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MTVKETRPAAPGAVSRAVRGAAIGNAVEWFDFAIYGFLATYIAEKFFPPGDETAALLNTFAIFAAAFFMR PLGGFFFGPLGDRIGRQRVLALVILLMSASTLAIGLVPGYDSIGVLAPILLLLLRCLQGFSAGGEYGSGA CFLAEYAPDRHRGFVVSFLVWSVVVGFLLGSVTVTALEATLSESAMNSFGWRIPFLIAGALGAVGLYIRL RLGDTPEFEALRESGEVSTTPLKEAVTTSWRPILQIIGLVVVHNVGFYVVYTFLPSYFTRTLEFSKIDAF YSITVASLVGIVLIPPLGALSDRVGRKPLLLAGSIGFAVFAYPLFLLLNTGSLAAAIAAHAALAAIEAVF VCASLAAGAELFATRVRSSGYSIGYNVSVAIFGGTAPYVATWLVSRTGNDIAPAFYVIAAAVVTFLTVLT MRETARQPLRKLVSD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4266 | - | - | 100% (435) | general substrate transporter |
| M. vanbaalenii PYR-1 | Mvan_5748 | - | e-168 | 67.78% (419) | general substrate transporter |
| M. vanbaalenii PYR-1 | Mvan_5839 | - | 1e-99 | 43.84% (422) | general substrate transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3503c | kgtP | 9e-59 | 32.63% (429) | dicarboxylic acid transport integral membrane protein KgtP |
| M. gilvum PYR-GCK | Mflv_2381 | - | 0.0 | 88.24% (425) | general substrate transporter |
| M. tuberculosis H37Rv | Rv3476c | kgtP | 2e-58 | 32.63% (429) | dicarboxylic acid transport integral membrane protein KgtP |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2263c | - | 1e-85 | 40.05% (422) | major facilitator transporter |
| M. marinum M | MMAR_4238 | - | 2e-55 | 33.26% (427) | integral membrane transport protein |
| M. avium 104 | MAV_4627 | - | 2e-61 | 33.90% (413) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4889 | - | 1e-169 | 70.50% (417) | integral membrane transport protein |
| M. thermoresistible (build 8) | TH_3722 | - | 1e-163 | 67.22% (424) | PUTATIVE General substrate transporter |
| M. ulcerans Agy99 | MUL_0949 | - | 8e-56 | 33.26% (427) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4266|M.vanbaalenii_PYR-1 ---------MTVKET--RP--AAPGAVS---RAVRGAAIGNAVEWFDFAI
Mflv_2381|M.gilvum_PYR-GCK ---------MTVDEDQRRPSGAEPAAVR---QAVRGAAIGNTVEWFDFAI
MSMEG_4889|M.smegmatis_MC2_155 -----------------MAVTDRETAVR---RAVMGASIGNAVEWFDFAI
TH_3722|M.thermoresistible__bu --------VSENPSIVSAPPAPDAVVIR---KAVTGASIGNAVEWFDFAI
MAB_2263c|M.abscessus_ATCC_199 MSSAGPREGETEPPPVPRPDFQSPEGRRQLHRAIAASAMGNATEWYDYGV
MMAR_4238|M.marinum_M -----------------------------MSRVALACVVGSTVEYYDFCI
MUL_0949|M.ulcerans_Agy99 -----------------------------MSRVALACVVGSTVEYYDFCI
MAV_4627|M.avium_104 MAATLPAPAPAGLADGHPLDESAEQQRRRLRIVVAASLLGTTVEWYDFFL
Mb3503c|M.bovis_AF2122/97 -----------MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYV
Rv3476c|M.tuberculosis_H37Rv -----------MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYV
*. .*::* :
Mvan_4266|M.vanbaalenii_PYR-1 YGFLATYIA-EKFFPPGDETAALLNTFAIFAAAFFMRPLGGFFFGPLGDR
Mflv_2381|M.gilvum_PYR-GCK YGFLATYIA-DKFFPSGDETAALLSTFAVFAAAFFMRPLGGFFFGPLGDR
MSMEG_4889|M.smegmatis_MC2_155 YGFLATSIA-ANFFPAGDETAALLNTFAIFAAAFFMRPLGGFVFGPLGDR
TH_3722|M.thermoresistible__bu YGFLATYIA-ANFFPAGDDTAALLNTFAIFAAAFVVRPLGGFFFGPLGDR
MAB_2263c|M.abscessus_ATCC_199 YAATTTFLT-QAFFPTLGTAFTMLG----YAISFLLRPLGGMVWGPLGDR
MMAR_4238|M.marinum_M YGTAAALVFPAVFYPGLSPALATIASMGTFATAFLSRPLGAAVFGHFGDR
MUL_0949|M.ulcerans_Agy99 YGTAAALVFPAVFYPGLSPALATIASMGTFATAFLSRPLGAAVFGHFGDR
MAV_4627|M.avium_104 YATAAGLVFNKVFFPNESSLVGTLLAFATFAVGFVMRPIGGLVFGHIGDR
Mb3503c|M.bovis_AF2122/97 YTVFATYFEDQFFDR--ADRNSTVYVYAIFAVTFVTRPVGSWFFGRFADR
Rv3476c|M.tuberculosis_H37Rv YTVFATYFEDQFFDR--ADRNSTVYVYAIFAVTFVTRPVGSWFLGRFADR
* : . * : :* *. **:*. . * :.**
Mvan_4266|M.vanbaalenii_PYR-1 IGRQRVLALVILLMSASTLAIGLVPGYDSIGVLAPILLLLLRCLQGFSAG
Mflv_2381|M.gilvum_PYR-GCK IGRQRVLAIVILLMSASTLAIGLVPSYDSIGVLAPILLLVLRCLQGFSAG
MSMEG_4889|M.smegmatis_MC2_155 LGRQRVLAIVILLMSAATLGIGLLPTYSTIGVVAPLLLLLLRCLQGFSAG
TH_3722|M.thermoresistible__bu IGRQRVLALVILLMSGATLTMGLLPTYESIGVLAPLLLLLLRCLQGFSAG
MAB_2263c|M.abscessus_ATCC_199 LGRKSVMAITIVLMALSTTLIGILPSWATIGMAAPALLILLRVIQGFSTG
MMAR_4238|M.marinum_M LGRKKTLVATLLIMALSTVTVGVVPSTATIGVSAPLILVALRLLQGFAVG
MUL_0949|M.ulcerans_Agy99 LGRKKTLVATLLIMALSTVTVGVVPSTATIGVSAPLILVALRLLQGFAVG
MAV_4627|M.avium_104 IGRKRSLALTMLIMGGATALIGVLPTAAQIGAWAPVLLLVLRVLQGFALG
Mb3503c|M.bovis_AF2122/97 RGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATG
Rv3476c|M.tuberculosis_H37Rv RGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATG
**: :. : :*. .: :.::* ** ** :*: * :***: *
Mvan_4266|M.vanbaalenii_PYR-1 GEYGSGACFLAEYAPDRHRGFVVSFLVWSVVVGFLLGSVTVTALEATLS-
Mflv_2381|M.gilvum_PYR-GCK GEYGSGACFLAEYAPNRHRGFVVSFLVWSVVVGFLAGAITVTALETWLS-
MSMEG_4889|M.smegmatis_MC2_155 GEYGGGAVYLAEYATQRRRGLTVTFIAWSGVLGFLLGSITVTVLAALLP-
TH_3722|M.thermoresistible__bu GEYGGGAVYLAEFAPDRRRGLIVTFMAWSGVLGFLLGSVTVTALQVALP-
MAB_2263c|M.abscessus_ATCC_199 GEYGGAATFMAEFAPDKKRGKYGSFLEFGTLGGFAVGAAFVLVLDATLS-
MMAR_4238|M.marinum_M GEWAGSALLSIESAPAHKRGYYGMFTVLGGGVALVVSGLTFLGVNYTIGE
MUL_0949|M.ulcerans_Agy99 GEWAGSALLSIESAPAHKRGYYGMFTVLGGGVALVVSGLTFLGVNYTIGE
MAV_4627|M.avium_104 GEWGGAVLLAVEHSPGDRRGRYGAVPQVGLALGLALGTGIFAFLQIVLG-
