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MYLSKRVRLQLAIFAMVTVVAGGSMAFAYLRLPSLLFGVGRYQVTMKLQDAASLYRDANVTYRGTTVGRV SDVRLSDAGVDAMLSLQSDTKIPADLDAHVGSQTAVGELFVDLVPRSGDGAPLKNGDVIPADRTSVPPDI NALLRAVNTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPALTTLIDDAKPILD TQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNGPPAADQVRQLFERVQPTLPILLANLVSLGQVAL TYQPNLEQILALYPIEIAGLQGAALANRNTKQDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSEVDYP PKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDENYVPLNEGTNWKGDPNATLSGQPV PQPPPDPPPPVPVTAPIAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0518 | - | - | 100% (484) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0368 | - | e-173 | 61.08% (483) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | e-169 | 60.13% (479) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 2e-82 | 36.48% (529) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0647 | - | 0.0 | 99.79% (484) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-143 | 60.37% (429) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-79 | 33.97% (527) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 4e-84 | 35.85% (516) | MCE-family protein |
| M. marinum M | MMAR_4056 | mce3F_1 | 1e-170 | 60.49% (486) | MCE-family protein Mce3F_1 |
| M. avium 104 | MAV_2537 | - | 1e-169 | 59.10% (489) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-161 | 58.04% (491) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_2736 | - | 0.0 | 65.57% (488) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 1e-170 | 60.49% (486) | MCE-family protein Mce3F_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0518|M.vanbaalenii_PYR-1 -MYLSKRVRLQLAIFAMVTVVAGGSMAFAYLRLPSLLFGVGRYQVTMKLQ
Mflv_0647|M.gilvum_PYR-GCK -MYLSKRVRLQLAIFAMVTVLAGGSMAFAYLRLPSLLFGVGRYQVTMKLQ
TH_2736|M.thermoresistible__bu -MNLSKRVRIQLGFFAVITVFAGGMMTFMYLRLPSTLFGIGQYRVTVNLP
MMAR_4056|M.marinum_M -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MUL_3923|M.ulcerans_Agy99 -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
MSMEG_0351|M.smegmatis_MC2_155 MIH--RRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
*: .* :: ::::* .*:. : :. .:
Mvan_0518|M.vanbaalenii_PYR-1 DAASLYRDANVTYRGTTVGRVSDVRLSDAG-VDAMLSLQSDTKIPADLDA
Mflv_0647|M.gilvum_PYR-GCK DAASLYRDANVTYRGTTVGRVSDVRLSDAG-VDAMLSLQSDTKIPADLDA
TH_2736|M.thermoresistible__bu VAAGLYPNSNVTYRGTEVGRVEAVRLTTVG-VDAVMSLRSDTKIPADLDA
MMAR_4056|M.marinum_M EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MUL_3923|M.ulcerans_Agy99 EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:..** .***:** :* * * : * . . : : . .:* : *
Mvan_0518|M.vanbaalenii_PYR-1 HVGSQTAVGELFVDLVPR-SGDGAPLKNGDVIPADRTSVPPDINALLRAV
Mflv_0647|M.gilvum_PYR-GCK HVGSQTAVGELFVDLVPR-SGDGAPLKNGDVIPADRTSVPPDINALLRAV
TH_2736|M.thermoresistible__bu IVHSHTAAGEQFVDLVPR-SGGEPHLRDGDVIPLHRASVPADINTVLRAA
MMAR_4056|M.marinum_M EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MUL_3923|M.ulcerans_Agy99 EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTIT--KSKIPIEIGPALDSV
* * :: ** :::*:. : *:.* :* ::. *
Mvan_0518|M.vanbaalenii_PYR-1 NTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPA
Mflv_0647|M.gilvum_PYR-GCK NTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPA
TH_2736|M.thermoresistible__bu NTGLQAIPHDNLKTVIDESFTAVGGLGAELSRIVRFSTELASDARAHLDA
MMAR_4056|M.marinum_M NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MUL_3923|M.ulcerans_Agy99 NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : .:. .: : *: *. * * : *: : : . :
Mvan_0518|M.vanbaalenii_PYR-1 LTTLIDDAKPILDTQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNG
Mflv_0647|M.gilvum_PYR-GCK LTTLIDDAKPILDTQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNG
TH_2736|M.thermoresistible__bu LTAVIDHSTPVLDSQIDTSDAIQVWASNMASITAQLEAQDSSIRTLLDEG
MMAR_4056|M.marinum_M LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MUL_3923|M.ulcerans_Agy99 LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : . : . : :: . : : :: .
