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VRRLNGVDAMMLYSETPEIHMHTLKIGVLDVSDVEGYDFDLFRRAALPRLHALAPLRYQLVDIPLKFHHP MWVQNAEIDVDYHLRRARVPAPGGRRELDQLIGEIASTPLDRDHPLWEMYIAEGLADNKIAVIHKVHHVL ADGVASANQLAMAIQPREPEVGGQLAESSADSRAPRNLLKAAARDHLRQLRRLPRLVNDTAAGVSRVRRL ARERGGHPDLARNFAPPPTFLNHVVTPGRRFATAPLALADVKETARHLGVTLNDVVLATAAGALRELQLR YDQKADAPLIAGVPVSFSTSPDRLVGNEFTYMTPSLPVHVADPMARVRLTATATAIAKENHRLLGPTLLP SWLAYLPPATTPRIFRMQARRLESAMVMNLTVSNVAGPKRRGVIEGAVVDEIYSVGPIVAGSGMNITVWS YVDQLSISVLTDDRTLKDPHEATDALIASFAEIRRAAGLPEELTPVEKALPVAPAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2253 | - | - | 100% (476) | hypothetical protein Mvan_2253 |
| M. vanbaalenii PYR-1 | Mvan_4224 | - | e-151 | 58.30% (482) | hypothetical protein Mvan_4224 |
| M. vanbaalenii PYR-1 | Mvan_0228 | - | e-144 | 54.62% (476) | hypothetical protein Mvan_0228 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0227 | - | 4e-69 | 54.17% (240) | hypothetical protein Mb0227 |
| M. gilvum PYR-GCK | Mflv_4091 | - | 0.0 | 84.66% (476) | hypothetical protein Mflv_4091 |
| M. tuberculosis H37Rv | Rv0221 | - | 1e-146 | 56.51% (476) | hypothetical protein Rv0221 |
| M. leprae Br4923 | MLBr_01244 | - | 5e-24 | 24.12% (481) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_0507 | - | 6e-68 | 33.90% (472) | hypothetical protein MAB_0507 |
| M. marinum M | MMAR_0464 | - | 1e-144 | 53.88% (477) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_4952 | - | 1e-144 | 55.86% (478) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 1e-148 | 54.33% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 1e-147 | 56.09% (476) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 2e-67 | 35.08% (476) | hypothetical protein MUL_1818 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2253|M.vanbaalenii_PYR-1 ----------MRRLNGVDAMMLYSET-PEIHMHTLKIGVLDVSDV--EGY
Mflv_4091|M.gilvum_PYR-GCK ----------MKRLNGVDAMMLYSET-PEIHMHTLKIGVLDVSGI--GGY
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEGIGDRTF
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLSDV-THPF
Mb0227|M.bovis_AF2122/97 ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDSD-RQEF
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDSD-RQEF
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDPD-RRAF
MAV_4952|M.avium_104 ----------MKRLSGWDSVLLYSEA-PNVHMHTIKAAVIELDAD-RRSL
MAB_0507|M.abscessus_ATCC_1997 ----------MQRLSGVDAAFWHAET-AGWHMHIGGLSIYDPTDA--PDY
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPTDA--PDY
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD-----
. .* . * : .*: . : : :
Mvan_2253|M.vanbaalenii_PYR-1 DFDLFRRAALPRLHALAPLRYQLVDIPLKFHHPMWVQNAEIDVDYHLRRA
Mflv_4091|M.gilvum_PYR-GCK DFEFFRRAALPRLHALAPLRYQLVDIPWKLHHPMWIQNAEIDVDYHLRRA
MSMEG_0290|M.smegmatis_MC2_155 GVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYHVRPW
TH_3760|M.thermoresistible__bu GLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHHIRGM
Mb0227|M.bovis_AF2122/97 GVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPW
Rv0221|M.tuberculosis_H37Rv GVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPW
MMAR_0464|M.marinum_M GVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYHIRPW
MAV_4952|M.avium_104 DVAAFRQVIAGRLNKLDPFCYQLVEVPFSFHHPMWRENCEIDLDYHIRPW
MAB_0507|M.abscessus_ATCC_1997 SFERVRALIVERLPSMPQLRWRVTDVPLGLDRPWFVEDEELDPDFHIRRI
MUL_1818|M.ulcerans_Agy99 SFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFHVRRI
MLBr_01244|M.leprae_Br4923 -WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRRV
.* : : ::. . * : . :.: :.*:*
Mvan_2253|M.vanbaalenii_PYR-1 RVPAPGGRRELDQLIGEIASTPLDRDHPLWEMYIAEGLADNKIAVIHKVH
Mflv_4091|M.gilvum_PYR-GCK KVAAPGGRRELDQLIGEIAGTPLDRTRPLWEMYIADGLADNKIAVIHKVH
MSMEG_0290|M.smegmatis_MC2_155 QVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVVNKIH
TH_3760|M.thermoresistible__bu RVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVVGKIH
Mb0227|M.bovis_AF2122/97 RLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIH
Rv0221|M.tuberculosis_H37Rv RLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIH
MMAR_0464|M.marinum_M QLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVVGKIH
MAV_4952|M.avium_104 RVSPPGGRRELDEAIGQIASTPLDRSRPLWEMYFVEGLANNRIAVVGKIH
MAB_0507|M.abscessus_ATCC_1997 GVPAPGGRKELEELAGRLMSYKLDRSRPLWELWVIEGVEGGRVATLTKMH
MUL_1818|M.ulcerans_Agy99 GVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLTKMH
MLBr_01244|M.leprae_Br4923 RVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQIS
: ** :*: : : :: *** . :*: : * : ::
Mvan_2253|M.vanbaalenii_PYR-1 HVLADGVASANQLAMAIQPREPEVGGQLAESSADSRAPRNLLKAAARDHL
Mflv_4091|M.gilvum_PYR-GCK HVLADGVASANQLAMAIQPREPAVGGQLEAVPADSMGRANLLAGAGRDHW
MSMEG_0290|M.smegmatis_MC2_155 HALADGIASANLLARGMDLREGPQRDRDSYVTDPEPSKGELVRTAFADHM
TH_3760|M.thermoresistible__bu HALADGVASGNLMARGMDLQPGPQRDHTFYRTDPPPGRSHLVRTAFVDHL
Mb0227|M.bovis_AF2122/97 HALADGVASANMMARGMDLLPGPEVGR--YVPDPAPTKRQLLSAAFIDHL
Rv0221|M.tuberculosis_H37Rv HALADGVASANMMARGMDLLPGPEVGR--YVPDPAPTKRQLLSAAFIDHL
MMAR_0464|M.marinum_M HALADGVASANLMARGMDLLPGPEGDP--YVSDPAPTKRELMSSAFLDHL
MAV_4952|M.avium_104 HALADGVASANLLARGMDLQPGPEAGP--YVCDPPPTTRQLMVSAFADHL
MAB_0507|M.abscessus_ATCC_1997 HAIVDGVSGAGLGEILLDIAPEPRPAPDDTVGSLVGLGLPSRERILLSAL
MUL_1818|M.ulcerans_Agy99 HAIVDGVSGAGLGEILLDVTPEPRPPQEETVG-FVGFQIPRLERRAVGAL
MLBr_01244|M.leprae_Br4923 HAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINHL
*.:.**:.. : .
Mvan_2253|M.vanbaalenii_PYR-1 ---RQLRRLPRLVNDTAAGVSRVRRLARERGGHPDLARN------FAPPP
Mflv_4091|M.gilvum_PYR-GCK ---RQVRRLPKLVGETASGVSRVRRKARERGANPDLAKN------FAPPP
MSMEG_0290|M.smegmatis_MC2_155 ---RQIGRIPATIRYTAQGVARVRRSSRKLS--PELTRP------FTPPP
TH_3760|M.thermoresistible__bu ---RQIGRIPSVMRYTYDGLRRVHRSTRKLS--PELTRP------FTPPP
Mb0227|M.bovis_AF2122/97 ---RHLGRIPATIRYTTQGLGRVRRSSRKLS--PALTMP------FTPPP
Rv0221|M.tuberculosis_H37Rv ---RHLGRIPATIRYTTQGLGRVRRSSRKLS--PALTMP------FTPPP
MMAR_0464|M.marinum_M ---RHLGRIPATMRYTAQGLARVRRSSRKLS--PELTRP------FTPPP
MAV_4952|M.avium_104 ---RHVGRLPHTIRYTAQGLGRVRRSARKLS--PELTRP------FEPPP
MAB_0507|M.abscessus_ATCC_1997 ---VNVG-VKTPYRVARLVQQTVRQQLAVFGMERKSPGY------FEAPH
MUL_1818|M.ulcerans_Agy99 ---INVG-IMTPFRIARLVEQTVRQQIAALGVSARPPRY------FDAPK
MLBr_01244|M.leprae_Br4923 PVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAEP
: : : : . .
Mvan_2253|M.vanbaalenii_PYR-1 TFLNHVVTPGRRFATAPLALADVKETARHLGVTLNDVVLATAAGALRELQ
Mflv_4091|M.gilvum_PYR-GCK TFFNHVVTPGRRFATAPLSLADVKETARHLGVTLNDIVLATAAGALRQLQ
MSMEG_0290|M.smegmatis_MC2_155 SFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGALRTLQ
TH_3760|M.thermoresistible__bu TFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLALSAGALRKLL
Mb0227|M.bovis_AF2122/97 TFMNR----------------------------------------IKKPL
Rv0221|M.tuberculosis_H37Rv TFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLL
MMAR_0464|M.marinum_M TFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLAMSTGALRNLL
MAV_4952|M.avium_104 TFMNHKLTPERRFATATLALADVKETGKRLGATINDMVLAMSTGALRTLL
MAB_0507|M.abscessus_ATCC_1997 TRFNAPVSPHRRISGARLDLARVKALKDAFGVKVNDVVLAIVAGAVRDYL
MUL_1818|M.ulcerans_Agy99 TRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLATVAGAAREYL
MLBr_01244|M.leprae_Br4923 SPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRYH
: : :
Mvan_2253|M.vanbaalenii_PYR-1 LRYDQKADAPLIAGVPVSF-STSPDRLVGNEFTYMTPSLPVHVADPMARV
Mflv_4091|M.gilvum_PYR-GCK LTYDGHANSPLIAGVPVSF-NSSPDRLMGNEFTYMTPSLPVHIEDPLERV
MSMEG_0290|M.smegmatis_MC2_155 LRYDGRADHPLLASVPMSF-DFSPDRIWGNRFSGVLVALPVDVADTGERV
TH_3760|M.thermoresistible__bu LRYDGHADHPLLASVPVSF-DFSPDRICGNYFTGMLVALPVDTAEPLDRI
Mb0227|M.bovis_AF2122/97 SKPSGRPP-PHTNRAPSS----------------MPLAM-----------
Rv0221|M.tuberculosis_H37Rv LRYDGKAE-PLLASVPVSY-DFSPERISGNRFTGMLVALPADSDDPLQRV
MMAR_0464|M.marinum_M LRYDGRAE-PLLASVPVSY-DFSPDRISGNYFSGMMVALPTDCADPLERV
MAV_4952|M.avium_104 LRYDGQAQ-PLLASVPVSF-DFSPERISGNRFTGMLVALPVDHDDPLERV
MAB_0507|M.abscessus_ATCC_1997 AKRDEFPDKPLIVQIPVSVRTEETDGVVGNQVSSMTVSLATDIDDPAERI
MUL_1818|M.ulcerans_Agy99 KKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLATHINDPAERL
MLBr_01244|M.leprae_Br4923 EALG-VSISTLPMAVPVNV-RTEADVVGSNRFVGVTLAAPLGTNDPAARM
. . . * . : :
Mvan_2253|M.vanbaalenii_PYR-1 RLTATATAIAKENHRLLGPTLLPSWLAYLPPATTPRIFRMQARR--LESA
Mflv_4091|M.gilvum_PYR-GCK KLTATATAIAKENHNLLGPTLLPSWLTYLPPGTTPQVFRSQARR--VESA
MSMEG_0290|M.smegmatis_MC2_155 RRTREAANLAKESHQLIGPELVARWAAYMPPVPVEALFKRLSSK--DGQN
TH_3760|M.thermoresistible__bu RATRDAALLAKESHQLIGPELISRWSQYLPPAPAERLFGWLSRI--DGQN
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv RVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRWLSER--DGQN
MMAR_0464|M.marinum_M QACHENALSAKESHQLLGPELISRWAAYWPPGATEAAFRWASSR--DGQN
MAV_4952|M.avium_104 AACHQNAISAKESHQLMGPELVSRWAAYMPPAPTRAFFQWASAR--DGHN
MAB_0507|M.abscessus_ATCC_1997 QAIYEGTQGAKEMARAMSAHQIMGLTDTTPPGLLQLAARAYTASGLSRNL
MUL_1818|M.ulcerans_Agy99 KAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARAYTATGLSHNL
MLBr_01244|M.leprae_Br4923 QKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVASS------
Mvan_2253|M.vanbaalenii_PYR-1 MVMNLTVSNVAGPKRRGVIEGAVVDEIYSVGPIVAGSGMNITVWSYVDQL
Mflv_4091|M.gilvum_PYR-GCK MVMNLTISNVPGPRERGCMEGAVIDEIYSVGPIVAGSGMNITVWSYVDQL
MSMEG_0290|M.smegmatis_MC2_155 KVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWSYVDQL
TH_3760|M.thermoresistible__bu KIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGLNITVWSYVDQL
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv KVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYVDQL
MMAR_0464|M.marinum_M KVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGLNITVWSYVDQL
MAV_4952|M.avium_104 KILNLNISNVPGPRERGRVGGALVTEIYSVGPLTAGSGLNITVWSYVDQL
MAB_0507|M.abscessus_ATCC_1997 APINLVLSNVPGPSFPLYMAGARLESMIPLGPPVMDVALNITCFSYLEHM
MUL_1818|M.ulcerans_Agy99 APINLVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVALNITCFSYQEHL
MLBr_01244|M.leprae_Br4923 ---DVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAMMAVLMSRGGFC
Mvan_2253|M.vanbaalenii_PYR-1 SISVLTDDRTLKDPHEATDALIASFAEIRRAAGLPEELTPVEKALPVAPA
Mflv_4091|M.gilvum_PYR-GCK SISVLTDDRTLKDPHEATDALLASFVEIRRAAGLPEELTPVEKSMPPAPA
MSMEG_0290|M.smegmatis_MC2_155 NISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMPQ---
TH_3760|M.thermoresistible__bu NISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELTVVETAMAR---
Mb0227|M.bovis_AF2122/97 --------------------------------------------------
Rv0221|M.tuberculosis_H37Rv NISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQA--
MMAR_0464|M.marinum_M NISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELTVIEAAMAQARS
MAV_4952|M.avium_104 NISVLTDGATCKDPHEVTEAMVQDFIEIRRAAGFSEDLTVVEAAMAPA--
MAB_0507|M.abscessus_ATCC_1997 DFGFVTTPEVAADIDEMADGLEAALVELEHAVGI----------------
MUL_1818|M.ulcerans_Agy99 DFGFVTTPEVANDIDEMADLIEPALAELERAAGL----------------
MLBr_01244|M.leprae_Br4923 TVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARSSG
Mvan_2253|M.vanbaalenii_PYR-1 L--------
Mflv_4091|M.gilvum_PYR-GCK L--------
MSMEG_0290|M.smegmatis_MC2_155 ---------
TH_3760|M.thermoresistible__bu ---------
Mb0227|M.bovis_AF2122/97 ---------
Rv0221|M.tuberculosis_H37Rv ---------
MMAR_0464|M.marinum_M MNEGAGSA-
MAV_4952|M.avium_104 ---------
MAB_0507|M.abscessus_ATCC_1997 ---------
MUL_1818|M.ulcerans_Agy99 ---------
MLBr_01244|M.leprae_Br4923 SPAGWLSSS