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MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELTKSGGLYSSGNVTYRGSEVGRV ESVQLTDTGVVAVLSLKSGIDIPSDLKAEVHSQTAIGETYVELLPRNATSPPLKDGDVIRLVNTSVPPDI NTLLSAANTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDPLIALIDQTPPVLD SQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNGGPALDEVNSLLERVQPTLPILLANLVSVGQVAL AYQNDIEQLLVVFPMAISAEQAGILANVNTKQAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPIFEDYP NRPAGDLYCRVPQDSPLNVRGARNIPCETVPGKRAPTVKLCESDEQYVPLNDGYNWKGDPNSTLSGQDIP QLPPGPSPPAAAGPGEAPPPPIAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2887 | mce3F | - | 100% (487) | MCE-family protein Mce3F |
| M. marinum M | MMAR_4056 | mce3F_1 | 0.0 | 64.26% (484) | MCE-family protein Mce3F_1 |
| M. marinum M | MMAR_4705 | - | 1e-90 | 36.93% (547) | MCE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 4e-84 | 39.06% (466) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-168 | 59.30% (484) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 0.0 | 80.46% (435) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 5e-77 | 34.03% (526) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 3e-85 | 35.87% (513) | MCE-family protein |
| M. avium 104 | MAV_2537 | - | 1e-179 | 61.19% (487) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-176 | 62.80% (492) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-173 | 60.62% (485) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 0.0 | 98.56% (487) | MCE-family protein Mce3F |
| M. vanbaalenii PYR-1 | Mvan_3977 | - | 0.0 | 69.42% (484) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 --MIDRLAKIQLSIFAVITVITLSVMAIFYLRLP-ATFGIGTYGVSADFV
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_3977|M.vanbaalenii_PYR-1 -MRLDRRMKIQLALFAVIALMAMGVMGVHFMKLPAKLFGVGRYTVTVQLP
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :* ::: : . ::* .*:. : :. ::
Mb3524c|M.bovis_AF2122/97 AGGGLYKNANVTYRGVAVGRVESVGLNPNG-VTAHMRLNSGTAIPSNVTA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_3977|M.vanbaalenii_PYR-1 QAGGLYSGGNVTYRGTEVGRVEAVRLTPGG-VDAVLSLKSGIDVPSDLRA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
.*** .***:** :* : * . * . * : :.. :* : *
Mb3524c|M.bovis_AF2122/97 TVRSVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQA
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLP-RNATSPPLKDGDVIRLVNTSVPPDINTLLSAA
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLP-RNATSPPLKDGDVIRLVNTSVPPDINTLLSAA
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLP-RNAASPPLKNGDVIALADTSVPPDINDLLSAA
Mvan_3977|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALLP-RSGDARPLRDGDVITPADTSVPPNVNTLLADA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLP-RSAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVP-QSGDGPALRNGDVISRDRARVPADVNTVLELT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLP-RGGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLP-RDGESPPLRDGDVVSRENVKVPPNINALVAAT
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVS-SGNPGKYLAPGQTIT--KSKIPIEIGPALDSV
*:* :*:** :: *:. . * * : : :: : .
Mb3524c|M.bovis_AF2122/97 ETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQ
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
MMAR_2887|M.marinum_M NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
MUL_2865|M.ulcerans_Agy99 NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
Mvan_3977|M.vanbaalenii_PYR-1 NVGLQAIPRDNLQTVVEESYAAVGGLGPELSRIVDSSTKLAIEARRHLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : : .: : *: * * * : *:: .: : . :
Mb3524c|M.bovis_AF2122/97 VSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGA
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
MMAR_2887|M.marinum_M LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
MUL_2865|M.ulcerans_Agy99 LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
Mvan_3977|M.vanbaalenii_PYR-1 LITLIDQSQPVLDSQTRTSEAIQAWAAQVATVTTQLQTQDQTLARVIDDG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *. ::* : : . : .: . : : : .
Mb3524c|M.bovis_AF2122/97 PDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALF
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
MMAR_2887|M.marinum_M GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
MUL_2865|M.ulcerans_Agy99 GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
Mvan_3977|M.vanbaalenii_PYR-1 GESADAVRQLVDRVKPTLPIVLANLVSVGQVAVTYHDNIEQLLVLFPAVV
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: . : :.* *.: : : *. .:*. ** :*
Mb3524c|M.bovis_AF2122/97 AAIITSAGGVPQDE-----GAKLDFKIDLHDPPPCMTGFLPPPLVRSPAD
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
MMAR_2887|M.marinum_M SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPIF
MUL_2865|M.ulcerans_Agy99 SAEQAGILANVNTK-QAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVPTF
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
Mvan_3977|M.vanbaalenii_PYR-1 SAEQAGLVANLHTK-QDYKGQYLSFNLNINLPPPCTTGFLPAQQQRSPVF
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
Mflv_2106|M.gilvum_PYR-GCK AVTQAVGVAKNGTK-QDYMGDYLVFNLNLNVPPPCTTGFLPAQQQRAPTF
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSPAL
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
: * : .: **** **:.* * .
Mb3524c|M.bovis_AF2122/97 ESVREIPR-DMYCKTAQND-PSTVRGARNYPCQEFPGKRAPTVQLCRDPR
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
MMAR_2887|M.marinum_M EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCESDE
MUL_2865|M.ulcerans_Agy99 EDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCESNE
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
Mvan_3977|M.vanbaalenii_PYR-1 EDAPERPPGDLYCRVPQDS-PLNVRGAHNIPCATRPGKRAPTVAICESDE
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
Mflv_2106|M.gilvum_PYR-GCK EDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVPGKRAPSAAMCESGE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
TH_3681|M.thermoresistible__bu VDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCESDE
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
* . **: . : .**::* ** *****.: *..
Mb3524c|M.bovis_AF2122/97 GYVPVGT-NPWRGPPIPYGTEVTDGRNILPPNKF-----PYIPPGADPDP
MAB_4148c|M.abscessus_ATCC_199 GYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNKF-----PNIPPGAEPDP
MMAR_2887|M.marinum_M QYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG-----
MUL_2865|M.ulcerans_Agy99 QYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG-----
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
Mvan_3977|M.vanbaalenii_PYR-1 IYVPLNDGFNWKG----------DPNATSSGQPV-----PQLPP------
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQSI-----PDLGPGQGES-
Mflv_2106|M.gilvum_PYR-GCK VYVPLNEGYIWKG----------DPNATLSGQAV-----PQLRPG-----
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQDV-----PQYRPG-----
TH_3681|M.thermoresistible__bu EYTPLNDGMNWKG----------DPNATLSGQDI-----PEVRRG-----
MLBr_02594|M.leprae_Br4923 PYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
: *:. * * * . .
Mb3524c|M.bovis_AF2122/97 GVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPE
MAB_4148c|M.abscessus_ATCC_199 GTP-----------------------------------------------
MMAR_2887|M.marinum_M --------------------------------------------------
MUL_2865|M.ulcerans_Agy99 --------------------------------------------------
Rv1971|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3977|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0351|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2106|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2537|M.avium_104 --------------------------------------------------
TH_3681|M.thermoresistible__bu --------------------------------------------------
MLBr_02594|M.leprae_Br4923 PTVDNG------------------------------------------LN
Mb3524c|M.bovis_AF2122/97 PPQVPYPATIPPPPPPEGTGPPPG------PAPGPQPQASGP-AYTIYDQ
MAB_4148c|M.abscessus_ATCC_199 --------TLPPPSPPAPEVPPAG------GDVMPVSAQSGPMAARAYDP
MMAR_2887|M.marinum_M -------PSPPAAAGPGEAPPP-------------------PIAAAEYDP
MUL_2865|M.ulcerans_Agy99 -------PPPPAAAGPGEAPPP-------------------PIAAAEYDP
Rv1971|M.tuberculosis_H37Rv -------------LGSGQDIP-----------------------------
Mvan_3977|M.vanbaalenii_PYR-1 -------------AAGPQAAPP-------------------ALAAAEYDP
MSMEG_0351|M.smegmatis_MC2_155 ----APETSPAPPAPPVEGDPV-------------------PMAIARYDP
Mflv_2106|M.gilvum_PYR-GCK ----QQP-AQASPP--PGPAPP-------------------PMAAAEYDP
MAV_2537|M.avium_104 ----EEPPGQVPPPSPPGPAPP-------------------PIAAVQYDP
TH_3681|M.thermoresistible__bu -------PGAAQVSTSGPVAPP-------------------SIAVTEYDP
MLBr_02594|M.leprae_Br4923 PAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSGPPSAVYSP
*
Mb3524c|M.bovis_AF2122/97 LSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL
MAB_4148c|M.abscessus_ATCC_199 KNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV
MMAR_2887|M.marinum_M TTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP
MUL_2865|M.ulcerans_Agy99 ATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP
Rv1971|M.tuberculosis_H37Rv -------------------------QTWQTMLLPPGS-
Mvan_3977|M.vanbaalenii_PYR-1 ATGSYIGPDGRSYTQADLAQGAPAGQTWQTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 ATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN
Mflv_2106|M.gilvum_PYR-GCK ANGTYVGPDGRVYTQSNLAEGATEEQTWQTMLLPPKGN
MAV_2537|M.avium_104 ATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN
TH_3681|M.thermoresistible__bu ATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG-
MLBr_02594|M.leprae_Br4923 QSGELVGPDGVAYAVENSTKTG--DDGWKEMLAPAG--
. * ::