Mvan_0518|M.vanbaalenii_PYR-1 PPAADQVRQLFERVQPTLPILLANLVSLGQVALTYQPNLEQILALYPIEI
Mflv_0647|M.gilvum_PYR-GCK PPAADQVRQLFERVQPTLPILLANLVSLGQVALTYQPNLEQILALYPIEI
TH_2736|M.thermoresistible__bu PPALDETRELFDRLLPSLPILAANLVSIADVALVYQPNLEQLLVLLPAGI
MMAR_4056|M.marinum_M PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MUL_3923|M.ulcerans_Agy99 PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: :. :: : :.* *.: : : *. .:*. *. *
Mvan_0518|M.vanbaalenii_PYR-1 AGLQGAALANRNTK-QDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSE
Mflv_0647|M.gilvum_PYR-GCK AGLQGAALANRNTK-QDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSE
TH_2736|M.thermoresistible__bu EALQGAGLANRDTR-QDYRGLYLSFNLNLNLPPPCTTGYLPARQMRPPSE
MMAR_4056|M.marinum_M AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
MUL_3923|M.ulcerans_Agy99 AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAINYPPPCLTGFLPASEWRSPAD
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
* : :. **** **::* * .:
Mvan_0518|M.vanbaalenii_PYR-1 VDYPPKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDE
Mflv_0647|M.gilvum_PYR-GCK VDYPPKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDE
TH_2736|M.thermoresistible__bu VDYPDRPPGYLYCRIPQDS-MFNVRGARNLPCAERPGKRAPTVEMCESDE
MMAR_4056|M.marinum_M EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
MUL_3923|M.ulcerans_Agy99 EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
Mb0180|M.bovis_AF2122/97 TSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKD
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
. **: . : .**:** ** *****.: . *..
Mvan_0518|M.vanbaalenii_PYR-1 NYVPLNEGTNWKG----------DPNATLSGQP--------------VPQ
Mflv_0647|M.gilvum_PYR-GCK NYVPLNEGTNWKG----------DPNATLSGQP--------------VPQ
TH_2736|M.thermoresistible__bu EYVPLNDGLNWKG----------DPNATLSGQA--------------VPQ
MMAR_4056|M.marinum_M VYVPLNDGYNWKG----------DPNSTLSGQP--------------IPQ
MUL_3923|M.ulcerans_Agy99 VYVPLNDGYNWKG----------DPNSTLSGQP--------------IPQ
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQD--------------VPQ
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQS--------------IPD
MAB_4148c|M.abscessus_ATCC_199 GYVPIGSNP-WRGPPAPYDTPVEDPRNILPPNK--------------FPN
Mb0180|M.bovis_AF2122/97 PYVPLGTNP-WFG----------DPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 PYVPLGTNP-WFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
::*:. . * * **. .
Mvan_0518|M.vanbaalenii_PYR-1 PPP------DPPP-------PVPVT-----------------------AP
Mflv_0647|M.gilvum_PYR-GCK PPP------DPPP-------PVPVT-----------------------AP
TH_2736|M.thermoresistible__bu PRAG-----DPALSSGPDQAPPAVA-----------------------AP
MMAR_4056|M.marinum_M LPP-----EPP--LEQSAPPGPAPP-----------------------AP
MUL_3923|M.ulcerans_Agy99 LPP-----EPP--LEQSAPPGPAPP-----------------------AP
MAV_2537|M.avium_104 YRPGE---EPPGQVPPPSPPGPAPP------------------------P
Rv1971|M.tuberculosis_H37Rv LGSGQ---------------------------------------------
MSMEG_0351|M.smegmatis_MC2_155 LGPGQGESAPETSPAPPAPPVEGDP-----------------------VP
MAB_4148c|M.abscessus_ATCC_199 IPPGAEPDPGTPTLPPPSPPAPEVPPA----------GGDVMPVSAQSGP
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
Mvan_0518|M.vanbaalenii_PYR-1 IAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
Mflv_0647|M.gilvum_PYR-GCK IAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
TH_2736|M.thermoresistible__bu IAIAEYDPETGAYVGPDGKHYTHFNLGRSGGSPATWQDLMLPPGN---
MMAR_4056|M.marinum_M IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK---
MUL_3923|M.ulcerans_Agy99 IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK---
MAV_2537|M.avium_104 IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN--
Rv1971|M.tuberculosis_H37Rv ------------------------DIP------QTWQTMLLPPGS---
MSMEG_0351|M.smegmatis_MC2_155 MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN--
MAB_4148c|M.abscessus_ATCC_199 MAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV--
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGWKEMLAPAS----
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGWKEMLAPAG----
* ::