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MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLDRTGGLYPTGNVTYRGTEVGRVE SVGLSENGGVRAVLKLKSGIDIPSDLRAEVHSQSAIGEQYVELLPRSAAAPPLQDGDVIAAKDVFIPPDI NSLLDAANTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGSLTTLIDLWQPVAE SQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQGAPAAEEARRLFERVQPTLPILLANLVSINEVAV TYQPGIEQILVLLPQGIAQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSFEDY PERPAGDLYCRTPQDSPFNARGARNIPCETVPGKRAPTVKLCESDENFVPLNDGYNWKGDPNATLSGQSI PDLGPGQGESAPETSPAPPAPPVEGDPVPMAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLT PHGMN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0351 | - | - | 100% (495) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_2860 | - | e-102 | 43.17% (505) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4785 | - | 8e-88 | 41.04% (463) | mce-family protein mce1f |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 1e-85 | 36.59% (533) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 1e-166 | 59.39% (490) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-157 | 63.51% (444) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 2e-78 | 35.05% (525) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 1e-83 | 36.33% (512) | MCE-family protein |
| M. marinum M | MMAR_2887 | mce3F | 1e-176 | 62.80% (492) | MCE-family protein Mce3F |
| M. avium 104 | MAV_2537 | - | 1e-170 | 57.95% (497) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-165 | 59.06% (491) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 1e-175 | 62.60% (492) | MCE-family protein Mce3F |
| M. vanbaalenii PYR-1 | Mvan_0368 | - | 0.0 | 64.69% (490) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2887|M.marinum_M -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
MUL_2865|M.ulcerans_Agy99 -MHLERRVMIQLTIFAVIALSVLAITFLHFAKLPAMLFGVGRYTVTMELT
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
Mvan_0368|M.vanbaalenii_PYR-1 -MHLHRRIKIQLAIFAVIALAAMAIMVFQFMKLPAQLFGVGRYTVIMQLS
MSMEG_0351|M.smegmatis_MC2_155 --MIHRRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
: ** :* ::: : ::* .*:. : : ::
MMAR_2887|M.marinum_M KSGGLYSSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
MUL_2865|M.ulcerans_Agy99 KSGGLYTSGNVTYRGSEVGRVESVQLTDTG-VVAVLSLKSGIDIPSDLKA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
Mvan_0368|M.vanbaalenii_PYR-1 KTGGLYSTGNVTYRGTEVGRVQEVRLTDDG-VEAVLSLKSGIEIPSDLEA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** .***:** :* : * : * . . : : . :* : *
MMAR_2887|M.marinum_M EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
MUL_2865|M.ulcerans_Agy99 EVHSQTAIGETYVELLPR-NATSPPLKDGDVIRLVNTSVPPDINTLLSAA
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
Mvan_0368|M.vanbaalenii_PYR-1 EVHSQSAIGEQYVALSPR-NGSSRPLREGDVITRANTSVPPDINTLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQ-SGDGPALRNGDVISRDRARVPADVNTVLELT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSV
*:* :*:** :: * . . : *:.: :* ::. :
MMAR_2887|M.marinum_M NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
MUL_2865|M.ulcerans_Agy99 NTALGAIPHENLQTVINESYTAVGGLGPELSRLITGTSNLAIDARKNLDP
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
Mvan_0368|M.vanbaalenii_PYR-1 NTGLQSIPADNLKTLIDESFIAVGGLGPELSRIVRGSTDLSIAARKNLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : :. .: : *: *. * * : *:: .: : . *
MMAR_2887|M.marinum_M LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
MUL_2865|M.ulcerans_Agy99 LIALIDQTPPVLDSQTHSSDAIAGWASHLAAVTTELQTHDQAVAATIDNG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
Mvan_0368|M.vanbaalenii_PYR-1 LLALIDRAQPVLDSQTDTAAEIQTWASHISNVTASLKERDESVAGFIDNG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : : . : :: : : : .
MMAR_2887|M.marinum_M GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
MUL_2865|M.ulcerans_Agy99 GPALDEVNSLLERVQPTLPILLANLVSVGQVALAYQNDIEQLLVVFPMAI
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
Mvan_0368|M.vanbaalenii_PYR-1 GPAAEEARAVLDRLQPTLPILMANLVSIGQVAMTYQDNIEQLLVLLPQAV
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: : :: : :.* *.: : : *. .:*. ** :*
MMAR_2887|M.marinum_M SAEQ--AGILAN-VNTKQAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVP
MUL_2865|M.ulcerans_Agy99 SAEQ--AGILAN-VNTKQAYHGQYLSFNLNLNLPPPCSTGFLPAQQQRVP
Rv1971|M.tuberculosis_H37Rv AAEQ--AGILAN-LNTKQAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIP
Mvan_0368|M.vanbaalenii_PYR-1 AVSQ--AGILAN-LNTKHP--GQYISFNLNINLPPPCTTGFLPAQQRRVP
MSMEG_0351|M.smegmatis_MC2_155 AQLQ--GPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPP
TH_3681|M.thermoresistible__bu AALQ--AAGVAN-FNTKQDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSP
Mflv_2106|M.gilvum_PYR-GCK AVTQ--AVGVAK-NGTKQDYMGDYLVFNLNLNVPPPCTTGFLPAQQQRAP
MAV_2537|M.avium_104 AEIQ--ATGVAN-RNTKQDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAA
MAB_4148c|M.abscessus_ATCC_199 SALLTVAG-------GAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTP
Mb0180|M.bovis_AF2122/97 AIAQ---------TVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSP
MLBr_02594|M.leprae_Br4923 SIAQ---------TASATFPNMAALDLALSINQPPPCLTGFIPAAEWRSP
: : : :. **** **:.* * .
MMAR_2887|M.marinum_M IFEDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVKLCES
MUL_2865|M.ulcerans_Agy99 TFEDYPNRPAGDLYCRVPQDS-PLNVRGARNIPCETVPGKRAPTVNLCES
Rv1971|M.tuberculosis_H37Rv TFEDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCES
Mvan_0368|M.vanbaalenii_PYR-1 TEVDSPERPPGDLYCRTPQDS-QFNVRGARNAPCATVPGKRAPTVRLCES
MSMEG_0351|M.smegmatis_MC2_155 SFEDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCES
TH_3681|M.thermoresistible__bu ALVDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCES
Mflv_2106|M.gilvum_PYR-GCK TFEDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVPGKRAPSAAMCES
MAV_2537|M.avium_104 SYEDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCES
MAB_4148c|M.abscessus_ATCC_199 ADETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRD
Mb0180|M.bovis_AF2122/97 ADTSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRS
MLBr_02594|M.leprae_Br4923 ADTSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRD
* . **: . : .**:** ** *****.: *..
MMAR_2887|M.marinum_M DEQYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG---
MUL_2865|M.ulcerans_Agy99 NEQYVPLNDGYNWKG----------DPNSTLSGQDI-----PQLPPG---
Rv1971|M.tuberculosis_H37Rv DAPYLPLNDGYNWKG----------DPNATVPG-----------------
Mvan_0368|M.vanbaalenii_PYR-1 DEQFVPLNDGFNWKG----------DPNATLSGQPI-----PDLG-----
MSMEG_0351|M.smegmatis_MC2_155 DENFVPLNDGYNWKG----------DPNATLSGQSI-----PDLGPGQGE
TH_3681|M.thermoresistible__bu DEEYTPLNDGMNWKG----------DPNATLSGQDI-----PEVRRG---
Mflv_2106|M.gilvum_PYR-GCK GEVYVPLNEGYIWKG----------DPNATLSGQAV-----PQLRPG---
MAV_2537|M.avium_104 DQTYVPLNDGFNWKG----------DPNATYSGQDV-----PQYRPG---
MAB_4148c|M.abscessus_ATCC_199 PRGYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNKF-----PNIPPGAEP
Mb0180|M.bovis_AF2122/97 KDPYVPLGT-NPWFG----------DPNQILTCPAPGARCDQPVKPGLVI
MLBr_02594|M.leprae_Br4923 SKPYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLVI
: *:. * * **. .
MMAR_2887|M.marinum_M -------PSPPAAAGPGEAPPPP---------------------------
MUL_2865|M.ulcerans_Agy99 -------PPPPAAAGPGEAPPPP---------------------------
Rv1971|M.tuberculosis_H37Rv -------------LGSGQDIP-----------------------------
Mvan_0368|M.vanbaalenii_PYR-1 -------PVPAAAPAQPAAQPPP---------------------------
MSMEG_0351|M.smegmatis_MC2_155 ---SAPETSPAPPAPPVEGDPVP---------------------------
TH_3681|M.thermoresistible__bu -------PGAAQVSTSGPVAPPS---------------------------
Mflv_2106|M.gilvum_PYR-GCK ----QQP-AQASPP--PGPAPPP---------------------------
MAV_2537|M.avium_104 ----EEPPGQVPPPSPPGPAPPP---------------------------
MAB_4148c|M.abscessus_ATCC_199 ---DPGTPTLPPPSPPAPEVPPAGGDVM----------------PVSAQS
Mb0180|M.bovis_AF2122/97 PAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTP
MLBr_02594|M.leprae_Br4923 PAPTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTP
*
MMAR_2887|M.marinum_M --IAAAEYDPTTGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPVP
MUL_2865|M.ulcerans_Agy99 --IAAAEYDPATGTYTGPDGRQYTRSDLAQTAPKDQTWQSMLLPPPLP
Rv1971|M.tuberculosis_H37Rv -----------------------------------QTWQTMLLPPGS-
Mvan_0368|M.vanbaalenii_PYR-1 --LAVAEYDPATGSYIGPDGKQYRQADLGQSAPGGQTWQTMLLPPN--
MSMEG_0351|M.smegmatis_MC2_155 --MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN
TH_3681|M.thermoresistible__bu --IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG-
Mflv_2106|M.gilvum_PYR-GCK --MAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTWQTMLLPPKGN
MAV_2537|M.avium_104 --IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN
MAB_4148c|M.abscessus_ATCC_199 GPMAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV
Mb0180|M.bovis_AF2122/97 TSGPSAVYSPASGELVGPDGVKYAVAN--SSTTGDDGWKEMLAPAS--
MLBr_02594|M.leprae_Br4923 SGPPSAVYSPQSGELVGPDGVAYAVEN--STKTGDDGWKEMLAPAG--
. * ::