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KSFAERSPLAIGIVGAAAVSAVVVGALQYQNLPLVNQVNSYSAYFADAGGLFTGATVEVSGYPAGRVSDI ELDGAAVLVRFTVDKNITMGELTEAGIKTKSLLGTKMLAVIPHGGGRLDGPIPMSRTVSPYQLPDALGDL ADTISGLDTDQLSDSLSTVSEAFAHTPEELRDAVQGVARFAQTLNERDAQLRKLLDDAAKATGVLAHRSD QVARLISDTNALLAQLRTQSDAVNQIWVNISAAAQQLKGFIAENRQQLRPALDKLNGVLAIVDNRKERLQ EAVKLLNKYAMSLGESLSSGPFFKAYVANLLPGQFVQPFVDAAFSDLGLDPNVLPPSQLTDPQTGQPGTP ALPVPYPRTGQGGEPHLNLPDAITGKPGDPRYPYREPLPAPAPGGPPPGPPALQPVGPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3980 | - | - | 100% (410) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | e-178 | 74.02% (408) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0924 | - | e-156 | 66.01% (409) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 2e-59 | 39.64% (333) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-154 | 64.93% (422) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-169 | 72.17% (406) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 4e-49 | 31.48% (432) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 1e-64 | 40.69% (349) | MCE-family protein |
| M. marinum M | MMAR_2884 | mce3C | 1e-170 | 72.55% (408) | MCE-family protein Mce3C |
| M. avium 104 | MAV_2534 | - | 1e-151 | 64.18% (416) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-160 | 68.49% (403) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4274 | - | 1e-163 | 68.95% (409) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-158 | 68.97% (406) | MCE-family protein, Mce3C_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
Rv1968|M.tuberculosis_H37Rv -----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAY
MMAR_2884|M.marinum_M -----MKSFAERNLLLVGTVGILTAAGVVGGALQYQKLPFFDQGTSVCAY
Mvan_3980|M.vanbaalenii_PYR-1 -----MKSFAERSPLAIGIVGAAAVSAVVVGALQYQNLPLVNQVNSYSAY
TH_4274|M.thermoresistible__bu -----VKSFSERNLLVVGLVGMATVTALALVALNFQKIPVFNQGRSHVAE
MSMEG_0348|M.smegmatis_MC2_155 -MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAY
Mflv_2103|M.gilvum_PYR-GCK -----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAH
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
MAV_2534|M.avium_104 -----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAY
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
. * . . : . : :*. .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
Rv1968|M.tuberculosis_H37Rv FADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTE
MMAR_2884|M.marinum_M FADVGGLRTGNTVEVSGYPVGKVSSIELDEPGARVTFKVDKNIRLGERTE
Mvan_3980|M.vanbaalenii_PYR-1 FADAGGLFTGATVEVSGYPAGRVSDIELDGAAVLVRFTVDKNITMGELTE
TH_4274|M.thermoresistible__bu FADAGGLYIGATVEVSGYPAGRVARIDLDGSRVVVAFTVDRDIHLGEKSE
MSMEG_0348|M.smegmatis_MC2_155 FADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSE
Mflv_2103|M.gilvum_PYR-GCK FAEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTE
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
MAV_2534|M.avium_104 FAEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTE
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:: **: . * ::* .* * : : . : *.: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
Rv1968|M.tuberculosis_H37Rv VAIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAA
MMAR_2884|M.marinum_M AAIKTKGLLGSKFVEVIPRGEGHLTG--PIPVERTMSPYQLPDALGDLAS
Mvan_3980|M.vanbaalenii_PYR-1 AGIKTKSLLGTKMLAVIPHGGGRLDG--PIPMSRTVSPYQLPDALGDLAD
TH_4274|M.thermoresistible__bu ARIRAKSLLGTKVLEVLPRGEEPLDA--PIPLSRTTSPYQLPDALGDLAS
MSMEG_0348|M.smegmatis_MC2_155 AAIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLAT
Mflv_2103|M.gilvum_PYR-GCK AAIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
MAV_2534|M.avium_104 AAIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTA
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*: :** : : * . * :*: :: :.* ..: :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
Rv1968|M.tuberculosis_H37Rv TISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLR
MMAR_2884|M.marinum_M TISGLNTGQLSESLDTLAQTFADTPADFRNAVQGVARLARTLNQRDVQLR
Mvan_3980|M.vanbaalenii_PYR-1 TISGLDTDQLSDSLSTVSEAFAHTPEELRDAVQGVARFAQTLNERDAQLR
TH_4274|M.thermoresistible__bu TISDLETDQLSESLATLSETFAHTPEQLKRAVAGVGRIAQTLGERDTNLR
MSMEG_0348|M.smegmatis_MC2_155 TVENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELR
Mflv_2103|M.gilvum_PYR-GCK TISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLR
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
MAV_2534|M.avium_104 TISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLR
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
. . :. :* ..: :: : .. *: *: :: ::. ** :.
