDPASYEAAWHRVTRSYRWLTRGLVL
MLBr_02276|M.leprae_Br4923 SALLPMGGAVSGVAGPN---WMLIGDAAACVNPLNG-EGIDYGLETGRLA
. : : .:.* . : .
MAB_3775c|M.abscessus_ATCC_199 AEAIAEALSEPSDLAAAWLAINRSARERRRSGVRNRMLSVRAQRVLDGSD
Mvan_4409|M.vanbaalenii_PYR-1 VEAIAKALSDP---ASARQIINAVATERRLAGIANRDAASSALVHMEARG
Mflv_5009|M.gilvum_PYR-GCK GFKLALVVRGL----AADDLLDTYEAERRPLATQVLRGTSAITRVNVAGN
MSMEG_1699|M.smegmatis_MC2_155 AGALSEVLDG-----APDTALDDYAADRRRTAQKIVAATGRLTDLATAS-
MMAR_4271|M.marinum_M GWKLAQVVNRR----SPESLLDTYHAERHPVAARVLRTTMAQVALRRLD-
MAV_2736|M.avium_104 GWKLALVVGGA----SPPALLDTYHAERHPVGERVLRNAIAQMALLRPD-
TH_1880|M.thermoresistible__bu GWKLAAAVGGW----APDGLLDTYHAERHPVAADVLNNTRAQMELMSPE-
MUL_0979|M.ulcerans_Agy99 ASAPRPARRAIVP--ACALLPPVFPVWGKYPGKLTAQSGGHQADAAHPGH
MLBr_02276|M.leprae_Br4923 AELLDLRDLSY----VWPSLLQQHYGRGFSVARRLALLLTFKRCLPAIGP
.
MAB_3775c|M.abscessus_ATCC_199 VSMRARRTMAAKSAPHVWIAG-----------------------------
Mvan_4409|M.vanbaalenii_PYR-1 RLLRLQQRLAALLARWFRRPG-----------------------------
Mflv_5009|M.gilvum_PYR-GCK PIVRFLRDRVAPRVFGLPAVQRWTTYTASQLWVSYRNGPLGGRGSKPRPG
MSMEG_1699|M.smegmatis_MC2_155 ARKRPLRNRIMRAAGSLPAVR-----------------------------
MMAR_4271|M.marinum_M YRKKALSDTIS-ELLMMDEPRKRFAAMMSGLDIRYH-----LGGGHPLLG
MAV_2736|M.avium_104 ERTRALRDLVT-ELLGMDEPRKRFAAMISGLDVRYD-----LGPGHPLLG
TH_1880|M.thermoresistible__bu PGPRAVRWLLA-ELMDFEEVNRYLTEKITAIGVRYHT----MGDGHGLLG
MUL_0979|M.ulcerans_Agy99 RLIPAPPKPSLPARIQIGPIPSAAHCQPSAPGVPLLP-------------
MLBr_02276|M.leprae_Br4923 SAMRSTSLITIAVRVMANLVT-----------------------------
MAB_3775c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK DRIDDAPCSRPDGTATRLHGELGGRWALLLPRGVPAVGAAAVRGPAGYLA
MSMEG_1699|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4271|M.marinum_M RRMPDLDLTTADGPRRVFTHLHAARPVLLNLAEPGRFDIAGWRHRVLLID
MAV_2736|M.avium_104 RRMPDLDLVTADGASRVFALLRNARPVLLNFAGAGRRSVAGWADRVRVVD
TH_1880|M.thermoresistible__bu RRMRDIPLTGG----RLYARMHAGRGVLLDRT--GTLSVSGWADRVDHIV
MUL_0979|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
MAB_3775c|M.abscessus_ATCC_199 -----------------------------AWLTAGLVRPTAIPHISRSGV
Mvan_4409|M.vanbaalenii_PYR-1 -----------------------------EWLDRAPMGP-SRPVSARSRF
Mflv_5009|M.gilvum_PYR-GCK DHVVTL-------HHDRDDVMLVRPDAHLAWRGAH-DDPTGLDRWLATAL
MSMEG_1699|M.smegmatis_MC2_155 --------------------------RALAWR------LSGLDRR-----
MMAR_4271|M.marinum_M AKYVGVWELPVLGAIAAPAAALIRPDGYVAWVGDD-LTDRGLFDALTAWF
MAV_2736|M.avium_104 AKCVADWELPVLGRVSAPPAVLIRPDGHVAWAGD--PNDPGLHDALTTWC
TH_1880|M.thermoresistible__bu DP----------GAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWF
MUL_0979|M.ulcerans_Agy99 --------------------------SAPAAPLPNWPYPPAPPEAAPPPA
MLBr_02276|M.leprae_Br4923 -------------------------DDDADWVARVWRSGGWASWLVDRRP
MAB_3775c|M.abscessus_ATCC_199 TWS------------
Mvan_4409|M.vanbaalenii_PYR-1 ---------------
Mflv_5009|M.gilvum_PYR-GCK HPGGTQ---------
MSMEG_1699|M.smegmatis_MC2_155 ---------------
MMAR_4271|M.marinum_M GRPAVPSPRLRASAP
MAV_2736|M.avium_104 GPPAAGG--------
TH_1880|M.thermoresistible__bu GAPA-----------
MUL_0979|M.ulcerans_Agy99 PPGPPG---------
MLBr_02276|M.leprae_Br4923 PFS------------