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MHLHRRIKIQLAIFAVIALAAMAIMVFQFMKLPAQLFGVGRYTVIMQLSKTGGLYSTGNVTYRGTEVGRV QEVRLTDDGVEAVLSLKSGIEIPSDLEAEVHSQSAIGEQYVALSPRNGSSRPLREGDVITRANTSVPPDI NTLLSAANTGLQSIPADNLKTLIDESFIAVGGLGPELSRIVRGSTDLSIAARKNLDPLLALIDRAQPVLD SQTDTAAEIQTWASHISNVTASLKERDESVAGFIDNGGPAAEEARAVLDRLQPTLPILMANLVSIGQVAM TYQDNIEQLLVLLPQAVAVSQAGILANLNTKHPGQYISFNLNINLPPPCTTGFLPAQQRRVPTEVDSPER PPGDLYCRTPQDSQFNVRGARNAPCATVPGKRAPTVRLCESDEQFVPLNDGFNWKGDPNATLSGQPIPDL GPVPAAAPAQPAAQPPPLAVAEYDPATGSYIGPDGKQYRQADLGQSAPGGQTWQTMLLPPN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0368 | - | - | 100% (481) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | 0.0 | 70.33% (482) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0518 | - | e-173 | 61.08% (483) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 5e-87 | 36.07% (524) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0647 | - | 1e-173 | 61.08% (483) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-166 | 62.03% (482) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-77 | 33.46% (520) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 4e-80 | 34.05% (511) | MCE-family protein |
| M. marinum M | MMAR_2887 | mce3F | 0.0 | 69.01% (484) | MCE-family protein Mce3F |
| M. avium 104 | MAV_2537 | - | 1e-170 | 59.51% (489) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 0.0 | 64.69% (490) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-173 | 61.03% (485) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 0.0 | 69.01% (484) | MCE-family protein Mce3F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_0368|M.vanbaalenii_PYR-1 -MHLHRRIKIQLAIFAVIALAAMAIMVFQFMKLPAQLFGVGRYTVIMQLS
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
Mflv_0647|M.gilvum_PYR-GCK -MYLSKRVRLQLAIFAMVTVLAGGSMAFAYLRLPSLLFGVGRYQVTMKLQ
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :* ::: ::* .*:. : : .:
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_0368|M.vanbaalenii_PYR-1 KTGGLYSTGNVTYRGTEVGRVQEVRLTDDG-VEAVLSLKSGIEIPSDLEA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
Mflv_0647|M.gilvum_PYR-GCK DAASLYRDANVTYRGTTVGRVSDVRLSDAG-VDAMLSLQSDTKIPADLDA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:..** .***:** :*:: * : * . . : : . .:* : *
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
Mvan_0368|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALSPR-NGSSRPLREGDVITRANTSVPPDINTLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
Mflv_0647|M.gilvum_PYR-GCK HVGSQTAVGELFVDLVPR-SGDGAPLKNGDVIPADRTSVPPDINALLRAV
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTIT--KSKIPIEIGPALDSV
* * :*:** :: * . . : *:.: :* ::. :
MMAR_2887|M.marinum_M NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
MUL_2865|M.ulcerans_Agy99 NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
Mvan_0368|M.vanbaalenii_PYR-1 NTGLQSIPADNLKTLIDESFIAVGGLGPELSRIVRGSTDLSIAARKNLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
Mflv_0647|M.gilvum_PYR-GCK NTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPA
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : :. .: : *: *. * * : *: .: : . *
MMAR_2887|M.marinum_M LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
MUL_2865|M.ulcerans_Agy99 LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
Mvan_0368|M.vanbaalenii_PYR-1 LLALIDRAQPVLDSQTDTAAEIQTWASHISNVTASLKERDESVAGFIDNG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
Mflv_0647|M.gilvum_PYR-GCK LTTLIDDAKPILDTQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : : . : :: : : : .
