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ERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVASGGLYQNANVTFRGVQIGRVTDVE LTPEGVTATMRLNDNVKVPGNVVAAVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTL LRQADGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTKLIDQVGPLLDAQI RSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYN KSIEQSLVILPALFSALLTVAGGAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPRDMY CKTAQNDPSAVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSNPWRGPPAPYDTPVEDPRNILPPNKF PNIPPGAEPDPGTPTLPPPSPPAPEVPPAGGDVMPVSAQSGPMAARAYDPKNGVFLDANNQPSVYAPALD RGTEAETWADLMLGPKPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4148c | - | - | 100% (509) | MCE-family protein |
| M. abscessus ATCC 19977 | MAB_4594c | - | 2e-22 | 26.42% (424) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1700 | - | 1e-21 | 25.54% (368) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 1e-176 | 55.69% (562) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_1561 | - | 1e-175 | 56.03% (564) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 1e-176 | 55.69% (562) | MCE-family protein MCE4F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-80 | 35.50% (524) | putative secreted protein |
| M. marinum M | MMAR_4982 | mce4F | 1e-176 | 55.56% (558) | MCE-family protein Mce4F |
| M. avium 104 | MAV_0953 | - | 6e-94 | 40.59% (478) | mce-family protein mce1f |
| M. smegmatis MC2 155 | MSMEG_5895 | - | 1e-177 | 56.23% (562) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_1738 | - | 1e-161 | 53.10% (548) | MCE-FAMILY PROTEIN MCE4F |
| M. ulcerans Agy99 | MUL_4057 | mce4F | 1e-175 | 55.02% (558) | MCE-family protein Mce4F |
| M. vanbaalenii PYR-1 | Mvan_5197 | - | 1e-175 | 54.71% (563) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
Rv3494c|M.tuberculosis_H37Rv MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
MMAR_4982|M.marinum_M MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
MUL_4057|M.ulcerans_Agy99 MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
Mflv_1561|M.gilvum_PYR-GCK MLDRLTRIQLSIFAIVTVLSVGAVALFYLHVPAAVGIGAYNVTANFVAGG
Mvan_5197|M.vanbaalenii_PYR-1 MLDRLTRLQLMIFAIVTVLSVGAVSLFYLHVPSAVGIGAYNVTANFVAGG
MSMEG_5895|M.smegmatis_MC2_155 MIDRLTRLQLTIFAIVTVFTVGAISLFYLQLPAAVGIGTYHVNANFVAGG
MAB_4148c|M.abscessus_ATCC_199 -MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVASG
TH_1738|M.thermoresistible__bu MLSRLVRMQLAVFTAVALISVLAIAVFYIQVPKTLGFGSYRVTADFAGSG
MLBr_02594|M.leprae_Br4923 MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSATG
MAV_0953|M.avium_104 MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPATG
: : : ** :* : : : ::*:: * .*:* :. :: . *
Mb3524c|M.bovis_AF2122/97 GLYKNANVTYRGVAVGRVESVGLNPN-GVTAHMRLNSGTAIPSNVTATVR
Rv3494c|M.tuberculosis_H37Rv GLYKNANVTYRGVAVGRVESVGLNPN-GVTAHMRLNSGTAIPSNVTATVR
MMAR_4982|M.marinum_M GLYKNANVTYRGVAVGRVESVGLNPN-GVTAQMRLNSGTAIPSNVTATVK
MUL_4057|M.ulcerans_Agy99 GLYKNANVTYRGVAVGRVESVGLNPN-GVTAQMRLNSGTAIPSNVTATVK
Mflv_1561|M.gilvum_PYR-GCK GIYQNANVTYRGVTIGHVESVGLSDN-SVVARMQLNSDTPVPENVTATVK
Mvan_5197|M.vanbaalenii_PYR-1 GIYQNANVTYRGVTIGHVKSVGLSDT-GVVAHMQLNSGTPVPENVTATVK
MSMEG_5895|M.smegmatis_MC2_155 GIYPNANVTYRGVTVGRVESVGLAPD-GVVAKMRLNSNTSIPENVTATVK
MAB_4148c|M.abscessus_ATCC_199 GLYQNANVTFRGVQIGRVTDVELTPE-GVTATMRLNDNVKVPGNVVAAVK
TH_1738|M.thermoresistible__bu GIYPNANVAYRGTTIGKVTGVSLTHDNDVRVEMRIDDDRKVPANVNAYVK
MLBr_02594|M.leprae_Br4923 GLYPTANVTYRGIAIGKVTDVEPTAT-GAEATMSIDSRYKIPIDSAANVH
MAV_0953|M.avium_104 GLYRFSNVTYRGVQLGKVTAVGLTPS-GVKATLSLSTSPKVPADLTAEVL
*:* :**::** :*:* * .. . : :. :* : * *
Mb3524c|M.bovis_AF2122/97 SVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETL
Rv3494c|M.tuberculosis_H37Rv SVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETL
MMAR_4982|M.marinum_M SVSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETL
MUL_4057|M.ulcerans_Agy99 SMSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETL
Mflv_1561|M.gilvum_PYR-GCK SVSAIGEQYIDLVPPEDASQQMLRDGSDIGLDRTAIGQDIAGLLAEADTL
Mvan_5197|M.vanbaalenii_PYR-1 SVSAIGEQYIDLVPPQEASDATLRDGSDIGVDRTAIGQDIAGLLAEAENL
MSMEG_5895|M.smegmatis_MC2_155 SVSAVGEQYIDLVPPDDTHVGKLRNGATIAQENTRVGQDISGLLHEADTL
MAB_4148c|M.abscessus_ATCC_199 SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
TH_1738|M.thermoresistible__bu SMSAIGEQYVDLVPPEHASTESLRGGSHIGRDRTFINGDIAGMLREAQAL
MLBr_02594|M.leprae_Br4923 SVSAVGEQYLDLVSSGNPG-KYLAPGQTITK--SKIPIEIGPALDSVNRG
MAV_0953|M.avium_104 SVSAVGEQYVDLRPRTNSP-PYLHDGSVIAMRDTKIPQPVGPMLDQVNAL
*:**:****:** . * * * : : :. * ..:
Mb3524c|M.bovis_AF2122/97 LGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQ
Rv3494c|M.tuberculosis_H37Rv LGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQ
MMAR_4982|M.marinum_M VNSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQ
MUL_4057|M.ulcerans_Agy99 VNSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQ
Mflv_1561|M.gilvum_PYR-GCK VQSVSDSRLQELLDETFTAFNGSGPELARLIQSSRLLVDEANANYPQVAQ
Mvan_5197|M.vanbaalenii_PYR-1 VQSVSNSRLQDLLSETFKAFNGSGPELARLIQSSRLLVDEANANYPEVSQ
MSMEG_5895|M.smegmatis_MC2_155 VSSVSNTRLQDLLRETFKAFNGSGPELARLIESSRLLIDEANANFPQTSQ
MAB_4148c|M.abscessus_ATCC_199 VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
TH_1738|M.thermoresistible__bu VDSLDRSRLRDVLKETFAAFNGSGPELARLLESSRLLVEEAGDATDDTIG
MLBr_02594|M.leprae_Br4923 LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
MAV_0953|M.avium_104 VQSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRA
: :: :: .:* *: . .* * * *:.*:: : .
Mb3524c|M.bovis_AF2122/97 LIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGAPDA
Rv3494c|M.tuberculosis_H37Rv LIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLADAPDA
MMAR_4982|M.marinum_M LIDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDA
MUL_4057|M.ulcerans_Agy99 LIDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDA
Mflv_1561|M.gilvum_PYR-GCK LIDQAGPFLDAQIRSGDDIRSLAEGLGRLTTEVAGADPQLRTTLQTVPGA
Mvan_5197|M.vanbaalenii_PYR-1 LIDQAGPFLDAQIRSGDDIRSLAEGLGRLTTEVADADPQLRTTLQTVPGT
MSMEG_5895|M.smegmatis_MC2_155 LIDQAGPFLEAQLRSGDDIRSLADGLARLTGEVNNADPQLRTTLRTAPGT
MAB_4148c|M.abscessus_ATCC_199 LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
TH_1738|M.thermoresistible__bu LVEQSQPLLDAQVTAGDDIRAVADGLARLTSHLREADPQFREVLQKAPAA
MLBr_02594|M.leprae_Br4923 IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
MAV_0953|M.avium_104 LTEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPET
: :: *:*::* : . *. . .: :: * :: * . :
Mb3524c|M.bovis_AF2122/97 IDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAI
Rv3494c|M.tuberculosis_H37Rv IDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAI
MMAR_4982|M.marinum_M IDEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAI
MUL_4057|M.ulcerans_Agy99 IDEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAI
Mflv_1561|M.gilvum_PYR-GCK AEVANETFDGIRPSFPMLAANLANFGRIGVIYNKSLEHALVVFPALLAAL
Mvan_5197|M.vanbaalenii_PYR-1 AEVVNETFDGIRPSFPMLAANLANFGRIGVIYHKSLEHALVVFPALLAAL
MSMEG_5895|M.smegmatis_MC2_155 TEAANTAFSGIRPSFPILAANLANFGRIGVIYSKSLEQALVIFPALMAAL
MAB_4148c|M.abscessus_ATCC_199 SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
TH_1738|M.thermoresistible__bu ADQATTLFDGIRPTFPVLAANLANAGRIGVIYHKSIEQVLVIIPAVTAAI
MLBr_02594|M.leprae_Br4923 ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIA
MAV_0953|M.avium_104 ANEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIE
: .. : :: ::* *.: : * .:*: **.:* :
Mb3524c|M.bovis_AF2122/97 ITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
Rv3494c|M.tuberculosis_H37Rv ITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
MMAR_4982|M.marinum_M TTAAGGVPQDEGAKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
MUL_4057|M.ulcerans_Agy99 TTAAGGVPQDEGAKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
Mflv_1561|M.gilvum_PYR-GCK NTVAGGVPTDEGGKLDFKIHLQDPPPCATGFIPATQIRSPADTTLRELPT
Mvan_5197|M.vanbaalenii_PYR-1 NTVAGGVPTDEGGKLDFKIHLQDPPPCSTGFVPATQIRSPADTTLRELPT
MSMEG_5895|M.smegmatis_MC2_155 NTVAGGVPSDEGGKLDFKIDLGDPPPCSVGFLPATEIRSPADTTLRDLPT
MAB_4148c|M.abscessus_ATCC_199 LTVAGGAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPR
TH_1738|M.thermoresistible__bu IAIANQFPADEGAKGDFKLNFGDPPPCITGFVPPSEIRSPADTTLRDVPK
MLBr_02594|M.leprae_Br4923 QTASAT-FPN-MAALDLALSINQPPPCLTGFIPAAEWRSPADTSLQPLPV
MAV_0953|M.avium_104 QAAAAPNHPEGTAQGDFALTIDDPPICTVGFMPPNTWRSPDDLSDIDTPD
: : : . *: : : :** * .**:*. *:* * : *
Mb3524c|M.bovis_AF2122/97 DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTN-
Rv3494c|M.tuberculosis_H37Rv DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTN-
MMAR_4982|M.marinum_M DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYVPVGRN-
MUL_4057|M.ulcerans_Agy99 DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYFPVGRN-
Mflv_1561|M.gilvum_PYR-GCK DLYCKVPQNDPS-VVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPLGSN-
Mvan_5197|M.vanbaalenii_PYR-1 DLYCKVPQSDPS-VVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGNN-
MSMEG_5895|M.smegmatis_MC2_155 DLYCKTAQNDPA-VVRGARNYPCQEFPGKRAPTVQLCRDPNGYVPIGSN-
MAB_4148c|M.abscessus_ATCC_199 DMYCKTAQNDPS-AVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSN-
TH_1738|M.thermoresistible__bu ELYCKVPHNDPA-VVRGARNYPCMEFPGKRAATVQQCRDPEGYVPIGSN-
MLBr_02594|M.leprae_Br4923 GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTN-
MAV_0953|M.avium_104 GLYCKLPQDSPL-SVRGARNYPCMGHPGKRAPTVEICNSDQPFMPLAMKQ
*** . . . ***:** ** *****.: . *.. . :.*:. :
Mb3524c|M.bovis_AF2122/97 ----PWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPP
Rv3494c|M.tuberculosis_H37Rv ----PWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPP
MMAR_4982|M.marinum_M ----PWRGPPVPYDTPVTDGLNVLPPNKFPYIPPDSDPDPGTPIVGPPPP
MUL_4057|M.ulcerans_Agy99 ----PWRGPPVPYDTPVTDGLNVLPPNKFPYIPPDSDPDPGTPIVGPPPP
Mflv_1561|M.gilvum_PYR-GCK ----PWRGPPVPVGTPVQDGRNILPPNKFPMIPPQVDPDPGPPSVQLPP-
Mvan_5197|M.vanbaalenii_PYR-1 ----PWRGPPVPVGTPIQDGRNILPPNKFPMIPPQVDPDPGPPSVQLPP-
MSMEG_5895|M.smegmatis_MC2_155 ----PWRGPPVPYGQPIEDGRNILPPNKFPMIPPQVDPDPGPPVVQLPP-
MAB_4148c|M.abscessus_ATCC_199 ----PWRGPPAPYDTPVEDPRNILPPNKFPNIPPGAEPDPGTPTLPPPS-
TH_1738|M.thermoresistible__bu ----PWRGPPVPVGTPITDPRMILPQNKYPYIPPQADYDPGPPVVQLPP-
MLBr_02594|M.leprae_Br4923 ----PWFGDPNQLLTCPAPGARCDQ-----------PVKPGLVIP-APTV
MAV_0953|M.avium_104 HVLGPYPLDPNLLAQGVPPDDRVTVNDRIFGPVEGTPLPPGAVPRGAPAG
*: * ** *.
Mb3524c|M.bovis_AF2122/97 GQVAGPGPAPHQPAQPAPPPNDNGP-PPPFTSWMPPG--YPPEPPQVPYP
Rv3494c|M.tuberculosis_H37Rv GQVAGPGPAPHQPAQPAPPPNDNGP-PPPFTSWMPPG--YPPEPPQVPYP
MMAR_4982|M.marinum_M GVIPGPPPAPNQPAQPAPPPNDNGP-PPPFTSWMPPD--YPPQAPQIPYP
MUL_4057|M.ulcerans_Agy99 GVIPGPPPAPNQPAQPAPPPNDNGP-PPPFTSWMPPD--YPPQAPQIPYP
Mflv_1561|M.gilvum_PYR-GCK GVTPGPGPAPHAPFPLPTPPNEQGPQPAPWPYFSPPDHVVPPYGRPPLAP
Mvan_5197|M.vanbaalenii_PYR-1 GVAPGPGPAPHAPFPLPVPPNEQGPPPPPWPYFAPPDQVVPPYGRPPLAP
MSMEG_5895|M.smegmatis_MC2_155 GVEPGPGPAPHAPFPLPVPPNTLGPPPPPLPYYAPPDQIVPPYGRTPPPP
MAB_4148c|M.abscessus_ATCC_199 ------PPAP------EVPPAGGDVMP-----------------------
TH_1738|M.thermoresistible__bu GVPPGPGPALTPPYPTQIPPVTPGPPPPPLPFQPPPDQIVPPYGRPPAPP
MLBr_02594|M.leprae_Br4923 DNGLNPAPADR------LPGTPPPVSDPLS--------------------
MAV_0953|M.avium_104 PRGENPPPGSVGAAVPPVPSSGPPALAPMSRMSADLPPIAPLDVPTPTEL
*. *
Mb3524c|M.bovis_AF2122/97 ATIPPPPPPEGTGPPPGPAPGPQPQASGPAYT---------IYDQLSGAF
Rv3494c|M.tuberculosis_H37Rv ATIPPPPPPEGTGPPPGPAPGPQPQASGPAYT---------IYDQLSGAF
MMAR_4982|M.marinum_M KTLPPPPPPVGVGP----EPGPQPQASGPAYT---------TYDPLTGVF
MUL_4057|M.ulcerans_Agy99 KTLPPPPPPVGVGP----EPGPQPQASGPAYT---------TYDPLTGVF
Mflv_1561|M.gilvum_PYR-GCK PPAPGPAPAPAPAPGAPPLPAEAPLASSTSVA---------TYDHN-GKF
Mvan_5197|M.vanbaalenii_PYR-1 PPAP-PAPAPAPAEGSPALPAEAPLASGTSVA---------TYDQN-GKF
MSMEG_5895|M.smegmatis_MC2_155 AGAPAPPPPAPPAPEG-ALPAEAPLAAPAGIG---------TYDQHSGVF
MAB_4148c|M.abscessus_ATCC_199 ---------------------VSAQSGPMAAR---------AYDPKNGVF
TH_1738|M.thermoresistible__bu PPAE----------------GDRPQAAGVDVA---------TYDPATGKF
MLBr_02594|M.leprae_Br4923 ------QPRSGSVQCNGQQPNTCVYTPSGPPS--------AVYSPQSGEL
MAV_0953|M.avium_104 PPPPPPPAPAAPDQVDGAAPQAAPSAFAGKASKPAPSVVVAKYDPRTGRY
: *. *
Mb3524c|M.bovis_AF2122/97 ADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL----
Rv3494c|M.tuberculosis_H37Rv ADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL----
MMAR_4982|M.marinum_M KDPAGGTGIFAGGISGASSAENWVDLMLAPRTM----
MUL_4057|M.ulcerans_Agy99 KDPAGGAGIFVGGISGASSAENWVDLMLAPRTM----
Mflv_1561|M.gilvum_PYR-GCK VDPAGGVGVYAPGSDKLAPAENWVDLMLAPKQV----
Mvan_5197|M.vanbaalenii_PYR-1 VDPAGGVGVYAPGSDKLAPAENWVDLMLAPKQV----
MSMEG_5895|M.smegmatis_MC2_155 ADADGGTGVYA-GADAIAPAETWVDLMLDPRQA----
MAB_4148c|M.abscessus_ATCC_199 LDANNQPSVYAPALDRGTEAETWADLMLGPKPV----
TH_1738|M.thermoresistible__bu LDPHTGISVYASGIAAPSIAENWVDLMTYPRTGSEPA
MLBr_02594|M.leprae_Br4923 VGPD-GVAYAVEN-STKTGDDGWKEMLAPAG------
MAV_0953|M.avium_104 VGPD-GKLYQQSDLVTPKAPKTWKDMLPT--------
.. . * :::