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
Rv1968|M.tuberculosis_H37Rv SLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISA
MMAR_2884|M.marinum_M SLLDNAARATGVLANRTDQIAGLVRDTNALLVQLRTQSAALDQIWANISA
Mvan_3980|M.vanbaalenii_PYR-1 KLLDDAAKATGVLAHRSDQVARLISDTNALLAQLRTQSDAVNQIWVNISA
TH_4274|M.thermoresistible__bu NLLDNAAAATGVLARRTDQVVALVRESNNLLAELRMQSAALDQIWHSLSA
MSMEG_0348|M.smegmatis_MC2_155 NLLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISR
Mflv_2103|M.gilvum_PYR-GCK GLLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISA
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
MAV_2534|M.avium_104 TLLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: .* .: :*. * :: *: : : :: : : *:. : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
Rv1968|M.tuberculosis_H37Rv VAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMS
MMAR_2884|M.marinum_M VARQLKGFIADNRQELRPALDKLNGVLDIVEARKERLQQAIPLINTYVMS
Mvan_3980|M.vanbaalenii_PYR-1 AAQQLKGFIAENRQQLRPALDKLNGVLAIVDNRKERLQEAVKLLNKYAMS
TH_4274|M.thermoresistible__bu AARQLEGFIDENRTELRPALEKLNGVLTIIDNRKERVQLALEGLHTYALA
MSMEG_0348|M.smegmatis_MC2_155 AATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALS
Mflv_2103|M.gilvum_PYR-GCK LSAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMS
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
MAV_2534|M.avium_104 LARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALG
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
. *: :: :* : :.:* : : :: : :: : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQ-----PGKLPDS-----
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYFQ-----PGKLPAS-----
Rv1968|M.tuberculosis_H37Rv LGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ----
MMAR_2884|M.marinum_M LGESVSSGPFFKAYVVNLLPGQFVQPFIGAAFSDLGLDPATLLPSQ----
Mvan_3980|M.vanbaalenii_PYR-1 LGESLSSGPFFKAYVANLLPGQFVQPFVDAAFSDLGLDPNVLPPSQ----
TH_4274|M.thermoresistible__bu LGESLGSGPFFKAYLSNLLPGQFVQPFVEAAFSDLGLDPAVLAPSE----
MSMEG_0348|M.smegmatis_MC2_155 LGESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ----
Mflv_2103|M.gilvum_PYR-GCK LGESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ----
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ----
MAV_2534|M.avium_104 LGESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ----
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
*.* :.:** *:. : .. * : . *. * : *
Mb3527c|M.bovis_AF2122/97 --------------------------------------LADYLRGFIQER
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------LSDYLNGLIGER
Rv1968|M.tuberculosis_H37Rv --------LTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDP
MMAR_2884|M.marinum_M --------LTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDP
Mvan_3980|M.vanbaalenii_PYR-1 --------LTDPQTGQPGTPALPVPYPRTGQGGEPHLNLPDAITGKPGDP
TH_4274|M.thermoresistible__bu --------LSDPQTGRPGTPALPVPYPRTGQGGEPRTTVPDAITGKPGDP
MSMEG_0348|M.smegmatis_MC2_155 --------LVDPPVGQPGTPALPVPYPRTGQGGEPRLNLPDAITGNPGDP
Mflv_2103|M.gilvum_PYR-GCK --------RSDPQVGQPGTPAMPVPFPRTGQGGEPRMTIPDAITGNPGDA
MUL_3920|M.ulcerans_Agy99 --------RTDPPIGQPGTPPLPLPFPRTGQGGEPHRKLPDAITGNPDDP
MAV_2534|M.avium_104 --------RADPQVGQPATPPLPMPFPRTGQGGEPRMTLPDAITGNPGDH
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
. .
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1968|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2884|M.marinum_M --------------------------------------------------
Mvan_3980|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4274|M.thermoresistible__bu --------------------------------------------------
MSMEG_0348|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2103|M.gilvum_PYR-GCK GCGPPGIPLPGPT-------------------------------------
MUL_3920|M.ulcerans_Agy99 --------------------------------------------------
MAV_2534|M.avium_104 PCGSPGAASSGP--------------------------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
Mb3527c|M.bovis_AF2122/97 ----WIIRPKSP--------------------------------------
MAB_4151c|M.abscessus_ATCC_199 ----QIMRPKSP--------------------------------------
Rv1968|M.tuberculosis_H37Rv ---RYPYRPEPPAP-PPGGPPPGP-------------PAQQPGDQP----
MMAR_2884|M.marinum_M ---RYPYREPPPAP-PPGGPPPGPPAVAPPGLASTPGPVQVPAPQPGGPS
Mvan_3980|M.vanbaalenii_PYR-1 ---RYPYREPLPAP-APGGPPPGP-------------PALQPVGPR----
TH_4274|M.thermoresistible__bu ---HYPYRQPPPAP-EPGGPPPGPP-----------APAAPASEESGGRQ
MSMEG_0348|M.smegmatis_MC2_155 ---RYPYREPPPAP-APGGPPPGPPAPPVPGLESTPSPTPSPVYVPAPGE
Mflv_2103|M.gilvum_PYR-GCK --GCYPYREPLPAP-PPGGPPPGPPAVSPPGLASTPTPDTG-LLVPAPGE
MUL_3920|M.ulcerans_Agy99 ---RYPYREPLPAP-PPGGPPPGPPAPAPPELASIPQPTPSSVLVPAPGE
MAV_2534|M.avium_104 --GCYPYREPLPAP-PPGGPPPGPPAQ-PGQGAGQSAPLPG----PAQ--
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
* *
Mb3527c|M.bovis_AF2122/97 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
Rv1968|M.tuberculosis_H37Rv --------------------------
MMAR_2884|M.marinum_M --------------------------
Mvan_3980|M.vanbaalenii_PYR-1 --------------------------
TH_4274|M.thermoresistible__bu --------------------------
MSMEG_0348|M.smegmatis_MC2_155 PT--TPIPAGEGR-------------
Mflv_2103|M.gilvum_PYR-GCK APPLVPVPGEGTR-------------
MUL_3920|M.ulcerans_Agy99 VS--APQTAGAGR-------------
MAV_2534|M.avium_104 -----PGEGGEGR-------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN