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AATLPAPAPAGLADGHPLDESAEQQRRRLRIVVAASLLGTTVEWYDFFLYATAAGLVFNKVFFPNESSLV GTLLAFATFAVGFVMRPIGGLVFGHIGDRIGRKRSLALTMLIMGGATALIGVLPTAAQIGAWAPVLLLVL RVLQGFALGGEWGGAVLLAVEHSPGDRRGRYGAVPQVGLALGLALGTGIFAFLQIVLGPARFLSYGWRIG FLLSVLLVAIGIVVRLRVEETPAFRELQDLQAASTVPIRDILRERRSRRNTVLGLLSRWAEGSAFNTWGV FAISYATGALGLNRVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFPAFALFGTKK LLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYTGLSFVYQFSGVYASGVTPMILTALIAALGGAP WLACGYLVATAVISVLATALIRDRDLYL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4627 | - | - | 100% (449) | major facilitator superfamily protein |
| M. avium 104 | MAV_4059 | - | 5e-89 | 41.57% (433) | monoxygenase |
| M. avium 104 | MAV_1344 | - | 4e-68 | 36.34% (410) | major facilitator family protein transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 1e-69 | 37.68% (422) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0140 | - | 1e-168 | 67.70% (418) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 1e-69 | 37.68% (422) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-07 | 29.63% (162) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2481 | - | 3e-89 | 40.95% (442) | putative integral membrane transporter |
| M. marinum M | MMAR_4238 | - | 6e-70 | 37.86% (420) | integral membrane transport protein |
| M. smegmatis MC2 155 | MSMEG_5051 | - | 1e-170 | 67.90% (433) | major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_2446 | - | 1e-174 | 68.95% (438) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0949 | - | 2e-69 | 37.62% (420) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5300 | - | 7e-82 | 40.91% (418) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1232|M.bovis_AF2122/97 ----------------------------------------------MKRV
Rv1200|M.tuberculosis_H37Rv ----------------------------------------------MKRV
MMAR_4238|M.marinum_M ----------------------------------------------MSRV
MUL_0949|M.ulcerans_Agy99 ----------------------------------------------MSRV
Mflv_0140|M.gilvum_PYR-GCK -----------------------MTLTNAPDDASTRET----VTPQARTA
TH_2446|M.thermoresistible__bu --------VQPYAHPPGSALLNAVTLLDAPVAPHHDDDSA--VTPQARTA
MSMEG_5051|M.smegmatis_MC2_155 -----------------------MTVTADLVDEQPNTPD---EKKTVRTA
MAV_4627|M.avium_104 -----------------MAATLPAPAPAGLADGHPLDESAEQQRRRLRIV
MAB_2481|M.abscessus_ATCC_1997 -----------------------MTTTSAVPAVHAGGPADG-DAPAARTV
Mvan_5300|M.vanbaalenii_PYR-1 --------------------------MSTQHDARPDGPPS--ITTGLKRV
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
Mflv_0140|M.gilvum_PYR-GCK LWASLVGTTIEWYDFFLYATAASLVFNQAFFPD-QSTFVGTMLSFATFAV
TH_2446|M.thermoresistible__bu LWASLVGTTIEWYDFFLYATAAGLVFNHAFFPD-QSTFVGTMLSFATFAV
MSMEG_5051|M.smegmatis_MC2_155 VLASVVGTTIEWYDFFLYATAASLVFNHAFFPD-QSSFVGTMLAFATFAV
MAV_4627|M.avium_104 VAASLLGTTVEWYDFFLYATAAGLVFNKVFFPN-ESSLVGTLLAFATFAV
MAB_2481|M.abscessus_ATCC_1997 ALSCMVGTTIEWYDFYLYATAAALVLKPLFFPS-VSPTAGTLASFATYAA
Mvan_5300|M.vanbaalenii_PYR-1 VVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTYAV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVA-IVALPKIQNELSLSDAGRSWGIT
. . .:.: : : .* * . . . .
Mb1232|M.bovis_AF2122/97 AFLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIG
Rv1200|M.tuberculosis_H37Rv AFLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIG
MMAR_4238|M.marinum_M AFLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIG
MUL_0949|M.ulcerans_Agy99 AFLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIG
Mflv_0140|M.gilvum_PYR-GCK GFVVRPIGGFVFG-HVGDRIGRKKTLALTMLLMGGATALMGVLPTAAQIG
TH_2446|M.thermoresistible__bu GFVVRPIGGVVFG-HVGDRIGRKRTLALTMVLMGGATALMGVLPTAAQIG
MSMEG_5051|M.smegmatis_MC2_155 GFVVRPIGGFVFG-HVGDRIGRKKTLALTMLLMGVATALMGFLPTAAQIG
MAV_4627|M.avium_104 GFVMRPIGGLVFG-HIGDRIGRKRSLALTMLIMGGATALIGVLPTAAQIG
MAB_2481|M.abscessus_ATCC_1997 GFGARPVGAVIAG-HLGDRVGRKAVLVGALLLMGVATAVIGALPTYSEAG
Mvan_5300|M.vanbaalenii_PYR-1 GFVARPLGGVVFG-HFGDKYGRKKLLQFAILLVGAVTFLMGCLPTYAQIG
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVA-------
.: * : * .** *** : : :. : .
Mb1232|M.bovis_AF2122/97 AAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMFT
Rv1200|M.tuberculosis_H37Rv AAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMFT
MMAR_4238|M.marinum_M VSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMFT
MUL_0949|M.ulcerans_Agy99 VSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMFT
Mflv_0140|M.gilvum_PYR-GCK ILAPILLLLLRIVQGFALG-GEWAGAVLLAVEHGPARRR----GLFGSIP
TH_2446|M.thermoresistible__bu ALAPILLLLLRIVQGFALG-GEWAGAVLLAVEHGPPRRR----GLCGSIP
MSMEG_5051|M.smegmatis_MC2_155 VLAPILLLVLRIVQGFALG-GEWAGAVLLAVEHSPRNRR----GLFGSIP
MAV_4627|M.avium_104 AWAPVLLLVLRVLQGFALG-GEWGGAVLLAVEHSPGDRR----GRYGAVP
MAB_2481|M.abscessus_ATCC_1997 VLAPAALATLRVLQGLAAG-AEWGGAALLAVEHAPVGRR----GLFGSFT
Mvan_5300|M.vanbaalenii_PYR-1 VWAPILLVVLRFMQGFAVG-GEWGGAVLLVAEHSPNKER----GFWASWP
MLBr_01562|M.leprae_Br4923 -WDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMT
* *.:**:. . .. * .*: . * . . .
Mb1232|M.bovis_AF2122/97 VVGGGIALVLT-------------------SLTFLGVNYTIGESSPTFMQ
Rv1200|M.tuberculosis_H37Rv VVGGGIALVLT-------------------SLTFLGVNYTIGESSPTFMQ
MMAR_4238|M.marinum_M VLGGGVALVVS-------------------GLTFLGVNYTIGESSSAFLQ
MUL_0949|M.ulcerans_Agy99 VLGGGVALVVS-------------------GLTFLGVNYTIGESSSALLQ
Mflv_0140|M.gilvum_PYR-GCK QVGLALGLALG-------------------TGVFALLQIALP--DEAFLT
TH_2446|M.thermoresistible__bu QIGLALGLALG-------------------TGVFALLQIALP--DDAFLT
MSMEG_5051|M.smegmatis_MC2_155 QVGLALGLALG-------------------TAVFVVLQVALT--PEAFLS
MAV_4627|M.avium_104 QVGLALGLALG-------------------TGIFAFLQIVLG--PARFLS
MAB_2481|M.abscessus_ATCC_1997 QLGSPAGMLLA-------------------TGVFGLTRALTG--PEAFLA
Mvan_5300|M.vanbaalenii_PYR-1 QAAVPVGNMLA-------------------TVVLLVLTGTLS--NDAFLS
MLBr_01562|M.leprae_Br4923 AIGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMK
. . : : :
Mb1232|M.bovis_AF2122/97 WGWRIPFLVSAALIAVALYVRFNIDETPV--------FAR--ERADEKTR
Rv1200|M.tuberculosis_H37Rv WGWRIPFLVSAALIAVALYVRFNIDETPV--------FAR--ERADEKTR
MMAR_4238|M.marinum_M WGWRVPFLLSALLIAFALYVRLEINETPV--------FARAMAQADDQES
MUL_0949|M.ulcerans_Agy99 WGWRVPFLLSALLIAFALYVRLEINETPV--------FARAMAQADDQES
Mflv_0140|M.gilvum_PYR-GCK YGWRIAFLFSIVLVVFGVVVRLKASETP-----------SFEKVRDSDD-
TH_2446|M.thermoresistible__bu YGWRIAFLLSIVLVVFGVVVRLRATETP-----------AFQRVRDTGD-
MSMEG_5051|M.smegmatis_MC2_155 YGWRIAFLVSIVLVIFGVVVRFRVAETP-----------AFEQVQREND-
MAV_4627|M.avium_104 YGWRIGFLLSVLLVAIGIVVRLRVEETP-----------AFRELQDLQA-
MAB_2481|M.abscessus_ATCC_1997 FGWRIPFLSSIVLVVVGLAIRLRLRDS-----------VVFRKVLERGE-
Mvan_5300|M.vanbaalenii_PYR-1 WGWRVAFWLSAVVVLVGYYIRTKVTDAPI--------FVAAQEEVERVK-
MLBr_01562|M.leprae_Br4923 LDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVV
. : : . .
