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RLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLPQAGGLYSGGNVTYRGTEVGRVE AVRLTPGGVDAVLSLKSGIDVPSDLRAEVHSQSAIGEQYVALLPRSGDARPLRDGDVITPADTSVPPNVN TLLADANVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRHLDPLITLIDQSQPVLDS QTRTSEAIQAWAAQVATVTTQLQTQDQTLARVIDDGGESADAVRQLVDRVKPTLPIVLANLVSVGQVAVT YHDNIEQLLVLFPAVVSAEQAGLVANLHTKQDYKGQYLSFNLNINLPPPCTTGFLPAQQQRSPVFEDAPE RPPGDLYCRVPQDSPLNVRGAHNIPCATRPGKRAPTVAICESDEIYVPLNDGFNWKGDPNATSSGQPVPQ LPPAAGPQAAPPALAAAEYDPATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | - | 100% (479) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0368 | - | 0.0 | 70.33% (482) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0518 | - | e-169 | 60.13% (479) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 1e-82 | 35.24% (525) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-171 | 61.16% (484) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-168 | 61.49% (483) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 7e-76 | 32.44% (521) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 2e-83 | 35.28% (513) | MCE-family protein |
| M. marinum M | MMAR_2887 | mce3F | 0.0 | 69.42% (484) | MCE-family protein Mce3F |
| M. avium 104 | MAV_2537 | - | 1e-178 | 62.42% (487) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-168 | 61.38% (492) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-176 | 62.83% (487) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 0.0 | 69.21% (484) | MCE-family protein Mce3F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_3977|M.vanbaalenii_PYR-1 -MRLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLP
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :* ::: : ::* .*:. : :. ::
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_3977|M.vanbaalenii_PYR-1 QAGGLYSGGNVTYRGTEVGRVEAVRLTPGG-VDAVLSLKSGIDVPSDLRA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** .***:** :* : * : * . . : : . :* : *
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
Mvan_3977|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALLPR-SGDARPLRDGDVITPADTSVPPNVNTLLADA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQ-SGDGPALRNGDVISRDRARVPADVNTVLELT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTIT--KSKIPIEIGPALDSV
*:* :*:** :: *:. . : *:.: :* ::. :
MMAR_2887|M.marinum_M NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
MUL_2865|M.ulcerans_Agy99 NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
Mvan_3977|M.vanbaalenii_PYR-1 NVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRHLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : .:. .: : *: *. * * : *:: .: : . :
MMAR_2887|M.marinum_M LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
MUL_2865|M.ulcerans_Agy99 LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
Mvan_3977|M.vanbaalenii_PYR-1 LITLIDQSQPVLDSQTRTSEAIQAWAAQVATVTTQLQTQDQTLARVIDDG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : : . : :: . : : : .
MMAR_2887|M.marinum_M GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
MUL_2865|M.ulcerans_Agy99 GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
Mvan_3977|M.vanbaalenii_PYR-1 GESADAVRQLVDRVKPTLPIVLANLVSVGQVAVTYHDNIEQLLVLFPAVV
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: :. : :.* *.: : : *. .:*. ** :*
MMAR_2887|M.marinum_M SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPIF
MUL_2865|M.ulcerans_Agy99 SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPTF
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
Mvan_3977|M.vanbaalenii_PYR-1 SAEQAGLVANLHTK-QDYKGQYLSFNLNINLPPPCTTGFLPAQQQRSPVF
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSPAL
Mflv_2106|M.gilvum_PYR-GCK AVTQAVGVAKNGTK-QDYMGDYLVFNLNLNVPPPCTTGFLPAQQQRAPTF
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAINYPPPCLTGFLPASEWRSPAD
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
: * : :. **** **:.* * .
MMAR_2887|M.marinum_M EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCESDE
MUL_2865|M.ulcerans_Agy99 EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCESNE
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
Mvan_3977|M.vanbaalenii_PYR-1 EDAPERPPGDLYCRVPQDS-PLNVRGAHNIPCATRPGKRAPTVAICESDE
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
TH_3681|M.thermoresistible__bu VDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCESDE
Mflv_2106|M.gilvum_PYR-GCK EDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVPGKRAPSAAMCESGE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
Mb0180|M.bovis_AF2122/97 TSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKD
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
* . **: . : .**::* ** *****.: *..
MMAR_2887|M.marinum_M QYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG-----
MUL_2865|M.ulcerans_Agy99 QYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG-----
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
Mvan_3977|M.vanbaalenii_PYR-1 IYVPLNDGFNWKG----------DPNATSSGQPV-----PQLPP------
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQSI-----PDLGPGQGE--
TH_3681|M.thermoresistible__bu EYTPLNDGMNWKG----------DPNATLSGQDI-----PEVRRG-----
Mflv_2106|M.gilvum_PYR-GCK VYVPLNEGYIWKG----------DPNATLSGQAV-----PQLRPG-----
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQDV-----PQYRPG-----
MAB_4148c|M.abscessus_ATCC_199 GYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNKF-----PNIPPGAEP--
Mb0180|M.bovis_AF2122/97 PYVPLGT-NPWFG----------DPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 PYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
: *:. * * **. .
MMAR_2887|M.marinum_M -----PSPPAAAGPGEAPPPP-----------------------------
MUL_2865|M.ulcerans_Agy99 -----PPPPAAAGPGEAPPPP-----------------------------
Rv1971|M.tuberculosis_H37Rv -----------LGSGQDIP-------------------------------
Mvan_3977|M.vanbaalenii_PYR-1 -----------AAGPQAAPPA-----------------------------
MSMEG_0351|M.smegmatis_MC2_155 -SAPETSPAPPAPPVEGDPVP-----------------------------
TH_3681|M.thermoresistible__bu -----PGAAQVSTSGPVAPPS-----------------------------
Mflv_2106|M.gilvum_PYR-GCK --QQP-AQASPP--PGPAPPP-----------------------------
MAV_2537|M.avium_104 --EEPPGQVPPPSPPGPAPPP-----------------------------
MAB_4148c|M.abscessus_ATCC_199 -DPGTPTLPPPSPPAPEVPPAGGDVM----------------PVSAQSGP
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
*
MMAR_2887|M.marinum_M IAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP
MUL_2865|M.ulcerans_Agy99 IAAAEYDPATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP
Rv1971|M.tuberculosis_H37Rv ---------------------------------QTWQTMLLPPGS-
Mvan_3977|M.vanbaalenii_PYR-1 LAAAEYDPATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN
TH_3681|M.thermoresistible__bu IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG-
Mflv_2106|M.gilvum_PYR-GCK MAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTWQTMLLPPKGN
MAV_2537|M.avium_104 IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN
MAB_4148c|M.abscessus_ATCC_199 MAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVAN--SSTTGDDGWKEMLAPAS--
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVEN--STKTGDDGWKEMLAPAG--
. * ::