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MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELVEAGGLYRTGNVTYRGFEVGR VAAVRLTDTGVQAVLALKSGIDIPSDLKAEVHSHTAIGETYVELLPRNAASPPLKNGDVIALADTSVPPD INDLLSAANTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDPLVALIDRAGPVL DSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRGGPALGETRQLLERLQPTVPILLANLVSVGQVA LTYHNDIEQLLVVFPMAIAAEQAGILANLNTKQAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTFEDY PDRPAGDLYCRVPQDSPFNVRGARNIPCETVPGKRAPTVKLCESDAPYLPLNDGYNWKGDPNATVPGLGS GQDIPQTWQTMLLPPGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1971 | mce3F | - | 100% (437) | MCE-FAMILY PROTEIN MCE3F |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 3e-79 | 39.31% (435) | MCE-family protein MCE4F |
| M. tuberculosis H37Rv | Rv0594 | mce2F | 2e-77 | 39.42% (411) | MCE-family protein MCE2F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 3e-79 | 39.31% (435) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_0647 | - | 1e-143 | 60.37% (429) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-69 | 35.06% (425) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 2e-75 | 37.65% (409) | MCE-family protein |
| M. marinum M | MMAR_2887 | mce3F | 0.0 | 80.46% (435) | MCE-family protein Mce3F |
| M. avium 104 | MAV_2537 | - | 1e-156 | 61.93% (436) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-157 | 63.51% (444) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_2983 | - | 1e-153 | 60.04% (458) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 0.0 | 80.23% (435) | MCE-family protein Mce3F |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | 1e-168 | 61.80% (479) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 --MIDRLAKIQLSIFAVITVITLSVMAIFYLRLP-ATFGIGTYGVSADFV
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_3977|M.vanbaalenii_PYR-1 -MRLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLP
TH_2983|M.thermoresistible__bu --MLHRRIKIQLVIFAVIAMTAMALMSTQYMRLPAKLFGIGRYSVIVQLP
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
Mflv_0647|M.gilvum_PYR-GCK -MYLSKRVRLQLAIFAMVTVLAGGSMAFAYLRLPSLLFGVGRYQVTMKLQ
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :* ::: : ::* .*:. : : .:
Mb3524c|M.bovis_AF2122/97 AGGGLYKNANVTYRGVAVGRVESVGLNPNG-VTAHMRLNSGTAIPSNVTA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_3977|M.vanbaalenii_PYR-1 QAGGLYSGGNVTYRGTEVGRVEAVRLTPGG-VDAVLSLKSGIDVPSDLRA
TH_2983|M.thermoresistible__bu EAAGLYPRGNVTYRGVEVGIVDSLHLTDTG-VDAVLSLKSGIDIPSDVTA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
Mflv_0647|M.gilvum_PYR-GCK DAASLYRDANVTYRGTTVGRVSDVRLSDAG-VDAMLSLQSDTKIPADLDA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
..** .***:** :* * : . * . * : :.. :* : *
Mb3524c|M.bovis_AF2122/97 TVRSVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQA
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLP-RNATSPPLKDGDVIRLVNTSVPPDINTLLSAA
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLP-RNATSPPLKDGDVIRLVNTSVPPDINTLLSAA
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLP-RNAASPPLKNGDVIALADTSVPPDINDLLSAA
Mvan_3977|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALLP-RSGDARPLRDGDVITPADTSVPPNVNTLLADA
TH_2983|M.thermoresistible__bu EVHSQSAIGEQYVMLLP-RDGTSPPLKDGDVIPPEQTRVPADINAILADA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLP-RSAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLP-RGGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
Mflv_0647|M.gilvum_PYR-GCK HVGSQTAVGELFVDLVP-RSGDGAPLKNGDVIPADRTSVPPDINALLRAV
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVS-SGNPGKYLAPGQTIT--KSKIPIEIGPALDSV
* * :*:** :: *:. . * * * : :: * .
