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MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELPQAGGLYPGGNVTYRGVEVGR VQAVKLTATGAEAVLQLNSDVHIPANLNAQVHSVSAVGEQYVELLPRGGQGPSLKNGDVIPVDRSYVPPD INSLLAATNRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDALVNLIDGSKPLL DSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREGGPAAAEARQLFDRLSPTLPIVLANLVSVGQVG VTYRDNLESLLVELPQGVAEIQATGVANRNTKQDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASYEDY PDSPNGDIYCRVPQDSVLNVRGARNMPCETRPGKRAPTVKMCESDQTYVPLNDGFNWKGDPNATYSGQDV PQYRPGEEPPGQVPPPSPPGPAPPPIAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKR N
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2537 | - | - | 100% (491) | virulence factor mce family protein |
| M. avium 104 | MAV_1807 | - | e-176 | 62.32% (475) | virulence factor mce family protein |
| M. avium 104 | MAV_2069 | - | e-153 | 53.48% (488) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 6e-84 | 35.62% (525) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-178 | 61.22% (490) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-156 | 61.93% (436) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 8e-80 | 35.35% (529) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 4e-87 | 35.99% (514) | MCE-family protein |
| M. marinum M | MMAR_4056 | mce3F_1 | 0.0 | 64.08% (490) | MCE-family protein Mce3F_1 |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-170 | 57.95% (497) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-171 | 59.22% (488) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 0.0 | 64.08% (490) | MCE-family protein Mce3F_1 |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | 1e-178 | 62.42% (487) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
MSMEG_0351|M.smegmatis_MC2_155 MIH--RRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
Mvan_3977|M.vanbaalenii_PYR-1 -MRLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLP
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
MMAR_4056|M.marinum_M -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MUL_3923|M.ulcerans_Agy99 -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
*: :* :: : :::* .*:. : :. ::
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
Mvan_3977|M.vanbaalenii_PYR-1 QAGGLYSGGNVTYRGTEVGRVEAVRLTPGG-VDAVLSLKSGIDVPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
MMAR_4056|M.marinum_M EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MUL_3923|M.ulcerans_Agy99 EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** .***:** :* : * : * . . : : . :* : *
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
Mvan_3977|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALLPR-SGDARPLRDGDVITPADTSVPPNVNTLLADA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
MMAR_4056|M.marinum_M EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MUL_3923|M.ulcerans_Agy99 EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQ-SGDGPALRNGDVISRDRARVPADVNTVLELT
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSV
*:* :::** :: *:. . : *:.: :* ::. :
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
Mvan_3977|M.vanbaalenii_PYR-1 NVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRHLDP
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
MMAR_4056|M.marinum_M NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MUL_3923|M.ulcerans_Agy99 NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : .:. .: : *: *. * * : *:: .: : . :
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
Mvan_3977|M.vanbaalenii_PYR-1 LITLIDQSQPVLDSQTRTSEAIQAWAAQVATVTTQLQTQDQTLARVIDDG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
MMAR_4056|M.marinum_M LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MUL_3923|M.ulcerans_Agy99 LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : : . : :: . : : .: .
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
Mvan_3977|M.vanbaalenii_PYR-1 GESADAVRQLVDRVKPTLPIVLANLVSVGQVAVTYHDNIEQLLVLFPAVV
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
MMAR_4056|M.marinum_M PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MUL_3923|M.ulcerans_Agy99 PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: :. : :.* *.: : : *. .:*. ** :*
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
Mvan_3977|M.vanbaalenii_PYR-1 SAEQAGLVANLHTK-QDYKGQYLSFNLNINLPPPCTTGFLPAQQQRSPVF
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSPAL
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
MMAR_4056|M.marinum_M AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
MUL_3923|M.ulcerans_Agy99 AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
Mflv_2106|M.gilvum_PYR-GCK AVTQAVGVAKNGTK-QDYMGDYLVFNLNLNVPPPCTTGFLPAQQQRAPTF
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAINYPPPCLTGFLPASEWRSPAD
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
: * : :. **** **:.* * .
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
Mvan_3977|M.vanbaalenii_PYR-1 EDAPERPPGDLYCRVPQDS-PLNVRGAHNIPCATRPGKRAPTVAICESDE
TH_3681|M.thermoresistible__bu VDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCESDE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
MMAR_4056|M.marinum_M EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
MUL_3923|M.ulcerans_Agy99 EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
Mflv_2106|M.gilvum_PYR-GCK EDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVPGKRAPSAAMCESGE
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
Mb0180|M.bovis_AF2122/97 TSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKD
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
. . **: . : .**::* ** *****.: *..
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQS----------------I
Mvan_3977|M.vanbaalenii_PYR-1 IYVPLNDGFNWKG----------DPNATSSGQP----------------V
TH_3681|M.thermoresistible__bu EYTPLNDGMNWKG----------DPNATLSGQD----------------I
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQD----------------V
MMAR_4056|M.marinum_M VYVPLNDGYNWKG----------DPNSTLSGQP----------------I
MUL_3923|M.ulcerans_Agy99 VYVPLNDGYNWKG----------DPNSTLSGQP----------------I
Mflv_2106|M.gilvum_PYR-GCK VYVPLNEGYIWKG----------DPNATLSGQA----------------V
MAB_4148c|M.abscessus_ATCC_199 GYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNK----------------F
Mb0180|M.bovis_AF2122/97 PYVPLGT-NPWFG----------DPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 PYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
: *:. * * **. .
Rv1971|M.tuberculosis_H37Rv --LGSGQ-------------------------------------------
MSMEG_0351|M.smegmatis_MC2_155 PDLGPGQGESAPETSPAPPAP---------------------PVEGDPVP
Mvan_3977|M.vanbaalenii_PYR-1 PQLPPAAG-----------------------------------PQAAPPA
TH_3681|M.thermoresistible__bu PEVRRGPGAAQVSTSG----------------------------PVAPPS
MAV_2537|M.avium_104 PQYRPGEEPPGQVPPPSP-------------------------PGPAPPP
MMAR_4056|M.marinum_M PQLPP-EPPLEQSAPP---------------------------GPAPPAP
MUL_3923|M.ulcerans_Agy99 PQLPP-EPPLEQSAPP---------------------------GPAPPAP
Mflv_2106|M.gilvum_PYR-GCK PQLRPGQQPAQASPPP---------------------------GPAPP-P
MAB_4148c|M.abscessus_ATCC_199 PNIPPGAEPDPGTPTLPPPSPPAPEVPPA--------GGDVMPVSAQSGP
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
Rv1971|M.tuberculosis_H37Rv ------------------------DIP------QTWQTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN
Mvan_3977|M.vanbaalenii_PYR-1 LAAAEYDPATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS-
TH_3681|M.thermoresistible__bu IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG-
MAV_2537|M.avium_104 IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN
MMAR_4056|M.marinum_M IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK-
MUL_3923|M.ulcerans_Agy99 IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK-
Mflv_2106|M.gilvum_PYR-GCK MAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTWQTMLLPPKGN
MAB_4148c|M.abscessus_ATCC_199 MAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGWKEMLAPAS--
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGWKEMLAPAG--
. * ::