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MKTFSERNPVVIGAIGVAVVAVIVTMALQYQKLPFLNPGKQYSAYFADAGGLFTGAGVEVSGYPVGKVSD ISLDGPRVLVTFKILGNINLGEQTEATIRTKSLLGTKVLNVMPRGAGKLDGPIPIERTSSPYQLPDALGD LARTVSGIDTNQLSDSLSMLAQTFADTPPHLKTAVEGVARFAETINQHDDQMRSLLDNAAKVTAVLAERT EQVVTLVHDTNALLAQLRTQSEALDAIWFNISAVSEQLRGFIAENRQELKPALEKLNGVLTIVDNRKDRL QKAVKLLNSYAMSLGESVSSGPFFKAYVANLLPGQFVQPFIDAAFSDLGLDPNVLAPSELTDPQLGQPGT PALPVPFPRTGQGGPPMLNLPDAITGNPGDPRYPYREPLPAPAPGGPPPGPPAIAPPGIASTPDPDPSAV FVPAPGEAPSVTAGAQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | - | 100% (437) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3980 | - | e-178 | 74.02% (408) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4602 | - | e-166 | 65.61% (442) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 5e-68 | 33.88% (484) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-172 | 66.82% (443) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-170 | 70.94% (406) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 1e-56 | 34.19% (465) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-66 | 42.46% (325) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-175 | 69.04% (436) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-158 | 63.04% (441) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-172 | 69.79% (427) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4274 | - | 1e-157 | 65.36% (407) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-171 | 67.89% (436) | MCE-family protein, Mce3C_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0365|M.vanbaalenii_PYR-1 ----MKTFSERNPVVIGAIGVAVVAVIVTMALQYQKLPFLNPGKQYSAYF
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4274|M.thermoresistible__bu ----VKSFSERNLLVVGLVGMATVTALALVALNFQKIPVFNQGRSHVAEF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Mflv_2103|M.gilvum_PYR-GCK ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
: : : * . : . : . : :*. . *
Mvan_0365|M.vanbaalenii_PYR-1 ADAGGLFTGAGVEVSGYPVGKVSDISLDGPRVLVTFKILGNINLGEQTEA
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4274|M.thermoresistible__bu ADAGGLYIGATVEVSGYPAGRVARIDLDGSRVVVAFTVDRDIHLGEKSEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIG-TNTIGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASRL
:::*** . * ::* .* * : : * : : *.: :* :
Mvan_0365|M.vanbaalenii_PYR-1 TIRTKSLLGTKVLNVMPRGAGKLDG--PIPIERTSSPYQLPDALGDLART
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
TH_4274|M.thermoresistible__bu RIRAKSLLGTKVLEVLPRGEEPLDA--PIPLSRTTSPYQLPDALGDLAST
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK AIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSAT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
*: :** * :.: . * :*: :: :.* .*: :
Mvan_0365|M.vanbaalenii_PYR-1 VSGIDTNQLSDSLSMLAQTFADTPPHLKTAVEGVARFAETINQHDDQMRS
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4274|M.thermoresistible__bu ISDLETDQLSESLATLSETFAHTPEQLKRAVAGVGRIAQTLGERDTNLRN
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* :: :. : .. *: **. :: *:. :* :
Mvan_0365|M.vanbaalenii_PYR-1 LLDNAAKVTAVLAERTEQVVTLVHDTNALLAQLRTQSEALDAIWFNISAV
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4274|M.thermoresistible__bu LLDNAAAATGVLARRTDQVVALVRESNNLLAELRMQSAALDQIWHSLSAA
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: :* .: :*. * :: *: : : :: : : *:. : :
Mvan_0365|M.vanbaalenii_PYR-1 SEQLRGFIAENRQELKPALEKLNGVLTIVDNRKDRLQKAVKLLNSYAMSL
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4274|M.thermoresistible__bu ARQLEGFIDENRTELRPALEKLNGVLTIIDNRKERVQLALEGLHTYALAL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. *: :: :* :. :::* : : ::* : :: : : .:
Mvan_0365|M.vanbaalenii_PYR-1 GESVSSGPFFKAYVANLLPGQFVQPFIDAAFSDLGLDPNVLAPSE-----
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4274|M.thermoresistible__bu GESLGSGPFFKAYLSNLLPGQFVQPFVEAAFSDLGLDPAVLAPSE-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *:. : .: * : ... *
Mvan_0365|M.vanbaalenii_PYR-1 --LTDPQLGQPGTPALPVPFPRTGQGGPPMLNLPDAITGNPGDP------
Rv1968|M.tuberculosis_H37Rv --LTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDP------
MSMEG_0348|M.smegmatis_MC2_155 --LVDPPVGQPGTPALPVPYPRTGQGGEPRLNLPDAITGNPGDP------
TH_4274|M.thermoresistible__bu --LSDPQTGRPGTPALPVPYPRTGQGGEPRTTVPDAITGKPGDP------
MMAR_4053|M.marinum_M --RTDPPIGQPGTPPLPLPFPRTGQGGEPHLKLPDAITGNPDDP------
MUL_3920|M.ulcerans_Agy99 --RTDPPIGQPGTPPLPLPFPRTGQGGEPHRKLPDAITGNPDDP------
Mflv_2103|M.gilvum_PYR-GCK --RSDPQVGQPGTPAMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPG
MAV_2534|M.avium_104 --RADPQVGQPATPPLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPG
MAB_4151c|M.abscessus_ATCC_199 ---------QPGKLPASLSDYLNGLIGERQIMRPKSP-------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
* . . . * * .
Mvan_0365|M.vanbaalenii_PYR-1 --------RYPYREPLPAPAPGGPPPGPPAIAPPGIASTPDPDPSAVFVP
Rv1968|M.tuberculosis_H37Rv --------RYPYRPEPPAPPPGGPPPGPPAQQP-----------------
MSMEG_0348|M.smegmatis_MC2_155 --------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVP
TH_4274|M.thermoresistible__bu --------HYPYRQPPPAPEPGGPPPGPPAPAAPASEESGGRQ-------
MMAR_4053|M.marinum_M --------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVP
MUL_3920|M.ulcerans_Agy99 --------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVP
Mflv_2103|M.gilvum_PYR-GCK IPLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVP
MAV_2534|M.avium_104 AASSGP-GCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------AP
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
Mvan_0365|M.vanbaalenii_PYR-1 APGEAPS--VTAGAQS----------------------------------
Rv1968|M.tuberculosis_H37Rv --GDQP--------------------------------------------
MSMEG_0348|M.smegmatis_MC2_155 APGEPTT--PIPAGEGR---------------------------------
TH_4274|M.thermoresistible__bu --------------------------------------------------
MMAR_4053|M.marinum_M APGEVS--APQTAGAGR---------------------------------
MUL_3920|M.ulcerans_Agy99 APGEVS--APQTAGAGR---------------------------------
Mflv_2103|M.gilvum_PYR-GCK APGEAPPLVPVPGEGTR---------------------------------
MAV_2534|M.avium_104 LPGPAQ---PGEGGEGR---------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
Mvan_0365|M.vanbaalenii_PYR-1 -------------------------------
Rv1968|M.tuberculosis_H37Rv -------------------------------
MSMEG_0348|M.smegmatis_MC2_155 -------------------------------
TH_4274|M.thermoresistible__bu -------------------------------
MMAR_4053|M.marinum_M -------------------------------
MUL_3920|M.ulcerans_Agy99 -------------------------------
Mflv_2103|M.gilvum_PYR-GCK -------------------------------
MAV_2534|M.avium_104 -------------------------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------------
Mb0177|M.bovis_AF2122/97 PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN