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ETDIRRVVTGASIGNAVEWFDFAIYGFLATFIAAHFFPAGNDTAALLNTFAIFAAAFFMRPLGGFFFGPL GDRIGRQKVLAVVILLMSAATLGIGLLPTYEAIGVAAPMLLLVLRCLQGFSAGGEYGGGAVYLAEFASDA RRGLTITFMAWSGVLGFLIGSVTVTLLQALLPAAAMESYGWRIPFLIAGPLGLVGLYIRLRLGDTPQFAE LDKAEKTADSPLREAVTTSWRQIIQVIGLFIVFNIGYYVVFTFLPTYFIKTLRFSKSEAFVSITLACLVA LILILPLAALSDRIGRRPLLIGGAVSFAVLGYPLFLLLTSGSLVAAITAHCLLAAIASVYISSAVSAGVE LFATRIRFSGFSVGYNVCVAVFGGTTPYVVTWLTAASGNAIAPAFYLIAAAVVSLAAVLTLRESAGRALA QVQERPANVGSGIHEGEMRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5748 | - | - | 100% (441) | general substrate transporter |
| M. vanbaalenii PYR-1 | Mvan_4266 | - | e-168 | 67.78% (419) | general substrate transporter |
| M. vanbaalenii PYR-1 | Mvan_5839 | - | 1e-89 | 38.07% (415) | general substrate transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 8e-58 | 33.33% (426) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1075 | - | 0.0 | 88.91% (433) | general substrate transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 8e-58 | 33.33% (426) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 3e-05 | 25.76% (132) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2263c | - | 1e-83 | 39.30% (430) | major facilitator transporter |
| M. marinum M | MMAR_4238 | - | 2e-56 | 33.88% (425) | integral membrane transport protein |
| M. avium 104 | MAV_1344 | - | 2e-60 | 33.96% (427) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_4889 | - | 0.0 | 78.28% (419) | integral membrane transport protein |
| M. thermoresistible (build 8) | TH_3722 | - | 1e-178 | 74.34% (417) | PUTATIVE General substrate transporter |
| M. ulcerans Agy99 | MUL_0949 | - | 9e-57 | 33.88% (425) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1232|M.bovis_AF2122/97 ----------------------------------------------MKRV
Rv1200|M.tuberculosis_H37Rv ----------------------------------------------MKRV
MMAR_4238|M.marinum_M ----------------------------------------------MSRV
MUL_0949|M.ulcerans_Agy99 ----------------------------------------------MSRV
MAV_1344|M.avium_104 --------------------------------MGEPSARATTPGTPMRRI
Mvan_5748|M.vanbaalenii_PYR-1 ----------------------------------ME--------TDIRRV
Mflv_1075|M.gilvum_PYR-GCK ------------------------------MEVQRD--------SDIRRV
MSMEG_4889|M.smegmatis_MC2_155 -----------------------------MAVTDRE--------TAVRRA
TH_3722|M.thermoresistible__bu --------------------VSENPSIVSAPPAPDA--------VVIRKA
MAB_2263c|M.abscessus_ATCC_199 -----------------MSSAGPREGETEPPPVPRPDFQSPEGRRQLHRA
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
:
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MAV_1344|M.avium_104 AAACLVGSAIEFYDFLIYGTAAALVFPAVFFPRLGPTVATIASMATFATA
Mvan_5748|M.vanbaalenii_PYR-1 VTGASIGNAVEWFDFAIYG-FLATFIAAHFFPAGNDTAALLNTFAIFAAA
Mflv_1075|M.gilvum_PYR-GCK VTGASIGNAVEWFDFAIYG-FLATFIAAQFFPAGNDTAALLNTFAIFAAA
MSMEG_4889|M.smegmatis_MC2_155 VMGASIGNAVEWFDFAIYG-FLATSIAANFFPAGDETAALLNTFAIFAAA
TH_3722|M.thermoresistible__bu VTGASIGNAVEWFDFAIYG-FLATYIAANFFPAGDDTAALLNTFAIFAAA
MAB_2263c|M.abscessus_ATCC_199 IAASAMGNATEWYDYGVYA-ATTTFLTQAFFPTLGTAFTMLG----YAIS
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLA-TMDSTVAIVALPKIQNELSLSDAGRSWGIT
. :. . . : . .. * : :. :
Mb1232|M.bovis_AF2122/97 FLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLA---------TVTVG
Rv1200|M.tuberculosis_H37Rv FLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLA---------TVTVG
MMAR_4238|M.marinum_M FLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALS---------TVTVG
MUL_0949|M.ulcerans_Agy99 FLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALS---------TVTVG
MAV_1344|M.avium_104 FLSRPLGAAVFG--YFGDRLGRKKTLVATLLIMGAS---------TVSVG
Mvan_5748|M.vanbaalenii_PYR-1 FFMRPLGGFFFG--PLGDRIGRQKVLAVVILLMSAA---------TLGIG
Mflv_1075|M.gilvum_PYR-GCK FFMRPLGGFFFG--PLGDRIGRQKVLAVVILLMSAA---------TLCIG
MSMEG_4889|M.smegmatis_MC2_155 FFMRPLGGFVFG--PLGDRLGRQRVLAIVILLMSAA---------TLGIG
TH_3722|M.thermoresistible__bu FVVRPLGGFFFG--PLGDRIGRQRVLALVILLMSGA---------TLTMG
MAB_2263c|M.abscessus_ATCC_199 FLLRPLGGMVWG--PLGDRLGRKSVMAITIVLMALS---------TTLIG
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV
.:*. . :** :**: .: : :: : :
Mb1232|M.bovis_AF2122/97 LVPTTVAIGAAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKRGW
Rv1200|M.tuberculosis_H37Rv LVPTTVAIGAAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKRGW
MMAR_4238|M.marinum_M VVPSTATIGVSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKRGY
MUL_0949|M.ulcerans_Agy99 VVPSTATIGVSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKRGY
MAV_1344|M.avium_104 LVPSTASIGIAAPLLLTVLRLLQGFAVG-AEWAGSVLLSAEYAPTDRRGW
Mvan_5748|M.vanbaalenii_PYR-1 LLPTYEAIGVAAPMLLLVLRCLQGFSAG-GEYGGGAVYLAEFASDARRGL
Mflv_1075|M.gilvum_PYR-GCK LLPTYDAIGVAAPLLLLVLRCLQGFSAG-GEYGGGAVYLAEFASDRRRGL
MSMEG_4889|M.smegmatis_MC2_155 LLPTYSTIGVVAPLLLLLLRCLQGFSAG-GEYGGGAVYLAEYATQRRRGL
TH_3722|M.thermoresistible__bu LLPTYESIGVLAPLLLLLLRCLQGFSAG-GEYGGGAVYLAEFAPDRRRGL
MAB_2263c|M.abscessus_ATCC_199 ILPSWATIGMAAPALLILLRVIQGFSTG-GEYGGAATFMAEFAPDKKRGK
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL
: ** . *: * .. . . * *
Mb1232|M.bovis_AF2122/97 YG--MFTVVGGGIALVLTS----LTFLGVNYTIGESSPTFMQWGWRIPFL
Rv1200|M.tuberculosis_H37Rv YG--MFTVVGGGIALVLTS----LTFLGVNYTIGESSPTFMQWGWRIPFL
MMAR_4238|M.marinum_M YG--MFTVLGGGVALVVSG----LTFLGVNYTIGESSSAFLQWGWRVPFL
MUL_0949|M.ulcerans_Agy99 YG--MFTVLGGGVALVVSG----LTFLGVNYTIGESSSALLQWGWRVPFL
MAV_1344|M.avium_104 YG--MFTLLGGGTAGILAS----LTFLAVNLTMGEHSPAFMHWGWRVPFL
Mvan_5748|M.vanbaalenii_PYR-1 TI--TFMAWSGVLGFLIGS----VTVTLLQALLP--AAAMESYGWRIPFL
Mflv_1075|M.gilvum_PYR-GCK TI--TFMAWSGVVGFLLGS----VTVTLLQALLP--AEAMESYGWRIPFL
MSMEG_4889|M.smegmatis_MC2_155 TV--TFIAWSGVLGFLLGS----ITVTVLAALLP--PEAMDTYGWRIPFL
TH_3722|M.thermoresistible__bu IV--TFMAWSGVLGFLLGS----VTVTALQVALP--DQVMTDVGWRIPFL
MAB_2263c|M.abscessus_ATCC_199 YG--SFLEFGTLGGFAVGA----AFVLVLDATLS--DDAMHTWGWRIPFL
MLBr_01562|M.leprae_Br4923 VVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAIL
: . . : . : . .:*
Mb1232|M.bovis_AF2122/97 VSAALIAVALYVRFNIDE--------TPVFAR--ERADEKTRLGPAETPI
Rv1200|M.tuberculosis_H37Rv VSAALIAVALYVRFNIDE--------TPVFAR--ERADEKTRLGPAETPI
MMAR_4238|M.marinum_M LSALLIAFALYVRLEINE--------TPVFARAMAQADDQESTAAARAPL
MUL_0949|M.ulcerans_Agy99 LSALLIAFALYVRLEINE--------TPVFARAMAQADDQESTAAARAPL
MAV_1344|M.avium_104 ISSGLIGIALYVRLNIDE--------TPIFVE------EKARHLVPKAPL
Mvan_5748|M.vanbaalenii_PYR-1 IAGPLGLVGLYIRLRLGD--------TPQFAE--LDKAE----KTADSPL
Mflv_1075|M.gilvum_PYR-GCK IAGPLGLVGLYIRLRLGD--------TPQFAE--LAKAD----KKAESPL
MSMEG_4889|M.smegmatis_MC2_155 IAAPLGLVGLYIRLRLDD--------TPEFEK--LDAAD----RVAKSPL
TH_3722|M.thermoresistible__bu LAGPLGLIGLYIRLRLDD--------TPAFTA--LSEQE----EVAQSPL
MAB_2263c|M.abscessus_ATCC_199 VALPMGLIGWYLRSRLDD--------PPLFKE--MQEQEPEGRETAFERL
MLBr_01562|M.leprae_Br4923 ATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENPV
: . . . : . :
Mb1232|M.bovis_AF2122/97 AQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFD
Rv1200|M.tuberculosis_H37Rv AQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFD
MMAR_4238|M.marinum_M AAVLCRQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYSRNLVLLI
MUL_0949|M.ulcerans_Agy99 AAVLCRQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYSRNLVLLI
MAV_1344|M.avium_104 TELLRLQRREIILVAGSFVGGMGFIYLGNTFLVMYAHNHLGYSRSFIWGI
Mvan_5748|M.vanbaalenii_PYR-1 REAVTTSWRQIIQVIGLFIVFNIGYYVVFTFLPTYFIKTLRFSKSEAFVS
Mflv_1075|M.gilvum_PYR-GCK REAVATSWRQILQVVGLFIVFNIGYYVVFTFLPTYFIKTLGFTKSYSFLS
MSMEG_4889|M.smegmatis_MC2_155 REALRTARKPILQVIGMFIVFNVGYYVVFTFIPTYFIKTLEFSKTESFVS
TH_3722|M.thermoresistible__bu REAVQTAWRSILQVIGLMIIFNVAYYVVFAYMPTYLIKELGLSSSDAFIS
MAB_2263c|M.abscessus_ATCC_199 RDLVRDYRRPMVVMMLLVIALNITNYTLLSYQPTYLKTRLGMSETQGQIV
MLBr_01562|M.leprae_Br4923 VPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGIG
: : . : * * :
Mb1232|M.bovis_AF2122/97 SVLGGLLCIVFTALSSALCDQLGRRRVLLAG---------------WAVA
Rv1200|M.tuberculosis_H37Rv SVLGGLLCIVFTALSSALCDQLGRRRVLLAG---------------WAVA
MMAR_4238|M.marinum_M GVLGGLVCIGFVALSAILCDRFGRRRVMLVG---------------WAVG
MUL_0949|M.ulcerans_Agy99 GVLGGLVCIGFVALSAILCDRFGRRRVMLVG---------------WAVG
MAV_1344|M.avium_104 GALGGLTSMACVACSAWISDRVGRRRVMLWG---------------LVAC
Mvan_5748|M.vanbaalenii_PYR-1 ITLACLVALILILPLAALSDRIGRRPLLIGG---------------AVSF
Mflv_1075|M.gilvum_PYR-GCK ITLACLVALILILPLAALSDRFGRRPLLIGG---------------AVAF
MSMEG_4889|M.smegmatis_MC2_155 ITLASLTALVLILPLAALSDRVGRKPLLLAG---------------SIGF
TH_3722|M.thermoresistible__bu STIACVVALVLILPLAALSDRIGRKPLLVGG---------------AIAF
MAB_2263c|M.abscessus_ATCC_199 ILIGEVAMMAFLPFCGALSDRVGRKPMWAFS---------------LTGL
MLBr_01562|M.leprae_Br4923 FIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRGV
: . : .:.. : : .
Mb1232|M.bovis_AF2122/97 LPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFG-----PTASFIPELF
Rv1200|M.tuberculosis_H37Rv LPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFG-----PTASFIPELF
MMAR_4238|M.marinum_M LFWSPLVMPLIGSGDTVGFTVALLGLYAVAASGFG-----PAASLIPELF
MUL_0949|M.ulcerans_Agy99 LFWSPLVMPLIGSGDTVGFTVALLGLYAVAASGFG-----PAASLIPELF
MAV_1344|M.avium_104 LPWAFVVIPLIDTGRPVCYVVAVLGMFGTAAVANG-----PTAAFVPELF
Mvan_5748|M.vanbaalenii_PYR-1 AVLGYPLFLLLTSGSLVAAITAHCLLAAIASVYIS-----SAVSAGVELF
Mflv_1075|M.gilvum_PYR-GCK IVLGYPLFLLITSGSPVAAITGHCLLAAIESVYIS-----CAVSAGVELF
MSMEG_4889|M.smegmatis_MC2_155 VVLAYPLFLLMTSGSVAAAIVGHCVLAAIESTYVA-----TAVSAGVELF
TH_3722|M.thermoresistible__bu AVLAYPLFLLLNSGSTAAAMIAHAGLAAIESVVIS-----VAVVTAVEQF
MAB_2263c|M.abscessus_ATCC_199 LVLSLPMFWLMGQG-FGWAIVGFAVLGLLYIPQLS-----TITATFPCMF
MLBr_01562|M.leprae_Br4923 PYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQSL
: :: * : :
Mb1232|M.bovis_AF2122/97 ATSYRYTGSALAANLAGVAGGALP---PVIAGALVATYG-SWAIGVMLAI
Rv1200|M.tuberculosis_H37Rv ATSYRYTGSALAANLAGVAGGALP---PVIAGALVATYG-SWAIGVMLAI
MMAR_4238|M.marinum_M ATRYRYTGTALALNVAGIVGGAAP---PLIAGTLLASYG-SSAVGLMMTA
MUL_0949|M.ulcerans_Agy99 ATRYRYTGTALALNVAGIVGGAAP---PLIAGTLLASYG-SSAVGLMMTA
MAV_1344|M.avium_104 ATRYRYSGAAVAMNLAGIVGAAVP---PLLAGTLLATYG-SWAIGLMMAS
Mvan_5748|M.vanbaalenii_PYR-1 ATRIRFSGFSVGYNVCVAVFGGTT---PYVVTWLTAASGNAIAPAFYLIA
Mflv_1075|M.gilvum_PYR-GCK ATRVRFSGFSVGYNICVAVFGGTT---PYVVTWLTATTGNSIAPAFYLIA
MSMEG_4889|M.smegmatis_MC2_155 ATRVRYSGFSIGYNISVAVFGGTT---PYVVTWLTAATGNHHAPALYLIV
TH_3722|M.thermoresistible__bu TTRVRYSGMSVGYNVCVALFGGTT---PYVMTWLIDTTANPLAPACAVTL
MAB_2263c|M.abscessus_ATCC_199 PTQVRYAGFAISYNLSTAAFGGTA---PLVNDLVVARTGWDLFPAAYLMV
MLBr_01562|M.leprae_Br4923 GGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWVA
: . .. . : .
Mb1232|M.bovis_AF2122/97 LALISLVCTYRLPETAGSALVSR-------------------
Rv1200|M.tuberculosis_H37Rv LALISLVCTYRLPETAGSALVSR-------------------
MMAR_4238|M.marinum_M LVAASLLCTYLLPETAGAPLTAA-------------------
MUL_0949|M.ulcerans_Agy99 LVAASLLCTYLLPETAGAPLTAA-------------------
MAV_1344|M.avium_104 LVLASFVSVYLLPETRGAALDAAAAAEKVAAR----------
Mvan_5748|M.vanbaalenii_PYR-1 AAVVSLAAVLTLRESAGRALAQVQERPANVGSGIHEGEMRR-
Mflv_1075|M.gilvum_PYR-GCK AAAVSLAAVLTLRETARRPLAQVPYNRADEAPGVALRQHRDR
MSMEG_4889|M.smegmatis_MC2_155 AAVVSVAAVLTLTENAGRPLPTGHADDAQRATMTS-------
TH_3722|M.thermoresistible__bu AAVVSLGVVMTLRETAARPLAGTP------------------
MAB_2263c|M.abscessus_ATCC_199 ACVVGLCALPFLIETAGASIAGTEIPCNEAAVPTDTVRA---
MLBr_01562|M.leprae_Br4923 GAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------
. : :