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MKPMTERNPLAVGAVGAVTVGAVLLGALNFDDLPFADGAADYSAYFADAAGLQPDAPVQVAGLRVGQVTD ISLDGPRVLVEFDVDKGVRLGDRTEAAIKTKTVLGAKYVEVIPRGAGGQSGPIPLERTTSPYQLTDVLGD LASTINGLDTAELSTSLDTLADTFSDTPPELRIAVQGVSRFADTINQRDEQLRSLLSNVSKVSGVLAERS DQIVRLVADTNALLSQLRQQSSSLDQISGNISAVSRQIKGFITENRPQFKPALDKLNGVLTIVERRKEKL QESITRLNGYSMSLGEAISSGPFFKGLIANLPPGQFIQPFVEAAFSDLGLDPNVLLPSQLTDPPVGQPAT PALPVPYPRTGQGGEPRLTLPDAITGNPGDPRYPYREPLPAPPPGGPPPGPPDPVLPAPTHGPVVTSDPT EPSTASSTGGSRPEEAPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0924 | - | - | 100% (438) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | e-158 | 62.82% (433) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3980 | - | e-156 | 66.01% (409) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 2e-66 | 33.91% (466) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-160 | 62.97% (451) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-153 | 66.42% (402) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 4e-55 | 30.02% (433) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 8e-67 | 39.47% (342) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 1e-159 | 62.64% (439) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-153 | 63.61% (415) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-154 | 60.27% (438) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4453 | - | 1e-153 | 62.17% (423) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-156 | 61.50% (439) | MCE-family protein, Mce3C_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4453|M.thermoresistible__bu VCTEMKPFAERNKRVMGAVGIGVGTIIIAGALQYDNLPVVSSDTRYSAYF
Mvan_0924|M.vanbaalenii_PYR-1 ----MKPMTERNPLAVGAVGAVTVGAVLLGALNFDDLPFADGAADYSAYF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
Mflv_2103|M.gilvum_PYR-GCK ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
* : : * . : . : :*. . *
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4453|M.thermoresistible__bu AESGGLRAGAAVQVSGMRVGKVSAVELDGPHVRVEFRVRPNIRLGELSEA
Mvan_0924|M.vanbaalenii_PYR-1 ADAAGLQPDAPVQVAGLRVGQVTDISLDGPRVLVEFDVDKGVRLGDRTEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNT-IGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-IGTASRL
:::.** . * ::* ** * : : * : : * : :* :
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
TH_4453|M.thermoresistible__bu AIKTKSLLGAKILDITSRGEGRLSA--SIPVERTVSPYELPDALGDLAST
Mvan_0924|M.vanbaalenii_PYR-1 AIKTKTVLGAKYVEVIPRGAGGQSG--PIPLERTTSPYQLTDVLGDLAST
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK AIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSAT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
.*: :** * :.: . * :*: :: :.* ..: :
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4453|M.thermoresistible__bu IAGLDTAGVSESLATLAETFENTPAEVQAAVRGVTRFSESLGRRDQQLRQ
Mvan_0924|M.vanbaalenii_PYR-1 INGLDTAELSTSLDTLADTFSDTPPELRIAVQGVSRFADTINQRDEQLRS
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* .:: :. : ... *: **: :: ::. ** :
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4453|M.thermoresistible__bu LLENARKATGVLGERSQQIAALVRDSNALLVQLRTESAALDQLSANISAL
Mvan_0924|M.vanbaalenii_PYR-1 LLSNVSKVSGVLAERSDQIVRLVADTNALLSQLRQQSSSLDQISGNISAV
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: :. ..: :*. * :: *: : : :: : . ::. : :
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4453|M.thermoresistible__bu AQQVSGFISENHDTLSPALEKLNGVLTIVENRKEQVQDALHLAQGYHTRL