Mb3503c|M.bovis_AF2122/97 GEYGTSVTYMSEAATRERRGYFSSFQYVTLVGGHVLAQFTLLVILAVFT-
Rv3476c|M.tuberculosis_H37Rv GEYGTSATYMSEAATRERRGYFSSFQYVTLVGGHVLAQFTLLVILAVFT-
**:. .. * :. :** . . . . : :
Mvan_4266|M.vanbaalenii_PYR-1 -ESAMNSFGWRIPFLIAGALGAVGLYIRLRLGDTPEFEALRESG------
Mflv_2381|M.gilvum_PYR-GCK -EDAMNSYGWRIPFMIAGLLGAVGLYIRLKLGDTPEFRSLRESG------
MSMEG_4889|M.smegmatis_MC2_155 -PEAMDTYGWRIPFLIAAPLGLVGLYIRLRLDDTPEFEKLDAAD------
TH_3722|M.thermoresistible__bu -DQVMTDVGWRIPFLLAGPLGLIGLYIRLRLDDTPAFTALSEQE------
MAB_2263c|M.abscessus_ATCC_199 -DDAMHTWGWRIPFLVALPMGLIGWYLRSRLDDPPLFKEMQEQEPEGR--
MMAR_4238|M.marinum_M SSSAFLQWGWRVPFLLSALLIAFALYVRLEINETPVFARAMAQADDQEST
MUL_0949|M.ulcerans_Agy99 SSSALLQWGWRVPFLLSALLIAFALYVRLEINETPVFARAMAQADDQEST
MAV_4627|M.avium_104 -PARFLSYGWRIGFLLSVLLVAIGIVVRLRVEETPAFR------ELQDLQ
Mb3503c|M.bovis_AF2122/97 -REQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAG---R
Rv3476c|M.tuberculosis_H37Rv -REQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAG---R
. ***: * :. . :* : :.
Mvan_4266|M.vanbaalenii_PYR-1 EVSTTPLKEAVT--TSWRPILQIIGLVVVHNVGFYVVYTFLPSYFTRTLE
Mflv_2381|M.gilvum_PYR-GCK EVSQSPLREAVT--TSWRPILQIIGLVVIHNVGFYIVYTFLPSYFTETLD
MSMEG_4889|M.smegmatis_MC2_155 RVAKSPLREALR--TARKPILQVIGMFIVFNVGYYVVFTFIPTYFIKTLE
TH_3722|M.thermoresistible__bu EVAQSPLREAVQ--TAWRSILQVIGLMIIFNVAYYVVFAYMPTYLIKELG
MAB_2263c|M.abscessus_ATCC_199 ETAFERLRDLVR--DYRRPMVVMMLLVIALNITNYTLLSYQPTYLKTRLG
MMAR_4238|M.marinum_M AAARAPLAAVLC--RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLG
MUL_0949|M.ulcerans_Agy99 AAARAPLAAVLC--RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLG
MAV_4627|M.avium_104 AASTVPIRDILRERRSRRNTVLGLLSRWAEGSAFNTWGVFAISYATGALG
Mb3503c|M.bovis_AF2122/97 DHDSGSLRELAT--HYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYG
Rv3476c|M.tuberculosis_H37Rv DHDSGSLRELAT--HYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYG
: : : :
Mvan_4266|M.vanbaalenii_PYR-1 FSKIDAFYSITVASLVGIVLIPPLGALSDRVGRKPLLLAGSIGFAVFAYP
Mflv_2381|M.gilvum_PYR-GCK FSKVDAFWSITVASLVGIVLIPPLGALSDRIGRKSLLIAGAVAFAVFAYP
MSMEG_4889|M.smegmatis_MC2_155 FSKTESFVSITLASLTALVLILPLAALSDRVGRKPLLLAGSIGFVVLAYP
TH_3722|M.thermoresistible__bu LSSSDAFISSTIACVVALVLILPLAALSDRIGRKPLLVGGAIAFAVLAYP
MAB_2263c|M.abscessus_ATCC_199 MSETQGQIVILIGEVAMMAFLPFCGALSDRVGRKPMWAFSLTGLLVLSLP
MMAR_4238|M.marinum_M YSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPL
MUL_0949|M.ulcerans_Agy99 YSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPL
MAV_4627|M.avium_104 LNRVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFP
Mb3503c|M.bovis_AF2122/97 SQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYV
Rv3476c|M.tuberculosis_H37Rv SQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYV
. :. : : . : *:.* : : . :
Mvan_4266|M.vanbaalenii_PYR-1 LFLLLNTGSLAAAIAAHAALA-AIEAVFVCASLAAGAELFATRVRSSGYS
Mflv_2381|M.gilvum_PYR-GCK LFLLLNTGSLAAAIAAHAALA-AIESVFVSASLAAGAELFATKVRSSGYS
MSMEG_4889|M.smegmatis_MC2_155 LFLLMTSGSVAAAIVGHCVLA-AIESTYVATAVSAGVELFATRVRYSGFS
TH_3722|M.thermoresistible__bu LFLLLNSGSTAAAMIAHAGLA-AIESVVISVAVVTAVEQFTTRVRYSGMS
MAB_2263c|M.abscessus_ATCC_199 MFWLMGQG-FGWAIVGFAVLG-LLYIPQLSTITATFPCMFPTQVRYAGFA
MMAR_4238|M.marinum_M VMPLIGSGDTVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGTA
MUL_0949|M.ulcerans_Agy99 VMPLIGSGDTVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGTA
MAV_4627|M.avium_104 AFALFGTKKLLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYTGLS
Mb3503c|M.bovis_AF2122/97 LVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVG
Rv3476c|M.tuberculosis_H37Rv LVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVG
. : : : :.:. * * .
Mvan_4266|M.vanbaalenii_PYR-1 IGYNVSVAIFGGTAPYVATWLVSRTGNDIAPAFYVIAAAVVTFLTVLTMR
Mflv_2381|M.gilvum_PYR-GCK IGYNVSVAVFGGTAPYVATWLVSRTGNDIAPAYYLIAAAIVSLLTVLTMR
MSMEG_4889|M.smegmatis_MC2_155 IGYNISVAVFGGTTPYVVTWLTAATGNHHAPALYLIVAAVVSVAAVLTLT
TH_3722|M.thermoresistible__bu VGYNVCVALFGGTTPYVMTWLIDTTANPLAPACAVTLAAVVSLGVVMTLR
MAB_2263c|M.abscessus_ATCC_199 ISYNLSTAAFGGTAPLVNDLVVARTGWDLFPAAYLMVACVVGLCALPFLI
MMAR_4238|M.marinum_M LALNVAGIVGGAAPPLIAGTLLASYGSSAVGLMMTALVAASLLCTYLLPE
MUL_0949|M.ulcerans_Agy99 LALNVAGIVGGAAPPLIAGTLLASYGSSAVGLMMTALVAASLLCTYLLPE
MAV_4627|M.avium_104 FVYQFSGVYASGVTPMILTALIAALGG-APWLACGYLVATAVISVLATAL
Mb3503c|M.bovis_AF2122/97 VGYALANSVFGGTAPLIYQALKERDQVPMFIAYVTACIAVSLIVYVFFIK
Rv3476c|M.tuberculosis_H37Rv VGYALANSVFGGTAPLIYQALKERDQVPMFIAYVTACIAVSLIVYVFFIK
. .. ....* : : . .
Mvan_4266|M.vanbaalenii_PYR-1 ETARQPLRKLVSD-------------
Mflv_2381|M.gilvum_PYR-GCK ETARKPLRKLVHP-------------
MSMEG_4889|M.smegmatis_MC2_155 ENAGRPLPTGHADDAQRATMTS----
TH_3722|M.thermoresistible__bu ETAARPLAG-----------TP----
MAB_2263c|M.abscessus_ATCC_199 ETAGASIAGTEIPCNEAAVPTDTVRA
MMAR_4238|M.marinum_M TAGAPLTAA-----------------
MUL_0949|M.ulcerans_Agy99 TAGAPLTAA-----------------
MAV_4627|M.avium_104 IRDRDLYL------------------
Mb3503c|M.bovis_AF2122/97 NKADTYLDREQGFAFYGHA-------
Rv3476c|M.tuberculosis_H37Rv NKADTYLDREQGFAFYGHA-------