Mb3524c|M.bovis_AF2122/97 ETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQ
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
MMAR_2887|M.marinum_M NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
MUL_2865|M.ulcerans_Agy99 NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
Mvan_3977|M.vanbaalenii_PYR-1 NVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRHLDP
TH_2983|M.thermoresistible__bu VTGLQAVPKDGLQTLIDESYTAVGGLGPELRRIVSASIDLSLDARDNLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
Mflv_0647|M.gilvum_PYR-GCK NTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPA
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : : : *: * * * : *: .: : . :
Mb3524c|M.bovis_AF2122/97 VSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGA
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
MMAR_2887|M.marinum_M LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
MUL_2865|M.ulcerans_Agy99 LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
Mvan_3977|M.vanbaalenii_PYR-1 LITLIDQSQPVLDSQTRTSEAIQAWAAQVATVTTQLQTQDQTLARVIDDG
TH_2983|M.thermoresistible__bu LVELIEKSQPVLDSQTDTSQAIRAWASQVATVTDSLRNHDAQLAGVLHQG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
Mflv_0647|M.gilvum_PYR-GCK LTTLIDDAKPILDTQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNG
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *. ::* : : . : .: : : : .
Mb3524c|M.bovis_AF2122/97 PDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALF
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
MMAR_2887|M.marinum_M GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
MUL_2865|M.ulcerans_Agy99 GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
Mvan_3977|M.vanbaalenii_PYR-1 GESADAVRQLVDRVKPTLPIVLANLVSVGQVAVTYHDNIEQLLVLFPAVV
TH_2983|M.thermoresistible__bu GPAFADTRDLIDRLHPTLPSTVAHLATLGDVAHQYHPAVEQLLVLFPQAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
Mflv_0647|M.gilvum_PYR-GCK PPAADQVRQLFERVQPTLPILLANLVSLGQVALTYQPNLEQILALYPIEI
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: . . : :.* * : : : *. :*. *. *
Mb3524c|M.bovis_AF2122/97 AAIITSAGGVPQDE-----GAKLDFKIDLHDPPPCMTGFLPPPLVRSPAD
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
MMAR_2887|M.marinum_M SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPIF
MUL_2865|M.ulcerans_Agy99 SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPTF
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
Mvan_3977|M.vanbaalenii_PYR-1 SAEQAGLVANLHTK-QDYKGQYLSFNLNINLPPPCTTGFLPAQQQRSPVF
TH_2983|M.thermoresistible__bu AEAQATHLANRNTE-QDYRGQYLSFNLNLNLPPPCTTGFLPAQQQRSPVH
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
Mflv_0647|M.gilvum_PYR-GCK AGLQGAALANRNTK-QDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSE
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
: * : .: **** **::* * .
Mb3524c|M.bovis_AF2122/97 ESVREIPR-DMYCKTAQND-PSTVRGARNYPCQEFPGKRAPTVQLCRDPR
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
MMAR_2887|M.marinum_M EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCESDE
MUL_2865|M.ulcerans_Agy99 EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCESNE
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
Mvan_3977|M.vanbaalenii_PYR-1 EDAPERPPGDLYCRVPQDS-PLNVRGAHNIPCATRPGKRAPTVAICESDE
TH_2983|M.thermoresistible__bu EDHPPREPGLLYCRTPQDS-MWNVRGAKNYPCITRPGKRAPTAQMCESDE
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
Mflv_0647|M.gilvum_PYR-GCK VDYPPKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDE
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
**: . : .**::* ** *****.: *..
Mb3524c|M.bovis_AF2122/97 GYVPVGTN-PWRGPP---------------------IPYGTEVTDGRNIL
MAB_4148c|M.abscessus_ATCC_199 GYVPIGSN-PWRGPP---------------------APYDTPVEDPRNIL
MMAR_2887|M.marinum_M QYVPLNDGYNWKG-------------------------------DPNSTL
MUL_2865|M.ulcerans_Agy99 QYVPLNDGYNWKG-------------------------------DPNSTL
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG-------------------------------DPNATV
Mvan_3977|M.vanbaalenii_PYR-1 IYVPLNDGFNWKG-------------------------------DPNATS
TH_2983|M.thermoresistible__bu HYIPLNDGNNWKG-------------------------------DPNATL
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG-------------------------------DPNATL
MAV_2537|M.avium_104 TYVPLNDGFNWKG-------------------------------DPNATY
Mflv_0647|M.gilvum_PYR-GCK NYVPLNEGTNWKG-------------------------------DPNATL
MLBr_02594|M.leprae_Br4923 PYVPLGTN-PWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNPA
::*:. . * * :
Mb3524c|M.bovis_AF2122/97 PPNKFPYIPPGADPDPGVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNG
MAB_4148c|M.abscessus_ATCC_199 PPNKFPNIPPGAEPDPGTP-------------------------------
MMAR_2887|M.marinum_M SGQDIPQLPPG---------------------------------------
MUL_2865|M.ulcerans_Agy99 SGQDIPQLPPG---------------------------------------
Rv1971|M.tuberculosis_H37Rv PG------------------------------------------------
Mvan_3977|M.vanbaalenii_PYR-1 SGQPVPQLPP----------------------------------------
TH_2983|M.thermoresistible__bu SGQDIPQLPP----------------------------------------
MSMEG_0351|M.smegmatis_MC2_155 SGQSIPDLGPGQGES-----------------------------------
MAV_2537|M.avium_104 SGQDVPQYRPGE--------------------------------------
Mflv_0647|M.gilvum_PYR-GCK SGQPVPQPPPD---------------------------------------
MLBr_02594|M.leprae_Br4923 PADRLPGTPPPVSDPLSQP-------------------------------
.
Mb3524c|M.bovis_AF2122/97 PPPPFTSWMPPGYPPEPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQAS
MAB_4148c|M.abscessus_ATCC_199 ------------------------TLPPPSPPAPEVPPAGGDVMPVSAQS
MMAR_2887|M.marinum_M ------------------------------------PSPPAAAGPGEAPP
MUL_2865|M.ulcerans_Agy99 ------------------------------------PPPPAAAGPGEAPP
Rv1971|M.tuberculosis_H37Rv ------------------------------------------LGSGQDIP
Mvan_3977|M.vanbaalenii_PYR-1 ------------------------------------------AAGPQAAP
TH_2983|M.thermoresistible__bu -------------------------------------------GTSQTPP
MSMEG_0351|M.smegmatis_MC2_155 ---------------------------------APETSPAPPAPPVEGDP
MAV_2537|M.avium_104 ----------------------------------EPPGQVPPPSPPGPAP
Mflv_0647|M.gilvum_PYR-GCK ------------------------------------------PPPPVPVT
MLBr_02594|M.leprae_Br4923 -------------------------------RSGSVQCNGQQPNTCVYTP
.
Mb3524c|M.bovis_AF2122/97 GP-AYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL--
MAB_4148c|M.abscessus_ATCC_199 GPMAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV--
MMAR_2887|M.marinum_M PPIAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP--
MUL_2865|M.ulcerans_Agy99 PPIAAAEYDPATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP--
Rv1971|M.tuberculosis_H37Rv -----------------------------------QTWQTMLLPPGS---
Mvan_3977|M.vanbaalenii_PYR-1 PALAAAEYDPATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS---
TH_2983|M.thermoresistible__bu AEPGDPTTDP-----------------------REQTWQSMLLPPR----
MSMEG_0351|M.smegmatis_MC2_155 VPMAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN--
MAV_2537|M.avium_104 PPIAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN--
Mflv_0647|M.gilvum_PYR-GCK APIAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
MLBr_02594|M.leprae_Br4923 SGPPSAVYSPQSGELVGPDGVAYAVEN--STKTGDDGWKEMLAPAG----
. * ::