Mb1232|M.bovis_AF2122/97 LGPAETPIAQVLRRQ--RREIVLAAGSAVCCFGFVYLASTYLASYAQTRL
Rv1200|M.tuberculosis_H37Rv LGPAETPIAQVLRRQ--RREIVLAAGSAVCCFGFVYLASTYLASYAQTRL
MMAR_4238|M.marinum_M TAAARAPLAAVLCRQ--RREIVLAAGAMLAAFGCLYLASTFLPSYAQLHL
MUL_0949|M.ulcerans_Agy99 TAAARAPLAAVLCRQ--RREIVLAAGAMLAAFGCLYLASTFLPSYAQLHL
Mflv_0140|M.gilvum_PYR-GCK --RAAVPLREVFRPP-VLKSTVLGMLSRWGEGAAFNTWGVFAIAYATGTL
TH_2446|M.thermoresistible__bu --RAAVPLRDVFRPP-VLRSTLLGLLSRWGEGAAFNTWGVFAIAYATTTL
MSMEG_5051|M.smegmatis_MC2_155 --RAAVPVRDVFRPP-VLRSTILGLLSRWGEGAAFNTWGVFTIAYATTTL
MAV_4627|M.avium_104 --ASTVPIRDILRERRSRRNTVLGLLSRWAEGSAFNTWGVFAISYATGAL
MAB_2481|M.abscessus_ATCC_1997 --AARLPVVEVLRTQ--SRNVLLTTGLRLSQIALFVLLTTFSLTYLQGSF
Mvan_5300|M.vanbaalenii_PYR-1 --SVSYGVVEVLKRY--PRGVFTAMGLRFAENIMYYLVVTFSIVYLKTHV
MLBr_01562|M.leprae_Br4923 ERTAENPVVPFDLFR--DRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDIL
: . : . . * .
Mb1232|M.bovis_AF2122/97 GYSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSL
Rv1200|M.tuberculosis_H37Rv GYSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSL
MMAR_4238|M.marinum_M GYSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSP
MUL_0949|M.ulcerans_Agy99 GYSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSP
Mflv_0140|M.gilvum_PYR-GCK GLAKVPVLLVVTAAALLMAALLPVSGLLADRYGPKRIYATGIALYAAAVF
TH_2446|M.thermoresistible__bu GLAKVPVLVAVTAAALLMAVLLPVSGVLTDRFGAKRIYTIGITAYALAVF
MSMEG_5051|M.smegmatis_MC2_155 GLDKVAVLIVVTVAALLMAVLLPVSGALADRFSPRTVYAAGIAAYGVIVF
MAV_4627|M.avium_104 GLNRVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAF
MAB_2481|M.abscessus_ATCC_1997 GGDSQIGLTAVLISSALGILSTPVWSALSDRVGRRPLYLFGSAAGPLALG
Mvan_5300|M.vanbaalenii_PYR-1 GADTSDILWWLLAAHAVHFLVVPQVGRLADRFGRRPVYIAGAMLAATWGF
MLBr_01562|M.leprae_Br4923 GYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAML
* . * .: . : : *
Mb1232|M.bovis_AF2122/97 LVMPLIDS--------------GSPSLFAV-AVVGMYAIGGFGFG-----
Rv1200|M.tuberculosis_H37Rv LVMPLIDS--------------GSPSLFAV-AVVGMYAIGGFGFG-----
MMAR_4238|M.marinum_M LVMPLIGS--------------GDTVGFTV-ALLGLYAVAASGFG-----
MUL_0949|M.ulcerans_Agy99 LVMPLIGS--------------GDTVGFTV-ALLGLYAVAASGFG-----
Mflv_0140|M.gilvum_PYR-GCK PVFALFGT--------------EDIALYALGMILVFGIVHALFYG-----
TH_2446|M.thermoresistible__bu PVFALFGT--------------GEIVFYTLGMLLVFGVIHALFYG-----
MSMEG_5051|M.smegmatis_MC2_155 PAFALFNT--------------GSIAAYAVGMILAFGVIHALFYG-----
MAV_4627|M.avium_104 PAFALFGT--------------KKLLWFGLAMVIVFGVVHALFYG-----
MAB_2481|M.abscessus_ATCC_1997 LFFLAAGS--------------GSKVLVVLSIVFGINVVHDAMYG-----
Mvan_5300|M.vanbaalenii_PYR-1 FAFPMMNS--------------GDYLLILGAVILGL-MIHALMYA-----
MLBr_01562|M.leprae_Br4923 YGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPV
. . : : :
Mb1232|M.bovis_AF2122/97 PTASFIPELFATSYRYTGSALAANLAGVAGGALP---PVIAGALVATYGS
Rv1200|M.tuberculosis_H37Rv PTASFIPELFATSYRYTGSALAANLAGVAGGALP---PVIAGALVATYGS
MMAR_4238|M.marinum_M PAASLIPELFATRYRYTGTALALNVAGIVGGAAP---PLIAGTLLASYGS
MUL_0949|M.ulcerans_Agy99 PAASLIPELFATRYRYTGTALALNVAGIVGGAAP---PLIAGTLLASYGS
Mflv_0140|M.gilvum_PYR-GCK AQGTLYASLFPARIRYTGLSTVYQLSGVYASGLT---PLILTALIGAAGG
TH_2446|M.thermoresistible__bu AQGTLYASLFPARIRYTGLSTVYQLSGIFASGVT---PMILTALIAAAGG
MSMEG_5051|M.smegmatis_MC2_155 AQGTLYASLFPTRSRYTGLSTVYQLSGVYASGLT---PLILTSLIAAGGG
MAV_4627|M.avium_104 AQGTLYSALYPTNTRYTGLSFVYQFSGVYASGVT---PMILTALIAALGG
MAB_2481|M.abscessus_ATCC_1997 PQAAWFAELFDTRVRYSGASLGYQIGAVLSGGFA---PLIAAALLAANHG
Mvan_5300|M.vanbaalenii_PYR-1 PQPAIMAEMFPTRMRYSGVSLGYQVTSIVAGSLA---PAIATWLLDR-FG
MLBr_01562|M.leprae_Br4923 SAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDH
. : : : .. . : :
Mb1232|M.bovis_AF2122/97 WA--IGVMLAILALISLVCTYRLPETAGSALVSR--------------
Rv1200|M.tuberculosis_H37Rv WA--IGVMLAILALISLVCTYRLPETAGSALVSR--------------
MMAR_4238|M.marinum_M SA--VGLMMTALVAASLLCTYLLPETAGAPLTAA--------------
MUL_0949|M.ulcerans_Agy99 SA--VGLMMTALVAASLLCTYLLPETAGAPLTAA--------------
Mflv_0140|M.gilvum_PYR-GCK SPWIACGYLVATAVISVVATLALKPAPLHTL-----------------
TH_2446|M.thermoresistible__bu APWLACGYLVATALISVVATTALRPAPLHRL-----------------
MSMEG_5051|M.smegmatis_MC2_155 KPWYACGYLVATAVISVVATLLLRPEH---------------------
MAV_4627|M.avium_104 APWLACGYLVATAVISVLATALIRDRDLYL------------------
MAB_2481|M.abscessus_ATCC_1997 DPRLIVCYYLALSVLTFGAACVARETY-----------RDQIGDSL--
Mvan_5300|M.vanbaalenii_PYR-1 TWVPIAVYLAGAAVITLVAAWFTRETNGIDLHSLDVADREQLAKAGIV
MLBr_01562|M.leprae_Br4923 GYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL---
.: