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VDDQVLLSTDRDGVRTLTLNRPERRNALDARLWVELADALRDLKRDHDVRALVLTGAGGAFCSGADIGTG EQIHPRYKLDRLTDVALALHELAVPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQIFSKRGLSVDLG GSWLLPRIVGLQQAKRLVLLAEMIGADEARDLGLVTWVKPSGEIDAFVDDLADRLAGGPPFALAQSKALL NDGANATLREALANEARAQPGNFATADSVEAYAAFAAKREPEFTGAWVQYEKPTQKDEE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4207 | - | - | 100% (270) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_1985 | - | 7e-44 | 40.87% (252) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_4579 | - | 4e-35 | 38.96% (249) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1174c | echA10 | 1e-30 | 34.78% (253) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2444 | - | 1e-135 | 88.76% (267) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv1142c | echA10 | 1e-30 | 34.78% (253) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02118 | echA6 | 2e-30 | 34.26% (251) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0905 | - | 3e-34 | 36.82% (258) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4022 | echA10_1 | 4e-41 | 39.77% (259) | enoyl-CoA hydratase EchA10_1 |
| M. avium 104 | MAV_5085 | - | 7e-42 | 43.20% (250) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2220 | - | 1e-40 | 37.60% (258) | enoyl-CoA hydratase/isomerase |
| M. thermoresistible (build 8) | TH_2905 | - | 8e-41 | 41.18% (255) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3887 | echA10_1 | 8e-42 | 39.53% (258) | enoyl-CoA hydratase EchA10_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4207|M.vanbaalenii_PYR-1 --------MVDDQVLLSTDRDGVRTLTLNRPERRNALDARLWVELADALR
Mflv_2444|M.gilvum_PYR-GCK --------MADTEVLLSSDRDGVRTLTLNRPHRRNALDARLWVELADALR
MAB_0905|M.abscessus_ATCC_1997 -----MTQTAPAAVAYSVNHAGVAAIVLDRPEASNALDRTMKTELLQALL
MAV_5085|M.avium_104 -----MTN------VLTSNDGPVRIVTLNRPGVRNAIDIPLRIELAEVLE
Mb1174c|M.bovis_AF2122/97 MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIE
Rv1142c|M.tuberculosis_H37Rv MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIE
MMAR_4022|M.marinum_M MSLEADS-AGPEGSVTSRRDGTLLRITLDRPSRRNSLTQNMIEMLLDTLG
MUL_3887|M.ulcerans_Agy99 MSLEADS-AGPEGSVTSRRDGTLLRITLDRPSRRNSLTRNMIEMLLDTLG
MSMEG_2220|M.smegmatis_MC2_155 MALERPGLLVSDGSVTVTRDGAVLRIVLDRPSRRNSLDHTMVSELVTTLT
TH_2905|M.thermoresistible__bu --------------VTVRRDGTVVRLTLDRPDRRNSLSPTMVDTLIRTLT
MLBr_02118|M.leprae_Br4923 -------------MIGITQAEGVMTIELQRPERRNALNSQLIEKLREAVQ
: : ::** *:: : : .:
Mvan_4207|M.vanbaalenii_PYR-1 DLKRDH---DVRALVLTGAGGAFCSGAD-----IGTGEQIHPRYKLDRLT
Mflv_2444|M.gilvum_PYR-GCK ALKREQ---DVRALVLTGAGGAFCSGAD-----IGTGEQIHPRYKLDRLT
MAB_0905|M.abscessus_ATCC_1997 AAGGDP---AVRAVVMSAAGKNFCVGQD--LAEHVEALRDDPAHAMDTVR
MAV_5085|M.avium_104 AADADE---SVRSIVLTGAGRVFCSGGD--ISTMQRMESEDAKHRADLAQ
Mb1174c|M.bovis_AF2122/97 GAATDP---RVKVVRLGGAGRGFSSGG------AISVDDVWASGPPTDTV
Rv1142c|M.tuberculosis_H37Rv GAATDP---RVKVVRLGGAGRGFSSGG------AISVDDVWASGPPTDTV
MMAR_4022|M.marinum_M GAATDD---SLRAILIRGAGADFCAGADWVAA-STGTQRPRTGDLLRRIP
MUL_3887|M.ulcerans_Agy99 GAATDD---SLRAILIRGAAADFCAGADWVAA-STGTQRHRTGDLLRRIP
MSMEG_2220|M.smegmatis_MC2_155 AAASDD---SLRAVSLSGAGEHFCTGSDWVATNSSG-HRPRTGDLVRRVP
TH_2905|M.thermoresistible__bu SAATDD---GLRAVLIEGAGDTFCSGSDWVATNESGSDRPRTGHLLRRLP
MLBr_02118|M.leprae_Br4923 KASSADSEVSTRVIVLTGQGTVFCAGAD-----------LSGDAFAADYP
: : : . . *. *
Mvan_4207|M.vanbaalenii_PYR-1 D----VALALHELAVPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQI
Mflv_2444|M.gilvum_PYR-GCK D----VALALHELAIPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQI
MAB_0905|M.abscessus_ATCC_1997 EHYNPVLEALDAIKVPVVVAINGACVGAGLGLALGADIRIAGQRAKFGTA
MAV_5085|M.avium_104 R----VIRAIWNTAKPVVAAVEGAAFGAGAALALACDRVVAARDARFATT
Mb1174c|M.bovis_AF2122/97 AEANRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLA
Rv1142c|M.tuberculosis_H37Rv AEANRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLA
MMAR_4022|M.marinum_M HAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVASSDATFWEP
MUL_3887|M.ulcerans_Agy99 HAAHRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVATSDATFWEP
MSMEG_2220|M.smegmatis_MC2_155 HAAHRIVELVATIQLPVVCTVRGWAVGLGCNLALAADFTVADADATFWEP
TH_2905|M.thermoresistible__bu HTGHRVIELVNTIHLPVVCAVRGWAVGLGCNLALAADFTVVADDAVLWEP
MLBr_02118|M.leprae_Br4923 DRLIELHRVMDAVPMPVIGAINGPAIGAGLQLAMQCDLRVVAPDAYFQFP
: *.: : * * * **: .* :. : :
Mvan_4207|M.vanbaalenii_PYR-1 FSKRGLSVDLGGSWLLPRIVGLQQAKRLVLLAEMIGADEARDLGLVTWVK
Mflv_2444|M.gilvum_PYR-GCK FSKRGLSVDLGGSWLLPKTVGLQQAKRLVLLADMIDADEAHGLGLVTWVK
MAB_0905|M.abscessus_ATCC_1997 FTGIGLAADSALSASLPRLIGASRATAMFLLGDTIDAPTAHTWGLVHEVV
MAV_5085|M.avium_104 FTNVGLAGDMGTFVSLPRRVGIARARQMLLLPQPIGAEEAAALGMVDALT
Mb1174c|M.bovis_AF2122/97 HTNVGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAEALSWGLVSAVY
Rv1142c|M.tuberculosis_H37Rv HTNVGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAEALSWGLVSAVY
MMAR_4022|M.marinum_M FVVRGFSPDSGSTWLLPRLVGLARARRMLLLGEQVTAPEAADWGLIHQVV
MUL_3887|M.ulcerans_Agy99 FVVRGFSPDSGSTWLLPRLVGLARARRMLLLGEQVTAPEAADWGLIHQVV
MSMEG_2220|M.smegmatis_MC2_155 FLSRGFSPDSGATWLLPRLAGLTRAKQMLLLGEKVSGTEAADWGLIHGAV
TH_2905|M.thermoresistible__bu FIDRGFTPDSGSTWLLPRLVGLARAKRMLLLGEQISGADAVDWGLVHASV
MLBr_02118|M.leprae_Br4923 TSKYGLALDNWSIRRLSSLVGHGRARAMLLTAEKLTADIALQTGMANRIG
*: * : * :* : * : : . * *:
Mvan_4207|M.vanbaalenii_PYR-1 PSGEIDAFVDDLADRLAGGPPFALAQSKALLNDGANATLREALANEARAQ
Mflv_2444|M.gilvum_PYR-GCK PAGEIDGFIDELADRLAAGPPFALAQSKALLNDGATATLREALANEARAQ
MAB_0905|M.abscessus_ATCC_1997 DEGSPADVANSVAGRLAGGPTAAFSEVKELLRRNAVAPLGDVLEREASAQ
MAV_5085|M.avium_104 DPGHTLEAATRDAQNLAAGPAEAFGVIKALLAIAPTLHPLDALEEEASYQ
Mb1174c|M.bovis_AF2122/97 PAADFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDGQ
Rv1142c|M.tuberculosis_H37Rv PAADFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDGQ
MMAR_4022|M.marinum_M DATALDSAVDELLTRLARGPTVAIGLAKQALNHGQHATLTESMTHELFSL
MUL_3887|M.ulcerans_Agy99 DATDLDSAVDELLTRLARGPTVAIGLAKQALNHGQHATLTESMTHELFNL
MSMEG_2220|M.smegmatis_MC2_155 PAAELETAAEDLIDRLASGPTVAIGLAKQAIAFGQHATLIQSMNQELSNL
TH_2905|M.thermoresistible__bu PAADVDRTATDLAARLAGGPTVAIGLAKHALNFSQQATLPQAMDNELYNV
MLBr_02118|M.leprae_Br4923 ALADAQAWAAEVTG----LAPLAIQHAKRVLND--DGSIEEAWPEHKKLF
.. *: * : ..
Mvan_4207|M.vanbaalenii_PYR-1 PGNFATADSVEAYAAFAAKREPEFTGAWVQYEKPTQKDEE
Mflv_2444|M.gilvum_PYR-GCK PGNFATADSAEAYAAFAAKRDPEFSGAWALYEQPEEQR--
MAB_0905|M.abscessus_ATCC_1997 QRLGASRDHSAAVEAFLAKDKPVFVGR-------------
MAV_5085|M.avium_104 ARLFGTDDFVEGVAAFRDKRRPSFGQRQGVRP--------
Mb1174c|M.bovis_AF2122/97 ALLLRTDDFAEGATAFQQRRTPMFTGR-------------
Rv1142c|M.tuberculosis_H37Rv ALLLRTDDFAEGATAFQQRRTPMFTGR-------------
MMAR_4022|M.marinum_M ELTCRTSDFKEGLTAFRQHRTPKFEGR-------------
MUL_3887|M.ulcerans_Agy99 ELTCRTSDFKEGLTAFRQHRTPKFEGR-------------
MSMEG_2220|M.smegmatis_MC2_155 ELSCRTHDFKEGLAAFRERRDPDFQGR-------------
TH_2905|M.thermoresistible__bu ELSCRTADFKEGLAAFRDRRAPEFQGR-------------
MLBr_02118|M.leprae_Br4923 DKAWTSQDVIEAQVARVEKRPPKFQGA-------------
: * . * : * *