Mvan_0924|M.vanbaalenii_PYR-1 SRQIKGFITENRPQFKPALDKLNGVLTIVERRKEKLQESITRLNGYSMSL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. *: :: :* : :::* : : :* : .:: : :
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4453|M.thermoresistible__bu GEAVSSGPFFNSYVANLLPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mvan_0924|M.vanbaalenii_PYR-1 GEAISSGPFFKGLIANLPPGQFIQPFVEAAFSDLGLDPNVLLPSQ-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *: : .: * : ... *
Rv1968|M.tuberculosis_H37Rv ----------------------LTDPPTGQPGTP----------------
MSMEG_0348|M.smegmatis_MC2_155 ----------------------LVDPPVGQPGTP----------------
TH_4453|M.thermoresistible__bu ----------------------LNDPQVGQPGTP----------------
Mvan_0924|M.vanbaalenii_PYR-1 ----------------------LTDPPVGQPATP----------------
MMAR_4053|M.marinum_M ----------------------RTDPPIGQPGTP----------------
MUL_3920|M.ulcerans_Agy99 ----------------------RTDPPIGQPGTP----------------
Mflv_2103|M.gilvum_PYR-GCK ----------------------RSDPQVGQPGTP----------------
MAV_2534|M.avium_104 ----------------------RADPQVGQPATP----------------
MAB_4151c|M.abscessus_ATCC_199 -----------------------------QPGKL----------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
*.
Rv1968|M.tuberculosis_H37Rv -------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP-------
MSMEG_0348|M.smegmatis_MC2_155 -------------ALPVPYPRTGQGGEPRLNLPDAITGNPGDP-------
TH_4453|M.thermoresistible__bu -------------AAPVPYPRTGQGGGPRLTLPDAITGNPGDP-------
Mvan_0924|M.vanbaalenii_PYR-1 -------------ALPVPYPRTGQGGEPRLTLPDAITGNPGDP-------
MMAR_4053|M.marinum_M -------------PLPLPFPRTGQGGEPHLKLPDAITGNPDDP-------
MUL_3920|M.ulcerans_Agy99 -------------PLPLPFPRTGQGGEPHRKLPDAITGNPDDP-------
Mflv_2103|M.gilvum_PYR-GCK -------------AMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPGI
MAV_2534|M.avium_104 -------------PLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPGA
MAB_4151c|M.abscessus_ATCC_199 -------------PASLSDYLNGLIGERQIMRPKSP--------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
. . . * * *
Rv1968|M.tuberculosis_H37Rv -------RYPYRPEPPAPPPGGPPPGPPAQ-------------------Q
MSMEG_0348|M.smegmatis_MC2_155 -------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVPA
TH_4453|M.thermoresistible__bu -------RYPYREPLPAPPPGGPPPGPPAAIPPVPVREPVFVPAPN-EVS
Mvan_0924|M.vanbaalenii_PYR-1 -------RYPYREPLPAPPPGGPPPGPPDPVLPAPTHGPVVTSDPTEPST
MMAR_4053|M.marinum_M -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
MUL_3920|M.ulcerans_Agy99 -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
Mflv_2103|M.gilvum_PYR-GCK PLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVPA
MAV_2534|M.avium_104 ASSGP-GCYPYREPLPAPPPGGPPPGPPAQPGQGAGQS---------APL
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
Rv1968|M.tuberculosis_H37Rv PGDQP--------------------------
MSMEG_0348|M.smegmatis_MC2_155 PGEPT--TPIPAGEGR---------------
TH_4453|M.thermoresistible__bu AGEPD--TPEIDGESQ---------------
Mvan_0924|M.vanbaalenii_PYR-1 ASSTG--GSRPEEAPQ---------------
MMAR_4053|M.marinum_M PGEVS--APQTAGAGR---------------
MUL_3920|M.ulcerans_Agy99 PGEVS--APQTAGAGR---------------
Mflv_2103|M.gilvum_PYR-GCK PGEAPPLVPVPGEGTR---------------
MAV_2534|M.avium_104 PGPAQ---PGEGGEGR---------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------------
Mb0177|M.bovis_AF2122/97 PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN