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MQKYRGSSLVRAGFIGAVLIALVIVVGLQPQQLWSMATSVRYQAVFAESGGLAAGNNVKVSGVTVGSVSD VELDRGTAVVTFSVAGAVPLGGDTTASIGIATVLGERVLVLRPAGRESLGAMGVIPLSRTGSPYSLTDAI GEFTSNTEQTDTAAINQSLDTLSDTIERIAPQLAPTFDGVTRLSKSLNSRNESLSGLLEAASDVTGVLSE RSAQVNSLLLNANDLLAVLQQRRYAIVNLLASTTAVAQQLSGMVADNERELAPTLEKLNTVAEMLERNRD NITASLKGLAKYQVTQGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGYRRGVDAGQPPDNAGPRAEFPF PYNGIPGGSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2853 | - | - | 100% (360) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | e-130 | 64.33% (356) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | 4e-61 | 36.69% (357) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 3e-57 | 39.68% (315) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_4536 | - | 1e-178 | 87.78% (360) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 3e-57 | 39.68% (315) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-43 | 31.16% (353) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 4e-53 | 39.12% (294) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 1e-121 | 60.28% (360) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 1e-106 | 55.31% (358) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 1e-153 | 75.14% (358) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2834 | - | 1e-154 | 75.98% (358) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4060 | mce4C | 6e-59 | 40.95% (315) | MCE-family protein Mce4C |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
Rv3497c|M.tuberculosis_H37Rv MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MUL_4060|M.ulcerans_Agy99 ----MPSSKHDRDSLRTGIFGVVLVICVVLIAFGYSGLPFLPQGKTYNAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
Mvan_2853|M.vanbaalenii_PYR-1 -----MQKYRGSSLVRAGFIGAVLIALVIVVGLQPQQLWSMATSVRYQAV
Mflv_4536|M.gilvum_PYR-GCK -----MQKYRGASLVRAGFLGAVLIALVIVVGLQPQQLWAMATSVRYQAV
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
TH_2834|M.thermoresistible__bu MRGALMHKYRESALIRSGVIGLVLVVLIIVVGLQTQQLWTMATSVRYHAE
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
. :::*.:* : :: :. . * .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
Rv3497c|M.tuberculosis_H37Rv FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MUL_4060|M.ulcerans_Agy99 FSDAGGITPGNNVYVSGFKVGTVSDVSLAGDAAKITFSVDRHVVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
Mvan_2853|M.vanbaalenii_PYR-1 FAESGGLAAGNNVKVSGVTVGSVSDVELDRGTAVVTFSVAGAVPLGGDTT
Mflv_4536|M.gilvum_PYR-GCK FAEAGGLAAGNEVKVSGVTVGSVSDVALDRGSALVTFSVDSAVRVGDATT
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
TH_2834|M.thermoresistible__bu FAEAGGLAAGNEVKVSGMTVGTVSDVRLQGGHAVVTFALNARIRLGEETT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: *. * ::*. ** *. : : . . : *:: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKS---TTIPLSRTTTPYTLNGVLQDLGR
Rv3497c|M.tuberculosis_H37Rv AAIRTDTILGERSIAVSPAGSGKS---TTIPLSRTTTPYTLNGVLQDLGR
MUL_4060|M.ulcerans_Agy99 AAIRTDTILGERSVAVTPAGSGNA---TTIPLSRTTTPYTLNGALKDLGG
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRI---TEIPLGRTTTPYTLNSALSDLGA
Mvan_2853|M.vanbaalenii_PYR-1 ASIGIATVLGERVLVLRPAGRESLGAMGVIPLSRTGSPYSLTDAIGEFTS
Mflv_4536|M.gilvum_PYR-GCK ATVGISTVLGERVLVLKPDGSRSLGSMGVIPLTRTGSPYSLTDAVGEFTT
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
TH_2834|M.thermoresistible__bu AHIRTGTLLGERVLTVEPRGNGRIRPAGVIPLSRTGSPYSLTDAVGDFTA
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
: ::**:: : : . * :*: :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
Rv3497c|M.tuberculosis_H37Rv NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MUL_4060|M.ulcerans_Agy99 SASNLDKPQFEHALQVLTETLHDATPQLRGALDGVTALSRTLNTRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
Mvan_2853|M.vanbaalenii_PYR-1 NTEQTDTAAINQSLDTLSDTIERIAPQLAPTFDGVTRLSKSLNSRNESLS
Mflv_4536|M.gilvum_PYR-GCK NTEGTDTAAINQSLDTLSETIERVAPQLGPTFDGVSRLSKSLNSRNESLG
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
TH_2834|M.thermoresistible__bu NTAQTDTAAINQSLDVLAETIDRIAPQLGPTFDGVTRLSQSLNSRNESLA
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
: :.::*...: :: *:: :.*.:: :* ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
Rv3497c|M.tuberculosis_H37Rv GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MUL_4060|M.ulcerans_Agy99 GLLAHAKTVTGVLSERAAQVDKLIQDGNQLFAALDERRSALGALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
Mvan_2853|M.vanbaalenii_PYR-1 GLLEAASDVTGVLSERSAQVNSLLLNANDLLAVLQQRRYAIVNLLASTTA
Mflv_4536|M.gilvum_PYR-GCK ALLDAAADVTGVLSERSAQVNTLLLNANDLLAVLQDRRYAIVNLLASTTA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
TH_2834|M.thermoresistible__bu ELLESASKVTGILSERSEQVNRMLLNANDLMGVLQQRRHAIVTLLANTSA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: * ::.:*.:*. *:: :: : . *: . * : *:
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
Rv3497c|M.tuberculosis_H37Rv VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MUL_4060|M.ulcerans_Agy99 VSVQLSGFVNDNRKEFGRALSKLNLVVSNLNERRDYITEALKRLPAYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
Mvan_2853|M.vanbaalenii_PYR-1 VAQQLSGMVADNERELAPTLEKLNTVAEMLERNRDNITASLKGLAKYQVT
Mflv_4536|M.gilvum_PYR-GCK VAQELSGMVEDNEQELAPTLEKLNTVSEMLERNRDNISASLKGLAKYQVT
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
TH_2834|M.thermoresistible__bu VAQQLSGLVADNEEELAPALEKLNRVLELLERNEDNLTQSLKGLAKYQLT
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.: :: :: ** :: .:.:* : * .. :: :* : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---------------
Rv3497c|M.tuberculosis_H37Rv LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---------------
MUL_4060|M.ulcerans_Agy99 LGEVVGSGPGFNVNVYSVLPAPMVAMVFDTVFQPG---------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYFQPG---------------
Mvan_2853|M.vanbaalenii_PYR-1 QGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGYR---------------
Mflv_4536|M.gilvum_PYR-GCK QGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGFR---------------
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFR---------------
TH_2834|M.thermoresistible__bu QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFR---------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFR---------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFR---------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.*.:.. : .. . .*
Mb3527c|M.bovis_AF2122/97 ----------------------------------------KLPDSLADYL
Rv3497c|M.tuberculosis_H37Rv ----------------------------------------KLPDSLADYL
MUL_4060|M.ulcerans_Agy99 ----------------------------------------KLPDSFADYL
MAB_4151c|M.abscessus_ATCC_199 ----------------------------------------KLPASLSDYL
Mvan_2853|M.vanbaalenii_PYR-1 ----------------------------------------RGV-DAGQPP
Mflv_4536|M.gilvum_PYR-GCK ----------------------------------------RGV-NAGQPP
MSMEG_2857|M.smegmatis_MC2_155 ----------------------------------------RGV-NAGQPP
TH_2834|M.thermoresistible__bu ----------------------------------------RGV-NAGQPP
MMAR_4708|M.marinum_M ----------------------------------------AHG-APGQPP
MAV_0950|M.avium_104 ----------------------------------------TFDTARGPGH
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
Mb3527c|M.bovis_AF2122/97 RGFIQERWIIRPKSP-----------------------------------
Rv3497c|M.tuberculosis_H37Rv RGFIQERWIIRPKSP-----------------------------------
MUL_4060|M.ulcerans_Agy99 RGLIQERWTIRPKSS-----------------------------------
MAB_4151c|M.abscessus_ATCC_199 NGLIGERQIMRPKSP-----------------------------------
Mvan_2853|M.vanbaalenii_PYR-1 DNAGPRAEFPFPYNGIP-----------GGSR------------------
Mflv_4536|M.gilvum_PYR-GCK DNAGPRAEFPWPYNGIP-----------GGSR------------------
MSMEG_2857|M.smegmatis_MC2_155 DNAGPRAEFPFPNNGIP-----------GG--------------------
TH_2834|M.thermoresistible__bu DNVGPRAEFPFPYNGIP-----------GG--------------------
MMAR_4708|M.marinum_M DNAGPRALFPFPFNQNP-----------GGSR------------------
MAV_0950|M.avium_104 PSPVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
. * .
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4060|M.ulcerans_Agy99 --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2853|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4536|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------------------------------
TH_2834|M.thermoresistible__bu --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------
MUL_4060|M.ulcerans_Agy99 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
Mvan_2853|M.vanbaalenii_PYR-1 --------------------------
Mflv_4536|M.gilvum_PYR-GCK --------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------
TH_2834|M.thermoresistible__bu --------------------------
MMAR_4708|M.marinum_M --------------------------
MAV_0950|M.avium_104 --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN