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VRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYFADAGGLNTGATVRVSGFAVG KVERIRLDGRKVLVDFTVDSAIHLGEQSEAAIKVKSLLGTKVIDVIPRGGGQLHEPIPLERTTSPYQLPD ALGDLATTVENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRNLLANARKATAVL ATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRAATQLRGFMADNRQQLRPMLDKLNGVLTIVDNR KDRLQEAVKLLNKYALSLGESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQLVDPPVG QPGTPALPVPYPRTGQGGEPRLNLPDAITGNPGDPRYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPT PSPVYVPAPGEPTTPIPAGEGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0348 | - | - | 100% (442) | mce-family protein mce3c |
| M. smegmatis MC2 155 | MSMEG_5898 | - | 3e-61 | 39.32% (351) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0136 | - | 9e-61 | 32.68% (459) | virulence factor Mce family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0606 | mce2C | 7e-68 | 34.45% (479) | MCE-family protein MCE2C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-159 | 62.03% (453) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-160 | 67.74% (403) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 3e-57 | 32.24% (456) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 6e-62 | 39.82% (339) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-166 | 64.84% (438) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-151 | 59.96% (452) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4274 | - | 1e-156 | 65.29% (412) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-164 | 64.38% (438) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | 1e-172 | 69.79% (427) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4274|M.thermoresistible__bu ----VKSFSERNLLVVGLVGMATVTALALVALNFQKIPVFNQGRSHVAEF
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
Mvan_0365|M.vanbaalenii_PYR-1 ----MKTFSERNPVVIGAIGVAVVAVIVTMALQYQKLPFLNPGKQYSAYF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Mflv_2103|M.gilvum_PYR-GCK ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0606|M.bovis_AF2122/97 ----MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
: : : * . . : . : :*. . *
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4274|M.thermoresistible__bu ADAGGLYIGATVEVSGYPAGRVARIDLDGSRVVVAFTVDRDIHLGEKSEA
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
Mvan_0365|M.vanbaalenii_PYR-1 ADAGGLFTGAGVEVSGYPVGKVSDISLDGPRVLVTFKILGNINLGEQTEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0606|M.bovis_AF2122/97 ADMGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLP-GKTIGMQSRA
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASRL
:: **: . * ::* .* * : : * * : *.: :* :
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGG--QLHEPIPLERTTSPYQLPDALGDLATT
TH_4274|M.thermoresistible__bu RIRAKSLLGTKVLEVLPRGEE--PLDAPIPLSRTTSPYQLPDALGDLAST
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDG--RLDSPIPIERTTSPYQLPDALGDLAAT
Mvan_0365|M.vanbaalenii_PYR-1 TIRTKSLLGTKVLNVMPRGAG--KLDGPIPIERTSSPYQLPDALGDLART
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDG--QLQGTIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDG--QLQGTIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK AIKTKGLLGTKILEVIARGEG--QQDGTIPIDRTTSPYQLPDALGELSAT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEG--QLTGPIPLQRTTSAYQLPDALGDLTAT
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAG--RIT-EIPLGRTTTPYTLNSALSDLGAS
Mb0606|M.bovis_AF2122/97 AIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
*: :** * :.: . * :*: :: :.* .*: :
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4274|M.thermoresistible__bu ISDLETDQLSESLATLSETFAHTPEQLKRAVAGVGRIAQTLGERDTNLRN
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
Mvan_0365|M.vanbaalenii_PYR-1 VSGIDTNQLSDSLSMLAQTFADTPPHLKTAVEGVARFAETINQHDDQMRS
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0606|M.bovis_AF2122/97 ATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQ
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* :: :: : .. *: ** :: *:. :. :.
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4274|M.thermoresistible__bu LLDNAAAATGVLARRTDQVVALVRESNNLLAELRMQSAALDQIWHSLSAA
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
Mvan_0365|M.vanbaalenii_PYR-1 LLDNAAKVTAVLAERTEQVVTLVHDTNALLAQLRTQSEALDAIWFNISAV
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0606|M.bovis_AF2122/97 LLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRILLTNVSEA
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: :* : :*. * :: *: : : :: : : *: : :
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4274|M.thermoresistible__bu ARQLEGFIDENRTELRPALEKLNGVLTIIDNRKERVQLALEGLHTYALAL
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
Mvan_0365|M.vanbaalenii_PYR-1 SEQLRGFIAENRQELKPALEKLNGVLTIVDNRKDRLQKAVKLLNSYAMSL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0606|M.bovis_AF2122/97 SAQVSGLITDN-PNLNHVLAQLRTVSEELVKRKNELADVAVLLGRYTAAL
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. *: :: :* :. : :* : : .:* : : : .*
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4274|M.thermoresistible__bu GESLGSGPFFKAYLSNLLPGQFVQPFVEAAFSDLGLDPAVLAPSE-----
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
Mvan_0365|M.vanbaalenii_PYR-1 GESVSSGPFFKAYVANLLPGQFVQPFIDAAFSDLGLDPNVLAPSE-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0606|M.bovis_AF2122/97 TEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
* :.:** *:. : .: * : ... *
MSMEG_0348|M.smegmatis_MC2_155 --LVDPPVGQPGTPALPVPYPRTGQGGEPRLNLPDAITGNPGDP------
TH_4274|M.thermoresistible__bu --LSDPQTGRPGTPALPVPYPRTGQGGEPRTTVPDAITGKPGDP------
Rv1968|M.tuberculosis_H37Rv --LTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDP------
Mvan_0365|M.vanbaalenii_PYR-1 --LTDPQLGQPGTPALPVPFPRTGQGGPPMLNLPDAITGNPGDP------
MMAR_4053|M.marinum_M --RTDPPIGQPGTPPLPLPFPRTGQGGEPHLKLPDAITGNPDDP------
MUL_3920|M.ulcerans_Agy99 --RTDPPIGQPGTPPLPLPFPRTGQGGEPHRKLPDAITGNPDDP------
Mflv_2103|M.gilvum_PYR-GCK --RSDPQVGQPGTPAMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPG
MAV_2534|M.avium_104 --RADPQVGQPATPPLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPG
MAB_4151c|M.abscessus_ATCC_199 ---------QPGKLPASLSDYLNGLIGERQIMRPKSP-------------
Mb0606|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAG----
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
* . . . * * .
MSMEG_0348|M.smegmatis_MC2_155 --------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVP
TH_4274|M.thermoresistible__bu --------HYPYRQPPPAPEPGGPPPGPPAPAAPASEESGGRQ-------
Rv1968|M.tuberculosis_H37Rv --------RYPYRPEPPAPPPGGPPPGPPAQQP-----------------
Mvan_0365|M.vanbaalenii_PYR-1 --------RYPYREPLPAPAPGGPPPGPPAIAPPGIASTPDPDPSAVFVP
MMAR_4053|M.marinum_M --------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVP
MUL_3920|M.ulcerans_Agy99 --------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVP
Mflv_2103|M.gilvum_PYR-GCK IPLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVP
MAV_2534|M.avium_104 AASSGP-GCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------AP
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 ------ALPRPDNPLPCAGATVGPFGGPDFPAPLDVQPSPPNPDGPPPTP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
MSMEG_0348|M.smegmatis_MC2_155 APGEPTT--PIPAGEGR---------------------------------
TH_4274|M.thermoresistible__bu --------------------------------------------------
Rv1968|M.tuberculosis_H37Rv --GDQP--------------------------------------------
Mvan_0365|M.vanbaalenii_PYR-1 APGEAPS--VTAGAQS----------------------------------
MMAR_4053|M.marinum_M APGEVS--APQTAGAGR---------------------------------
MUL_3920|M.ulcerans_Agy99 APGEVS--APQTAGAGR---------------------------------
Mflv_2103|M.gilvum_PYR-GCK APGEAPPLVPVPGEGTR---------------------------------
MAV_2534|M.avium_104 LPGPAQ---PGEGGEGR---------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 GILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEP-------------
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHEP
MSMEG_0348|M.smegmatis_MC2_155 -------------------------
TH_4274|M.thermoresistible__bu -------------------------
Rv1968|M.tuberculosis_H37Rv -------------------------
Mvan_0365|M.vanbaalenii_PYR-1 -------------------------
MMAR_4053|M.marinum_M -------------------------
MUL_3920|M.ulcerans_Agy99 -------------------------
Mflv_2103|M.gilvum_PYR-GCK -------------------------
MAV_2534|M.avium_104 -------------------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------
Mb0606|M.bovis_AF2122/97 ---------FPDGTGGSNQ------
MLBr_02591|M.leprae_Br4923 REQLSAPLINPGGTGGSGGAGGSRN