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VADTEVLLSSDRDGVRTLTLNRPHRRNALDARLWVELADALRALKREQDVRALVLTGAGGAFCSGADIGT GEQIHPRYKLDRLTDVALALHELAIPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQIFSKRGLSVDL GGSWLLPKTVGLQQAKRLVLLADMIDADEAHGLGLVTWVKPAGEIDGFIDELADRLAAGPPFALAQSKAL LNDGATATLREALANEARAQPGNFATADSAEAYAAFAAKRDPEFSGAWALYEQPEEQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2444 | - | - | 100% (268) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_4359 | - | 1e-37 | 36.88% (263) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_2125 | - | 1e-31 | 35.29% (255) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1174c | echA10 | 6e-31 | 34.41% (247) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1142c | echA10 | 6e-31 | 34.41% (247) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-28 | 33.46% (254) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0905 | - | 1e-34 | 36.26% (262) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4022 | echA10_1 | 5e-40 | 38.87% (265) | enoyl-CoA hydratase EchA10_1 |
| M. avium 104 | MAV_5085 | - | 1e-41 | 42.13% (254) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2220 | - | 4e-39 | 36.36% (264) | enoyl-CoA hydratase/isomerase |
| M. thermoresistible (build 8) | TH_2905 | - | 2e-37 | 39.22% (255) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_3887 | echA10_1 | 8e-41 | 38.64% (264) | enoyl-CoA hydratase EchA10_1 |
| M. vanbaalenii PYR-1 | Mvan_4207 | - | 1e-135 | 88.76% (267) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1174c|M.bovis_AF2122/97 MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIE
Rv1142c|M.tuberculosis_H37Rv MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIE
MMAR_4022|M.marinum_M MSLEADS-AGPEGSVTSRRDGTLLRITLDRPSRRNSLTQNMIEMLLDTLG
MUL_3887|M.ulcerans_Agy99 MSLEADS-AGPEGSVTSRRDGTLLRITLDRPSRRNSLTRNMIEMLLDTLG
MSMEG_2220|M.smegmatis_MC2_155 MALERPGLLVSDGSVTVTRDGAVLRIVLDRPSRRNSLDHTMVSELVTTLT
TH_2905|M.thermoresistible__bu --------------VTVRRDGTVVRLTLDRPDRRNSLSPTMVDTLIRTLT
Mflv_2444|M.gilvum_PYR-GCK -----MADTE---VLLSSDRDGVRTLTLNRPHRRNALDARLWVELADALR
Mvan_4207|M.vanbaalenii_PYR-1 -----MVDDQ---VLLSTDRDGVRTLTLNRPERRNALDARLWVELADALR
MAV_5085|M.avium_104 -----MTN------VLTSNDGPVRIVTLNRPGVRNAIDIPLRIELAEVLE
MAB_0905|M.abscessus_ATCC_1997 -----MTQTAPAAVAYSVNHAGVAAIVLDRPEASNALDRTMKTELLQALL
MLBr_02402|M.leprae_Br4923 ---------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAK
: :.::** *:: : : .
Mb1174c|M.bovis_AF2122/97 GAATDPRVKVVRLGGAGRGFSSGG------AISVDDVWASGPPTDTVAEA
Rv1142c|M.tuberculosis_H37Rv GAATDPRVKVVRLGGAGRGFSSGG------AISVDDVWASGPPTDTVAEA
MMAR_4022|M.marinum_M GAATDDSLRAILIRGAGADFCAGADWVAA-STGTQRPRTGDLLRRIPHAA
MUL_3887|M.ulcerans_Agy99 GAATDDSLRAILIRGAAADFCAGADWVAA-STGTQRHRTGDLLRRIPHAA
MSMEG_2220|M.smegmatis_MC2_155 AAASDDSLRAVSLSGAGEHFCTGSDWVATNSSG-HRPRTGDLVRRVPHAA
TH_2905|M.thermoresistible__bu SAATDDGLRAVLIEGAGDTFCSGSDWVATNESGSDRPRTGHLLRRLPHTG
Mflv_2444|M.gilvum_PYR-GCK ALKREQDVRALVLTGAGGAFCSGAD--IGTGEQIHP---RYKLDRLTD--
Mvan_4207|M.vanbaalenii_PYR-1 DLKRDHDVRALVLTGAGGAFCSGAD--IGTGEQIHP---RYKLDRLTD--
MAV_5085|M.avium_104 AADADESVRSIVLTGAGRVFCSGGD--ISTMQRMESEDAKHRADLAQR--
MAB_0905|M.abscessus_ATCC_1997 AAGGDPAVRAVVMSAAGKNFCVGQD--LAEHVEALRDDPAHAMDTVREHY
MLBr_02402|M.leprae_Br4923 ELDIDPDVGAILITGSPKVFAAGAD--------IKEMASLTFTDAFDADF
: : : : .: *. *
Mb1174c|M.bovis_AF2122/97 NRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLAHTN
Rv1142c|M.tuberculosis_H37Rv NRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLAHTN
MMAR_4022|M.marinum_M HRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVASSDATFWEPFVV
MUL_3887|M.ulcerans_Agy99 HRVIELLHTIHLPVVCGVQGWAAGLGANLALAADFTVATSDATFWEPFVV
MSMEG_2220|M.smegmatis_MC2_155 HRIVELVATIQLPVVCTVRGWAVGLGCNLALAADFTVADADATFWEPFLS
TH_2905|M.thermoresistible__bu HRVIELVNTIHLPVVCAVRGWAVGLGCNLALAADFTVVADDAVLWEPFID
Mflv_2444|M.gilvum_PYR-GCK --VALALHELAIPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQIFSK
Mvan_4207|M.vanbaalenii_PYR-1 --VALALHELAVPTIAKVTGIAVGAGWNLALGCDLVVATPESRFCQIFSK
MAV_5085|M.avium_104 --VIRAIWNTAKPVVAAVEGAAFGAGAALALACDRVVAARDARFATTFTN
MAB_0905|M.abscessus_ATCC_1997 NPVLEALDAIKVPVVVAINGACVGAGLGLALGADIRIAGQRAKFGTAFTG
MLBr_02402|M.leprae_Br4923 FSAWGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIK
: * : : * * * **: .* :. : :
Mb1174c|M.bovis_AF2122/97 VGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAEALSWGLVSAVYPAA
Rv1142c|M.tuberculosis_H37Rv VGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAEALSWGLVSAVYPAA
MMAR_4022|M.marinum_M RGFSPDSGSTWLLPRLVGLARARRMLLLGEQVTAPEAADWGLIHQVVDAT
MUL_3887|M.ulcerans_Agy99 RGFSPDSGSTWLLPRLVGLARARRMLLLGEQVTAPEAADWGLIHQVVDAT
MSMEG_2220|M.smegmatis_MC2_155 RGFSPDSGATWLLPRLAGLTRAKQMLLLGEKVSGTEAADWGLIHGAVPAA
TH_2905|M.thermoresistible__bu RGFTPDSGSTWLLPRLVGLARAKRMLLLGEQISGADAVDWGLVHASVPAA
Mflv_2444|M.gilvum_PYR-GCK RGLSVDLGGSWLLPKTVGLQQAKRLVLLADMIDADEAHGLGLVTWVKPAG
Mvan_4207|M.vanbaalenii_PYR-1 RGLSVDLGGSWLLPRIVGLQQAKRLVLLAEMIGADEARDLGLVTWVKPSG
MAV_5085|M.avium_104 VGLAGDMGTFVSLPRRVGIARARQMLLLPQPIGAEEAAALGMVDALTDPG
MAB_0905|M.abscessus_ATCC_1997 IGLAADSALSASLPRLIGASRATAMFLLGDTIDAPTAHTWGLVHEVVDEG
MLBr_02402|M.leprae_Br4923 LGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLAD
*. . . : * :* : * : . * *::
Mb1174c|M.bovis_AF2122/97 DFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDGQALL
Rv1142c|M.tuberculosis_H37Rv DFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDGQALL
MMAR_4022|M.marinum_M ALDSAVDELLTRLARGPTVAIGLAKQALNHGQHATLTESMTHELFSLELT
MUL_3887|M.ulcerans_Agy99 DLDSAVDELLTRLARGPTVAIGLAKQALNHGQHATLTESMTHELFNLELT
MSMEG_2220|M.smegmatis_MC2_155 ELETAAEDLIDRLASGPTVAIGLAKQAIAFGQHATLIQSMNQELSNLELS
TH_2905|M.thermoresistible__bu DVDRTATDLAARLAGGPTVAIGLAKHALNFSQQATLPQAMDNELYNVELS
Mflv_2444|M.gilvum_PYR-GCK EIDGFIDELADRLAAGPPFALAQSKALLNDGATATLREALANEARAQPGN
Mvan_4207|M.vanbaalenii_PYR-1 EIDAFVDDLADRLAGGPPFALAQSKALLNDGANATLREALANEARAQPGN
MAV_5085|M.avium_104 HTLEAATRDAQNLAAGPAEAFGVIKALLAIAPTLHPLDALEEEASYQARL
MAB_0905|M.abscessus_ATCC_1997 SPADVANSVAGRLAGGPTAAFSEVKELLRRNAVAPLGDVLEREASAQQRL
MLBr_02402|M.leprae_Br4923 DLLPEAKAVATTISQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHST
: . * * : : .*
Mb1174c|M.bovis_AF2122/97 LRTDDFAEGATAFQQRRTPMFTGR-------------
Rv1142c|M.tuberculosis_H37Rv LRTDDFAEGATAFQQRRTPMFTGR-------------
MMAR_4022|M.marinum_M CRTSDFKEGLTAFRQHRTPKFEGR-------------
MUL_3887|M.ulcerans_Agy99 CRTSDFKEGLTAFRQHRTPKFEGR-------------
MSMEG_2220|M.smegmatis_MC2_155 CRTHDFKEGLAAFRERRDPDFQGR-------------
TH_2905|M.thermoresistible__bu CRTADFKEGLAAFRDRRAPEFQGR-------------
Mflv_2444|M.gilvum_PYR-GCK FATADSAEAYAAFAAKRDPEFSGAWALYEQPEEQR--
Mvan_4207|M.vanbaalenii_PYR-1 FATADSVEAYAAFAAKREPEFTGAWVQYEKPTQKDEE
MAV_5085|M.avium_104 FGTDDFVEGVAAFRDKRRPSFG--QRQGVRP------
MAB_0905|M.abscessus_ATCC_1997 GASRDHSAAVEAFLAKDKPVFVGR-------------
MLBr_02402|M.leprae_Br4923 FVTDDQSEGMAAFIEKRAPQFTHR-------------
: * . ** : * *