MMAR_2887|M.marinum_M GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
MUL_2865|M.ulcerans_Agy99 GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
Mvan_0368|M.vanbaalenii_PYR-1 GPAAEEARAVLDRLQPTLPILMANLVSIGQVAMTYQDNIEQLLVLLPQAV
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
Mflv_0647|M.gilvum_PYR-GCK PPAADQVRQLFERVQPTLPILLANLVSLGQVALTYQPNLEQILALYPIEI
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: : :: : :.* *.: : : *. .:*. *. *
MMAR_2887|M.marinum_M SAEQAGILAN-VNTKQAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPIF
MUL_2865|M.ulcerans_Agy99 SAEQAGILAN-VNTKQAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPTF
Rv1971|M.tuberculosis_H37Rv AAEQAGILAN-LNTKQAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
Mvan_0368|M.vanbaalenii_PYR-1 AVSQAGILAN-LNTKHP--GQYISFNLNINLPPPCTTGFLPAQQRRVPTE
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
TH_3681|M.thermoresistible__bu AALQAAGVAN-FNTKQDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSPAL
MAV_2537|M.avium_104 AEIQATGVAN-RNTKQDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
Mflv_0647|M.gilvum_PYR-GCK AGLQGAALAN-RNTKQDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSE
MAB_4148c|M.abscessus_ATCC_199 SALLT--VAG---GAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
Mb0180|M.bovis_AF2122/97 AIAQTVLTPT-------PGAAQLPLAPAINYPPPCLTGFLPASEWRSPAD
MLBr_02594|M.leprae_Br4923 SIAQTASATF-------PNMAALDLALSINQPPPCLTGFIPAAEWRSPAD
: . : : :. **** **:.* * .
MMAR_2887|M.marinum_M EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCESDE
MUL_2865|M.ulcerans_Agy99 EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCESNE
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
Mvan_0368|M.vanbaalenii_PYR-1 VDSPERPPGDLYCRTPQDS-QFNVRGARNAPCATVPGKRAPTVRLCESDE
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
TH_3681|M.thermoresistible__bu VDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCESDE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
Mflv_0647|M.gilvum_PYR-GCK VDYPPKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDE
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
Mb0180|M.bovis_AF2122/97 TSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKD
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
* . **: . : .**:** ** *****.: . *..
MMAR_2887|M.marinum_M QYVPLNDGYNWKG----------DPNSTLSGQD--------------IPQ
MUL_2865|M.ulcerans_Agy99 QYVPLNDGYNWKG----------DPNSTLSGQD--------------IPQ
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
Mvan_0368|M.vanbaalenii_PYR-1 QFVPLNDGFNWKG----------DPNATLSGQP--------------IPD
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQS--------------IPD
TH_3681|M.thermoresistible__bu EYTPLNDGMNWKG----------DPNATLSGQD--------------IPE
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQD--------------VPQ
Mflv_0647|M.gilvum_PYR-GCK NYVPLNEGTNWKG----------DPNATLSGQP--------------VPQ
MAB_4148c|M.abscessus_ATCC_199 GYVPIGSNP-WRGPPAPYDTPVEDPRNILPPNK--------------FPN
Mb0180|M.bovis_AF2122/97 PYVPLGTNP-WFG----------DPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 PYVPLGTNP-WFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
: *:. . * * **. .
MMAR_2887|M.marinum_M LPPG-------PSPPAAAGPGEAPPPP-----------------------
MUL_2865|M.ulcerans_Agy99 LPPG-------PPPPAAAGPGEAPPPP-----------------------
Rv1971|M.tuberculosis_H37Rv -----------------LGSGQDIP-------------------------
Mvan_0368|M.vanbaalenii_PYR-1 LG---------PVPAAAPAQPAAQPPP-----------------------
MSMEG_0351|M.smegmatis_MC2_155 LGPGQGESAPETSPAPPAPPVEGDPVP-----------------------
TH_3681|M.thermoresistible__bu VRRG-------PGAAQVSTSGPVAPPS-----------------------
MAV_2537|M.avium_104 YRPGE----EPPGQVPPPSPPGPAPPP-----------------------
Mflv_0647|M.gilvum_PYR-GCK -------------PPPDPPPPVPVTAP-----------------------
MAB_4148c|M.abscessus_ATCC_199 IPPGAEPDPGTPTLPPPSPPAPEVPPAGGDVMPVSAQSGP----------
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
.
MMAR_2887|M.marinum_M IAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP--
MUL_2865|M.ulcerans_Agy99 IAAAEYDPATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP--
Rv1971|M.tuberculosis_H37Rv ---------------------------------QTWQTMLLPPGS---
Mvan_0368|M.vanbaalenii_PYR-1 LAVAEYDPATGSYIGPDGKQYRQADLGQSAPGGQTWQTMLLPPN----
MSMEG_0351|M.smegmatis_MC2_155 MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN--
TH_3681|M.thermoresistible__bu IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG---
MAV_2537|M.avium_104 IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN--
Mflv_0647|M.gilvum_PYR-GCK IAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
MAB_4148c|M.abscessus_ATCC_199 MAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV--
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVAN--SSTTGDDGWKEMLAPAS----
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVEN--STKTGDDGWKEMLAPAG----
. * ::